{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:14:31Z","timestamp":1760238871566,"version":"build-2065373602"},"reference-count":24,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T00:00:00Z","timestamp":1660262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicines"],"abstract":"<jats:p>Background: Multiple sclerosis (MS) is an autoimmune, chronic, inflammatory, demyelinating, and axonal degeneration disease of the central nervous system. Trigeminal neuralgia (TN), a neuropathic facial paroxysmal pain, is prevalent among MS patients. Because of the inadequacy of the comprehension of MS-related TN pathophysiological mechanisms, TN remains arduous in its treatment approaches. Acupuncture as a non-pharmacological therapy could be a promising complementary therapy for the treatment of TN. MS gradual neural damage might affect the muscles\u2019 function. This can lead to acute or paroxysmal pain in the form of spasms that might progress to formation of myofascial trigger points also known in traditional Chinese medicine as Ashi points (AP). Localising these AP through palpation and pain sensation feedback in patients with MS is an indicator of disease progression. Pathologically, these points reveal the disharmony of soft tissue and internal organs. Methods: This case report examined the pain relief outcome with Ashi scalp acupuncture (ASA) in a secondary TN patient who was unsuccessfully treated multiple times with body acupuncture. The main outline measure was to quantify pain intensity using a numerical rating scale (NRS) before and after each acupuncture therapy. The patient was treated on the scalp for a total of eight times, twice a week over four weeks. Results: A reduction in secondary TN pain intensity was observed after each session. On average, the patient expressed severe pain (NRS: 8.0 \u00b1 2.20) before ASA treatment, which significantly decreased after therapy to mild pain (NRS: 2.0 \u00b1 1.64). Conclusions: Significant improvements in pain intensity reduction after each acupuncture treatment without any adverse effects were observed.<\/jats:p>","DOI":"10.3390\/medicines9080044","type":"journal-article","created":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T03:33:20Z","timestamp":1660534400000},"page":"44","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ashi Scalp Acupuncture in the Treatment of Secondary Trigeminal Neuralgia Induced by Multiple Sclerosis: A Case Report"],"prefix":"10.3390","volume":"9","author":[{"given":"Qiong","family":"Sch\u00fcrer","sequence":"first","affiliation":[{"name":"Research Department, Swiss TCM UNI, 5330 Bad Zurzach, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamdy","family":"Shaban","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Private Clinic of UPK, The University Psychiatric Clinics, 4002 Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas R.","family":"Gantenbein","sequence":"additional","affiliation":[{"name":"Neurology & Neurorehabilitation Department Rehaklinik, ZURZACH Care, 5300 Bad Zurzach, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giada","family":"Todeschini","sequence":"additional","affiliation":[{"name":"Neurology & Neurorehabilitation Department Rehaklinik, ZURZACH Care, 5300 Bad Zurzach, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9396-3428","authenticated-orcid":false,"given":"Saroj K.","family":"Pradhan","sequence":"additional","affiliation":[{"name":"Research Department, Swiss TCM UNI, 5330 Bad Zurzach, Switzerland"},{"name":"Research Department Rehaklinik Bad Zurzach, TCM Ming Dao Bad Zurzach\/ZURZACH Care, 5330 Bad Zurzach, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,12]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Multiple Sclerosis: Pathogenesis, Symptoms, Diagnoses and Cell-Based Therapy","volume":"19","author":"Ghasemi","year":"2017","journal-title":"Cell J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"101545","DOI":"10.1016\/j.msard.2019.11.020","article-title":"Budget impact analysis of cladribine tablets in relapsing-remitting multiple sclerosis (RRMS) patients in Kingdom of Saudi Arabia","volume":"37","author":"Bohlega","year":"2020","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_3","unstructured":"(2018). Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia, 38, 1\u2013211."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Orofacial Pain Classification Committee (2020). International classification of orofacial pain, (ICOP). Cephalalgia, 40, 129\u2013221.","DOI":"10.1177\/0333102419893823"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1177\/1756285609359317","article-title":"Treatment options in trigeminal neuralgia","volume":"3","author":"Obermann","year":"2010","journal-title":"Ther. Adv. Neurol. Disord."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1177\/0964528420924042","article-title":"Acupuncture in the management of trigeminal neuralgia","volume":"39","author":"Edwards","year":"2021","journal-title":"Acupunct. Med."},{"key":"ref_7","first-page":"25","article-title":"Chinese acupuncture and moxibustion","volume":"75","author":"Liangyue","year":"2001","journal-title":"Tradit. Med. Asia"},{"key":"ref_8","first-page":"223","article-title":"Traditional Theories and the Development of Motion Acupuncture: A Historical Perspective","volume":"24","author":"Chen","year":"2015","journal-title":"Int. J. Clin. Acupunct."},{"key":"ref_9","first-page":"180","article-title":"Modern medical explanation on Ashi points","volume":"32","author":"Yang","year":"2012","journal-title":"Zhongguo Zhen Jiu = Chin. Acpuncture Moxibustion"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jams.2015.07.012","article-title":"Acupuncture for pain management in evidence-based medicine","volume":"8","author":"Ning","year":"2015","journal-title":"J. Acupunct. Meridian Stud."},{"key":"ref_11","first-page":"30","article-title":"A systematic review on acupuncture for trigeminal neuralgia","volume":"16","author":"Liu","year":"2010","journal-title":"Altern. Ther. Health Med."},{"key":"ref_12","first-page":"1123","article-title":"Acupuncture treatment in trigeminal neuralgia","volume":"5","author":"Zhu","year":"2019","journal-title":"Int. J. Curr. Multidiscip. Stud."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1590\/S0104-11692006000100003","article-title":"Morbimortalidade porcausas externas na popula\u00e7\u00e3o idosa residente em munic\u00edpio da regi\u00e3o sul do Brasil","volume":"14","year":"2006","journal-title":"Rev. Lat. Am. Enferm."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.ejpain.2003.09.004","article-title":"Minimal clinically important changes in chronic musculoskeletal pain intensity measured on a numerical rating scale","volume":"8","author":"Salaffi","year":"2004","journal-title":"Eur. J. Pain"},{"key":"ref_15","first-page":"21","article-title":"Estimating the size of treatment effects: Moving beyond p values","volume":"6","author":"McGough","year":"2009","journal-title":"Psychiatry"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jclinepi.2016.11.016","article-title":"The minimal clinically important difference raised the significance of out come effects above the statistical level, with methodological implications for future studies","volume":"82","author":"Angst","year":"2017","journal-title":"J. Clin. Epidemiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"8","DOI":"10.7453\/gahmj.2013.2.1.002","article-title":"Treatment of multiple sclerosis with chinese scalp acupuncture","volume":"2","author":"Hao","year":"2013","journal-title":"Glob. Adv. Health Med."},{"key":"ref_18","first-page":"845","article-title":"Scalp-acupuncture for patients with hemiplegic paralysis of acute ischaemic stroke: A randomized controlled clinical trial","volume":"40","author":"Wang","year":"2020","journal-title":"J. Tradit. Chin. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"746567","DOI":"10.3389\/fneur.2021.746567","article-title":"Efficacy of Scalp Acupuncture in Patients with Post-stroke Hemiparesis: Meta-Analysis of Randomized Controlled Trials","volume":"12","author":"Huang","year":"2021","journal-title":"Front. Neurol."},{"key":"ref_20","first-page":"6621993","article-title":"Efficacy and safety of scalp acupuncture for insomnia: A systematic review and meta-analysis","volume":"2021","author":"Liu","year":"2021","journal-title":"Evid. Based Complementary Altern. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e14880","DOI":"10.1097\/MD.0000000000014880","article-title":"Scalp acupuncture treatment for children\u2019s autism spectrum disorders: A systematic review and meta-analysis","volume":"98","author":"Liu","year":"2019","journal-title":"Medicine"},{"key":"ref_22","unstructured":"Wang, F., Li, T., Yu, X., and Deng, Y. (2007). Scalp Acupuncture Therapy, People\u2019s Medical Publishing House."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"972935","DOI":"10.1155\/2014\/972935","article-title":"Acupuncture and multiple sclerosis: A review of the evidence","volume":"2014","author":"Karpatkin","year":"2014","journal-title":"Evid. Based Complementary Altern. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1590\/S1807-59322009001200014","article-title":"Successful treatment of a resistance trigeminal neuralgia patient by acupuncture","volume":"64","author":"Sert","year":"2009","journal-title":"Clinics"}],"container-title":["Medicines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2305-6320\/9\/8\/44\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:07:36Z","timestamp":1760141256000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2305-6320\/9\/8\/44"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,12]]},"references-count":24,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["medicines9080044"],"URL":"https:\/\/doi.org\/10.3390\/medicines9080044","relation":{},"ISSN":["2305-6320"],"issn-type":[{"type":"electronic","value":"2305-6320"}],"subject":[],"published":{"date-parts":[[2022,8,12]]}}}