{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:18:33Z","timestamp":1782937113924,"version":"3.54.5"},"reference-count":59,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017638","name":"Identification of predictors of drug-resistant course and outcomes of surgical treatment of epilepsy","doi-asserted-by":"publisher","award":["1023022100003-4"],"award-info":[{"award-number":["1023022100003-4"]}],"id":[{"id":"10.13039\/501100017638","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>Background: Epilepsy is a group of disorders characterized by a cluster of clinical and EEG signs leading to the formation of abnormal synchronous excitation of neurons in the brain. It is one of the most common neurological disorders worldwide; and is characterized by aberrant expression patterns; both at the level of matrix transcripts and at the level of regulatory RNA sequences. Aberrant expression of a number of microRNAs can mark a particular epileptic syndrome; which will improve the quality of differential diagnosis. Materials and Methods: In this work; the expression profile of six microRNAs was analyzed: hsa-miR-106b-5p; hsa-miR-134-5p; hsa-miR-122-5p; hsa-miR-132-3p; hsa-miR-155-5p; and hsa-miR-206-5p in the blood plasma of patients suffering from temporal lobe epilepsy (n = 52) and juvenile myoclonic epilepsy (n = 42); n\u2014amount of participants; in comparison with healthy volunteers. The expression analysis was carried out using RT-PCR. Mathematical processing of the data was carried out according to the Livak method. Results: A statistically significant change in the expression of hsa-miR-106b-5p; hsa-miR-134-5p; hsa-miR-122-5p; and hsa-miR-132-3p was found. An increase in the expression of hsa-miR-134-5p and hsa-miR-122-5p was registered in the group of patients with temporal lobe epilepsy compared to the control; as well as an increase in the expression of hsa-miR-132-3p and hsa-miR-106b-5p in the juvenile myoclonic epilepsy group compared to the control. hsa-miR-122-5p; 106b-5p; 132-3p are also able to discriminate groups with different syndromes. Additionally; a number of microRNAs are able to discriminate patients with drug-resistant and drug-sensitive forms of epilepsy from the control; as well as patients with hippocampal sclerosis and patients without hippocampal sclerosis from the control. Conclusion. Our data allow us to propose these microRNAs as plasma biomarkers of various epileptic syndromes<\/jats:p>","DOI":"10.3390\/medsci13010007","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T09:30:45Z","timestamp":1736328645000},"page":"7","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Circulating microRNAs as Biomarkers of Various Forms of Epilepsy"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4555-7457","authenticated-orcid":false,"given":"Elena E.","family":"Timechko","sequence":"first","affiliation":[{"name":"Department of Medical Genetics, Clinical Neurophysiology of Postgraduate Education, V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Russian National Research, Krasnoyarsk 660022, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2728-5830","authenticated-orcid":false,"given":"Kristina D.","family":"Lysova","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Clinical Neurophysiology of Postgraduate Education, V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Russian National Research, Krasnoyarsk 660022, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0479-126X","authenticated-orcid":false,"given":"Alexey M.","family":"Yakimov","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Clinical Neurophysiology of Postgraduate Education, V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Russian National Research, Krasnoyarsk 660022, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia I.","family":"Paramonova","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Clinical Neurophysiology of Postgraduate Education, V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Russian National Research, Krasnoyarsk 660022, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3369-1537","authenticated-orcid":false,"given":"Anastasia A.","family":"Vasilieva","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Clinical Neurophysiology of Postgraduate Education, V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Russian National Research, Krasnoyarsk 660022, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena A.","family":"Kantimirova","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Clinical Neurophysiology of Postgraduate Education, V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Russian National Research, Krasnoyarsk 660022, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9678-6719","authenticated-orcid":false,"given":"Anna A.","family":"Usoltseva","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Clinical Neurophysiology of Postgraduate Education, V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Russian National Research, Krasnoyarsk 660022, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albina V.","family":"Yakunina","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Educational Institution, Samara State Medical University, Ministry of Healthcare of the Russian, Samara 443079, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irirna G.","family":"Areshkina","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Clinical Neurophysiology of Postgraduate Education, V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Russian National Research, Krasnoyarsk 660022, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4639-6365","authenticated-orcid":false,"given":"Diana V.","family":"Dmitrenko","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Clinical Neurophysiology of Postgraduate Education, V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Russian National Research, Krasnoyarsk 660022, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1111\/epi.17262","article-title":"Introduction to the Epilepsy Syndrome Papers","volume":"63","author":"Wirrell","year":"2022","journal-title":"Epilepsia"},{"key":"ref_2","unstructured":"(2024, October 22). Epilepsy. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/epilepsy."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1111\/epi.17237","article-title":"Methodology for Classification and Definition of Epilepsy Syndromes with List of Syndromes: Report of the ILAE Task Force on Nosology and Definitions","volume":"63","author":"Wirrell","year":"2022","journal-title":"Epilepsia"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1055\/s-0028-1091791","article-title":"The Development of the Electroencephalogram in Normal Children from the Age of 1 through 15 Years. Paroxysmal Activity","volume":"2","year":"1971","journal-title":"Neuropadiatrie"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1528-1157.1980.tb04043.x","article-title":"Longitudinal Study of Epileptiform EEG Patterns in Normal Children","volume":"21","author":"Cavazzuti","year":"1980","journal-title":"Epilepsia"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1111\/epi.12688","article-title":"Focal Abnormalities in Idiopathic Generalized Epilepsy: A Critical Review of the Literature","volume":"55","author":"Seneviratne","year":"2014","journal-title":"Epilepsia"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"100684","DOI":"10.1016\/j.ebr.2024.100684","article-title":"A Complex Case with Generalized Epilepsy, Probable Focal Seizures, and Functional Seizures","volume":"27","author":"Elshetihy","year":"2024","journal-title":"Epilepsy Behav. Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e208076","DOI":"10.1212\/WNL.0000000000208076","article-title":"Idiopathic Generalized Epilepsy Misunderstandings, Challenges, and Opportunities","volume":"102","author":"Devinsky","year":"2023","journal-title":"Neurology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.fmre.2022.07.011","article-title":"Molecular Biomarkers, Network Biomarkers, and Dynamic Network Biomarkers for Diagnosis and Prediction of Rare Diseases","volume":"2","author":"Tang","year":"2022","journal-title":"Fundam. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/s44222-023-00050-8","article-title":"Analytical Device Miniaturization for the Detection of Circulating Biomarkers","volume":"1","author":"Natalia","year":"2023","journal-title":"Nat. Rev. Bioeng."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.semcdb.2014.10.003","article-title":"Blood\u2013Brain Barrier Dysfunction, Seizures and Epilepsy","volume":"38","author":"Aronica","year":"2015","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_12","first-page":"196","article-title":"Blood\u2013Brain Barrier Disruption Following Seizures","volume":"19","author":"Kiani","year":"2023","journal-title":"Nat. Rev. Neurol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Panina, Y.S., Timechko, E.E., Usoltseva, A.A., Yakovleva, K.D., Kantimirova, E.A., and Dmitrenko, D.V. (2023). Biomarkers of Drug Resistance in Temporal Lobe Epilepsy in Adults. Metabolites, 13.","DOI":"10.3390\/metabo13010083"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1172\/JCI92001","article-title":"Molecular Isoforms of High-Mobility Group Box 1 Are Mechanistic Biomarkers for Epilepsy","volume":"127","author":"Walker","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"106707","DOI":"10.1016\/j.eplepsyres.2021.106707","article-title":"Brain-Derived Neurotrophic Factor in Blood Serum and Lacrimal Fluid of Patients with Focal Epilepsy","volume":"176","author":"Shpak","year":"2021","journal-title":"Epilepsy Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/ene.12232","article-title":"Serum Brain-Derived Neurotrophic Factor Levels in Epilepsy","volume":"21","author":"Hong","year":"2014","journal-title":"Eur. J. Neurol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"527","DOI":"10.3390\/jpm12040527","article-title":"Prospective Evaluation of Ghrelin and Des-Acyl Ghrelin Plasma Levels in Children with Newly Diagnosed Epilepsy: Evidence for Reduced Ghrelin-to-Des-Acyl Ghrelin Ratio in Generalized Epilepsies","volume":"12","author":"Costa","year":"2022","journal-title":"J. Pers. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3752","DOI":"10.1007\/s00415-022-11004-2","article-title":"Neuron Specific Enolase, S100-Beta Protein and Progranulin as Diagnostic Biomarkers of Status Epilepticus","volume":"269","author":"Hanin","year":"2022","journal-title":"J. Neurol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Liang, K.G., Mu, R.Z., Liu, Y., Jiang, D., Jia, T.T., and Huang, Y.J. (2019). Increased Serum S100B Levels in Patients with Epilepsy: A Systematic Review and Meta-Analysis Study. Front. Neurosci., 13.","DOI":"10.3389\/fnins.2019.00456"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/ane.13616","article-title":"Blood Biomarkers in Epilepsy","volume":"146","author":"Banote","year":"2022","journal-title":"Acta Neurol. Scand."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"O\u2019Brien, J., Hayder, H., Zayed, Y., and Peng, C. (2018). Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation. Front. Endocrinol., 9.","DOI":"10.3389\/fendo.2018.00402"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"5127","DOI":"10.1523\/JNEUROSCI.0600-12.2013","article-title":"Comprehensive Expression Analyses of Neural Cell-Type-Specific MiRNAs Identify New Determinants of the Specification and Maintenance of Neuronal Phenotypes","volume":"33","author":"Roshan","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"8499","DOI":"10.12659\/MSM.916458","article-title":"MicroRNA-27a-3p Downregulation Inhibits Inflammatory Response and Hippocampal Neuronal Cell Apoptosis by Upregulating Mitogen-Activated Protein Kinase 4 (MAP2K4) Expression in Epilepsy: In Vivo and In Vitro Studies","volume":"25","author":"Lu","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"dmm031708","DOI":"10.1242\/dmm.031708","article-title":"The Role of the MicroRNA-146a\/Complement Factor H\/Interleukin-1\u03b2-Mediated Inflammatory Loop Circuit in the Perpetuate Inflammation of Chronic Temporal Lobe Epilepsy","volume":"11","author":"Li","year":"2018","journal-title":"Dis. Model. Mech."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Wang, J., and Zhao, J. (2021). MicroRNA Dysregulation in Epilepsy: From Pathogenetic Involvement to Diagnostic Biomarker and Therapeutic Agent Development. Front. Mol. Neurosci., 14.","DOI":"10.3389\/fnmol.2021.650372"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"667","DOI":"10.5732\/cjc.012.10271","article-title":"Centrifugation: An Important Pre-Analytic Procedure That Influences Plasma MicroRNA Quantification during Blood Processing","volume":"32","author":"Zheng","year":"2013","journal-title":"Chin. J. Cancer"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2\u2212\u0394\u0394CT Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/j.surg.2015.04.025","article-title":"Housekeeping Genes for Studies of Plasma MicroRNA: A Need for More Precise Standardization","volume":"158","author":"Rice","year":"2015","journal-title":"Surgery"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Avansini, S.H., De Sousa Lima, B.P., Secolin, R., Santos, M.L., Coan, A.C., Vieira, A.S., Torres, F.R., Carvalho, B.S., Alvim, M.K.M., and Morita, M.E. (2017). MicroRNA Hsa-MiR-134 Is a Circulating Biomarker for Mesial Temporal Lobe Epilepsy. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0173060"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s12031-013-9953-3","article-title":"Expression Patterns of MiR-124, MiR-134, MiR-132, and MiR-21 in an Immature Rat Model and Children with Mesial Temporal Lobe Epilepsy","volume":"50","author":"Peng","year":"2013","journal-title":"J. Mol. Neurosci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.omtn.2016.11.002","article-title":"Potent Anti-Seizure Effects of Locked Nucleic Acid Antagomirs Targeting MiR-134 in Multiple Mouse and Rat Models of Epilepsy","volume":"6","author":"Reschke","year":"2016","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nrneurol.2012.129","article-title":"Silencing of MiR-134 Suppresses Seizures in Mice","volume":"8","author":"Wood","year":"2012","journal-title":"Nat. Rev. Neurol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1038\/nm.2834","article-title":"Silencing MicroRNA-134 Produces Neuroprotective and Prolonged Seizure-Suppressive Effects","volume":"18","author":"Engel","year":"2012","journal-title":"Nat. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nature04367","article-title":"A Brain-Specific MicroRNA Regulates Dendritic Spine Development","volume":"439","author":"Schratt","year":"2006","journal-title":"Nature"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Gao, X., Guo, M., Meng, D., Sun, F., Guan, L., Cui, Y., Zhao, Y., Wang, X., Gu, X., and Sun, J. (2019). Silencing MicroRNA-134 Alleviates Hippocampal Damage and Occurrence of Spontaneous Seizures After Intraventricular Kainic Acid-Induced Status Epilepticus in Rats. Front. Cell Neurosci., 13.","DOI":"10.3389\/fncel.2019.00145"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1111\/epi.16502","article-title":"Circulating MiR-146a and MiR-134 in Predicting Drug-Resistant Epilepsy in Patients with Focal Impaired Awareness Seizures","volume":"61","author":"Leontariti","year":"2020","journal-title":"Epilepsia"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"109154","DOI":"10.1016\/j.neuropharm.2022.109154","article-title":"Knockdown of MiRNA-134-5p Rescues Dendritic Deficits by Promoting AMPK-Mediated Mitophagy in a Mouse Model of Depression","volume":"214","author":"Wang","year":"2022","journal-title":"Neuropharmacology"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Wang, J., Yu, J.T., Tan, L., Tian, Y., Ma, J., Tan, C.C., Wang, H.F., Liu, Y., Tan, M.S., and Jiang, T. (2015). Genome-Wide Circulating MicroRNA Expression Profiling Indicates Biomarkers for Epilepsy. Sci. Rep., 5.","DOI":"10.1038\/srep09522"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.eplepsyres.2019.04.010","article-title":"Expression of Plasma MicroRNA-145-5p and Its Correlation with Clinical Features in Patients with Refractory Epilepsy","volume":"154","author":"Shen","year":"2019","journal-title":"Epilepsy Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"5318","DOI":"10.3892\/mmr.2016.5906","article-title":"Identification of Serum MiRNAs Differentially Expressed in Human Epilepsy at Seizure Onset and Post-Seizure","volume":"14","author":"Sun","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s41983-020-00214-y","article-title":"Role of Circulating MiR 194-5p, MiR 106b, and MiR 146a as Potential Biomarkers for Epilepsy: A Case-Control Study","volume":"56","author":"Moustafa","year":"2020","journal-title":"Egypt. J. Neurol. Psychiatry Neurosurg."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.brainres.2010.08.023","article-title":"MiR-106b Aberrantly Expressed in a Double Transgenic Mouse Model for Alzheimer\u2019s Disease Targets TGF-\u03b2 Type II Receptor","volume":"1357","author":"Wang","year":"2010","journal-title":"Brain Res."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Wang, J., Tan, L., Tan, L., Tian, Y., Ma, J., Tan, C.C., Wang, H.F., Liu, Y., Tan, M.S., and Jiang, T. (2015). Circulating MicroRNAs Are Promising Novel Biomarkers for Drug-Resistant Epilepsy. Sci. Rep., 5.","DOI":"10.1038\/srep10201"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Yu, Y., Li, P., Chen, M., Zhan, W., Zhu, T., Min, L., Liu, H., and Lv, B. (2024). MiR-122 Overexpression Alleviates Oxygen\u2013Glucose Deprivation-Induced Neuronal Injury by Targeting SPLA2-IIA. Front. Neurol., 15.","DOI":"10.3389\/fneur.2024.1395833"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1206420","DOI":"10.1155\/2017\/1206420","article-title":"A Decrease of Brain MicroRNA-122 Level Is an Early Marker of Cerebrovascular Disease in the Stroke-Prone Spontaneously Hypertensive Rat","volume":"2017","author":"Stanzione","year":"2017","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s12974-024-03162-z","article-title":"Dysregulated Expression of MiR-140 and MiR-122 Compromised Microglial Chemotaxis and Led to Reduced Restriction of AD Pathology","volume":"21","author":"Song","year":"2024","journal-title":"J. Neuroinflamm."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.yexcr.2018.04.027","article-title":"Up-Regulation of MiR-122 Protects against Neuronal Cell Death in Ischemic Stroke through the Heat Shock Protein 70-Dependent NF-\u039aB Pathway by Targeting FOXO3","volume":"369","author":"Guo","year":"2018","journal-title":"Exp. Cell Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.1007\/s11064-023-04014-7","article-title":"MiR-122-5p Promotes Peripheral and Central Nervous System Inflammation in a Mouse Model of Intracerebral Hemorrhage via Disruption of the MLLT1\/PI3K\/AKT Signaling","volume":"48","author":"Yu","year":"2023","journal-title":"Neurochem. Res."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Li, W., Wu, J., Zeng, Y., and Zheng, W. (2023). Neuroinflammation in Epileptogenesis: From Pathophysiology to Therapeutic Strategies. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1269241"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/glia.23700","article-title":"MicroRNA-132 Is Overexpressed in Glia in Temporal Lobe Epilepsy and Reduces the Expression of Pro-epileptogenic Factors in Human Cultured Astrocytes","volume":"68","author":"Korotkov","year":"2019","journal-title":"Glia"},{"key":"ref_51","first-page":"1639","article-title":"MicroRNA-132 Silencing Decreases the Spontaneous Recurrent Seizures","volume":"7","author":"Huang","year":"2014","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"8853018","DOI":"10.1155\/2024\/8853018","article-title":"Diagnostic Panel of Three Genetic Biomarkers Based on Artificial Neural Network for Patients With Idiopathic Generalized Epilepsy","volume":"2024","author":"Tak","year":"2024","journal-title":"Acta Neurol. Scand."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s10142-023-01220-y","article-title":"The Dysregulation of MiRNAs in Epilepsy and Their Regulatory Role in Inflammation and Apoptosis","volume":"23","author":"Xie","year":"2023","journal-title":"Funct. Integr. Genom."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"5057","DOI":"10.1007\/s11033-022-07188-5","article-title":"Aberrant Expression of MiRNAs in Epilepsy","volume":"49","author":"Hussen","year":"2022","journal-title":"Mol. Biol. Rep."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/ene.14129","article-title":"Circulating MicroRNAs as Potential Biomarkers for Genetic Generalized Epilepsies: A Three MicroRNA Panel","volume":"27","author":"Chaves","year":"2020","journal-title":"Eur. J. Neurol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s10616-019-00324-3","article-title":"MiR-206 Inhibits Epilepsy and Seizure-Induced Brain Injury by Targeting CCL2","volume":"71","author":"Wu","year":"2019","journal-title":"Cytotechnology"},{"key":"ref_57","first-page":"1577","article-title":"MicroRNA-155 Contributes to the Occurrence of Epilepsy through the PI3K\/Akt\/MTOR Signaling Pathway","volume":"42","author":"Duan","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"ref_58","first-page":"429","article-title":"Evaluation of MicroRNAs in Pediatric Epilepsy","volume":"58","author":"Tekin","year":"2023","journal-title":"Turk. Arch. Pediatr."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.brainres.2017.11.019","article-title":"Silencing Rno-MiR-155-5p in Rat Temporal Lobe Epilepsy Model Reduces Pathophysiological Features and Cell Apoptosis by Activating Sestrin-3","volume":"1689","author":"Huang","year":"2018","journal-title":"Brain Res."}],"container-title":["Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3271\/13\/1\/7\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:25:08Z","timestamp":1759919108000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3271\/13\/1\/7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,8]]},"references-count":59,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["medsci13010007"],"URL":"https:\/\/doi.org\/10.3390\/medsci13010007","relation":{},"ISSN":["2076-3271"],"issn-type":[{"value":"2076-3271","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,8]]}}}