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Vail, and Patricia Ann Hanson Funds held by the Community Foundation for Southern Arizona","award":["1R25GM127199-01"],"award-info":[{"award-number":["1R25GM127199-01"]}]},{"name":"Sidney Hopkins and Mayola B. Vail, and Patricia Ann Hanson Funds held by the Community Foundation for Southern Arizona","award":["U54CA143924"],"award-info":[{"award-number":["U54CA143924"]}]},{"name":"Sidney Hopkins and Mayola B. Vail, and Patricia Ann Hanson Funds held by the Community Foundation for Southern Arizona","award":["U54CA143925"],"award-info":[{"award-number":["U54CA143925"]}]},{"name":"Sidney Hopkins and Mayola B. Vail, and Patricia Ann Hanson Funds held by the Community Foundation for Southern Arizona","award":["U54MD012388"],"award-info":[{"award-number":["U54MD012388"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>Cervical cancer is the 4th most common type of cancer in women world-wide. Many factors play a role in cervical cancer development\/progression that include genetics, social behaviors, social determinants of health, and even the microbiome. The prevalence of HPV infections and cervical cancer is high and often understudied among Native American communities. While effective HPV vaccines exist, less than 60% of 13- to 17-year-olds in the general population are up to date on their HPV vaccination as of 2020. Vaccination rates are higher among Native American adolescents, approximately 85% for females and 60% for males in the same age group. Unfortunately, the burden of cervical cancer remains high in many Native American populations. In this paper, we will discuss HPV infection, vaccination and the cervicovaginal microbiome with a Native American perspective. We will also provide insight into new strategies for developing novel methods and therapeutics to prevent HPV infections and limit HPV persistence and progression to cervical cancer in all populations.<\/jats:p>","DOI":"10.3390\/medsci10030052","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T22:37:28Z","timestamp":1663108648000},"page":"52","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Novel Vaccine Strategies and Factors to Consider in Addressing Health Disparities of HPV Infection and Cervical Cancer Development among Native American Women"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2711-0432","authenticated-orcid":false,"given":"Crystal G.","family":"Morales","sequence":"first","affiliation":[{"name":"Department of Biology, Northern Arizona University, Flagstaff, AZ 86011, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9755-0022","authenticated-orcid":false,"given":"Nicole R.","family":"Jimenez","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, College of Medicine, University of Arizona, Phoenix, AZ 85004, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8540-5917","authenticated-orcid":false,"given":"Melissa M.","family":"Herbst-Kralovetz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, College of Medicine, University of Arizona, Phoenix, AZ 85004, USA"},{"name":"Department of Basic Medical Sciences, College of Medicine, University of Arizona, Phoenix, AZ 85004, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0010-6668","authenticated-orcid":false,"given":"Naomi R.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Northern Arizona University, Flagstaff, AZ 86011, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3322\/caac.21609","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"70","author":"Bray","year":"2020","journal-title":"CA Cancer J. 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