{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T07:33:47Z","timestamp":1774510427772,"version":"3.50.1"},"reference-count":211,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006545","name":"National Institute on Minority Health and Health Disparities","doi-asserted-by":"crossref","award":["U54 MD007582"],"award-info":[{"award-number":["U54 MD007582"]}],"id":[{"id":"10.13039\/100006545","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicines"],"abstract":"<jats:p>Cadmium (Cd) is an environmental toxicant originating from both natural processes and human activities. Cd has been strongly associated with multiple diseases, including breast cancer (BC). Background\/Objective: Environmental Cd exposure represents a significant contributor to BC onset and progression. Cd-induced breast carcinogenesis is driven by a constellation of molecular events, including DNA damage, oxidative stress (OS), and the dysregulation of key signaling pathways. These include the ERK\/JNK\/p38 MAPK cascade, the PI3K\/AKT\/mTOR axis, NF \u03baB activation, and Wnt signaling, all of which collectively promote tumor initiation, survival, and metastasis. This review underscores the complex interplay between Cd exposure and its effects on cancer-triggering factors. Methods: The complexity of the mechanisms Cd-induced BC, underlying Cd-induced BC makes it challenging to treat, highlighting the need for novel therapeutic strategies that complement or enhance conventional chemotherapy. Therefore, this review was developed by reviewing the literature and presenting the different aspects of the challenge associated with Cd exposure and BC therapy. Results: Phytochemicals, especially phenolics, alkaloids, carotenoids, terpenoids, and related plant-derived compounds, have emerged as promising candidates for mitigating Cd-induced BC. Their antioxidants, anti-estrogenic, and anti-inflammatory properties position them as potential chemopreventive and therapeutic agents capable of counteracting Cd\u2019s molecular toxicity. Conclusions: The review presents current evidence linking Cd exposure to BC development and highlights the protective potential of selected phytochemicals in preventing or attenuating Cd-induced BC. Understanding these interactions reinforces the importance of phytochemical-based interventions as a strategy to reduce Cd-related cancer risk and support breast health.<\/jats:p>","DOI":"10.3390\/medicines13020011","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T09:11:14Z","timestamp":1774429874000},"page":"11","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi-Targeted Mechanisms of Phytochemicals in Mitigating Cadmium-Induced Breast Cancer"],"prefix":"10.3390","volume":"13","author":[{"given":"Fidara F.","family":"Fidudusola","sequence":"first","affiliation":[{"name":"College of Science and Technology, Florida A&M University, Tallahassee, FL 32307, USA"},{"name":"College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health, Florida A&M University, Tallahassee, FL 32307, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline O.","family":"Odewumi","sequence":"additional","affiliation":[{"name":"College of Science and Technology, Florida A&M University, Tallahassee, FL 32307, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lekan M.","family":"Latinwo","sequence":"additional","affiliation":[{"name":"College of Science and Technology, Florida A&M University, Tallahassee, FL 32307, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oluwatobi A.","family":"Oguntunde","sequence":"additional","affiliation":[{"name":"College of Science and Technology, Florida A&M University, Tallahassee, FL 32307, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8322-8067","authenticated-orcid":false,"given":"Samia S.","family":"Messeha","sequence":"additional","affiliation":[{"name":"College of Science and Technology, Florida A&M University, Tallahassee, FL 32307, USA"},{"name":"College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health, Florida A&M University, Tallahassee, FL 32307, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0600-1085","authenticated-orcid":false,"given":"Karam F. A.","family":"Soliman","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health, Florida A&M University, Tallahassee, FL 32307, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"key":"ref_1","unstructured":"Engwa, G.A., Ferdinand, P.U., Nwalo, F.N., and Unachukwu, M.N. (2019). Heavy metal toxicity in humans. Poisoning in the Modern World: New Tricks for an Old Dog?, IntechOpen."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1080\/15376516.2019.1701594","article-title":"The effects of heavy metals on human metabolism","volume":"30","author":"Fu","year":"2020","journal-title":"Toxicol. Mech. Methods"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/bmb\/ldg032","article-title":"Hazards of heavy metal contamination","volume":"68","year":"2003","journal-title":"Br. Med. 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