{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T21:37:36Z","timestamp":1768253856852,"version":"3.49.0"},"reference-count":24,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>Colorectal cancer (CRC) is the third leading cause of cancer-related death. We aimed to investigate the clinicopathological characteristics and 5-year survival in CRC. This retrospective study reviewed King Abdulaziz University Hospital records from 2009 to 2019. Tumor staging was performed using Dukes\u2019 pathological classification. Additionally, we measured the frequency of qualitative data and performed the chi-square and Mann\u2013Whitney U-tests. Kaplan\u2013Meier analysis was performed to calculate overall survival. Of the 574 included patients (age (mean \u00b1 standard deviation), 55.51 \u00b1 14.28 years), 43.2% were Saudis, and most were male (58.7%). The rectum was the most common location of CRC (30.8%); 33.1% of patients presented with abdominal pain. The dominant histological variant was mucinous adenocarcinoma (95.5%). Age at diagnosis was significantly associated with Dukes\u2019 staging; 36.3% of individuals aged &lt;50 years had Dukes\u2019 D stage. The 5-year survival rate was 47.9%. Better survival was noted for those of Saudi nationality, those with Dukes\u2019 A stage, and those who were overweight (51.6%, 56.3%, and 46.8%, respectively). Significantly better survival was seen in Saudi patients due to accessible healthcare and in overweight patients due to better treatment tolerance. The outcome of CRC was not related to sex or metformin use in patients with diabetes mellitus.<\/jats:p>","DOI":"10.3390\/medsci10030042","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T04:20:32Z","timestamp":1660105232000},"page":"42","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinicopathological Characteristics and Overall 5-Year Survival of Colorectal Cancer: A Retrospective Study"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2779-4966","authenticated-orcid":false,"given":"Rahaf","family":"Almuhanna","sequence":"first","affiliation":[{"name":"Department of Surgery, Faculty of Medicine, King Abdulaziz University, Jeddah 22254, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"Al-Thoubaity","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine, King Abdulaziz University, Jeddah 22254, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khadijah","family":"Almalki","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine, King Abdulaziz University, Jeddah 22254, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nada","family":"Algarni","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine, King Abdulaziz University, Jeddah 22254, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renad","family":"Hamad","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine, King Abdulaziz University, Jeddah 22254, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toleen","family":"Makhtoum","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine, King Abdulaziz University, Jeddah 22254, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,9]]},"reference":[{"key":"ref_1","first-page":"89","article-title":"Epidemiology of Colorectal Cancer: Incidence, Mortality, Survival, and Risk Factors","volume":"14","author":"Rawla","year":"2019","journal-title":"Prz. 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