{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:55:45Z","timestamp":1783479345486,"version":"3.55.0"},"reference-count":140,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Heart, Lung, and Blood Institute (NHLBI)","award":["NIH 1R01HL133624"],"award-info":[{"award-number":["NIH 1R01HL133624"]}]},{"name":"National Heart, Lung, and Blood Institute (NHLBI)","award":["2R56HL133624"],"award-info":[{"award-number":["2R56HL133624"]}]},{"name":"National Heart, Lung, and Blood Institute (NHLBI)","award":["1472420231352"],"award-info":[{"award-number":["1472420231352"]}]},{"name":"National Heart, Lung, and Blood Institute (NHLBI)","award":["NIH T32HL160517"],"award-info":[{"award-number":["NIH T32HL160517"]}]},{"name":"National Heart, Lung, and Blood Institute (NHLBI)","award":["R01HL46716"],"award-info":[{"award-number":["R01HL46716"]}]},{"name":"National Heart, Lung, and Blood Institute (NHLBI)","award":["R01HL128831"],"award-info":[{"award-number":["R01HL128831"]}]},{"name":"Rhode Island Foundation","award":["NIH 1R01HL133624"],"award-info":[{"award-number":["NIH 1R01HL133624"]}]},{"name":"Rhode Island Foundation","award":["2R56HL133624"],"award-info":[{"award-number":["2R56HL133624"]}]},{"name":"Rhode Island Foundation","award":["1472420231352"],"award-info":[{"award-number":["1472420231352"]}]},{"name":"Rhode Island Foundation","award":["NIH T32HL160517"],"award-info":[{"award-number":["NIH T32HL160517"]}]},{"name":"Rhode Island Foundation","award":["R01HL46716"],"award-info":[{"award-number":["R01HL46716"]}]},{"name":"Rhode Island Foundation","award":["R01HL128831"],"award-info":[{"award-number":["R01HL128831"]}]},{"name":"Alfaisal Medical University, Riyadh, Saudi Arabia","award":["NIH 1R01HL133624"],"award-info":[{"award-number":["NIH 1R01HL133624"]}]},{"name":"Alfaisal Medical University, Riyadh, Saudi Arabia","award":["2R56HL133624"],"award-info":[{"award-number":["2R56HL133624"]}]},{"name":"Alfaisal Medical University, Riyadh, Saudi Arabia","award":["1472420231352"],"award-info":[{"award-number":["1472420231352"]}]},{"name":"Alfaisal Medical University, Riyadh, Saudi Arabia","award":["NIH T32HL160517"],"award-info":[{"award-number":["NIH T32HL160517"]}]},{"name":"Alfaisal Medical University, Riyadh, Saudi Arabia","award":["R01HL46716"],"award-info":[{"award-number":["R01HL46716"]}]},{"name":"Alfaisal Medical University, Riyadh, Saudi Arabia","award":["R01HL128831"],"award-info":[{"award-number":["R01HL128831"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>The extracellular matrix (ECM) is a three-dimensional, acellular network of diverse structural and nonstructural proteins embedded within a gel-like ground substance composed of glycosaminoglycans and proteoglycans. The ECM serves numerous roles that vary according to the tissue in which it is situated. In the myocardium, the ECM acts as a collagen-based scaffold that mediates the transmission of contractile signals, provides means for paracrine signaling, and maintains nutritional and immunologic homeostasis. Given this spectrum, it is unsurprising that both the composition and role of the ECM has been found to be modulated in the context of cardiac pathology. Myocardial infarction (MI) provides a familiar example of this; the ECM changes in a way that is characteristic of the progressive phases of post-infarction healing. In recent years, this involvement in infarct pathophysiology has prompted a search for therapeutic targets: if ECM components facilitate healing, then their manipulation may accelerate recovery, or even reverse pre-existing damage. This possibility has been the subject of numerous efforts involving the integration of ECM-based therapies, either derived directly from biologic sources or bioengineered sources, into models of myocardial disease. In this paper, we provide a thorough review of the published literature on the use of the ECM as a novel therapy for ischemic heart disease, with a focus on biologically derived models, of both the whole ECM and the components thereof.<\/jats:p>","DOI":"10.3390\/medsci12010008","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T11:35:34Z","timestamp":1706614534000},"page":"8","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Current State of Extracellular Matrix Therapy for Ischemic Heart Disease"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4698-723X","authenticated-orcid":false,"given":"Khaled","family":"Hamsho","sequence":"first","affiliation":[{"name":"Division of Cardiothoracic Surgery, Department of Surgery, Cardiovascular Research Center, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI 02903, USA"},{"name":"College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0393-9983","authenticated-orcid":false,"given":"Mark","family":"Broadwin","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Department of Surgery, Cardiovascular Research Center, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI 02903, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R.","family":"Stone","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Department of Surgery, Cardiovascular Research Center, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI 02903, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8886-801X","authenticated-orcid":false,"given":"Frank W.","family":"Sellke","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Department of Surgery, Cardiovascular Research Center, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI 02903, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Ruhul","family":"Abid","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Department of Surgery, Cardiovascular Research Center, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI 02903, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6850","DOI":"10.1111\/febs.15776","article-title":"A guide to the composition and functions of the extracellular matrix","volume":"288","author":"Karamanos","year":"2021","journal-title":"FEBS J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"eabp8964","DOI":"10.1126\/science.abp8964","article-title":"The extracellular matrix and the immune system: A mutually dependent relationship","volume":"379","author":"Sutherland","year":"2023","journal-title":"Science"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Lieber, R.L., and Meyer, G. (2023). Structure-Function relationships in the skeletal muscle extracellular matrix. J. Biomech., 152.","DOI":"10.1016\/j.jbiomech.2023.111593"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"100115","DOI":"10.1016\/j.jhepr.2020.100115","article-title":"The liver matrisome\u2014Looking beyond collagens","volume":"2","author":"Arteel","year":"2020","journal-title":"JHEP Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.stem.2022.07.006","article-title":"Wound healing, fibroblast heterogeneity, and fibrosis","volume":"29","author":"Talbott","year":"2022","journal-title":"Cell Stem Cell"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/0735-1097(89)90360-4","article-title":"Cardiac interstitium in health and disease: The fibrillar collagen network","volume":"13","author":"Weber","year":"1989","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00018-013-1349-6","article-title":"The Pathogenesis of Cardiac Fibrosis","volume":"71","author":"Kong","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1172\/JCI31044","article-title":"ECM remodeling in hypertensive heart disease","volume":"117","author":"Berk","year":"2007","journal-title":"J. Clin. Investig."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.yjmcc.2015.11.005","article-title":"Aging and the cardiac collagen matrix: Novel mediators of fibrotic remodelling","volume":"93","author":"Horn","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.addr.2015.11.001","article-title":"Extracellular matrix structure","volume":"97","author":"Theocharis","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0022-2828(89)91498-3","article-title":"Localization of types I, III and IV collagen mRNAs in rat heart cells by in situ hybridization","volume":"21","author":"Eghbali","year":"1989","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"H1015","DOI":"10.1152\/ajpheart.00023.2006","article-title":"Cardiac fibroblasts: Friend or foe?","volume":"291","author":"Baudino","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1172\/JCI87491","article-title":"The extracellular matrix in myocardial injury, repair, and remodeling","volume":"127","author":"Frangogiannis","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1006\/excr.1997.3512","article-title":"Human Fibroblasts Bind Directly to Fibrinogen at RGD Sites through Integrin \u03b1v\u03b23","volume":"232","author":"Gailit","year":"1997","journal-title":"Exp. Cell Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1242\/jcs.110.7.861","article-title":"Fibronectin provides a conduit for fibroblast transmigration from collagenous stroma into fibrin clot provisional matrix","volume":"110","author":"Greiling","year":"1997","journal-title":"J. Cell Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/S0955-0674(02)00361-7","article-title":"Matricellular proteins: Extracellular modulators of cell function","volume":"14","author":"Bornstein","year":"2002","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1093\/cvr\/cvaa287","article-title":"Angiogenesis after acute myocardial infarction","volume":"117","author":"Wu","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1161\/CIRCRESAHA.116.309624","article-title":"Macrophages in the Remodeling Failing Heart","volume":"119","author":"Chen","year":"2016","journal-title":"Circ. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/s41577-018-0065-8","article-title":"Cardioimmunology: The immune system in cardiac homeostasis and disease","volume":"18","author":"Swirski","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1093\/eurheartj\/ehac223","article-title":"Left ventricular remodelling post-myocardial infarction: Pathophysiology, imaging, and novel therapies","volume":"43","author":"Frantz","year":"2022","journal-title":"Eur. Heart J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3389\/fphys.2020.00301","article-title":"Leukocyte-Dependent Regulation of Cardiac Fibrosis","volume":"11","author":"Okyere","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1016\/j.jacc.2019.10.036","article-title":"Transition of Macrophages to Fibroblast-Like Cells in Healing Myocardial Infarction","volume":"74","author":"Haider","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3389\/fcvm.2019.00101","article-title":"The Role of Macrophages in the Infarcted Myocardium: Orchestrators of ECM Remodeling","volume":"6","author":"Dunne","year":"2019","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1161\/CIRCRESAHA.113.301720","article-title":"Remodeling of the mononuclear phagocyte network underlies chronic inflammation and disease progression in heart failure critical importance of the cardiosplenic axis","volume":"114","author":"Ismahil","year":"2014","journal-title":"Circ. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e003688","DOI":"10.1161\/CIRCHEARTFAILURE.116.003688","article-title":"Activated T-Lymphocytes are Essential Drivers of Pathological Remodeling in Ischemic Heart Failure","volume":"10","author":"Bansal","year":"2017","journal-title":"Circ. Heart Fail."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1161\/CIRCULATIONAHA.118.036065","article-title":"Dysfunctional and Pro-Inflammatory Regulatory T-Lymphocytes Are Essential for Adverse Cardiac Remodeling in Ischemic Cardiomyopathy","volume":"139","author":"Bansal","year":"2019","journal-title":"Circulation"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"992653","DOI":"10.3389\/fcvm.2022.992653","article-title":"CD4+ T-lymphocytes exhibit biphasic kinetics post-myocardial infarction","volume":"9","author":"Kumar","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.jacc.2005.04.056","article-title":"Thickening of the Infarcted Wall by Collagen Injection Improves Left Ventricular Function in Rats: A Novel Approach to Preserve Cardiac Function After Myocardial Infarction","volume":"46","author":"Dai","year":"2005","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"4866","DOI":"10.1038\/s41467-019-12748-8","article-title":"Injectable human recombinant collagen matrices limit adverse remodeling and improve cardiac function after myocardial infarction","volume":"10","author":"McLaughlin","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.jacc.2004.04.040","article-title":"Injectable fibrin scaffold improves cell transplant survival, reduces infarct expansion, and induces neovasculature formation in ischemic myocardium","volume":"44","author":"Christman","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jtcvs.2008.08.036","article-title":"Restoration of left ventricular geometry and improvement of left ventricular function in a rodent model of chronic ischemic cardiomyopathy","volume":"137","author":"Yu","year":"2009","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1093\/icvts\/ivt277","article-title":"Hyaluronic acid-based hydrogel induces neovascularization and improves cardiac function in a rat model of myocardial infarction","volume":"17","author":"Abdalla","year":"2013","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/jbm.b.31386","article-title":"Regeneration of ischemic heart using hyaluronic acid-based injectable hydrogel","volume":"91","author":"Yoon","year":"2009","journal-title":"J. Biomed. Mater. Res. Part B Appl. Biomater."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.7150\/thno.31073","article-title":"Hyaluronic Acid Oligosaccharides Improve Myocardial Function Reconstruction and Angiogenesis against Myocardial Infarction by Regulation of Macrophages","volume":"9","author":"Wang","year":"2019","journal-title":"Theranostics"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.biomaterials.2015.08.011","article-title":"MRI Evaluation of Injectable Hyaluronic Acid-Based Hydrogel Therapy to Limit Ventricular Remodeling after Myocardial Infarction","volume":"69","author":"Dorsey","year":"2015","journal-title":"Biomaterials"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Ladage, D., Yaniz-Galende, E., Rapti, K., Ishikawa, K., Tilemann, L., Shapiro, S., Takewa, Y., Muller-Ehmsen, J., Schwarz, M., and Garcia, M.J. (2013). Stimulating Myocardial Regeneration with Periostin Peptide in Large Mammals Improves Function Post-Myocardial Infarction but Increases Myocardial Fibrosis. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0059656"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1161\/CIRCULATIONAHA.119.045116","article-title":"Agrin Promotes Coordinated Therapeutic Processes Leading to Improved Cardiac Repair in Pigs","volume":"142","author":"Baehr","year":"2020","journal-title":"Circulation"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature22978","article-title":"The extracellular matrix protein agrin promotes heart regeneration in mice","volume":"547","author":"Bassat","year":"2017","journal-title":"Nature"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e119","DOI":"10.1097\/TP.0000000000002653","article-title":"Laminin-511 Supplementation Enhances Stem Cell Localization with Suppression in the Decline of Cardiac Function in Acute Infarct Rats","volume":"103","author":"Sougawa","year":"2019","journal-title":"Transplantation"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1098\/rsif.2011.0301","article-title":"Biomaterial strategies for alleviation of myocardial infarction","volume":"9","author":"Venugopal","year":"2012","journal-title":"J. R. Soc. Interface"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nm1394","article-title":"Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts","volume":"12","author":"Zimmermann","year":"2006","journal-title":"Nat. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1002\/jbm.a.36874","article-title":"Current advances in biodegradable synthetic polymer based cardiac patches","volume":"108","author":"McMahan","year":"2020","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.biomaterials.2014.11.004","article-title":"Timing underpins the benefits associated with injectable collagen biomaterial therapy for the treatment of myocardial infarction","volume":"39","author":"Blackburn","year":"2015","journal-title":"Biomaterials"},{"key":"ref_44","first-page":"920","article-title":"Collagen biomaterial for the treatment of myocardial infarction: An update on cardiac tissue engineering and myocardial regeneration","volume":"9","author":"Wu","year":"2019","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1089\/ten.2005.11.1860","article-title":"Injectable biopolymers enhance angiogenesis after myocardial infarction","volume":"11","author":"Huang","year":"2005","journal-title":"Tissue Eng."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/978-3-319-49674-0_13","article-title":"Fibrin Formation, Structure and Properties","volume":"82","author":"Weisel","year":"2017","journal-title":"Subcell. Biochem."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Nakamuta, J.S., Danoviz, M.E., Marques, F.L.N., Dos Santos, L., Becker, C., Gon\u00e7alves, G.A., Vassallo, P.F., Schettert, I.T., Tucci, P.J.F., and Krieger, J.E. (2009). Cell therapy attenuates cardiac dysfunction post myocardial infarction: Effect of timing, routes of injection and a fibrin scaffold. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0006005"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/stem.580","article-title":"A fibrin patch-based enhanced delivery of human embryonic stem cell-derived vascular cell transplantation in a porcine model of postinfarction LV remodeling","volume":"29","author":"Xiong","year":"2011","journal-title":"Stem Cells"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1016\/j.yexcr.2013.06.006","article-title":"In Vitro Models of Angiogenesis and Vasculogenesis in Fibrin Gel","volume":"319","author":"Morin","year":"2013","journal-title":"Exp. Cell Res."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Abatangelo, G., Vindigni, V., Avruscio, G., Pandis, L., and Brun, P. (2020). Hyaluronic Acid: Redefining Its Role. Cells, 9.","DOI":"10.3390\/cells9071743"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1186\/s13287-015-0237-4","article-title":"In vivo experience with natural scaffolds for myocardial infarction: The times they are a-changin\u2019","volume":"6","year":"2015","journal-title":"Stem Cell Res. Ther."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nrc1391","article-title":"Hyaluronan: From extracellular glue to pericellular cue","volume":"4","author":"Toole","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1016\/S0151-9638(10)70007-7","article-title":"Hyaluronic acid: Structure, metabolism and implication in cicatrisation","volume":"137","author":"Gall","year":"2010","journal-title":"Ann. Dermatol. Venereol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1161\/CIRCULATIONAHA.121.055468","article-title":"hapln1 Defines an Epicardial Cell Subpopulation Required for Cardiomyocyte Expansion During Heart Morphogenesis and Regeneration","volume":"146","author":"Sun","year":"2022","journal-title":"Circulation"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ydbio.2007.07.041","article-title":"Cartilage link protein 1 (Crtl1), an extracellular matrix component playing an important role in heart development","volume":"310","author":"Wirrig","year":"2007","journal-title":"Dev. Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1007\/s00018-013-1494-y","article-title":"The role of periostin in tissue remodeling across health and disease","volume":"71","author":"Conway","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s12079-022-00674-2","article-title":"Periostin: An emerging activator of multiple signaling pathways","volume":"16","author":"Wang","year":"2022","journal-title":"J. Cell Commun. Signal."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1084\/jem.20071297","article-title":"Periostin is essential for cardiac healing after acute myocardial infarction","volume":"205","author":"Shimazaki","year":"2008","journal-title":"J. Exp. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.6061\/clinics\/2013(10)09","article-title":"Periostin as a modulator of chronic cardiac remodeling after myocardial infarction","volume":"68","author":"Minicucci","year":"2013","journal-title":"Clinics"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1093\/cvr\/cvx001","article-title":"Ablation of periostin inhibits post-infarction myocardial regeneration in neonatal mice mediated by the phosphatidylinositol 3 kinase\/glycogen synthase kinase 3\u03b2\/cyclin D1 signalling pathway","volume":"113","author":"Chen","year":"2017","journal-title":"Cardiovasc. Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s12265-010-9207-5","article-title":"Protein Therapeutics for Cardiac Regeneration after Myocardial Infarction","volume":"3","author":"Segers","year":"2010","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/nm1619","article-title":"Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair","volume":"13","author":"Hajjar","year":"2007","journal-title":"Nat. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"5634","DOI":"10.7150\/thno.57243","article-title":"An exosomal-carried short periostin isoform induces cardiomyocyte proliferation","volume":"11","author":"Balbi","year":"2021","journal-title":"Theranostics"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Sarrazin, S., Lamanna, W.C., and Esko, J.D. (2011). Heparan Sulfate Proteoglycans. Cold Spring Harb. Perspect. Biol., 3.","DOI":"10.1101\/cshperspect.a004952"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1136\/annrheumdis-2015-207316","article-title":"Agrin mediates chondrocyte homeostasis and requires both LRP4 and \u03b1-dystroglycan to enhance cartilage formation in vitro and in vivo","volume":"75","author":"Eldridge","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Burden, S.J., Yumoto, N., and Zhang, W. (2013). The Role of MuSK in Synapse Formation and Neuromuscular Disease. Cold Spring Harb. Perspect. Biol., 5.","DOI":"10.1101\/cshperspect.a009167"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3727\/105221619X15617324583639","article-title":"The Hippo Pathway and YAP Signaling: Emerging Concepts in Regulation, Signaling, and Experimental Targeting Strategies with Implications for Hepatobiliary Malignancies","volume":"20","author":"Werneburg","year":"2020","journal-title":"Gene Expr."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"48","DOI":"10.4161\/cam.22826","article-title":"The laminin family","volume":"7","author":"Aumailley","year":"2013","journal-title":"Cell Adh. Migr."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/ki.1992.95","article-title":"Basement membrane proteins","volume":"41","author":"Weber","year":"1992","journal-title":"Kidney Int."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s00441-009-0838-2","article-title":"Laminins","volume":"339","author":"Durbeej","year":"2010","journal-title":"Cell Tissue Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2143\/AC.64.3.2038017","article-title":"Increased levels of laminin and collagen type VI may reflect early remodelling in patients with acute myocardial infarction","volume":"64","author":"Dinh","year":"2009","journal-title":"Acta Cardiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1253\/jcj.60.108","article-title":"Sequential changes in laminin and type IV collagen in the infarct zone\u2014Immunohistochemical study in rat myocardial infarction","volume":"60","author":"Morishita","year":"1996","journal-title":"Jpn. Circ. J."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"936983","DOI":"10.3389\/fcvm.2022.936983","article-title":"Correlation between serum laminin levels and prognosis of acute myocardial infarction","volume":"9","author":"Xu","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1016\/j.celrep.2019.02.083","article-title":"In Vivo Generation of Post-infarct Human Cardiac Muscle by Laminin-Promoted Cardiovascular Progenitors","volume":"26","author":"Yap","year":"2019","journal-title":"Cell Rep."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"22243","DOI":"10.1038\/s41598-021-00918-y","article-title":"Combined administration of laminin-221 and prostacyclin agonist enhances endogenous cardiac repair in an acute infarct rat heart","volume":"11","author":"Sougawa","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Dalton, C.J., and Fibronectin, C.A.L. (2021). Fibrillar Structure and Mechanochemical Signaling. Cells, 10.","DOI":"10.20944\/preprints202108.0010.v1"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.ydbio.2013.08.012","article-title":"Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration","volume":"382","author":"Wang","year":"2013","journal-title":"Dev. Biol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1161\/CIRCRESAHA.110.224428","article-title":"Lack of Fibronectin-EDA Promotes Survival and Prevents Adverse Remodeling and Heart Function Deterioration After Myocardial Infarction","volume":"108","author":"Arslan","year":"2011","journal-title":"Circ. Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1161\/CIRCRESAHA.119.316303","article-title":"Modulation of Mammalian Cardiomyocyte Cytokinesis by the Extracellular Matrix","volume":"127","author":"Wu","year":"2020","journal-title":"Circ. Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0092-8674(00)80590-5","article-title":"Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance","volume":"96","author":"Brose","year":"1999","journal-title":"Cell"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"878","DOI":"10.7150\/ijms.71780","article-title":"Nephronectin promotes cardiac repair post myocardial infarction via activating EGFR\/JAK2\/STAT3 pathway","volume":"19","author":"Zhang","year":"2022","journal-title":"Int. J. Med. Sci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"e1801217","DOI":"10.1002\/adhm.201801217","article-title":"Decellularized Extracellular Matrix Materials for Cardiac Repair and Regeneration","volume":"8","author":"Bejleri","year":"2019","journal-title":"Adv. Healthc. Mater."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2017.12.019","article-title":"Extracellular matrix hydrogel therapies: In vivo applications and development","volume":"68","author":"Spang","year":"2018","journal-title":"Acta Biomater."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1089\/ten.tea.2009.0768","article-title":"Design and Characterization of an Injectable Pericardial Matrix Gel: A Potentially Autologous Scaffold for Cardiac Tissue Engineering","volume":"16","author":"Salvatore","year":"2010","journal-title":"Tissue Eng. Part A"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"I-135","DOI":"10.1161\/CIRCULATIONAHA.104.525436","article-title":"Extracellular Matrix Scaffold for Cardiac Repair","volume":"112","author":"Robinson","year":"2005","journal-title":"Circulation"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.actbio.2016.12.027","article-title":"Human placenta hydrogel reduces scarring in a rat model of cardiac ischemia and enhances cardiomyocyte and stem cell cultures","volume":"52","author":"Francis","year":"2017","journal-title":"Acta Biomater."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"7736","DOI":"10.1016\/j.biomaterials.2012.07.010","article-title":"Effect of bone marrow-derived extracellular matrix on cardiac function after ischemic injury","volume":"33","author":"Ravi","year":"2012","journal-title":"Biomaterials"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"5409","DOI":"10.1016\/j.biomaterials.2009.06.045","article-title":"Naturally derived myocardial matrix as an injectable scaffold for cardiac tissue engineering","volume":"30","author":"Singelyn","year":"2009","journal-title":"Biomaterials"},{"key":"ref_89","first-page":"173ra25","article-title":"Safety and efficacy of an injectable extracellular matrix hydrogel for treating myocardial infarction","volume":"5","author":"Singelyn","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1089\/ten.tec.2009.0111","article-title":"Acellular Cardiac Extracellular Matrix as a Scaffold for Tissue Engineering: In Vitro Cell Support, Remodeling, and Biocompatibility","volume":"16","author":"Eitan","year":"2009","journal-title":"Tissue Eng. Part C Methods"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.actbio.2013.08.037","article-title":"Young developmental age cardiac extracellular matrix promotes the expansion of neonatal cardiomyocytes in vitro","volume":"10","author":"Williams","year":"2014","journal-title":"Acta Biomater."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"e1600844","DOI":"10.1126\/sciadv.1600844","article-title":"Decellularized zebrafish cardiac extracellular matrix induces mammalian heart regeneration","volume":"2","author":"Chen","year":"2016","journal-title":"Sci. Adv."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"31980","DOI":"10.1039\/C7RA03780E","article-title":"Injectable and thermoresponsive pericardial matrix derived conductive scaffold for cardiac tissue engineering","volume":"7","author":"Roshanbinfar","year":"2017","journal-title":"RSC Adv."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.1016\/j.actbio.2012.07.033","article-title":"A Naturally-Derived Cardiac Extracellular Matrix Enhances Cardiac Progenitor Cell Behavior In Vitro","volume":"8","author":"French","year":"2012","journal-title":"Acta Biomater."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"494015","DOI":"10.1088\/0957-4484\/22\/49\/494015","article-title":"Tailoring material properties of a nanofibrous extracellular matrix derived hydrogel","volume":"22","author":"Johnson","year":"2011","journal-title":"Nanotechnology"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1002\/mabi.201000423","article-title":"Modulation of material properties of a decellularized myocardial matrix scaffold","volume":"11","author":"Singelyn","year":"2011","journal-title":"Macromol. Biosci."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"DeQuach, J.A., Mezzano, V., Miglani, A., Lange, S., Keller, G.M., Sheikh, F., and Christman, K.L. (2010). Simple and High Yielding Method for Preparing Tissue Specific Extracellular Matrix Coatings for Cell Culture. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0013039"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1089\/ten.tea.2014.0337","article-title":"Differential \u03b23 Integrin Expression Regulates the Response of Human Lung and Cardiac Fibroblasts to Extracellular Matrix and Its Components","volume":"21","author":"Merna","year":"2015","journal-title":"Tissue Eng. Part A"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.3727\/096368915X689794","article-title":"Cardiac-Derived Extracellular Matrix Enhances Cardiogenic Properties of Human Cardiac Progenitor Cells","volume":"25","author":"Gaetani","year":"2016","journal-title":"Cell Transplant."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.jacc.2015.12.035","article-title":"Evidence for Mechanisms Underlying the Functional Benefits of a Myocardial Matrix Hydrogel for Post-MI Treatment","volume":"67","author":"Wassenaar","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.jacc.2011.10.888","article-title":"Catheter-deliverable hydrogel derived from decellularized ventricular extracellular matrix increases endogenous cardiomyocytes and preserves cardiac function post-myocardial infarction","volume":"59","author":"Singelyn","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1600549","DOI":"10.1002\/adhm.201600549","article-title":"Full Thickness Heart Repair with an Engineered Multilayered Myocardial Patch in Rat Model","volume":"6","author":"Pok","year":"2017","journal-title":"Adv. Healthc. Mater."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.actbio.2016.08.031","article-title":"Natural myocardial ECM patch drives cardiac progenitor based restoration even after scarring","volume":"44","author":"Sarig","year":"2016","journal-title":"Acta Biomater."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2741\/2692","article-title":"Macrophage activation and polarization","volume":"13","author":"Martinez","year":"2008","journal-title":"Front. Biosci."},{"key":"ref_105","unstructured":"(2023, September 22). A Study of VentriGel in Post-MI Patients, Available online: https:\/\/clinicaltrials.gov\/study\/NCT02305602."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1039\/C3BM60283D","article-title":"Human versus porcine tissue sourcing for an injectable myocardial matrix hydrogel","volume":"2","author":"Johnson","year":"2014","journal-title":"Biomater. Sci."},{"key":"ref_107","first-page":"158","article-title":"Aging and Cardiac Fibrosis","volume":"2","author":"Biernacka","year":"2011","journal-title":"Aging Dis."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.biomaterials.2010.09.006","article-title":"The Effect of Source Animal Age Upon Extracellular Matrix Scaffold Properties","volume":"32","author":"Tottey","year":"2011","journal-title":"Biomaterials"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.1016\/j.actbio.2012.06.030","article-title":"Injectable extracellular matrix derived hydrogel provides a platform for enhanced retention and delivery of a heparin-binding growth factor","volume":"8","author":"Horn","year":"2012","journal-title":"Acta Biomater."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1093\/ejcts\/ezu163","article-title":"Human cardiac extracellular matrix supports myocardial lineage commitment of pluripotent stem cells","volume":"47","author":"Oberwallner","year":"2015","journal-title":"Eur. J. Cardio-Thorac. Surg."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s12265-011-9293-z","article-title":"Patient-to-patient variability in autologous pericardial matrix scaffolds for cardiac repair","volume":"4","author":"Horn","year":"2011","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s12265-011-9304-0","article-title":"Hybrid Gel Composed of Native Heart Matrix and Collagen Induces Cardiac Differentiation of Human Embryonic Stem Cells without Supplemental Growth Factors","volume":"4","author":"Duan","year":"2011","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"11053","DOI":"10.1021\/acsami.5b03195","article-title":"Tailoring Material Properties of Cardiac Matrix Hydrogels to Induce Endothelial Differentiation of Human Mesenchymal Stem Cells","volume":"7","author":"Jeffords","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.jacbts.2021.01.003","article-title":"Injectable Myocardial Matrix Hydrogel Mitigates Negative Left Ventricular Remodeling in a Chronic Myocardial Infarction Model","volume":"6","author":"Diaz","year":"2021","journal-title":"JACC Basic Transl. Sci."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"e2102265","DOI":"10.1002\/adhm.202102265","article-title":"Injectable Extracellular Matrix Microparticles Promote Heart Regeneration in Mice with Post-ischemic Heart Injury","volume":"11","author":"Wang","year":"2022","journal-title":"Adv. Healthc. Mater."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2301244","DOI":"10.1002\/advs.202301244","article-title":"Extracellular Matrix\/Glycopeptide Hybrid Hydrogel as an Immunomodulatory Niche for Endogenous Cardiac Repair after Myocardial Infarction","volume":"10","author":"Kong","year":"2023","journal-title":"Adv. Sci."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.yjmcc.2021.06.001","article-title":"Exogenous extracellular matrix proteins decrease cardiac fibroblast activation in stiffening microenvironment through CAPG","volume":"159","author":"Wang","year":"2021","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1016\/j.actbio.2009.10.048","article-title":"Small Intestinal Submucosa Gel as a Potential Scaffolding Material for Cardiac Tissue Engineering","volume":"6","author":"Crapo","year":"2010","journal-title":"Acta Biomater."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1016\/j.athoracsur.2013.06.063","article-title":"Injectable small intestine submucosal extracellular matrix in an acute myocardial infarction model","volume":"96","author":"Toeg","year":"2013","journal-title":"Ann. Thorac. Surg."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"7678","DOI":"10.1016\/j.biomaterials.2010.06.056","article-title":"Differential efficacy of gels derived from small intestinal submucosa as an injectable biomaterial for myocardial infarct repair","volume":"31","author":"Okada","year":"2010","journal-title":"Biomaterials"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1002\/adhm.201500035","article-title":"Partially Digested Adult Cardiac Extracellular Matrix Promotes Cardiomyocyte Proliferation in Vitro","volume":"4","author":"Williams","year":"2015","journal-title":"Adv. Healthc. Mater."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1177\/1074248412472257","article-title":"Intramyocardial injection of heart tissue-derived extracellular matrix improves postinfarction cardiac function in rats","volume":"18","author":"Dai","year":"2013","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.actbio.2019.01.062","article-title":"Decellularized Neonatal Cardiac Extracellular Matrix Prevents Widespread Ventricular Remodeling in Adult Mammals after Myocardial Infarction","volume":"87","author":"Wang","year":"2019","journal-title":"Acta Biomater."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1089\/ten.tea.2009.0288","article-title":"Age-Related Changes in Material Behavior of Porcine Mitral and Aortic Valves and Correlation to Matrix Composition","volume":"16","author":"Stephens","year":"2010","journal-title":"Tissue Eng. Part A"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1089\/ten.tea.2008.0111","article-title":"Effect of scaffold stiffness on myoblast differentiation","volume":"15","author":"Zoldan","year":"2009","journal-title":"Tissue Eng. Part A"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"12741","DOI":"10.1073\/pnas.1735463100","article-title":"Differentiation of human embryonic stem cells on three-dimensional polymer scaffolds","volume":"100","author":"Levenberg","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1146\/annurev-bioeng-071812-152423","article-title":"Self-Organization and the Self-Assembling Process in Tissue Engineering","volume":"15","author":"Athanasiou","year":"2013","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"H2031","DOI":"10.1152\/ajpheart.00743.2011","article-title":"Functional scaffold-free 3-D cardiac microtissues: A novel model for the investigation of heart cells","volume":"302","author":"Desroches","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Tejavibulya, N., Youssef, J., Bao, B., Ferruccio, T.-M., and Morgan, J.R. (2011). Directed Self-Assembly of Large Scaffold-free Multicellular Honeycomb Structures. Biofabrication, 3.","DOI":"10.1088\/1758-5082\/3\/3\/034110"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.biomaterials.2015.10.080","article-title":"Harnessing cellular-derived forces in self-assembled microtissues to control the synthesis and alignment of ECM","volume":"77","author":"Schell","year":"2016","journal-title":"Biomaterials"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"C1385","DOI":"10.1152\/ajpcell.00248.2005","article-title":"Potential of fibroblasts to regulate the formation of three-dimensional vessel-like structures from endothelial cells in vitro","volume":"290","author":"Schroeder","year":"2006","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1089\/ten.tec.2014.0439","article-title":"Place, and Perfuse: A New Instrument for Three-Dimensional Tissue Engineering","volume":"21","author":"Blakely","year":"2015","journal-title":"Tissue Eng. Part C Methods"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1089\/ten.tea.2013.0620","article-title":"Use of Myocardial Matrix in a Chitosan-Based Full-Thickness Heart Patch","volume":"20","author":"Pok","year":"2014","journal-title":"Tissue Eng. Part A"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1002\/jbm.a.35850","article-title":"Elastic, silk-cardiac extracellular matrix hydrogels exhibit time-dependent stiffening that modulates cardiac fibroblast response","volume":"104","author":"Stoppel","year":"2016","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.biomaterials.2014.12.021","article-title":"Delivery of an engineered HGF fragment in an extracellular matrix-derived hydrogel prevents negative LV remodeling post-myocardial infarction","volume":"45","author":"Sonnenberg","year":"2015","journal-title":"Biomaterials"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/ejhf.449","article-title":"One-year follow-up results from AUGMENT-HF: A multicentre randomized controlled clinical trial of the efficacy of left ventricular augmentation with Algisyl in the treatment of heart failure","volume":"18","author":"Mann","year":"2016","journal-title":"Eur. J. Heart Fail."},{"key":"ref_137","unstructured":"(2023, September 23). A Randomized, Controlled Study to Evaluate Algisyl-LVRTM as a Method of Left Ventricular Augmentation for Heart Failure (AUGMENT-HF), Available online: https:\/\/clinicaltrials.gov\/study\/NCT01311791."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"16812","DOI":"10.1002\/jcp.28350","article-title":"A review on coronary artery disease, its risk factors, and therapeutics","volume":"234","author":"Malakar","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_139","first-page":"e362","article-title":"2013 ACCF\/AHA guideline for the management of ST-elevation myocardial infarction: A report of the American College of Cardiology Foundation\/American Heart Association Task Force on practice guidelines","volume":"127","author":"Kushner","year":"2013","journal-title":"Circulation"},{"key":"ref_140","first-page":"e123","article-title":"2016 ACC\/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients with Coronary Artery Disease: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines: An Update of the 2011 ACCF\/AHA\/SCAI Guideline for Percutaneous Coronary Intervention, 2011 ACCF\/AHA Guideline for Coronary Artery Bypass Graft Surgery, 2012 ACC\/AHA\/ACP\/AATS\/PCNA\/SCAI\/STS Guideline for the Diagnosis and Management of Patients With Stable Ischem","volume":"134","author":"Levine","year":"2016","journal-title":"Circulation"}],"container-title":["Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3271\/12\/1\/8\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:51:21Z","timestamp":1760104281000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3271\/12\/1\/8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,29]]},"references-count":140,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["medsci12010008"],"URL":"https:\/\/doi.org\/10.3390\/medsci12010008","relation":{},"ISSN":["2076-3271"],"issn-type":[{"value":"2076-3271","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,29]]}}}