{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:03:42Z","timestamp":1784545422141,"version":"3.55.0"},"reference-count":61,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T00:00:00Z","timestamp":1609804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicines"],"abstract":"<jats:p>Helicobacter pylori (H. pylori) is a bacterial pathogen implicated in gastritis, gastric ulceration, and gastric carcinoma. This study aimed to synthesize literature in providing evidence on the causative role of H. pylori in gastric carcinoma development. This study is based on assessing public literature using an applied meta-analysis, namely, quantitative evidence synthesis (QES). The analytic procedure uses DerSimonian-Laird, including assessing heterogeneity. The QES also utilizes meta-regression and the environmental effect associated with H. pylori in gastric cancer development. Eighteen studies are included in the QES. There is increased prevalence of H. pylori exposure among the cases. The heterogeneity between the CES and individual effect sizes is also significant. Despite controlling for the confoundings, there is increased exposure to H. pylori among the gastric cancer cases, regardless of the differences in the geographic location. H. pylori in this synthesized literature illustrates the contributory role of this microbe in gastric carcinoma. Additionally, regardless of geographic locale, namely, South Korea or Spain, H. pylori is implicated in gastric cancer development.<\/jats:p>","DOI":"10.3390\/medicines8010001","type":"journal-article","created":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T10:35:12Z","timestamp":1609842912000},"page":"1","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Predictive Effect of Helicobacter pylori in Gastric Carcinoma Development: Systematic Review and Quantitative Evidence Synthesis"],"prefix":"10.3390","volume":"8","author":[{"suffix":"Jr.","given":"Laurens","family":"Holmes","sequence":"first","affiliation":[{"name":"Nemours Healthcare System for Children, Wilmington, DE 19803, USA"},{"name":"Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9728-2048","authenticated-orcid":false,"given":"Jasmine","family":"Rios","sequence":"additional","affiliation":[{"name":"Nemours Healthcare System for Children, Wilmington, DE 19803, USA"},{"name":"History of Science and Medicine Department, Yale University, New Haven, CT 06511, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0544-149X","authenticated-orcid":false,"given":"Betyna","family":"Berice","sequence":"additional","affiliation":[{"name":"Nemours Healthcare System for Children, Wilmington, DE 19803, USA"},{"name":"Master of Public Health, Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Davie, FL 33328, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8902-7589","authenticated-orcid":false,"given":"Jacqueline","family":"Benson","sequence":"additional","affiliation":[{"name":"Nemours Healthcare System for Children, Wilmington, DE 19803, USA"},{"name":"Master of Public Health Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nastocia","family":"Bafford","sequence":"additional","affiliation":[{"name":"Nemours Healthcare System for Children, Wilmington, DE 19803, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kadedrah","family":"Parson","sequence":"additional","affiliation":[{"name":"Nemours Healthcare System for Children, Wilmington, DE 19803, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4508-9112","authenticated-orcid":false,"given":"Daniel","family":"Halloran","sequence":"additional","affiliation":[{"name":"Nemours Healthcare System for Children, Wilmington, DE 19803, USA"},{"name":"Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e12403","DOI":"10.1111\/hel.12403","article-title":"Epidemiology of Helicobacter pylori infection","volume":"22","author":"Burucoa","year":"2017","journal-title":"Helicobacter"},{"key":"ref_2","unstructured":"Rosario, D.F. (2020, June 25). Helicobacter Pylori. Available online: https:\/\/kidshealth.org\/en\/parents\/h-pylori.htm."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1128\/CMR.00011-10","article-title":"Helicobacter pylori and gastric cancer: Factors that modulate disease risk","volume":"23","author":"Wroblewski","year":"2010","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/nrc2857","article-title":"Helicobacter pylori: Gastric cancer and beyond","volume":"10","author":"Polk","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"ref_5","first-page":"386905","article-title":"Helicobacter pylori: Genomic Insight into the Host-Pathogen Interaction","volume":"2015","author":"Haley","year":"2015","journal-title":"Int. J. Genom."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3892\/ijo.2012.1701","article-title":"pylori infection and gastric cancer: State of the art (review)","volume":"42","author":"Conteduca","year":"2013","journal-title":"Int. J. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1155\/2005\/390932","article-title":"Canadian Helicobacter Study Group Consensus Conference: Update on the approach to Helicobacter pylori infection in children and adolescents\u2014An evidence-based evaluation","volume":"19","author":"Bourke","year":"2005","journal-title":"Can. J. Gastroenterol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.micres.2018.09.011","article-title":"Helicobacter pylori evasion strategies of the host innate and adaptive immune responses to survive and develop gastrointestinal diseases","volume":"218","author":"Karkhah","year":"2019","journal-title":"Microbiol. Res."},{"key":"ref_9","first-page":"263","article-title":"Bacterial infection as a cause of cancer","volume":"103","author":"Parsonnet","year":"1995","journal-title":"Environ. Health Perspect."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00203-018-1580-5","article-title":"Status (on\/off) of oipA gene: Their associations with gastritis and gastric cancer and geographic origins","volume":"201","author":"Sallas","year":"2019","journal-title":"Arch. Microbiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1478-811X-9-26","article-title":"Helicobacter pylori vacuolating toxin A and apoptosis","volume":"9","author":"Rassow","year":"2011","journal-title":"Cell Commun. Signal."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/35073084","article-title":"Living dangerously: How Helicobacter pylori survives in the human stomach","volume":"2","author":"Montecucco","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.3748\/wjg.v17.i11.1383","article-title":"Molecular cross-talk between Helicobacter pylori and human gastric mucosa","volume":"17","author":"Ricci","year":"2011","journal-title":"World J. Gastroenterol."},{"key":"ref_14","first-page":"112","article-title":"Helicobacter pylori infection and atrophic gastritis","volume":"13","author":"Ebule","year":"2013","journal-title":"Afr. Health Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.3748\/wjg.v24.i22.2373","article-title":"Treatment of","volume":"24","author":"Lahner","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.3748\/wjg.v22.i3.1311","article-title":"Helicobacter pylori associated gastric intestinal metaplasia: Treatment and surveillance","volume":"22","author":"Liu","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"434039","DOI":"10.1155\/2015\/434039","article-title":"The Prevalence of Gastric Intestinal Metaplasia and Distribution of Helicobacter pylori Infection, Atrophy, Dysplasia, and Cancer in Its Subtypes","volume":"2015","author":"Olmez","year":"2015","journal-title":"Gastroenterol. Res. Pract."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1128\/iai.63.5.1669-1673.1995","article-title":"Helicobacter pylori requires an acidic environment to survive in the presence of urea","volume":"63","author":"Clyne","year":"1995","journal-title":"Infect. Immun."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Ansari, S., and Yamaoka, Y. (2017). Survival of Helicobacter pylori in gastric acidic territory. Helicobacter, 22.","DOI":"10.1111\/hel.12386"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"187","DOI":"10.25122\/jml-2018-0035","article-title":"MALT lymphoma: Epidemiology, clinical diagnosis and treatment","volume":"11","author":"Cuciureanu","year":"2018","journal-title":"J. Med. Life"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e7811","DOI":"10.1097\/MD.0000000000007811","article-title":"Helicobacter pylori infection, atrophic gastritis, and pancreatic cancer risk: A meta-analysis of prospective epidemiologic studies","volume":"96","author":"Liu","year":"2017","journal-title":"Medicine"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"252","DOI":"10.5144\/0256-4947.2002.252","article-title":"Hypergastrinemia and H. pylori infection as a risk factor for colorectal cancer","volume":"22","author":"Mohammad","year":"2002","journal-title":"Ann. Saudi Med."},{"key":"ref_23","first-page":"658","article-title":"Helicobacter Pylori Infection and Lung Cancer: New Insights and Future Challenges","volume":"21","author":"Araya","year":"2018","journal-title":"Zhongguo Fei Ai Za Zhi"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3389\/fmicb.2020.00090","article-title":"Gastric Damage and Cancer-Associated Biomarkers in","volume":"11","author":"George","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref_25","first-page":"121","article-title":"Infection Is Associated with Decreased Expression of SLC5A8, a Cancer Suppressor Gene, in Young Children","volume":"6","author":"Lagomarcino","year":"2016","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S1286-4579(03)00111-4","article-title":"Burden of Helicobacter pylori and H. pylori-related diseases in developed countries: Recent developments and future implications","volume":"5","author":"Rothenbacher","year":"2003","journal-title":"Microbes. Infect."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1651-2227.2009.01542.x","article-title":"Helicobacter pylori infection in children: Population-based age-specific prevalence and risk factors in a developing country","volume":"99","author":"Jafri","year":"2010","journal-title":"Acta Paediatr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s12664-010-0024-1","article-title":"The enigma of Helicobacter pylori infection and gastric cancer","volume":"29","author":"Ghoshal","year":"2010","journal-title":"Indian J. Gastroenterol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.3748\/wjg.v20.i6.1503","article-title":"Helicobacter pylori and gastric cancer: Indian enigma","volume":"20","author":"Misra","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4407","DOI":"10.3748\/wjg.v23.i24.4407","article-title":"Risk factors for metachronous gastric carcinoma development after endoscopic resection of gastric dysplasia: Retrospective, single-center study","volume":"23","author":"Moon","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1158\/1055-9965.EPI-10-1258","article-title":"Race, African ancestry, and Helicobacter pylori infection in a low-income United States population","volume":"20","author":"Epplein","year":"2011","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1757-4749-2-2","article-title":"Helicobacter pylori: A poor man\u2019s gut pathogen?","volume":"2","author":"Khalifa","year":"2010","journal-title":"Gut Pathog."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1053\/j.gastro.2019.10.019","article-title":"Risk Factors and Incidence of Gastric Cancer After Detection of Helicobacter pylori Infection: A Large Cohort Study","volume":"158","author":"Kumar","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2147\/CEG.S144967","article-title":"Ethnic\/racial differences in gastrointestinal symptoms and diagnosis associated with the risk of","volume":"11","author":"Banderas","year":"2018","journal-title":"Clin. Exp. Gastroenterol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1572-0241.2006.00885.x","article-title":"Ethnicity and H. pylori as risk factors for gastric cancer in Malaysia: A prospective case control study","volume":"102","author":"Goh","year":"2007","journal-title":"Am. J. Gastroenterol."},{"key":"ref_36","first-page":"e4846","article-title":"Rapid evolution of the","volume":"6","author":"Acevedo","year":"2018","journal-title":"PeerJ"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s11832-014-0566-3","article-title":"Treatment of unicameral bone cyst: Systematic review and meta analysis","volume":"8","author":"Kadhim","year":"2014","journal-title":"J. Child Orthop."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Holmes, L., Lim, A., Comeaux, C.R., Dabney, K.W., and Okundaye, O. (2019). DNA Methylation of Candidate Genes (ACE II, IFN-\u03b3, AGTR 1, CKG, ADD1, SCNN1B and TLR2) in Essential Hypertension: A Systematic Review and Quantitative Evidence Synthesis. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16234829"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Holmes, L., Shutman, E., Chinaka, C., Deepika, K., Pelaez, L., and Dabney, K.W. (2019). Aberrant Epigenomic Modulation of Glucocorticoid Receptor Gene (NR3C1) in Early Life Stress and Major Depressive Disorder Correlation: Systematic Review and Quantitative Evidence Synthesis. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16214280"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1002\/(SICI)1097-0258(19960630)15:12<1237::AID-SIM301>3.0.CO;2-N","article-title":"Meta-analysis in the design and monitoring of clinical trials","volume":"15","author":"DerSimonian","year":"1996","journal-title":"Stat. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control. Clin. Trials"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1007\/s005350170003","article-title":"Association between Helicobacter pylori infection and the risk of gastric cancer in the Korean population: Prospective case-controlled study","volume":"36","author":"Chang","year":"2001","journal-title":"J. Gastroenterol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"466","DOI":"10.5009\/gnl.2010.4.4.466","article-title":"Helicobacter pylori Seropositivity Is Associated with Gastric Cancer Regardless of Tumor Subtype in Korea","volume":"4","author":"Cho","year":"2010","journal-title":"Gut Liver"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3236","DOI":"10.1002\/cam4.926","article-title":"Additive interactions between PRKAA1 polymorphisms and Helicobacter pylori CagA infection associated with gastric cancer risk in Koreans","volume":"5","author":"Eom","year":"2016","journal-title":"Cancer Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/jgh.12387","article-title":"Risk factors and clinical outcomes of gastric cancer identified by screening endoscopy: A case-control study","volume":"29","author":"Gong","year":"2014","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/sj.bjc.6603309","article-title":"CagA-producing Helicobacter pylori and increased risk of gastric cancer: A nested case-control study in Korea","volume":"95","author":"Gwack","year":"2006","journal-title":"Br. J. Cancer"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/j.1523-5378.2012.00958.x","article-title":"Prevalence and clinicopathologic characteristics of gastric cardia cancer in South Korea","volume":"17","author":"Kim","year":"2012","journal-title":"Helicobacter"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1440-1746.1997.tb00391.x","article-title":"Helicobacter pylori infection and the risk of gastric cancer among the Korean population","volume":"12","author":"Kim","year":"1997","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"510","DOI":"10.3346\/jkms.2000.15.5.510","article-title":"Efficacy of screening for gastric cancer in a Korean adult population: A case-control study","volume":"15","author":"Kim","year":"2000","journal-title":"J. Korean Med. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s10654-004-1027-y","article-title":"Effect modification by vitamin C on the relation between gastric cancer and Helicobacter pylori","volume":"20","author":"Kim","year":"2005","journal-title":"Eur. J. Epidemiol."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Kim, J.H., Lee, J., Choi, I.J., Kim, Y.I., Kwon, O., Kim, H., and Kim, J. (2018). Dietary Carotenoids Intake and the Risk of Gastric Cancer: A Case-Control Study in Korea. Nutrients, 10.","DOI":"10.3390\/nu10081031"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1007\/s10120-014-0429-0","article-title":"Relationship between body mass index and the risk of early gastric cancer and dysplasia regardless of Helicobacter pylori infection","volume":"18","author":"Kim","year":"2015","journal-title":"Gastric Cancer"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"4961","DOI":"10.3390\/nu6114961","article-title":"Dietary flavonoids and gastric cancer risk in a Korean population","volume":"6","author":"Woo","year":"2014","journal-title":"Nutrients"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"6630","DOI":"10.18632\/oncotarget.14250","article-title":"Effects of alcohol consumption, ALDH2 rs671 polymorphism, and Helicobacter pylori infection on the gastric cancer risk in a Korean population","volume":"8","author":"Yang","year":"2017","journal-title":"Oncotarget"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.canep.2017.08.002","article-title":"Helicobacter pylori serological biomarkers of gastric cancer risk in the MCC-Spain case-control Study","volume":"50","author":"Michel","year":"2017","journal-title":"Cancer Epidemiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1002\/ijc.29500","article-title":"Association of PSCA rs2294008 gene variants with poor prognosis and increased susceptibility to gastric cancer and decreased risk of duodenal ulcer disease","volume":"137","author":"Bujanda","year":"2015","journal-title":"Int. J. Cancer"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1111\/j.1572-0241.2007.01423.x","article-title":"Gastric cancer susceptibility is not linked to pro-and anti-inflammatory cytokine gene polymorphisms in whites: A Nationwide Multicenter Study in Spain","volume":"102","author":"Lanas","year":"2007","journal-title":"Am. J. Gastroenterol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2302\/kjm.51.supplement2_63","article-title":"pylori infection and the development of gastric cancer","volume":"51","author":"Uemura","year":"2002","journal-title":"Keio J. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1111\/j.1469-0691.2009.03031.x","article-title":"Helicobacter pylori and gastric adenocarcinoma","volume":"15","author":"Herrera","year":"2009","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41423-019-0339-5","article-title":"Molecular anatomy and pathogenic actions of Helicobacter pylori CagA that underpin gastric carcinogenesis","volume":"17","author":"Knight","year":"2020","journal-title":"Cell. Mol. Immunol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3748\/wjg.v9.i1.54","article-title":"Helicobacter pylori infection generated gastric cancer through p53-Rb tumor-suppressor system mutation and telomerase reactivation","volume":"9","author":"Lan","year":"2003","journal-title":"World J. Gastroenterol."}],"container-title":["Medicines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2305-6320\/8\/1\/1\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:07:06Z","timestamp":1760159226000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2305-6320\/8\/1\/1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,5]]},"references-count":61,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1]]}},"alternative-id":["medicines8010001"],"URL":"https:\/\/doi.org\/10.3390\/medicines8010001","relation":{},"ISSN":["2305-6320"],"issn-type":[{"value":"2305-6320","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,5]]}}}