{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T12:01:46Z","timestamp":1780920106250,"version":"3.54.1"},"reference-count":23,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010712","name":"Vietnam National University Ho Chi Minh City (VNU-HCM)","doi-asserted-by":"publisher","award":["C2024-44-04\/H\u0110-KHCN"],"award-info":[{"award-number":["C2024-44-04\/H\u0110-KHCN"]}],"id":[{"id":"10.13039\/501100010712","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>Objective: This study aims to investigate the correlation between the morphological and functional characteristics of the left atrial appendage (LAA) and the incidence of thromboembolic events by transesophageal echocardiography (TEE) in patients with acute ischemic stroke. Methods: This cross-sectional study included 171 patients with acute ischemic stroke, running from November 2022 to September 2024. Transesophageal echocardiography was performed to evaluate the presence of LAA thrombus. Multivariable logistic regression analysis was performed to identify risk factors for LAA thrombus. Results: Of the 171 patients, 19 (11.1%) were found to have LAA thrombus. Multivariable logistic regression identified two independent predictors of LAA thrombus formation: (1) left atrial spontaneous echo contrast (OR = 8, 95% CI: 3\u201319, p &lt; 0.001) and (2) atrial fibrillation (OR = 8, 95% CI: 1.057\u201376.095, p = 0.044). Conclusions: Left atrial spontaneous echo contrast and atrial fibrillation are independent predictors of LAA thrombus in patients with acute ischemic stroke. The use of transesophageal echocardiography for early detection of LAA thrombus may help improve treatment strategies and prevent recurrent strokes.<\/jats:p>","DOI":"10.3390\/medsci13020063","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T08:49:57Z","timestamp":1747903797000},"page":"63","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Left Atrial Appendage Morphology and Function on Thrombosis Risk in Acute Ischemic Stroke: Insights from Transesophageal Echocardiography"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5157-2830","authenticated-orcid":false,"given":"Dung N. Q.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Health Sciences, Viet Nam National University, Ho Chi Minh City 7000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dung Thuong","family":"Ho","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Health Sciences, Viet Nam National University, Ho Chi Minh City 7000, Vietnam"},{"name":"Thong Nhat Hospital, Ho Chi Minh City 7000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanh N. H.","family":"Tran","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Health Sciences, Viet Nam National University, Ho Chi Minh City 7000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.ncl.2008.07.003","article-title":"Epidemiology of Ischemic and Hemorrhagic Stroke: Incidence, Prevalence, Mortality, and Risk Factors","volume":"26","author":"Grysiewicz","year":"2008","journal-title":"Neurol. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jacc.2019.01.011","article-title":"2019 AHA\/ACC\/HRS Focused Update of the 2014 Guideline for the Management of Patients with Atrial Fibrillation","volume":"74","author":"January","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1136\/adc.2008.142836","article-title":"Cerebrovascular Disease and Stroke","volume":"93","author":"Pappachan","year":"2008","journal-title":"Arch. Dis. Child."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/nrneurol.2010.36","article-title":"Ischemic Stroke in the Elderly: An Overview of Evidence","volume":"6","author":"Chen","year":"2010","journal-title":"Nat. Rev. Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1001\/jama.2019.10436","article-title":"Management of Patients with Acute Ischemic Stroke","volume":"322","author":"Brorson","year":"2019","journal-title":"JAMA"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/s00059-019-4803-x","article-title":"Cardiac Imaging after Ischemic Stroke: Echocardiography, CT, or MRI?","volume":"44","author":"Camen","year":"2019","journal-title":"Herz"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e364","DOI":"10.1161\/STR.0000000000000375","article-title":"2021 Guideline for the Prevention of Stroke in Patients with Stroke and Transient Ischemic Attack","volume":"52","author":"Kleindorfer","year":"2021","journal-title":"Stroke"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/s00392-018-1256-9","article-title":"Expert Opinion Paper on Atrial Fibrillation Detection after Ischemic Stroke","volume":"107","author":"Haeusler","year":"2018","journal-title":"Clin. Res. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.jacc.2012.04.032","article-title":"Left Atrial Appendage Morphology and Stroke Risk in Atrial Fibrillation","volume":"60","author":"Santangeli","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Korhonen, M., Muuronen, A., Arponen, O., Mustonen, P., Hedman, M., J\u00e4k\u00e4l\u00e4, P., and Taina, M. (2015). Left Atrial Appendage Morphology in Patients with Suspected Cardiogenic Stroke. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0118822"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/0735-1097(94)90644-0","article-title":"Left Atrial Appendage Blood Flow Velocity and Thromboembolic Risk","volume":"23","author":"Fatkin","year":"1994","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.hrthm.2013.01.036","article-title":"Left Atrial Appendage in Cardiogenic Stroke with Low CHADS2 Scores","volume":"10","author":"Kimura","year":"2013","journal-title":"Heart Rhythm."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/j.1540-8167.2010.01814.x","article-title":"Left Atrial Appendage Studied by CT for Device Placement Planning","volume":"21","author":"Wang","year":"2010","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1590\/1806-9282.66.10.1437","article-title":"Predictors of Left Atrial Thrombus in Stroke Patients without Atrial Fibrillation","volume":"66","author":"Cinar","year":"2020","journal-title":"Rev. Assoc. Med. Bras."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Anaissie, J., Monlezun, D., Seelochan, A., Chavez-Keatts, M., Tiu, J., Pineda, D., George, A., Shaban, A., Abi Rafeh, N., and Schluter, L. (2016). Left Atrial Enlargement Predicts Thrombus in Stroke Patients. BioMed Res. Int., 2016.","DOI":"10.1155\/2016\/7194676"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/echo.12089","article-title":"Left Atrial Deformation Parameters Predict Thrombus","volume":"30","author":"Karabay","year":"2013","journal-title":"Echocardiography"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ipej.2019.01.005","article-title":"Incidence and Predictors of Left Atrial Thrombus in Atrial Fibrillation","volume":"19","author":"Jia","year":"2019","journal-title":"Indian Pacing Electrophysiol. J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1161\/CIRCRESAHA.116.308407","article-title":"Cardioembolic Stroke","volume":"120","author":"Kamel","year":"2017","journal-title":"Circ. Res."},{"key":"ref_19","first-page":"59","article-title":"Left Atrial Appendage Morphology and Flow Velocity","volume":"17","author":"Fukushima","year":"2016","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/0735-1097(91)90592-W","article-title":"Left Atrial Spontaneous Echo Contrast","volume":"18","author":"Black","year":"1991","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1530\/ERP-18-0083","article-title":"Left Atrial Spontaneous Echo Contrast: Relationship with Clinical Parameters","volume":"6","author":"Takahide","year":"2019","journal-title":"Echo Res. Pract."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/clc.23284","article-title":"Atrial Fibrillation-Related Stroke in Women: Evidence and Inequalities","volume":"43","author":"Kostopoulou","year":"2020","journal-title":"Clin. Cardiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1161\/STROKEAHA.115.012004","article-title":"Atrial Fibrillation and Mechanisms of Stroke: Time for a New Model","volume":"47","author":"Kamel","year":"2016","journal-title":"Stroke"}],"container-title":["Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3271\/13\/2\/63\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:38:19Z","timestamp":1760031499000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3271\/13\/2\/63"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,22]]},"references-count":23,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["medsci13020063"],"URL":"https:\/\/doi.org\/10.3390\/medsci13020063","relation":{},"ISSN":["2076-3271"],"issn-type":[{"value":"2076-3271","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,22]]}}}