{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:16:09Z","timestamp":1789827369370,"version":"4.0.1"},"reference-count":38,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"USANA Health Sciences, Inc."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>Participant recruitment is one of the most challenging aspects of a clinical trial, directly impacting both the study\u2019s duration and the quality of its results. Therefore, reporting successful recruitment strategies is crucial. This study aimed to document the recruitment tactics and experiences of a research team during a university-based randomized clinical trial, conducted as part of a clinical research immersion program. Recruitment took place from October 2021 to October 2022. Before the study commenced, study team members received formal training in clinical trial participant recruitment from the Principal Investigator. The recruitment strategies were integrated into initial study design, which was approved by the Institutional Review Board. A multimodal approach was employed, incorporating both direct and indirect recruitment methods. These strategies successfully met the enrollment target within the twelve-month period. Throughout the process, team members acquired valuable knowledge in recruitment design and implementation, along with transferable interpersonal and networking skills. In-person recruitment was the most efficient and cost-effective strategy, followed by personal referrals. The primary challenge was accommodating participants\u2019 availability. Other study teams should consider these recruitment strategies during their study designs. Additionally, the knowledge and skills gained by this study team underscore the value of experiential learning in research education.<\/jats:p>","DOI":"10.3390\/medsci12030039","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T03:49:36Z","timestamp":1723693776000},"page":"39","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Successes and Challenges in Clinical Trial Recruitment: The Experience of a New Study Team"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2827-3740","authenticated-orcid":false,"given":"Man","family":"Hung","sequence":"first","affiliation":[{"name":"College of Dental Medicine, Roseman University of Health Sciences, South Jordan, UT 84095, USA"},{"name":"Division of Public Health, University of Utah, Salt Lake City, UT 84108, USA"},{"name":"College of Engineering, University of Utah, Salt Lake City, UT 84108, USA"},{"name":"Department of Educational Psychology, University of Utah, Salt Lake City, UT 84108, USA"},{"name":"Huntsman Cancer Institute, Salt Lake City, UT 84112, USA"},{"name":"Department of Veterans Affairs Medical Center, Salt Lake City, UT 84148, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7277-1291","authenticated-orcid":false,"given":"Amir","family":"Mohajeri","sequence":"additional","affiliation":[{"name":"College of Dental Medicine, Roseman University of Health Sciences, South Jordan, UT 84095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinia","family":"Almpani","sequence":"additional","affiliation":[{"name":"College of Dental Medicine, Roseman University of Health Sciences, South Jordan, UT 84095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Carberry","sequence":"additional","affiliation":[{"name":"College of Dental Medicine, Roseman University of Health Sciences, South Jordan, UT 84095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Wisniewski","sequence":"additional","affiliation":[{"name":"College of Dental Medicine, Roseman University of Health Sciences, South Jordan, UT 84095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kade","family":"Janes","sequence":"additional","affiliation":[{"name":"College of Dental Medicine, Roseman University of Health Sciences, South Jordan, UT 84095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooklyn","family":"Janes","sequence":"additional","affiliation":[{"name":"College of Dental Medicine, Roseman University of Health Sciences, South Jordan, UT 84095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chase","family":"Hardy","sequence":"additional","affiliation":[{"name":"College of Dental Medicine, Roseman University of Health Sciences, South Jordan, UT 84095, 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5985-6538","authenticated-orcid":false,"given":"Val J.","family":"Cheever","sequence":"additional","affiliation":[{"name":"College of Dental Medicine, Roseman University of Health Sciences, South Jordan, UT 84095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Garibyan","sequence":"additional","affiliation":[{"name":"College of Dental Medicine, Roseman University of Health Sciences, South Jordan, UT 84095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perry","family":"Bachstein","sequence":"additional","affiliation":[{"name":"College of Dental Medicine, Roseman University of Health Sciences, South Jordan, UT 84095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank W.","family":"Licari","sequence":"additional","affiliation":[{"name":"College of Dental Medicine, Roseman University of Health Sciences, 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Trials"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Williams, R.J., Tse, T., DiPiazza, K., and Zarin, D.A. (2015). Terminated Trials in the ClinicalTrials.gov Results Database: Evaluation of Availability of Primary Outcome Data and Reasons for Termination. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0127242"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1001\/jama.2014.1361","article-title":"Prevalence, characteristics, and publication of discontinued randomized trials","volume":"311","author":"Kasenda","year":"2014","journal-title":"J. Am. Med. Assoc."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jclinepi.2016.07.016","article-title":"A systematic review of discontinued trials suggested that most reasons for recruitment failure were preventable","volume":"80","author":"Briel","year":"2016","journal-title":"J. Clin. Epidemiol."},{"key":"ref_5","first-page":"Mr000013","article-title":"Strategies to improve recruitment to randomised trials","volume":"2","author":"Treweek","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Caldwell, P.H., Hamilton, S., Tan, A., and Craig, J.C. (2010). Strategies for increasing recruitment to randomised controlled trials: Systematic review. PLoS Med., 7.","DOI":"10.1371\/journal.pmed.1000368"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1200\/JCO.2003.02.105","article-title":"Public attitudes toward participation in cancer clinical trials","volume":"21","author":"Comis","year":"2003","journal-title":"J. Clin. Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1200\/JOP.0922001","article-title":"Physician-related factors involved in patient decisions to enroll onto cancer clinical trials","volume":"5","author":"Comis","year":"2009","journal-title":"J. Oncol. Pract."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e22810","DOI":"10.2196\/22810","article-title":"The Role of Social Media in Enhancing Clinical Trial Recruitment: Scoping Review","volume":"22","author":"Darmawan","year":"2020","journal-title":"J. Med. Internet Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e161","DOI":"10.2196\/resprot.5747","article-title":"The Effectiveness Of Social Media (Facebook) Compared with More Traditional Advertising Methods for Recruiting Eligible Participants to Health Research Studies: A Randomized, Controlled Clinical Trial","volume":"5","author":"Frandsen","year":"2016","journal-title":"JMIR Res. Protoc."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.invent.2016.01.001","article-title":"Facebook as an effective recruitment strategy for mental health research of hard to reach populations","volume":"4","author":"Kayrouz","year":"2016","journal-title":"Internet Interv."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e286","DOI":"10.2196\/jmir.5698","article-title":"The Use of Social Media in Recruitment for Medical Research Studies: A Scoping Review","volume":"18","author":"Natarajan","year":"2016","journal-title":"J. Med. Internet Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"100748","DOI":"10.1016\/j.conctc.2021.100748","article-title":"Recruitment strategies for a pragmatic cluster randomized oral health trial in pediatric primary care settings","volume":"21","author":"Curtan","year":"2021","journal-title":"Contemp. Clin. Trials Commun."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1186\/s13063-019-3710-z","article-title":"Designing and using incentives to support recruitment and retention in clinical trials: A scoping review and a checklist for design","volume":"20","author":"Parkinson","year":"2019","journal-title":"Trials"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Watson, J.M., and Torgerson, D.J. (2006). Increasing recruitment to randomised trials: A review of randomised controlled trials. BMC Med. Res. Methodol., 6.","DOI":"10.1186\/1471-2288-6-34"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"137","DOI":"10.4103\/2229-3485.184820","article-title":"Challenges in recruitment and retention of clinical trial subjects","volume":"7","author":"Kadam","year":"2016","journal-title":"Perspect. Clin. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s13063-018-2578-7","article-title":"Patient-centered recruitment and retention for a randomized controlled study","volume":"19","author":"Chhatre","year":"2018","journal-title":"Trials"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.cdp.2005.12.001","article-title":"Recruitment and participation in clinical trials: Socio-demographic, rural\/urban, and health care access predictors","volume":"30","author":"Baquet","year":"2006","journal-title":"Cancer Detect. Prev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1093\/ageing\/afx057","article-title":"Evidence for strategies that improve recruitment and retention of adults aged 65 years and over in randomised trials and observational studies: A systematic review","volume":"46","author":"Lacey","year":"2017","journal-title":"Age Ageing"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1111\/pde.14817","article-title":"Strategies to enhance pediatric clinical trial participation: A systematic review with narrative synthesis","volume":"38","author":"McKenzie","year":"2021","journal-title":"Pediatr. Dermatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1365-2702.2009.03041.x","article-title":"Clinical trials: The challenge of recruitment and retention of participants","volume":"19","author":"Gul","year":"2010","journal-title":"J. Clin. Nurs."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/S0197-2456(96)00236-X","article-title":"Recruitment for controlled clinical trials: Literature summary and annotated bibliography","volume":"18","author":"Lovato","year":"1997","journal-title":"Control. Clin. Trials"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1046\/j.1365-2648.2001.02029.x","article-title":"Recruitment of frail older people to research: Lessons learnt through experience","volume":"36","author":"Harris","year":"2001","journal-title":"J. Adv. Nurs."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1081\/JAS-120033991","article-title":"Recruitment into a long-term pediatric asthma study during emergency department visits","volume":"41","author":"Smith","year":"2004","journal-title":"J. Asthma"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1014610325059","article-title":"Recruitment of older participants in frailty\/injury prevention studies","volume":"3","author":"Ory","year":"2002","journal-title":"Prev. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Chang, B.-H., Hendricks, A.M., Slawsky, M.T., and Locastro, J.S. (2004). Patient recruitment to a randomized clinical trial of behavioral therapy for chronic heart failure. BMC Med. Res. Methodol., 4.","DOI":"10.1186\/1471-2288-4-8"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1023\/A:1008342222205","article-title":"Attitudes towards and participation in randomised clinical trials in oncology: A review of the literature","volume":"11","author":"Ellis","year":"2000","journal-title":"Ann Oncol"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1006\/pmed.1999.0543","article-title":"Challenges faced in recruiting patients from primary care practices into a physical activity intervention trial","volume":"29","author":"Sevick","year":"1999","journal-title":"Prev. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0197-2456(96)00132-8","article-title":"Recruiting older adults for clinical trials","volume":"18","author":"Adams","year":"1997","journal-title":"Control. Clin. Trials"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e183","DOI":"10.2196\/jmir.4359","article-title":"Online recruitment methods for Web-based and mobile health studies: A review of the literature","volume":"17","author":"Lane","year":"2015","journal-title":"J. Med. Internet Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1177\/17407745211015924","article-title":"Clinical trials site recruitment optimisation: Guidance from Clinical Trials: Impact and Quality","volume":"18","author":"Zahren","year":"2021","journal-title":"Clin. Trials"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/1745-6215-14-166","article-title":"A reinvestigation of recruitment to randomised, controlled, multicenter trials: A review of trials funded by two UK funding agencies","volume":"14","author":"Sully","year":"2013","journal-title":"Trials"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Littman, A.J., True, G., Ashmore, E., Wellens, T., and Smith, N.L. (2018). How can we get Iraq- and Afghanistan-deployed US Veterans to participate in health related research? Findings from a national focus group study. BMC Med. Res. Methodol., 18.","DOI":"10.1186\/s12874-018-0546-2"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1177\/1077801208323976","article-title":"Combining ethical considerations with recruitment and follow-up strategies for partner violence victimization research","volume":"14","author":"Logan","year":"2008","journal-title":"Violence Against Women"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cct.2009.10.002","article-title":"Overall and minority-focused recruitment strategies in the PREMIER multicenter trial of lifestyle interventions for blood pressure control","volume":"31","author":"Kennedy","year":"2010","journal-title":"Contemp. Clin. Trials"},{"key":"ref_36","unstructured":"Clinical Trials: Thinking Smarter (2023, April 15). Assessing the Site Barriers and Enablers to Clinical Trial Recruitment, Identifying Any Strategies That May Inform Best Practices in Participant Recruitment. Available online: https:\/\/ctiq.com.Au\/wp-content\/uploads\/GREET-Literature-Review-5-FINAL-with-logo.docx."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/jep.12100","article-title":"Assessing the challenges of multi-scope clinical research sites: An example from NIH HIV\/AIDS clinical trials networks","volume":"20","author":"Rosas","year":"2013","journal-title":"J. Eval. Clin. Pract."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1177\/1740774514543539","article-title":"Site-specific predictors of successful recruitment to a perinatal clinical trial","volume":"11","author":"Levett","year":"2014","journal-title":"Clin. Trials"}],"container-title":["Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3271\/12\/3\/39\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:36:45Z","timestamp":1760110605000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3271\/12\/3\/39"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,14]]},"references-count":38,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["medsci12030039"],"URL":"https:\/\/doi.org\/10.3390\/medsci12030039","relation":{},"ISSN":["2076-3271"],"issn-type":[{"value":"2076-3271","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,14]]}}}