{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T07:46:55Z","timestamp":1791013615552,"version":"4.1.0"},"reference-count":60,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T00:00:00Z","timestamp":1507680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicines"],"abstract":"<jats:p>Background: Ocimum gratissimum (OG) is used in the traditional management of diabetes in Nigeria. This study investigated the anti-diabetic potential of OG leaf fractions (OGLF) in a rat model of Type-2 diabetes (T2D). Method: Methanol crude extract of OG leaf was fractionated with solvents of increasing order of polarity (n-hexane, chloroform, ethyl-acetate, n-butanol and water). The anti-diabetic potential of the fractions was evaluated in vivo. T2D was induced in Albino Wistar rats and treated with OGLF. Result: The T2D rats showed significant elevation in serum levels of fasting blood glucose (FBG), liver and kidney function biomarkers. At 4-weeks of intervention with OGLF, the untreated diabetic control group maintained severe hyperglycaemia in the presence of 61.7% serum insulin, 17.3% pancreatic \u03b2-cell function (HOMA-\u03b2) and 51.5% Insulin sensitivity. The glucose tolerance ability was enhanced in the n-butanol-fraction (OGb) treated group. With 74.8% available serum insulin and 38.6% improvement in insulin sensitivity, the OGb treated group had a 63.5% reduction in FBG and it was found to be most effective as it ameliorates a majority of the changes caused in the studied parameters in diabetic rats. Conclusions: The data from this study suggest that OGb fraction is a potential candidate for the development of an effective drug for the management of T2D.<\/jats:p>","DOI":"10.3390\/medicines4040073","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T12:17:47Z","timestamp":1507724267000},"page":"73","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Anti-Diabetic Potential of Ocimum gratissimum Leaf Fractions in Fortified Diet-Fed Streptozotocin Treated Rat Model of Type-2 Diabetes"],"prefix":"10.3390","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3542-495X","authenticated-orcid":false,"given":"Stanley","family":"Okoduwa","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Ahmadu Bello University, Zaria 811104, Nigeria"},{"name":"Directorate of Research and Development, Nigerian Institute of Leather and science Technology, Zaria 810221, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isamila","family":"Umar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Ahmadu Bello University, Zaria 811104, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorcas","family":"James","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Ahmadu Bello University, Zaria 811104, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajiya","family":"Inuwa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Ahmadu Bello University, Zaria 811104, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,10,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"American Diabetes Association (ADA) (2014). 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