{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:15:38Z","timestamp":1790007338542,"version":"4.0.1"},"reference-count":68,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T00:00:00Z","timestamp":1551312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicines"],"abstract":"<jats:p>Dental caries and periodontal disease are two major diseases in the dentistry. As the society is aging, their pathological meaning has been changing. An increasing number of patients are displaying symptoms of systemic disease and so we need to pay more attention to immunologic aggression in our medical treatment. For this reason, we focused on natural products. Kampo consists of natural herbs\u2014roots and barks\u2014and has more than 3000 years of history. It was originated in China as traditional medicine and introduced to Japan. Over the years, Kampo medicine in Japan has been formulated in a way to suit Japan\u2019s natural features and ethnic characteristics. Based on this traditional Japanese Kampo medicine, we have manufactured a Kampo gargle and Mastic Gel dentifrice. In order to practically utilize the effectiveness of mastic, we have developed a dentifrice (product name: IMPLA CARE) and treated implant periodontitis and severe periodontitis.<\/jats:p>","DOI":"10.3390\/medicines6010034","type":"journal-article","created":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T03:29:21Z","timestamp":1551410961000},"page":"34","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Kampo Therapies and the Use of Herbal Medicines in the Dentistry in Japan"],"prefix":"10.3390","volume":"6","author":[{"given":"Shuji","family":"Watanabe","sequence":"first","affiliation":[{"name":"Division of Microbiology, Department of Oral Science, Kanagawa Dental University, 82 Inaoka-cho, Yokosuka 238-8580, Japan"},{"name":"Odoriba Medical Center, Totsuka Green Dental Clinic, 1-10-46 Gumizawa, Totsuka-ku, Yokohama 245-0061, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshizo","family":"Toyama","sequence":"additional","affiliation":[{"name":"Division of Microbiology, Department of Oral Science, Kanagawa Dental University, 82 Inaoka-cho, Yokosuka 238-8580, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takenori","family":"Sato","sequence":"additional","affiliation":[{"name":"Division of Microbiology, Department of Oral Science, Kanagawa Dental University, 82 Inaoka-cho, Yokosuka 238-8580, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuo","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Division of Microbiology, Department of Oral Science, Kanagawa Dental University, 82 Inaoka-cho, Yokosuka 238-8580, Japan"},{"name":"Dental Design Clinic, 3-7-10 Kita-aoyama, Minato-ku, Tokyo 107-0061, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Morozumi","sequence":"additional","affiliation":[{"name":"Morozumi Dental Clinic, 1-3-1 Miyamaedaira, Miyamae-ku, Kawasaki 216-0006, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Sakagami","sequence":"additional","affiliation":[{"name":"Meikai University Research Institute of Odontology (M-RIO), 1-1 Keyakidai, Sakado, Saitama 350-0283, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobushiro","family":"Hamada","sequence":"additional","affiliation":[{"name":"Division of Microbiology, Department of Oral Science, Kanagawa Dental University, 82 Inaoka-cho, Yokosuka 238-8580, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,2,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Motoo, Y., Arai, I., and Tsutani, K. 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