{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:16:58Z","timestamp":1777511818137,"version":"3.51.4"},"reference-count":44,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T00:00:00Z","timestamp":1674518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust Clinical Research Career Development Fellowships","doi-asserted-by":"publisher","award":["220703\/Z\/20\/Z"],"award-info":[{"award-number":["220703\/Z\/20\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>There remains a debate whether the ventricular volume within prolapsing mitral valve (MV) leaflets should be included in the left ventricular (LV) end-systolic volume, and therefore factored in LV stroke volume (SV), in cardiac magnetic resonance (CMR) assessments. This study aims to compare LV volumes during end-systolic phases, with and without the inclusion of the volume of blood on the left atrial aspect of the atrioventricular groove but still within the MV prolapsing leaflets, against the reference LV SV by four-dimensional flow (4DF). A total of 15 patients with MV prolapse (MVP) were retrospectively enrolled in this study. We compared LV SV with (LV SVMVP) and without (LV SVstandard) MVP left ventricular doming volume, using 4D flow (LV SV4DF) as the reference value. Significant differences were observed when comparing LV SVstandard and LV SVMVP (p &lt; 0.001), and between LV SVstandard and LV SV4DF (p = 0.02). The Intraclass Correlation Coefficient (ICC) test demonstrated good repeatability between LV SVMVP and LV SV4DF (ICC = 0.86, p &lt; 0.001) but only moderate repeatability between LV SVstandard and LV SV4DF (ICC = 0.75, p &lt; 0.01). Calculating LV SV by including the MVP left ventricular doming volume has a higher consistency with LV SV derived from the 4DF assessment. In conclusion, LV SV short-axis cine assessment incorporating MVP dooming volume can significantly improve the precision of LV SV assessment compared to the reference 4DF method. Hence, in cases with bi-leaflet MVP, we recommend factoring in MVP dooming into the left ventricular end-systolic volume to improve the accuracy and precision of quantifying mitral regurgitation.<\/jats:p>","DOI":"10.3390\/medsci11010013","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T03:23:49Z","timestamp":1674617029000},"page":"13","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Importance of Mitral Valve Prolapse Doming Volume in the Assessment of Left Ventricular Stroke Volume with Cardiac MRI"],"prefix":"10.3390","volume":"11","author":[{"given":"Rui","family":"Li","sequence":"first","affiliation":[{"name":"Norwich Medical School, University of East Anglia, Norfolk NR4 7TJ, UK"},{"name":"Norfolk and Norwich University Hospitals NHS Foundation Trust, Norfolk NR4 7UY, 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School, University of East Anglia, Norfolk NR4 7TJ, UK"},{"name":"Norfolk and Norwich University Hospitals NHS Foundation Trust, Norfolk NR4 7UY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilmar","family":"Spohr","sequence":"additional","affiliation":[{"name":"Norfolk and Norwich University Hospitals NHS Foundation Trust, Norfolk NR4 7UY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Zhong","sequence":"additional","affiliation":[{"name":"National Heart Research Institute Singapore, National Heart Centre Singapore, 5 Hospital Drive, Singapore 169609, Singapore"},{"name":"Cardiovascular Sciences Academic Clinical Programme, Duke-NUS Medical School, 8 College Road, Singapore 169856, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodan","family":"Zhao","sequence":"additional","affiliation":[{"name":"National Heart Research Institute Singapore, National Heart Centre Singapore, 5 Hospital Drive, Singapore 169609, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Sawh","sequence":"additional","affiliation":[{"name":"Norfolk and Norwich University Hospitals NHS Foundation Trust, Norfolk NR4 7UY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Duehmke","sequence":"additional","affiliation":[{"name":"Cardiology Department, Queen Elizabeth Hospital King\u2019s Lynn NHS Foundation Trust, King\u2019s Lynn PE30 4ET, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4005-7752","authenticated-orcid":false,"given":"Vassilios S.","family":"Vassiliou","sequence":"additional","affiliation":[{"name":"Norwich Medical School, University of East Anglia, Norfolk NR4 7TJ, UK"},{"name":"Norfolk and Norwich University Hospitals NHS Foundation Trust, Norfolk NR4 7UY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faye","family":"Nelthorpe","sequence":"additional","affiliation":[{"name":"Norfolk and Norwich University Hospitals NHS Foundation Trust, Norfolk NR4 7UY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Ashman","sequence":"additional","affiliation":[{"name":"Norfolk and Norwich University Hospitals NHS Foundation Trust, Norfolk NR4 7UY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Curtin","sequence":"additional","affiliation":[{"name":"Norwich Medical School, University of East Anglia, Norfolk NR4 7TJ, UK"},{"name":"Norfolk and Norwich University Hospitals NHS Foundation Trust, Norfolk NR4 7UY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gurung-Koney","family":"Yashoda","sequence":"additional","affiliation":[{"name":"Norfolk and Norwich University Hospitals NHS Foundation Trust, Norfolk NR4 7UY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9084-5597","authenticated-orcid":false,"given":"Rob J.","family":"Van der Geest","sequence":"additional","affiliation":[{"name":"Department of Radiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samer","family":"Alabed","sequence":"additional","affiliation":[{"name":"Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield S10 2TN, UK"},{"name":"Department of Clinical Radiology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield S10 2JF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Swift","sequence":"additional","affiliation":[{"name":"Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield S10 2TN, UK"},{"name":"Department of Clinical Radiology, Sheffield Teaching 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