{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:38:29Z","timestamp":1773923909929,"version":"3.50.1"},"reference-count":49,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T00:00:00Z","timestamp":1498262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicines"],"abstract":"<jats:p>Background: This study was planned to evaluate the efficacy of topical application of an Aloe vera-based cream (AVC) for the prevention of ionizing radiation (X ray)-induced dermatitis in head and neck cancer patients requiring therapeutic radiation treatment (&gt;62 Gy). Methods: From July 2012 to December 2012, a total of 60 head and neck cancer patients requiring curative radiotherapy (RT) of more than 66 Gy were prospectively enrolled and treated with AVC or a comparator Johnson\u2019s Baby Oil (JBO). Acute skin reaction was monitored and classified according to the Radiation Therapy Oncology Group (RTOG) four-point rating scale on a weekly basis. Results: The results indicate that there was a statistically significant delay in the incidence (p = 0.04) of dermatitis at week three in the AVC application group. Application of AVC reduced the incidence of Grade 1, 2, and 3 dermatitis at subsequent time points, while Grade 4 dermatitis was not seen in either cohort. The other most important observation was that the continued application of AVC two weeks after the completion of RT was effective in reducing the average grade of dermatitis and was statistically significant (p &lt; 0.02). Conclusions: Prophylactic use of an AVC-based cream is thus effective in delaying radiation dermatitis in head and neck cancer.<\/jats:p>","DOI":"10.3390\/medicines4030044","type":"journal-article","created":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T02:58:05Z","timestamp":1498532285000},"page":"44","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["An Aloe Vera-Based Cosmeceutical Cream Delays and Mitigates Ionizing Radiation-Induced Dermatitis in Head and Neck Cancer Patients Undergoing Curative Radiotherapy: A Clinical Study"],"prefix":"10.3390","volume":"4","author":[{"given":"Suresh","family":"Rao","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Mangalore Institute of Oncology, Mangalore 575002, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanath","family":"Hegde","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Mangalore Institute of Oncology, Mangalore 575002, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manjeshwar","family":"Baliga-Rao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Division, Mangalore Institute of Oncology, Mangalore 575002, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Princy","family":"Palatty","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Father Muller Medical College, Kankanady, Mangalore 575002; India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"George","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Father Muller Medical College, Kankanady, Mangalore 575002; India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manjeshwar","family":"Baliga","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Mangalore Institute of Oncology, Mangalore 575002, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,6,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","unstructured":"World Health Organization (WHO) (2005). Oral Health Programme: Global Data on Incidence of Oral Cancer, WHO."},{"key":"ref_3","unstructured":"De Vita, V.T., Lawrence, T.S., and Rosenberg, S.A. (2004). Cancer: Principles & Practice of Oncology, Lippincott Williams & Wilkins. [8th ed.]."},{"key":"ref_4","first-page":"419","article-title":"Induction chemotherapy followed by concomitant chemoradiation therapy in advanced head and neck cancer: A phase II study for organ-sparing purposes evaluating feasibility, effectiveness and toxicity","volume":"20","author":"Mantovani","year":"2002","journal-title":"Int. J. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0140-6736(00)90011-4","article-title":"Chemotherapy added to locoregional treatment for head and neck squamous cell carcinoma: Three meta analyses of updated individual data. MACHNC Collaborative Group. Meta Analysis of Chemotherapy on Head and Neck Cancer","volume":"355","author":"Pignon","year":"2000","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3747\/co.v17i4.493","article-title":"Prophylaxis and management of acute radiation-induced skin reactions: A systematic review of the literature","volume":"17","author":"Salvo","year":"2010","journal-title":"Curr. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1017\/S1460396900000133","article-title":"Intervention for acute radiotherapy induced skin reactions in cancer patients: The development of a clinical guideline recommended for use by the college of radiographers","volume":"2","author":"Glean","year":"2001","journal-title":"J. Radiother Pract."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"20130490","DOI":"10.1259\/bjr.20130490","article-title":"Topical application of a sandal wood oil and turmeric based cream prevents radiodermatitis in head and neck cancer patients undergoing external beam radiotherapy: A pilot study","volume":"87","author":"Palatty","year":"2014","journal-title":"Br. J. Radiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jaad.2005.08.054","article-title":"Radiation dermatitis: Clinical presentation, pathophysiology, and treatment 2006","volume":"54","author":"Hymes","year":"2006","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.12968\/bjon.1999.8.17.6503","article-title":"Radiation-induced reactions 1: An examination of the phenomenon","volume":"8","year":"1999","journal-title":"Br. J. Nurs."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.12968\/bjon.1999.8.18.6490","article-title":"Radiation-induced reactions 2: Development of a measurement tool","volume":"8","year":"1999","journal-title":"Br. J. Nurs."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1007\/s00520-006-0063-4","article-title":"Supportive Care Guidelines Group of Cancer Care Ontario Program in Evidence-Based Care. The prevention and management of acute skin reactions related to radiation therapy: A systematic review and practice guideline","volume":"14","author":"Bolderston","year":"2006","journal-title":"Support. Care Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.2146\/ajhp120467","article-title":"Prevention and management of radiation-induced dermatitis, mucositis, and xerostomia","volume":"70","author":"Radvansky","year":"2013","journal-title":"Am. J. Health Syst. Pharm."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/S0360-3016(00)00782-3","article-title":"Randomized phase III study comparing Best Supportive Care to Biafine as a prophylactic agent for radiation-induced skin toxicity for women undergoing breast irradiation: Radiation Therapy Oncology Group (RTOG)","volume":"48","author":"Fisher","year":"2000","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_15","first-page":"543","article-title":"The effect of Aloe vera gel\/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy","volume":"28","author":"Olsen","year":"2001","journal-title":"Oncol. Nurs. Forum."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1097\/00002820-200212000-00007","article-title":"A Phase III study on the efficacy of topical Aloe vera gel on irradiated breast tissue","volume":"25","author":"Heggie","year":"2002","journal-title":"Cancer Nurs."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00066-011-2204-z","article-title":"Topical use of a silymarin-based preparation to prevent radiodermatitis: Results of a prospective study in breast cancer patients","volume":"187","author":"Mengs","year":"2011","journal-title":"Strahlenther Onkol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1200\/JCO.2004.07.063","article-title":"Phase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer","volume":"22","author":"Pommier","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Watson, R.R., and Zibadi, S. (2013). Review on the Use of Aloe vera (Aloe) in Dermatology, Springer. Bioactive Dietary Factors and Plant Extracts in Dermatology.","DOI":"10.1007\/978-1-62703-167-7"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1159\/000114871","article-title":"Investigation of the anti-inflammatory potential of Aloe vera gel (97.5%) in the ultraviolet erythema test","volume":"21","author":"Reuter","year":"2008","journal-title":"Skin Pharmacol. Physiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/1523-1747.ep12371762","article-title":"Prevention of ultraviolet radiation-induced suppression of contact and delayed hypersensitivity by Aloe barbadensis gel extract","volume":"102","author":"Strickland","year":"1994","journal-title":"J. Investig. Dermatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1177\/1534735407309079","article-title":"Chemopreventive potential of Aloe vera against 7,12-dimethylbenz(a)anthracene induced skin papillomagenesis in mice","volume":"6","author":"Chaudhary","year":"2007","journal-title":"Integr. Cancer Ther."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1615\/JEnvironPatholToxicolOncol.v29.i2.60","article-title":"Anti-tumor activity of Aloe vera against DMBA\/croton oil-induced skin papillomagenesis in Swiss albino mice","volume":"29","author":"Saini","year":"2010","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"6","DOI":"10.5021\/ad.2009.21.1.6","article-title":"Dietary Aloe vera Supplementation Improves Facial Wrinkles and Elasticity and It Increases the Type I Procollagen Gene Expression in Human Skin in vivo","volume":"21","author":"Cho","year":"2009","journal-title":"Ann. Dermatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/j.1468-3083.2004.01186.x","article-title":"A double-blind, placebo-controlled study of a commercial Aloe vera gel in the treatment of slight to moderate psoriasis vulgaris","volume":"19","author":"Paulsen","year":"2005","journal-title":"J. Eur. Acad. Dermatol Venereol."},{"key":"ref_26","first-page":"403","article-title":"Effect of Aloe vera gel to healing of burn wound a clinical and histologic study","volume":"78","author":"Visuthikosol","year":"1995","journal-title":"J. Med. Assoc. Thai."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1200\/JCO.1984.2.3.187","article-title":"Karnofsky performance status revisited: Reliability, validity, and guidelines","volume":"2","author":"Schag","year":"1984","journal-title":"J. Clin. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1177\/1534735413503549","article-title":"The Indian Spice Turmeric Delays and Mitigates Radiation-Induced Oral Mucositis in Patients Undergoing Treatment for Head and Neck Cancer: An Investigational Study","volume":"5","author":"Rao","year":"2014","journal-title":"Integr. Cancer Ther."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/0360-3016(95)00060-C","article-title":"Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC)","volume":"31","author":"Cox","year":"1995","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.soncn.2006.04.004","article-title":"Evidence-based skin care management in radiation therapy","volume":"22","author":"McQuestion","year":"2006","journal-title":"Sem. Oncol. Nurs."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/jid.2011.411","article-title":"Ionizing radiation: The good, the bad, and the ugly","volume":"132","author":"Ryan","year":"2012","journal-title":"J. Investig. Dermatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1667\/RR3031.1","article-title":"Cytokines in radiobiological responses: A review","volume":"178","author":"Schaue","year":"2012","journal-title":"Radiat. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"323","DOI":"10.18388\/abp.2012_2116","article-title":"NF-\u03baB signaling pathway and free radical impact","volume":"59","author":"Siomek","year":"2012","journal-title":"Acta Biochim. Pol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1055\/s-0031-1298453","article-title":"Anticancer potential of aloes: Antioxidant, antiproliferative, and immunostimulatory attributes","volume":"78","author":"Harlev","year":"2012","journal-title":"Planta Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jphotobiol.2014.02.019","article-title":"Anti-inflammatory and antioxidant effects of Aloe saponaria Haw in a model of UVB-induced paw sunburn in rats","volume":"5","author":"Silva","year":"2014","journal-title":"J. Photochem. Photobiol. B."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1248\/yakushi1947.115.1_24","article-title":"Studies on chemical radioprotectors against X-irradiation used by soft X-ray accelerator","volume":"115","author":"Shinoda","year":"1995","journal-title":"Yakugaku Zasshi"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1615\/JEnvironPatholToxicolOncol.v28.i1.60","article-title":"Radioprotective effects of Aloe vera leaf extract on Swiss albino mice against whole-body gamma irradiation","volume":"28","author":"Goyal","year":"2009","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/ptr.938","article-title":"Aloe arborescens extract inhibits TPA-induced ear oedema, putrescine increase and tumour promotion in mouse skin","volume":"16","author":"Shimpo","year":"2002","journal-title":"Phytother Res."},{"key":"ref_39","first-page":"801","article-title":"Early and late radiation-induced skin alterations. Part I: Mechanism of skin changes","volume":"19","author":"Sitton","year":"1992","journal-title":"Oncol. Nurs. Forum."},{"key":"ref_40","first-page":"239","article-title":"Effects of Aloe vera on leukocyte adhesion and TNF-alpha and IL-6 levels in burn wounded rats","volume":"29","author":"Duansak","year":"2003","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.molimm.2013.05.005","article-title":"Aloe vera downregulates LPS-induced inflammatory cytokine production and expression of NLRP3 inflammasome in human macrophages","volume":"56","author":"Budai","year":"2013","journal-title":"Mol. Immunol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jep.2008.08.008","article-title":"Preliminary evaluation: The effects of Aloe ferox Miller and Aloe arborescens Miller on wound healing","volume":"120","author":"Jia","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0378-8741(97)00112-8","article-title":"Influence of Aloe vera on the glycosaminoglycans in the matrix of healing dermal wounds in rats","volume":"59","author":"Chithra","year":"1998","journal-title":"J. Ethnopharmacol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1023\/A:1006813510959","article-title":"Influence of Aloe vera on collagen characteristics in healing dermal wounds in rats","volume":"181","author":"Chithra","year":"1998","journal-title":"Mol. Cell Biochem."},{"key":"ref_45","first-page":"896","article-title":"Influence of Aloe vera on collagen turnover in healing of dermal wounds in rats","volume":"36","author":"Chithra","year":"1998","journal-title":"Indian J. Exp. Biol."},{"key":"ref_46","first-page":"2","article-title":"Effect of aloe cream versus silver sulfadiazine for healing burn wounds in rats","volume":"18","author":"Hosseinimehr","year":"2010","journal-title":"Acta Dermatovenerol Croat."},{"key":"ref_47","first-page":"362","article-title":"The effects of aloe extract on nitric oxide and endothelin levels in deep-partial thickness burn wound tissue in rat","volume":"22","author":"Lv","year":"2006","journal-title":"Zhonghua Shao Shang Za Zhi"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/0360-3016(94)00467-Y","article-title":"Acemannan-containing wound dressing gel reduces radiation-induced skin reactions in C3H mice","volume":"32","author":"Roberts","year":"1995","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.amjsurg.2010.06.017","article-title":"Aloe vera oral administration accelerates acute radiation-delayed wound healing by stimulating transforming growth factor-\u03b2 and fibroblast growth factor production","volume":"201","author":"Atiba","year":"2011","journal-title":"Am. J. Surg."}],"container-title":["Medicines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2305-6320\/4\/3\/44\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:40:16Z","timestamp":1760208016000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2305-6320\/4\/3\/44"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,24]]},"references-count":49,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,9]]}},"alternative-id":["medicines4030044"],"URL":"https:\/\/doi.org\/10.3390\/medicines4030044","relation":{},"ISSN":["2305-6320"],"issn-type":[{"value":"2305-6320","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,24]]}}}