{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T23:40:50Z","timestamp":1787701250134,"version":"build-2784847793"},"reference-count":13,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:00:00Z","timestamp":1728000000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"institutional funding"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>Chronic Obstructive Pulmonary Disease (COPD) is a disease characterized by local and systemic inflammation independently of the risk factor; during the exacerbations, such inflammation is accentuated and amplified. A practical inflammatory marker and one with an applicable predictive value in the follow-up has been sought. FeNO has shown an excellent performance in that respect within the context of asthma and has also been studied in tobacco-smoke COPD (COPD-TS). In Biomass-smoke COPD (COPD-BS), this, to our knowledge, has not been evaluated. Objective: To measure FeNO levels in patients with COPD-BS and to compare these with those of patients with stable COPD-TS and in healthy controls. Methods: Transversal, observational, descriptive, comparative, and analytical study. A total of 57 patients, including 23 with COPD-BS, 17 with COPD-TS, and 17 healthy control subjects. The measurement of FeNO was carried out on all of these by means of the on-line chemiluminescence technique; the values were expressed in parts per billion (ppb) for their analysis. Results: It was observed that the FeNO values were similar between COPD-BS and COPD-TS and were significantly different between the healthy and stable COPD (both groups). No correlation was found between pulmonary function and symptoms with FeNO in any of the groups. Conclusions: The level of FeNO in stable COPD is found to be increased in a similar manner in COPD-BS and COPD-TS, with a significant difference on comparing it with that of the healthy subjects.<\/jats:p>","DOI":"10.3390\/medsci12040052","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T03:26:36Z","timestamp":1728012396000},"page":"52","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Fractional Exhaled Nitric Oxide (FeNO) in Biomass Smoke-Associated Chronic Obstructive Pulmonary Disease"],"prefix":"10.3390","volume":"12","author":[{"given":"Juan","family":"Silva-Gallardo","sequence":"first","affiliation":[{"name":"Hospital General Regional 25, Mexican Social Security Institute, Mexico City 09100, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal H.","family":"Sansores","sequence":"additional","affiliation":[{"name":"Respiratory Department, M\u00e9dica Sur Hospital, Mexico City 14050, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Ram\u00edrez-Venegas","sequence":"additional","affiliation":[{"name":"Tobacco and COPD Research Department, Ismael Cos\u00edo Villegas National Institute of Respiratory Diseases, Mexico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3708-7368","authenticated-orcid":false,"given":"Robinson E.","family":"Robles Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Tobacco and COPD Research Department, Ismael Cos\u00edo Villegas National Institute of Respiratory Diseases, Mexico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8019-5238","authenticated-orcid":false,"given":"Gustavo I.","family":"Centeno-Saenz","sequence":"additional","affiliation":[{"name":"Tobacco and COPD Research Department, Ismael Cos\u00edo Villegas National Institute of Respiratory Diseases, Mexico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8710-160X","authenticated-orcid":false,"given":"Rafael J.","family":"Hern\u00e1ndez-Zenteno","sequence":"additional","affiliation":[{"name":"COPD and Bronchiectasis Clinic, Ismael Cos\u00edo Villegas National Institute of Respiratory Diseases, Mexico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2300239","DOI":"10.1183\/13993003.00239-2023","article-title":"Global Initiative for Chronic Obstructive Lung Disease 2023 Report: GOLD Executive Summary","volume":"61","author":"Celli","year":"2023","journal-title":"Eur. 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Monit."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Ambrosino, P., Fuschillo, S., Accardo, M., Mosella, M., Molino, A., Spedicato, G.A., Motta, A., and Maniscalco, M. (2022). Fractional Exhaled Nitric Oxide (FeNO) in Patients with Stable Chronic Obstructive Pulmonary Disease: Short-Term Variability and Potential Clinical Implications. J. Pers. Med., 12.","DOI":"10.3390\/jpm12111906"}],"container-title":["Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3271\/12\/4\/52\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:10:21Z","timestamp":1760112621000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3271\/12\/4\/52"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,4]]},"references-count":13,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["medsci12040052"],"URL":"https:\/\/doi.org\/10.3390\/medsci12040052","relation":{},"ISSN":["2076-3271"],"issn-type":[{"value":"2076-3271","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,4]]}}}