{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:14:10Z","timestamp":1792793650320,"version":"4.5.0"},"reference-count":35,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>Background: Burn injuries remain a major clinical problem worldwide, which require special management by experienced plastic surgeons. However, they cannot be available in every healthcare unit; consequently, there is a need for effective treatment options that could be utilized by a wide range of non-expert healthcare professionals. The aim of the present experimental study was to investigate the safety and efficacy of using a fibrin sealant (TISSEELTM) compared to the conventional treatment with sulfadiazine on partial-thickness burn in a rat animal model. Methods: A cohort of Sprague Dawley rats underwent partial-thickness contact thermal burn wounds and were divided into three study groups: control group (no treatment), silver sulfadiazine cream group and TISSEELTM group. Following animal sacrifice, a blinded histopathologic analysis was conducted regarding inflammatory response, healing and tissue regeneration. Results: In total, 30 animals were included with a median weight of 236 \u00b1 10 g. Two animals from the control group died on the first postoperative day. Animals in the TISSEELTM group presented dominant collagen expression compared to animals in the control and silver sulfadiazine cream group (p = 0.000). Histopathologic analysis also demonstrated marked leukocyte infiltration (p = 0.009), increased neovascularization (p = 0.000) and higher fibroblast expression (p = 0.002) in the TISSEELTM group compared to the other two groups. Conclusions: TISSEELTM seems to be a safe alternative (or even principal) option for the initial therapeutic approach of partial-thickness burn injuries. Moreover, it seems to be superior to silver sulfadiazine in terms of tissue healing and regeneration. However, additional experimental as well as clinical research is necessary prior to implementation in clinical practice.<\/jats:p>","DOI":"10.3390\/medsci12040075","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T08:04:14Z","timestamp":1734595454000},"page":"75","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Could Fibrin Sealants (TISSEELTM) Be Effective in the Management of Burn Injuries? A Histopathological Study in Rats"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4937-704X","authenticated-orcid":false,"given":"Christina","family":"Nikolaou","sequence":"first","affiliation":[{"name":"Laboratory of Experimental Surgery and Surgical Research \u201cN.S. Christeas\u201d, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece"},{"name":"Department of Plastic & Reconstructive Surgery, Burn Center, General Hospital of Athens \u201cG. Genimatas\u201d, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9157-9860","authenticated-orcid":false,"given":"Maximos","family":"Frountzas","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Surgery and Surgical Research \u201cN.S. Christeas\u201d, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7046-0112","authenticated-orcid":false,"given":"Dimitrios","family":"Schizas","sequence":"additional","affiliation":[{"name":"First Department of Surgery, \u201cLaikon\u201d General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasilios","family":"Pergialiotis","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Surgery and Surgical Research \u201cN.S. Christeas\u201d, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece"},{"name":"First Department of Obstetrics and Gynecology, Unit of Gynecologic Oncology, \u201cAlexandra\u201d Hospital, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8354-4641","authenticated-orcid":false,"given":"Emmanouil I.","family":"Kapetanakis","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, \u201cAttikon\u201d University Hospital, School of Medicine, National and Kapodistrian University of Athens, 12461 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Kontzoglou","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Surgery and Surgical Research \u201cN.S. Christeas\u201d, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece"},{"name":"Second Department of Propaedeutic Surgery, \u201cLaikon\u201d General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Despina N.","family":"Perrea","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Surgery and Surgical Research \u201cN.S. Christeas\u201d, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efthymios","family":"Koniaris","sequence":"additional","affiliation":[{"name":"First Department of Pathology, \u201cHippocration\u201d General Hospital, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stylianos","family":"Kykalos","sequence":"additional","affiliation":[{"name":"Second Department of Propaedeutic Surgery, \u201cLaikon\u201d General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Iliopoulos","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Surgery and Surgical Research \u201cN.S. Christeas\u201d, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/bjs.11045","article-title":"Systematic review of fibrin glue in burn wound reconstruction","volume":"106","author":"Miller","year":"2019","journal-title":"Br. J. 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