{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T10:42:03Z","timestamp":1787913723997,"version":"build-2784847793"},"reference-count":45,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T00:00:00Z","timestamp":1683590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>Previous studies have demonstrated gender disparities in mortality and vascular complications after transcatheter aortic valve replacement (TAVR) with early generation transcatheter heart valves (THVs). It is unclear, however, whether gender-related differences persist with the newer generation THVs. We aim to assess gender disparities after TAVR with newer generation THVs. The MEDLINE and Embase databases were thoroughly searched from inception to April 2023 to identify studies that reported gender-specific outcomes after TAVR with newer generation THVs (Sapien 3, Corevalve Evolut R, and Evolut Pro). The outcomes of interest included 30-day mortality, 1-year mortality, and vascular complications. In total, 5 studies (4 databases) with a total of 47,933 patients (21,073 females and 26,860 males) were included. Ninety-six percent received TAVR via the transfemoral approach. The females had higher 30-day mortality rates (odds ratio (OR) = 1.53, 95% confidence interval (CI) 1.31\u20131.79, p-value (p) &lt; 0.001) and vascular complications (OR = 1.43, 95% CI 1.23\u20131.65, p &lt; 0.001). However, one-year mortality was similar between the two groups (OR = 0.78, 95% CI 0.61\u20131.00, p = 0.28). The female gender continues to be associated with higher 30-day mortality rates and vascular complications after TAVR with newer generation transcatheter heart valves, while there was no difference in 1-year mortality between the genders. More data is needed to explore the causes and whether we can improve TAVR outcomes in females.<\/jats:p>","DOI":"10.3390\/medsci11020033","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T01:57:51Z","timestamp":1683683871000},"page":"33","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Gender Disparities after Transcatheter Aortic Valve Replacement with Newer Generation Transcatheter Heart Valves: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1855-029X","authenticated-orcid":false,"given":"Angkawipa","family":"Trongtorsak","sequence":"first","affiliation":[{"name":"Ascension Saint Francis Hospital, Internal Medicine Residency Program, Evanston, IL 60202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5846-4620","authenticated-orcid":false,"given":"Sittinun","family":"Thangjui","sequence":"additional","affiliation":[{"name":"Bassett Healthcare Network, Internal Medicine Residency Program, New York, NY 13326, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5153-629X","authenticated-orcid":false,"given":"Pabitra","family":"Adhikari","sequence":"additional","affiliation":[{"name":"Ascension Saint Francis Hospital, Internal Medicine Residency Program, Evanston, IL 60202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biraj","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Reading Hospital\u2014Tower Health, Internal Medicine Residency Program, West Reading, PA 19611, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0959-5576","authenticated-orcid":false,"given":"Jakrin","family":"Kewcharoen","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Loma Linda University Health, Loma Linda, CA 92350, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7087-1707","authenticated-orcid":false,"given":"Leenhapong","family":"Navaravong","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, School of Medicine, University of Utah, Salt Lake City, UT 84112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somsupha","family":"Kanjanauthai","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, University of Southern California, Los Angeles, CA 90007, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Attanasio","sequence":"additional","affiliation":[{"name":"Rush University Medical Center, Division of Cardiovascular Medicine, Chicago, IL 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hammad A.","family":"Saudye","sequence":"additional","affiliation":[{"name":"Ascension Saint Francis Hospital, Division of Cardiovascular Medicine, Evanston, IL 60202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.amjcard.2013.10.024","article-title":"Influence of gender on clinical outcomes following transcatheter aortic valve implantation from the UK transcatheter aortic valve implantation registry and the National Institute for Cardiovascular Outcomes Research","volume":"113","author":"Broyd","year":"2014","journal-title":"Am. 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