{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T08:00:56Z","timestamp":1768550456400,"version":"3.49.0"},"reference-count":56,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>Background: Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that leads to nerve atrophy. Ultrasonography has a significant role in the diagnosis of ALS. Aim: We aimed to sonographically assess the size of all peripheral nerves and cervical nerve roots in ALS compared to controls. Methods: We searched MEDLINE (PubMed), Web of Science, Cochrane Central Register of Controlled Trials (CENTRAL), Embase, and Scopus using comprehensive MeSH terms for the keywords nerve, ultrasound, and ALS. We extracted data regarding cross-sectional area (CSA) or diameter for the following nerves: vagus, phrenic, tibial, fibular, sural, radial, ulnar, and median nerves, and the roots of C5, C6, C7, and C8 in both ALS patients and controls. Results: Our study included 2683 participants, of which 1631 were ALS patients (mean age = 60.36), 792 were healthy controls (mean age = 57.79), and 260 were patients with other neurological disorders. ALS patients had significantly smaller nerve size compared to controls. Nerve size differences were observed in the vagus nerve [MD = \u22120.23], phrenic nerve [MD = \u22120.25], C5 nerve root [SMD = \u22120.94], C6 nerve root [SMD = \u22121.56], C7 nerve root [SMD = \u22121.18], C8 nerve root [MD = \u22121.9], accessory nerve [MD = \u22120.32], sciatic nerve [MD = \u221211], tibial nerve [MD = \u22120.68], sural nerve [MD = \u22120.32,], ulnar nerve [MD = \u22120.80], and median nerve [MD = \u22121.21]. Conclusions: Our findings showed that ALS patients have a sonographically smaller nerve size than healthy controls. Therefore, this is a potential marker for neuronal diseases.<\/jats:p>","DOI":"10.3390\/medsci13020067","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T12:27:09Z","timestamp":1748867229000},"page":"67","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sonographic Evaluation of Peripheral Nerves and Cervical Nerve Roots in Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"13","author":[{"given":"Anas","family":"Elgenidy","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Cairo University, Cairo 12613, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim A.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Suez Canal University, Suez 41522, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasser","family":"Hamed","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Al-Azhar University, Assiut 71111, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan Ahmed","family":"Hashem","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Al-Azhar University, Assiut 71111, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osama","family":"Abuel-naga","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine, Ain Shams University, Cairo 11591, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hazem I.","family":"Abdel-Rahman","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine, Ain Shams University, Cairo 11591, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kawashty R.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Al-Azhar University, Assiut 71111, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belal Mohamed","family":"Hamed","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Al-Azhar University, Cairo 11884, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mennatullah A.","family":"Shehab","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Cairo University, Cairo 12613, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Zeyada","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Kafr El-Sheikh University, Kafr El-Sheikh 33516, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somaia","family":"Kassab","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaimaa Sabri Abdelkarim","family":"Abdelgawad","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelbaki Idriss","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Cairo University, Cairo 12613, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekram Hassan","family":"Hasanin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Tripoli, Tripoli 13932, Libya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amira A.","family":"Elhoufey","sequence":"additional","affiliation":[{"name":"Department of Community Health Nursing, Alddrab University College, Jazan University, Jazan 45142, Saudi Arabia"},{"name":"Department of Community Health Nursing, Faculty of Nursing, Assiut University, Assiut 71516, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid Hashim","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Shaqra University, Dawadmi 11911, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8473-6116","authenticated-orcid":false,"given":"Khaled","family":"Saad","sequence":"additional","affiliation":[{"name":"Pediatric Department, Faculty of Medicine, Assiut University, Assiut 71516, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,1]]},"reference":[{"key":"ref_1","first-page":"1489","article-title":"Amyotrophic Lateral Sclerosis: Lou Gehrig\u2019s Disease","volume":"59","author":"Walling","year":"1999","journal-title":"Am. 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