{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:12:55Z","timestamp":1790035975845,"version":"4.0.1"},"reference-count":93,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T00:00:00Z","timestamp":1662768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>Capsaicin acts on sensory nerves via vanilloid receptors. TRPV1 has been extensively studied with respect to functional lower urinary tract (LUT) conditions in rodents and humans. We aimed to (1) provide background information on capsaicin and TRPV1 and its mechanisms of action and basis for clinical use, (2) review the use of acute intravesical capsaicin instillation (AICI) in rodents to mimic various LUT disorders in which capsaicin sensitive C-fibers are involved and (3) discuss future innovative treatments. A comprehensive search of the major literature databases until June 2022 was conducted. Both capsaicin-sensitive and resistant unmyelinated bladder afferent C-fibers are involved in non-neurogenic overactive bladder\/detrusor overactivity (OAB\/DO). AICI is a suitable model to study afferent hyperactivity mimicking human OAB. Capsaicin-sensitive C-fibers are also involved in neurogenic DO (NDO) and potential targets for NDO treatment. AICI has been successfully tested for NDO treatment in humans. Capsaicin-sensitive bladder afferents are targets for NDO treatment. TRPV1-immunoreactive nerve fibers are involved in the pathogenesis of interstitial cystitis\/painful bladder syndrome (IC\/PBS). The AICI experimental model appears relevant for the preclinical study of treatments targeting bladder afferents for refractory IC\/BPS. The activity of capsaicin-sensitive bladder afferents is increased in experimental bladder outlet obstruction (BOO). The AICI model may also be relevant for bladder disorders resulting from C-fiber hyperexcitabilities related to BOO. In conclusion, there is a rationale for the selective blockade of TRPV1 channels for various bladder disorders. The AICI model is clinically relevant for the investigation of pathophysiological conditions in which bladder C-fiber afferents are overexcited and for assessing innovative treatments for bladder disorders based on their pathophysiology.<\/jats:p>","DOI":"10.3390\/medsci10030050","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T01:44:03Z","timestamp":1663033443000},"page":"50","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Acute Intravesical Capsaicin for the Study of TRPV1 in the Lower Urinary Tract: Clinical Relevance and Potential for Innovation"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0665-3486","authenticated-orcid":false,"given":"Karl-Erik","family":"Andersson","sequence":"first","affiliation":[{"name":"Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27101, USA"},{"name":"Division of Clinical Chemistry and Pharmacology, Lund University, 22242 Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9840-9108","authenticated-orcid":false,"given":"Delphine","family":"Behr-Roussel","sequence":"additional","affiliation":[{"name":"Pelvipharm SAS, 78180 Montigny-le-Bretonneux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4831-6499","authenticated-orcid":false,"given":"Pierre","family":"Denys","sequence":"additional","affiliation":[{"name":"Neuro-Uro-Andrology R.Poincare Academic Hospital, AP-HP, 104 bvd R. Poincare, 92380 Garches, France"},{"name":"Faculty of Medicine, U1179 Inserm\/Versailles Saint Quentin University, Paris Saclay, 78180 Montigny-le-Bretonneux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Giuliano","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, U1179 Inserm\/Versailles Saint Quentin University, Paris Saclay, 78180 Montigny-le-Bretonneux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/0024-3205(90)90518-V","article-title":"Minireview: Resiniferatoxin and its analogs provide novel insights into the pharmacology of the vanilloid (capsaicin) receptor","volume":"47","author":"Szallasi","year":"1990","journal-title":"Life Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2010.09.074","article-title":"Recent advances in the study on capsaicinoids and capsinoids","volume":"650","author":"Luo","year":"2011","journal-title":"Eur. 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