{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T23:46:28Z","timestamp":1773099988226,"version":"3.50.1"},"reference-count":30,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T00:00:00Z","timestamp":1589932800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicines"],"abstract":"<jats:p>Background: The pharmacologic management of heart failure with preserved ejection fraction (HFpEF) involves far fewer options with demonstrated additional benefit. Therefore, we examined the effect of combination of multiple classes of HF medication in the 30-day hospital readmission in patients with HFpEF. Methods: All adult patients discharged with a diagnosis of HFpEF and a left ventricular ejection fraction (LVEF) of \u2265 50% reported during the admission or within the previous six months from our institution were retrospectively studied for a 30-day hospital readmission risk. Individual as well as combination drug therapy at the time of hospital discharge were evaluated using Pearson chi2 test and multivariate logistic regression. Results: The overall 30-day readmission rate in this HFpEF cohort of 445 discharges was 29%. Therapy with loop diuretics (p = 0.011), loop diuretics and angiotensin receptor blocker (p = 0.043) and loop diuretics and beta blockers (p = 0.049) were associated with a lower risk of 30-day hospital readmission. Multivariate logistic regression revealed only loop diuretics to be associated with a lower risk of hospital readmission in patients with HFpEF (OR 0.59; 95% CI, 0.39-0.90; p = 0.013). Conclusions: Our study revealed that loop diuretics at discharge decreases early readmission in patients with HFpEF. Further, our study highlights the implication of a lack of guidelines and treatment challenges in HFpEF patients and emphasizes the importance of a conservative approach in preventing early readmission in patients with HFpEF.<\/jats:p>","DOI":"10.3390\/medicines7050030","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T10:37:38Z","timestamp":1589971058000},"page":"30","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Heart Failure Drug Class Effects on 30-Day Readmission Rates in Patients with Heart Failure with Preserved Ejection Fraction: A Retrospective Single Center Study"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3816-2019","authenticated-orcid":false,"given":"Priyanka","family":"Parajuli","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL 62702, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Odalys","family":"Lara-Garcia","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL 62702, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4246-8456","authenticated-orcid":false,"given":"Manjari","family":"Regmi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL 62702, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warren","family":"Skoza","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL 62702, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mukul","family":"Bhattarai","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL 62702, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhishek","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL 62702, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6059-650X","authenticated-orcid":false,"given":"Robert","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL 62702, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e147","DOI":"10.1016\/j.jacc.2013.05.019","article-title":"2013 ACCF\/AHA guideline for the management of heart failure: A report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"62","author":"Yancy","year":"2013","journal-title":"J. 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Heart Fail."}],"container-title":["Medicines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2305-6320\/7\/5\/30\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:30:34Z","timestamp":1760175034000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2305-6320\/7\/5\/30"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,20]]},"references-count":30,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,5]]}},"alternative-id":["medicines7050030"],"URL":"https:\/\/doi.org\/10.3390\/medicines7050030","relation":{},"ISSN":["2305-6320"],"issn-type":[{"value":"2305-6320","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,20]]}}}