{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T22:08:43Z","timestamp":1778882923796,"version":"3.51.4"},"reference-count":23,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T00:00:00Z","timestamp":1708300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>Background: Tobacco use disorder (TUD) adversely impacts older patients with established cardiovascular disease (CVD) risk. However, CVD risk in chronic habitual cannabis users without the confounding impact of TUD hasn\u2019t been explored. We aimed to determine the risk of major adverse cardiac and cerebrovascular events (MACCE) in older non-tobacco smokers with established CVD risk with vs. without cannabis use disorder (CUD). Methods: We queried the 2019 National Inpatient Sample for hospitalized non-tobacco smokers with established traditional CVD risk factors aged \u226565 years. Relevant ICD-10 codes were used to identify patients with vs. without CUD. Using multivariable logistic regression, we evaluated the odds of MACCE in CUD cohorts compared to non-CUD cohorts. Results: Prevalence of CUD in the sample was 0.3% (28,535\/10,708,815, median age 69), predominantly male, black, and non-electively admitted from urban teaching hospitals. Of the older patients with CVD risk with CUD, 13.9% reported MACCE. The CUD cohort reported higher odds of MACCE (OR 1.20, 95% CI 1.11\u20131.29, p &lt; 0.001) compared to the non-CUD cohort. Comorbidities such as hypertension (OR 1.9) and hyperlipidemia (OR 1.3) predicted a higher risk of MACCE in the CUD cohort. The CUD cohort also had higher unadjusted rates of acute myocardial infarction (7.6% vs. 6%) and stroke (5.2% vs. 4.8%). Conclusions: Among older non tobacco smokers with known CVD risk, chronic cannabis use had a 20% higher likelihood of MACCE compared to those who did not use cannabis.<\/jats:p>","DOI":"10.3390\/medsci12010013","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T11:23:57Z","timestamp":1708341837000},"page":"13","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association of Cannabis Use Disorder with Major Adverse Cardiac and Cerebrovascular Events in Older Non-Tobacco Users: A Population-Based Analysis"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6761-5390","authenticated-orcid":false,"given":"Avilash","family":"Mondal","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Nazareth Hospital, Philadelphia, PA 19152, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3634-2763","authenticated-orcid":false,"given":"Sriharsha","family":"Dadana","sequence":"additional","affiliation":[{"name":"Department of Hospital Medicine, Cheyenne Regional Medical Center, Cheyenne, WY 82001, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poojan","family":"Parmar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dr. M. K. Shah Medical College and Research Center, Ahmedabad 382424, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2367-9615","authenticated-orcid":false,"given":"Maneeth","family":"Mylavarapu","sequence":"additional","affiliation":[{"name":"Department of Public Health, Adelphi University, Garden City, NY 11530, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3457-9578","authenticated-orcid":false,"given":"Qiming","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Greater Baltimore Medical Center, Towson, MD 21204, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samia Rauf","family":"Butt","sequence":"additional","affiliation":[{"name":"Department of Medicine, University College of Medicine and Dentistry, Lahore 55150, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abeera","family":"Kali","sequence":"additional","affiliation":[{"name":"Department of Medicine, Allama Iqbal Medical College, Lahore 54550, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhaswanth","family":"Bollu","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, All India Institute of Medical Sciences, New Delhi 110029, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5315-6426","authenticated-orcid":false,"given":"Rupak","family":"Desai","sequence":"additional","affiliation":[{"name":"Independent Researcher, Atlanta, GA 30033, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1001\/jamainternmed.2019.7517","article-title":"Trends in Cannabis Use Among Older Adults in the United States, 2015\u20132018","volume":"180","author":"Han","year":"2020","journal-title":"JAMA Intern Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1089\/can.2023.0056","article-title":"Prevalence and Frequency of Cannabis Use Among Adults Ages 50\u201380 in the United States","volume":"9","author":"Fernandez","year":"2024","journal-title":"Cannabis Cannabinoid Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/j.mayocp.2019.05.008","article-title":"Cannabis abuse and elevated risk of myocardial infarction in the young: A population-based study","volume":"94","author":"Chami","year":"2019","journal-title":"Mayo Clin. 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