{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T16:13:33Z","timestamp":1773332013875,"version":"3.50.1"},"reference-count":48,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T00:00:00Z","timestamp":1528156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["CAPES\/MES 183\/12"],"award-info":[{"award-number":["CAPES\/MES 183\/12"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicines"],"abstract":"<jats:p>Background: Leishmaniasis is a complex protozoa disease caused by Leishmania genus (Trypanosomatidae family). Currently, there have been renewed interests worldwide in plants as pharmaceutical agents. In this study, the in vivo efficacy of Solanum spp. is assessed in an L. amazonensis BALB\/c mice model for experimental cutaneous leishmaniasis. Methods: Animals were infected with 5 \u00d7 106 metacyclic promastigotes and 30-day post-infection, a treatment with 30 mg\/kg of Solanum extracts or Glucantime\u00ae (GTM) was applied intralesionally every four days to complete 5 doses. Results: Neither death nor loss of weight higher than 10% was observed. All the tested extracts were able to control the infection, compared with the infected and untreated group. Solanum havanense Jacq. extract showed the highest efficacy and was superior (p &lt; 0.05) to GTM. Solanum myriacanthum Dunal., S. nudum Dunal. and S. seaforthianum Andr. extracts demonstrated a similar effect (p &gt; 0.05) to GTM. An increase of IFN-\u03b3 (p &lt; 0.05) was displayed only by animals treated with S. nudum compared to the group treated with a vehicle, while no differences (p &gt; 0.05) were observed for IL-12. Conclusions: In vivo effects of Solanum extracts were demonstrated, suggesting that this genus could be further explored as a new antileishmanial alternative.<\/jats:p>","DOI":"10.3390\/medicines5020049","type":"journal-article","created":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T06:25:52Z","timestamp":1528179952000},"page":"49","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of Four Solanum spp. Extracts in an Animal Model of Cutaneous Leishmaniasis"],"prefix":"10.3390","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4361-8911","authenticated-orcid":false,"given":"Paul","family":"Cos","sequence":"first","affiliation":[{"name":"Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, 2000 Antwerpen, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo","family":"Janssens","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, 2000 Antwerpen, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abel","family":"Pi\u00f1\u00f3n","sequence":"additional","affiliation":[{"name":"Parasitology Department, Institute of Tropical Medicine \u201cPedro Kouri\u201d, Havana 10400, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osmany","family":"Cuesta-Rubio","sequence":"additional","affiliation":[{"name":"Academic Unit of Chemical Sciences and Health, Technical University of Machala, Machala 070101, Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arianna","family":"Yglesias-Rivera","sequence":"additional","affiliation":[{"name":"Research Department, Laboratories of Biopharmaceuticals and Chemistries Productions (LABIOFAM), Havana 10400, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"D\u00edaz-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Research Department, Laboratories of Biopharmaceuticals and Chemistries Productions (LABIOFAM), Havana 10400, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3032-2556","authenticated-orcid":false,"given":"Wagner","family":"Vilegas","sequence":"additional","affiliation":[{"name":"UNESP\u2014S\u00e3o Paulo State University, Coastal Campus of S\u00e3o Vicente, S\u00e3o Paulo 19014-020, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianet","family":"Monzote","sequence":"additional","affiliation":[{"name":"Parasitology Department, Institute of Tropical Medicine \u201cPedro Kouri\u201d, Havana 10400, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,6,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/bmb\/ldp046","article-title":"Neglected tropical diseases","volume":"93","author":"Feasey","year":"2010","journal-title":"Br. 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