{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T03:51:23Z","timestamp":1790308283011,"version":"4.1.0"},"reference-count":216,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>Wound care in military and combat environments poses distinct challenges that set it apart from conventional medical practice in civilian settings. The nature of injuries sustained on the battlefield\u2014often complex, contaminated, and involving extensive tissue damage\u2014combined with limited access to immediate medical intervention, significantly increases the risk of infection, delayed healing, and adverse outcomes. Traditional wound dressings frequently prove inadequate under such extreme conditions, as they have not been designed to address the specific physiological and logistical constraints present during armed conflicts. This review provides a comprehensive overview of recent progress in the development of advanced wound dressings tailored for use in military scenarios. Special attention has been given to multifunctional dressings that go beyond basic wound coverage by incorporating biologically active macromolecules such as collagen, chitosan, thrombin, alginate, therapeutic peptides, and growth factors. These compounds contribute to properties including moisture balance control, exudate absorption, microbial entrapment, and protection against secondary infection. This review highlights the critical role of advanced wound dressings in improving medical outcomes for injured military personnel. The potential of these technologies to reduce complications, enhance healing rates, and ultimately save lives underscores their growing importance in modern battlefield medicine.<\/jats:p>","DOI":"10.3390\/medsci13030106","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T09:41:17Z","timestamp":1754300477000},"page":"106","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Biological Macromolecule-Based Dressings for Combat Wounds: From Collagen to Growth Factors\u2014A Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5335-3043","authenticated-orcid":false,"given":"Wojciech","family":"Kamysz","sequence":"first","affiliation":[{"name":"Department of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, 80-416 Gdansk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8389-0920","authenticated-orcid":false,"given":"Patrycja","family":"Kleczkowska","sequence":"additional","affiliation":[{"name":"Department of Biomedical Research, National Medicines Institute, 00-725 Warsaw, Poland"},{"name":"Maria Sklodowska-Curie Medical Academy in Warsaw, 03-411 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,1]]},"reference":[{"key":"ref_1","unstructured":"Mair, T.S., Love, S., Schumacher, J., Smith, R.K.W., and Frazer, G. (2012). Principles of wound management. Equine Medicine, Surgery and Reproduction, 2nd ed, Saunders Ltd."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"103564","DOI":"10.1016\/j.jddst.2022.103564","article-title":"Recent advances in 3D printing for wound healing: A systematic review","volume":"74","author":"Tabriz","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/bjs.1800770604","article-title":"Interaction of penetrating missiles with tissues: Some common misapprehensions and implications for wound management","volume":"77","author":"Cooper","year":"1990","journal-title":"Br. J. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1002\/jps.21210","article-title":"Wound healing dressings and drug delivery systems: A review","volume":"97","author":"Boateng","year":"2008","journal-title":"J. Pharm. Sci."},{"key":"ref_5","unstructured":"Chehade, M., and Granick, M. (2007). Surgical Wound Management, Informa."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1053\/j.sult.2018.10.018","article-title":"Gunshot wounds: Ballistics and imaging Findings","volume":"40","author":"Pinto","year":"2019","journal-title":"Semin. Ultrasound CT MRI"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1136\/jramc-147-01-03","article-title":"Blast injuries: Biophysics, pathophysiology and management principles","volume":"147","author":"Horrocks","year":"2000","journal-title":"J. R. Army Med. Corps"},{"key":"ref_8","first-page":"6","article-title":"Professional Committee and Youth Committee on Disaster Medicine. Expert consensus on the evaluation and diagnosis of combat injuries of the Chinese People\u2019s Liberation Army","volume":"5","author":"Zong","year":"2018","journal-title":"Mil. Med. Res."},{"key":"ref_9","unstructured":"(2025, May 14). Available online: https:\/\/medcoeckapwstorprd01.blob.core.usgovcloudapi.net\/pfw-images\/dbimages\/Ch%201.pdf."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.spinee.2011.11.014","article-title":"Wartime spine injuries: Understanding the improvised explosive device and biophysics of blast trauma","volume":"12","author":"Kang","year":"2012","journal-title":"Spine J."},{"key":"ref_11","unstructured":"(2025, May 13). Available online: https:\/\/shop.icrc.org\/classification-croix-rouge-des-plaies-perforantes-pdf-en.html."},{"key":"ref_12","first-page":"37","article-title":"Infection and treatment of chronic wounds","volume":"3","author":"Bartoszewicz","year":"2017","journal-title":"Lek. POZ"},{"key":"ref_13","unstructured":"Giannou, C., and Baldan, M. (2020). War Surgery: Working with Limited Resources in Armed Conflict and Other Situations of Violence Volume 1, International Committee of the Red Cross."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/milmed\/154.6.311","article-title":"Infections in war wounds\u2014Experience in recent military conflicts and future considerations","volume":"154","author":"Jacob","year":"1989","journal-title":"Mil. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.injury.2009.02.014","article-title":"Battlefield extremity injuries in Operation Iraqi Freedom","volume":"40","author":"Dougherty","year":"2009","journal-title":"Injury"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.fcl.2009.10.007","article-title":"Unique complications of foot and ankle injuries secondary to warfare","volume":"15","author":"Ursone","year":"2010","journal-title":"Foot Ankle Clin."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/j.1742-481X.2008.00541.x","article-title":"Hydrocolloid dressings in the management of acute wounds: A review of the literature","volume":"5","author":"Thomas","year":"2008","journal-title":"Int. Wound J."},{"key":"ref_18","unstructured":"(2025, May 13). Available online: https:\/\/www.woundsource.com\/sites\/default\/files\/whitepapers\/types_of_wound_dressings_-_features_indications_and_contraindications.pdf."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"289","DOI":"10.7181\/acfs.2019.00472","article-title":"Wound healing effect of regenerated oxidized cellulose versus fibrin sealant patch: An in vivo study","volume":"20","author":"Yoon","year":"2019","journal-title":"Arch. Craniofac. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.colsurfb.2018.05.016","article-title":"Graphene-kaolin composite sponge for rapid and riskless hemostasis","volume":"169","author":"Liang","year":"2018","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.colsurfb.2017.10.021","article-title":"Synergy in thrombin-graphene sponge for improved hemostatic efficacy and facile utilization","volume":"161","author":"Li","year":"2018","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"tkab019","DOI":"10.1093\/burnst\/tkab019","article-title":"Hemostatic materials in wound care","volume":"9","author":"Yu","year":"2021","journal-title":"Burns Trauma"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.biologicals.2010.07.001","article-title":"The long term immunological response of swine after two exposures to a salmon thrombin and fibrinogen hemostatic bandage","volume":"38","author":"Rothwell","year":"2010","journal-title":"Biologicals"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1271\/bbb.80649","article-title":"Effects of collagen peptide ingestion on UV-B-induced skin damage","volume":"73","author":"Tanaka","year":"2009","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Mathew-Steiner, S.S., Roy, S., and Sen, C.K. (2021). Collagen in wound healing. Bioengineering, 8.","DOI":"10.3390\/bioengineering8050063"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Diller, R.B., and Tabor, A.J. (2022). The role of the extracellular matrix (ECM) in wound healing: A review. Biomimetics, 7.","DOI":"10.3390\/biomimetics7030087"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/nature07039","article-title":"Wound repair and regeneration","volume":"453","author":"Gurtner","year":"2008","journal-title":"Nature"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Hu, Z., Yang, P., Zhou, C., Li, S., and Hong, P. (2017). Marine collagen peptides from the skin of Nile tilapia (Oreochromis niloticus): Characterization and wound healing evaluation. Mar. Drugs, 15.","DOI":"10.3390\/md15040102"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1089\/wound.2013.0485","article-title":"Extracellular matrix reorganization during wound healing and its impact on abnormal scarring","volume":"4","author":"Xue","year":"2015","journal-title":"Adv. Wound Care"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/MBC.0000000000001130","article-title":"The role of thrombin in haemostasis","volume":"33","year":"2022","journal-title":"Blood Coagul. Fibrinolysis"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.thromres.2011.11.001","article-title":"Mechanisms of platelet activation by thrombin: A short history","volume":"129","year":"2012","journal-title":"Thromb. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.2741\/1715","article-title":"Platelet aggregation: Involvement of thrombin and fibrin(ogen)","volume":"10","author":"Lisman","year":"2005","journal-title":"Front. Biosci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1055\/s-0041-1727116","article-title":"Thrombin: A pivotal player in hemostasis and beyond","volume":"47","author":"Larsen","year":"2021","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_34","first-page":"8","article-title":"Thrombin as a regulator of inflammation and reparative processes in tissues","volume":"66","author":"Strukova","year":"2001","journal-title":"Biochemistry"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"10313","DOI":"10.1016\/S0021-9258(18)67526-X","article-title":"The kinetics of inhibition of alpha-thrombin in human plasma","volume":"261","author":"Jesty","year":"1986","journal-title":"J. Biol. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ijpharm.2017.09.056","article-title":"Kaolinite in pharmaceutics and biomedicine","volume":"533","author":"Awad","year":"2017","journal-title":"Int. J. Pharm."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1136\/jcp.11.5.406","article-title":"The kaolin clotting time; a rapid one-stage method for diagnosis of coagulation defects","volume":"11","author":"Margolis","year":"1958","journal-title":"J. Clin. Pathol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.ijbiomac.2022.07.186","article-title":"Electrospun kaolin-loaded chitosan\/PEO nanofibers for rapid hemostasis and accelerated wound healing","volume":"217","author":"Liu","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"9937","DOI":"10.1021\/acs.chemmater.0c02823","article-title":"Two-Pronged strategy of biomechanically active and biochemically multifunctional hydrogel wound dressing to accelerate wound closure and wound healing","volume":"32","author":"Li","year":"2020","journal-title":"Chem. Mater."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"012080","DOI":"10.1088\/1757-899X\/536\/1\/012080","article-title":"Comparison between surfactant and chitosan organo-kaolin adsorbents to remove metal and organic compound in peat water","volume":"536","author":"Syafruddin","year":"2019","journal-title":"IOP Conf. Ser. Mater. Sci. Eng."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Feng, P., Luo, Y., Ke, C., Qiu, H., Wei, W., Zhu, Y., Hou, R., Xu, L., and Wu, S. (2021). Chitosan-based functional materials for skinn wound repair: Mechanisms and applications. Front. Bioeng. Biotechnol., 9.","DOI":"10.3389\/fbioe.2021.650598"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.tifs.2020.08.016","article-title":"Recent insights into the extraction, characterization, and bioactivities of chitin and chitosan from insects","volume":"105","author":"Mohan","year":"2020","journal-title":"Trends Food Sci. Technol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1007\/s10439-008-9543-7","article-title":"Exothermic reaction in zeolite hemostatic dressings: QuikClot ACS and ACS+","volume":"36","author":"Arnaud","year":"2008","journal-title":"Ann. Biomed. Eng."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ijcard.2010.10.030","article-title":"A new kaolin-based hemostatic bandage use after coronary diagnostic and interventional procedures","volume":"156","author":"Trabattoni","year":"2012","journal-title":"Int. J. Cardiol."},{"key":"ref_45","first-page":"51","article-title":"Use of kaolin-impregnated gauze for improvement of intraoperative hemostasis and postoperative wound healing in blepharoplasty","volume":"9","author":"Kondapalli","year":"2016","journal-title":"J. Clin. Aesthet. Dermatol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0304-3959(98)00090-6","article-title":"Treatment with either high or low frequency TENS reduces the secondary hyperalgesia observed after injection of kaolin and carrageenan into the knee joint","volume":"77","author":"Sluka","year":"1998","journal-title":"Pain"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/BF01972814","article-title":"Kaolin-induced writhing in mice, a new model of possible bradykinin-induced pain for assessment of analgesic agents","volume":"27","author":"Fujiyoshi","year":"1989","journal-title":"Agents Actions"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1097\/00005373-200009000-00021","article-title":"United States Army Rangers in Somalia: An analysis of combat casualties on an urban battlefield","volume":"49","author":"Mabry","year":"2000","journal-title":"J. Trauma"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1097\/01.TA.0000068258.99048.70","article-title":"Comparative analysis of hemostatic agents in a swine model of lethal groin injury","volume":"54","author":"Alam","year":"2003","journal-title":"J. Trauma"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1097\/00005373-200003000-00013","article-title":"Comparison of poly-N-acetylglucosamine with absorbable collagen and fibrin sealant for achieving hemostasis in a swine model of splenic hemorrhage","volume":"48","author":"Chan","year":"2000","journal-title":"J. Trauma"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1097\/01.TA.0000075336.92129.27","article-title":"Advanced hemostatic dressing development program: Animal model selection criteria and results of a study of nine hemostatic dressings in a model of severe large venous hemorrhage and hepatic injury in swine","volume":"55","author":"Pusateri","year":"2003","journal-title":"J. Trauma"},{"key":"ref_52","first-page":"1413","article-title":"Advanced hemostatic dressing are not superior to gauze for care under fire scenario","volume":"70","author":"Watters","year":"2011","journal-title":"J. Trauma"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.jid.2017.12.001","article-title":"A modeling conundrum: Murine models for cutaneous wound healing","volume":"138","author":"Elliot","year":"2018","journal-title":"J. Invesetig. Dermatol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"91-e27","DOI":"10.1111\/vde.13032","article-title":"Wound healing in animals: A review of physiology and clinical evaluation","volume":"33","author":"Lux","year":"2022","journal-title":"Vet. Dermatol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/jid.2010.291","article-title":"Exploring the \u201chair growth\u2013wound healing connection\u201d: Anagen phase promotes wound re-epithelialization","volume":"131","author":"Ansell","year":"2011","journal-title":"J. Investig. Dermatol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/0002-9610(92)90108-4","article-title":"Comparative efficacy of topical hemostatic agents in a rat kidney model","volume":"163","author":"Raccuia","year":"1992","journal-title":"Am. J. Surg."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1111\/j.1538-7836.2006.01861.x","article-title":"Fibrin structure and wound healing","volume":"4","author":"Laurens","year":"2006","journal-title":"J. Thromb. Haemost."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1742-481X.2007.00367.x","article-title":"Effect of oxidized regenerated cellulose\/collagen matrix on proteases in wound exudate of patients with chronic venous ulceration","volume":"5","author":"Ulrich","year":"2008","journal-title":"Int. Wound. J."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jcma.2012.03.007","article-title":"Effect of oxidized regenerated cellulose on the healing of pharyngeal wound: An experimental animal study","volume":"75","author":"Liu","year":"2012","journal-title":"J. Chin. Med. Assoc."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Ezer, M., Do\u011fantekin, E., \u00c7aydere, M., Ko\u00e7, A., \u00d6ktem, C., and H\u00fcc\u00fcmeno\u011flu, S. (2025). The impact of absorbable hemostatic agents on wound healing in an experimental penile fracture rat model. BMC Urol., 25.","DOI":"10.1186\/s12894-025-01697-8"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"100353","DOI":"10.1016\/j.esxm.2021.100353","article-title":"Sexual function outcomes after surgical treatment of penile fracture","volume":"9","author":"Ouanes","year":"2021","journal-title":"Sex Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.chemosphere.2016.01.077","article-title":"Role of bentonite clays on cell growth","volume":"149","author":"Kaufhold","year":"2016","journal-title":"Chemosphere"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1002\/vms3.908","article-title":"Regenerative and anti-inflammatory effect of a novel bentonite complex on burn wounds","volume":"8","author":"Lee","year":"2022","journal-title":"Vet. Med. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.jss.2015.08.023","article-title":"The effect of CoolClot hemostatic agent on skin wound healing in rats","volume":"200","author":"Khoshmohabat","year":"2016","journal-title":"J. Surg. Res."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Albahri, G., Badran, A., Hijazi, A., Daou, A., Baydoun, E., Nasser, M., and Merah, O. (2023). The therapeutic wound healing bioactivities of various medicinal plants. Life, 13.","DOI":"10.3390\/life13020317"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.ijpharm.2016.11.006","article-title":"Novel nanofibrous dressings containing rhEGF and Aloe vera for wound healing applications","volume":"523","author":"Gainza","year":"2017","journal-title":"Int. J. Pharm."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3109\/13880209.2015.1028079","article-title":"Antibacterial, antioxidant, and topical anti-inflammatory activities of Bergia ammannioides: A wound-healing plant","volume":"54","author":"Ezzat","year":"2016","journal-title":"Pharmaceutic. Biol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2684108","DOI":"10.1155\/2019\/2684108","article-title":"Wound healing and the use of medicinal plants","volume":"2019","author":"Shedoeva","year":"2019","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"ref_69","first-page":"403","article-title":"Limb salvage in extensive diabetic foot ulceration-a preliminary clinical study using simple debridement and herbal drinks","volume":"7","author":"Wong","year":"2001","journal-title":"Hong Kong Med. J."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1111\/j.1524-475X.2008.00422.x","article-title":"Enhanced wound healing by an epigallocatechin gallate-incorporated collagen sponge in diabetic mice","volume":"16","author":"Kim","year":"2008","journal-title":"Wound Repair Regen."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Zouari Bouassida, K., Bardaa, S., Khimiri, M., Rebaii, T., Tounsi, S., Jlaiel, L., and Trigui, M. (2017). Exploring the Urtica dioica leaves hemostatic and wound-healing potential. Biomed. Res. Int., 2017.","DOI":"10.1155\/2017\/1047523"},{"key":"ref_72","first-page":"100025","article-title":"Herbal hemostatic biopolymeric dressings of alginate\/pectin coated with Croton oblongifolius extract","volume":"2","author":"Sutar","year":"2021","journal-title":"Carbohyd. Polym. Technol. Appl."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.ijbiomac.2019.08.202","article-title":"Spongy wound dressing of pectin\/carboxymethyl tamarind seed polysaccharide loaded with moxifloxacin beads for effective wound heal","volume":"140","author":"Pandit","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1016\/j.biomaterials.2012.12.008","article-title":"A mechanistic investigation of the effect of keratin-based hemostatic agents on coagulation","volume":"34","author":"Rahmany","year":"2013","journal-title":"Biomaterials"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Shah, A., and Amini-Nik, S. (2017). The role of phytochemicals in the inflammatory phase of wound healing. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18051068"},{"key":"ref_76","first-page":"18","article-title":"Anti-oxidative and anti-inflammatory effects of Carissa spinarum L., Croton oblongifolius Roxb and Dioscorea bulbifera L., in LPS-induced RAW265.7 cell","volume":"11","author":"Thida","year":"2019","journal-title":"J. Chem Pharm. Res."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Urrutia-Hern\u00e1ndez, T.A., Santos-L\u00f3pez, J.A., Bened\u00ed, J., S\u00e1nchez-Muniz, F.J., Vel\u00e1zquez-Gonz\u00e1lez, C., De la O-Arciniega, M., Jaramillo-Morales, O.A., and Bautista, M. (2019). Antioxidant and hepatoprotective effects of croton hypoleucus extract in an induced-necrosis model in rats. Molecules, 24.","DOI":"10.3390\/molecules24142533"},{"key":"ref_78","first-page":"1059","article-title":"Hemostatic effecs of traditional Inula viscosa and Capsella bursa-pastoris plant mixture extract on rat liver parenchymal bleeding model","volume":"28","author":"Ozturk","year":"2022","journal-title":"Ulus Taramva Acil. Cerrahi. Derg."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"95","DOI":"10.4274\/tjps.galenos.2023.03746","article-title":"Determination of the effects of ankaferd wound dressing on the wound healing process in rats","volume":"21","author":"Erdal","year":"2024","journal-title":"Turk. J. Pharm. Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1155\/2010\/896819","article-title":"Ankaferd Blood Stopper for controlling gastrointestinal bleeding due to distinct benign lesions refractory to conventional antihemorrhagic measures","volume":"24","author":"Kurt","year":"2010","journal-title":"Can. J. Gastroenterol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1177\/147323000803600121","article-title":"Haemostatic actions of the folkloric medicinal plant extract, Ankaferd Blood Stopper","volume":"36","author":"Goker","year":"2008","journal-title":"J. Int. Med. Res."},{"key":"ref_82","first-page":"218","article-title":"The effects of Ankaferd, a hemostatic agent, on wound healing","volume":"49","author":"Sezgin","year":"2015","journal-title":"Turkderm Turk Arch. Dermatol. Venereol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"244","DOI":"10.5152\/TurkThoracJ.2019.244","article-title":"Fatigue frequency and related factors in patients with sarcoidosis","volume":"20","author":"Balbay","year":"2019","journal-title":"Turk. Thorac. J."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Xie, Y., Gao, P., He, F., and Zhang, C. (2022). Application of alginate-based hydrogels in hemostasis. Gels, 8.","DOI":"10.3390\/gels8020109"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Atepileva, A., Ogay, V., Kudaibergen, G., Kaukabaeva, G., Mukhambetova, A., Balgazarov, S., Batpen, A., and Ramazanov, Z. (2024). Exploring the antibacterial and regenerative properties of a two-stage alginate wound dressing in a rat model of purulent wounds. Biomedicines, 12.","DOI":"10.3390\/biomedicines12092122"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jddst.2019.02.032","article-title":"Chitosan\/alginate hydrogels containing alpha-tocopherol for wound healing in rat model","volume":"51","author":"Ehterami","year":"2019","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1016\/j.ijbiomac.2020.07.311","article-title":"Alginate hydrogel dressings for advanced wound management","volume":"162","author":"Zhang","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/mabi.200900129","article-title":"Hemostatic efficacy of biological self-assembling peptide nanofibers in a rat kidney model","volume":"10","author":"Song","year":"2010","journal-title":"Macromol. Biosci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.1021\/bm100894j","article-title":"Rational design of responsive self-assembling peptides from native protein sequences","volume":"11","author":"Huang","year":"2010","journal-title":"Biomacromol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"4814","DOI":"10.1002\/adfm.201501489","article-title":"A highly elastic and rapidly crosslinkable elastin-like polypeptide-based hydrogel for biomedical applications","volume":"25","author":"Zhang","year":"2015","journal-title":"Adv. Funct. Mater."},{"key":"ref_91","unstructured":"Desai, M.S. (2025, June 03). Development of Diverse Hydrogels from the Protean Polimer, Elastin-Like Polypeptides. Available online: https:\/\/escholarship.org\/content\/qt3xn136g6\/qt3xn136g6_noSplash_03f707a4846017c14217d3cd1273aff1.pdf."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1021\/acs.biomac.0c00740","article-title":"Catechol-functionalized elastin-like polypeptides as tissue adhesives","volume":"21","author":"Desai","year":"2020","journal-title":"Biomacromolecules"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.1039\/D0SM02202K","article-title":"Elastin-inspired supramolecular hydrogels: A multifaceted extracellular matrix protein in biomedical engineering","volume":"17","author":"Sharma","year":"2021","journal-title":"Soft Matter"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"5557","DOI":"10.1016\/j.biomaterials.2004.01.013","article-title":"Comparative evaluation of absorbable hemostats: Advantages of fibrin-based sheets","volume":"25","author":"Krishnan","year":"2004","journal-title":"Biomaterials"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1001\/archsurg.133.1.32","article-title":"Efficacy of a dry fibrin sealant dressing for hemorrhage control following ballistic injury","volume":"113","author":"Holcomb","year":"1998","journal-title":"Arch. Surg."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ijpharm.2008.03.021","article-title":"Development of polyvinyl alcohol-sodium alginate gel-matrix-based wound dressing system containing nitrofurazone","volume":"359","author":"Kim","year":"2008","journal-title":"Int. J. Pharm."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1093\/milmed\/usaa403","article-title":"Efficacy of hemostatic gauzes in a swine model of prolonged field care with limb movement","volume":"186","author":"Landers","year":"2021","journal-title":"Mil. Med."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Li, H., Wang, L., Alwaal, A., Lee, Y.C., Reed-Maldonado, A., Spangler, T.A., Banie, L., O\u2019Hara, R.B., and Lin, G. (2016). Comparison of topical hemostatic agents in a swine model of extremity arterial hemorrhage: BloodSTOP iV battle matrix vs. QuikClot combat gauze. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17040545"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"88","DOI":"10.14235\/bas.galenos.2021.5544","article-title":"Investigation of the effectiveness of plant based algan hemostatic agent in a rat model of femoral arterial bleeding","volume":"10","author":"Ekici","year":"2022","journal-title":"Bezmialem Sci."},{"key":"ref_100","first-page":"50","article-title":"Principles of wound dressings: A review","volume":"35","author":"Obagi","year":"2019","journal-title":"Surg. Technol. Int."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3390\/ebj5010005","article-title":"Burn wound care strategies for the battlefield and austere settings","volume":"5","author":"Shingleton","year":"2024","journal-title":"Eur. Burn J."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/BCR.0000000000000368","article-title":"Guidelines for burn care under austere conditions: Surgical and nonsurgical wound management","volume":"38","author":"Cancio","year":"2017","journal-title":"J. Burn Care Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"282","DOI":"10.21037\/qims-21-1164","article-title":"Safety and efficiency of femoral artery access closure using QuikClot Combat Gauze in patients with severe arterial calcification of access sites","volume":"13","author":"Meng","year":"2013","journal-title":"Quant. Imaging Med. Surg."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.amsu.2014.03.001","article-title":"The effects of QuikClot Combat Gauze on hemorrhage control in the presence of hemodilution and hypothermia","volume":"3","author":"Johnson","year":"2014","journal-title":"Ann. Med. Surg."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"e26023","DOI":"10.5812\/traumamon.26023","article-title":"Overview of agents used for emergency hemostasis","volume":"21","author":"Khoshmohabat","year":"2016","journal-title":"Trauma Mon."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"57","DOI":"10.55460\/J6YJ-1GY1","article-title":"The effects of movement on hemorrhage when QuikClot\u00ae Combat Gauze\u2122 is used in a hypothermic hemodiluted porcine model","volume":"15","author":"Gegel","year":"2015","journal-title":"J. Spec. Oper. Med."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1097\/01.TA.0000105916.30158.06","article-title":"Thermal injury resulting from application of a granular mineral hemostatic agent","volume":"57","author":"Wright","year":"2004","journal-title":"J. Trauma"},{"key":"ref_108","first-page":"1093","article-title":"QuikClot use in trauma for hemorrhage control: Case series of 103 documented uses","volume":"64","author":"Rhee","year":"2008","journal-title":"J. Trauma"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"716","DOI":"10.7205\/MILMED.169.9.716","article-title":"Hemostatic dressings for the first responder: A review","volume":"169","author":"Neuffer","year":"2004","journal-title":"Mil. Med."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1553-2712.2007.00009.x","article-title":"An alternative hemostatic dressing: Comparison of CELOX, HemCon, and QuikClot","volume":"15","author":"Kozen","year":"2008","journal-title":"Acad. Emerg. Med."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"e23862","DOI":"10.5812\/traumamon.23862","article-title":"Celox-coated gauze for the treatment of civilian penetrating trauma: A randomized clinical trial","volume":"20","author":"Hatamabadi","year":"2015","journal-title":"Trauma Mon."},{"key":"ref_112","unstructured":"(2025, May 21). Available online: https:\/\/celoxmedical.com."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"e13-14","DOI":"10.1016\/j.athoracsur.2008.09.046","article-title":"A new hemostatic agent: Initial life-saving experience with Celox (chitosan) in cardiothoracic surgery","volume":"87","author":"Millner","year":"2009","journal-title":"Ann. Thorac. Surg."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/MEJ.0b013e32833a5ee4","article-title":"Celox (chitosan) for haemostasis in massive traumatic bleeding: Experience in Afghanistan","volume":"18","author":"Pozza","year":"2011","journal-title":"Eur. J. Emerg. Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/j.1553-2712.2011.01036.x","article-title":"Comparison of Celox-A, ChitoFlex, WoundStat, and combat gauze hemostatic agents versus standard gauze dressing in control of hemorrhage in a swine model of penetrating trauma","volume":"18","author":"Littlejohn","year":"2011","journal-title":"Acad. Emerg. Med."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Perri, P., Curcio, F., De Luca, M., Piro, P., Trombino, S., and Cassano, R. (2025). Endovascular procedures in patients with leriche syndrome on anticoagulant therapy. Pharmaceuticals, 18.","DOI":"10.3390\/ph18040584"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"109746","DOI":"10.1016\/j.compositesb.2022.109746","article-title":"Double cross linking chitosan sponge with antibacterial and hemostatic properties for accelerating wound repair","volume":"234","author":"Cao","year":"2022","journal-title":"Compos. Part B Eng."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Ciarlantini, C., Lacolla, E., Francolini, I., Fern\u00e1ndez-Garc\u00eda, M., Mu\u00f1oz-N\u00fa\u00f1ez, C., Mu\u00f1oz-Bonilla, A., and Piozzi, A. (2024). Development of antioxidant and antimicrobial membranes based on functionalized and crosslinked chitosan for tissue regeneration. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25041961"},{"key":"ref_119","first-page":"e5527","article-title":"Pre-hospital hemorrhagic control effectiveness of Axiostat\u00ae dressing versus conventional method in acute hemorrhage due to trauma","volume":"11","author":"Kabeer","year":"2019","journal-title":"Cureus"},{"key":"ref_120","unstructured":"(2025, April 04). Available online: https:\/\/axiobio.com\/axiostat\/z-fold-haemostatic-gauze\/."},{"key":"ref_121","first-page":"234","article-title":"Evaluation of the safety and efficacy of the Axiostat\u00ae dressing device to achieve radial artery access hemostasis: The R3A study","volume":"104","author":"Nakache","year":"2024","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_122","unstructured":"(2025, April 04). Available online: https:\/\/woundclot.org\/battlefield-tested-hemostatic-agents-their-applications-for-hemorrhage-control-in-hospital-settings\/."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/CNQ.0000000000000249","article-title":"Hemorrhage control","volume":"42","author":"Allison","year":"2019","journal-title":"Crit. Care Nurs. Q."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"64","DOI":"10.55460\/RAYH-IZJP","article-title":"Evaluation of XSTAT\u00ae and QuickClot\u00ae Combat Gauze\u00ae in a swine model of lethal junctional hemorrhage in coagulopathic swine","volume":"17","author":"Cox","year":"2017","journal-title":"J. Spec. Oper. Med."},{"key":"ref_125","first-page":"256","article-title":"Evaluation of hemostatic devices in a randomized porcine model of junctional hemorrhage and 72-hour prolonged field care","volume":"96","author":"Pratt","year":"2024","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"e41465","DOI":"10.1016\/j.heliyon.2024.e41465","article-title":"Mutli-functional dressings for recovery and creenable treatment of wounds: A review","volume":"11","author":"Moradifar","year":"2025","journal-title":"Heliyon"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Zhang, W., Qu, H., Wu, X., Shi, J., and Wang, X. (2024). Rapid, sensitive, and user-friendly detection of Pseudomonas aeruginosa using the RPA\/CRISPR\/Cas12a system. BMC Infect. Dis., 24.","DOI":"10.1186\/s12879-024-09348-3"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"8097","DOI":"10.1128\/AEM.05316-11","article-title":"Expression of virulence factors by Staphylococcus aureus grown in serum","volume":"77","author":"Oogai","year":"2011","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/s41392-022-01056-1","article-title":"Pseudomonas aeruginosa: Pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics","volume":"7","author":"Qin","year":"2022","journal-title":"Signal Transduct. Target Ther."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"6903","DOI":"10.1021\/nn102272n","article-title":"Controlled release of biologically active silver from nanosilver surfaces","volume":"4","author":"Liu","year":"2010","journal-title":"ACS Nano"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1089\/sur.2008.9941","article-title":"History of the medical use of silver","volume":"10","author":"Alexander","year":"2009","journal-title":"Surg. Infect."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Yildiz, T., Durdu, S., Ozcan, K., and Usta, K.M. (2023). Characterization and investigation of biological properties of silver nanoparticle-doped hydroxyapatite-based surfaces on zirconium. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-33992-5"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Mohamed, D.S., El-Baky, R.M.A., Sandle, T., Mandour, S.A., and Ahmed, E.F. (2020). Antimicrobial activity of silver-treated bacteria against other multi-drug resistant pathogens in their environment. Antibiotics, 9.","DOI":"10.3390\/antibiotics9040181"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"176","DOI":"10.4103\/0970-0358.59276","article-title":"A comparative study to evaluate the effect of honey dressing and silver sulfadiazene dressing on wound healing in burn patients","volume":"42","author":"Baghel","year":"2009","journal-title":"Indian J. Plast. Surg."},{"key":"ref_135","first-page":"193","article-title":"To assess the efficacy of honey in comparison with 1% silver sulfadiazine cream as a burn wound dressing in superficial and partial thickness of burns","volume":"2","author":"Mujalde","year":"2014","journal-title":"Sch. J. Appl. Med. Sci."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"118313","DOI":"10.1016\/j.envres.2024.118313","article-title":"Mechanisms of bacterial resistance to environmental silver and antimicrobial strategies for silver: A review","volume":"248","author":"Li","year":"2024","journal-title":"Environ. Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"e2390","DOI":"10.1097\/GOX.0000000000002390","article-title":"Silver in wound care-friend or foe: A comprehensive review","volume":"7","author":"Khansa","year":"2019","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.burns.2003.09.030","article-title":"In vitro cytotoxity of silver: Implication for clinical wound care","volume":"30","author":"Poon","year":"2004","journal-title":"Burns"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/jbcr\/irx026","article-title":"The use of a silver-nylon dressing during evacuation of military burn casualties","volume":"39","author":"Aurora","year":"2018","journal-title":"J. Burn Care Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.55460\/4HMG-7SO2","article-title":"Experience in treating combat burns in Afghanistan by using silver-nylon dressing","volume":"14","author":"Pozza","year":"2014","journal-title":"J. Spec. Oper. Med."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1016\/j.burns.2014.09.017","article-title":"A literature review of the military uses of silver-nylon dressings with emphasis on wartime operations","volume":"40","author":"Barillo","year":"2014","journal-title":"Burns"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/01.BCR.0000155540.31879.FB","article-title":"Burn support for Operation Iraqi Freedom and related operations, 2003\u20132004","volume":"26","author":"Cancio","year":"2005","journal-title":"J. Burn Care Rehab."},{"key":"ref_143","unstructured":"(2025, June 08). Available online: https:\/\/www.silverlon.com\/silverlon-advantage\/mrsa-kill-rate."},{"key":"ref_144","unstructured":"(2025, June 01). Available online: https:\/\/l1enterprises.com\/wp-content\/uploads\/2020\/01\/L1-Enterprises-Silverlon-Literature.pdf."},{"key":"ref_145","unstructured":"Albrecht, M.C., Renz, E., Cancio, L.C., White, C.E., Blackbourne, L.H., Chung, K., Horvath, E.E., Bielke, P., Wolf, S.E., and Holcomb, J.B. (2025, April 14). Comparison of Silverlon Dressing to Xeroform Gauze in the Treatment of Skin Graft Donor Site Wounds. Available online: https:\/\/173839.fs1.hubspotusercontent-na1.net\/hubfs\/173839\/Studies%20with%20Disclaimers\/Comparison%20of%20Silverlon%20Dressing%20to%20Xeroform%20Gauze%20in%20the%20Treatment%20of%20Skin%20Graft%20Donor%20Site%20Wounds.pdf."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.jamcollsurg.2007.09.017","article-title":"Outcomes of bacteremia in burn patients involved in combat operations overseas","volume":"206","author":"Ressner","year":"2008","journal-title":"J. Am. Coll. Surg."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.injury.2013.12.005","article-title":"Prospective randomised controlled trial of nanocrystalline silver dressing versus plain gauze as the initial post-debridement management of military wounds on wound microbiology and healing","volume":"45","author":"Fries","year":"2014","journal-title":"Injury"},{"key":"ref_148","first-page":"149","article-title":"Antiseptics on wounds: An area of controversy","volume":"15","author":"Drosou","year":"2013","journal-title":"Wounds"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"233","DOI":"10.4103\/njms.NJMS_154_20","article-title":"Manuka honey: A promising wound dressing material for the chronic nonhealing discharging wounds: A retrospective study","volume":"12","author":"Kapoor","year":"2021","journal-title":"Natl. J. Maxillofac. Surg."},{"key":"ref_150","first-page":"12","article-title":"Debridement of wounds with honey","volume":"5","author":"Molan","year":"2009","journal-title":"J. Wound Technol."},{"key":"ref_151","first-page":"50","article-title":"Properties of honey: Its mode of action and clinical outcomes","volume":"7","author":"Haynes","year":"2011","journal-title":"Wounds UK"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.injury.2014.05.007","article-title":"A pre-clinical evaluation of silver, iodine and Manuka honey based dressings in a model of traumatic extremity wounds contaminated with Staphylococcus aureus","volume":"45","author":"Guthrie","year":"2014","journal-title":"Injury"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"332","DOI":"10.12968\/jowc.1998.7.7.332","article-title":"A povidone-iodine medicated dressing","volume":"7","author":"Lawrence","year":"1998","journal-title":"J. Wound Care"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/iwj.12602","article-title":"The role of inadine in wound care: A consensus document","volume":"14","author":"Sibbald","year":"2017","journal-title":"Int. Wound J."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0190-9622(85)70211-3","article-title":"Evaluation of a new povidone-iodine-impregnated polyethylene oxide gel occlusive dressing","volume":"13","author":"Mandy","year":"1985","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.12968\/jowc.2021.30.Sup4.S28","article-title":"Comparison of topical honey and povidone iodine-based dressings for wound healing: A systematic review and meta-analysis","volume":"30","author":"Zhang","year":"2021","journal-title":"J. Wound Care"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"e077902","DOI":"10.1136\/bmjopen-2023-077902","article-title":"Effectiveness of silver and iodine dressings on wound healing: A systematic review and meta-analysis","volume":"14","author":"Jiang","year":"2024","journal-title":"BMJ Open"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1097\/00129334-200509000-00011","article-title":"A toxicity index of skin and wound cleansers used on in vitro fibroblasts and keratinocytes","volume":"18","author":"Wilson","year":"2005","journal-title":"Adv. Skin Wound Care"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1089\/wound.2012.0401","article-title":"Wound dressings and comparative effectiveness data","volume":"3","author":"Sood","year":"2014","journal-title":"Adv. Wound Care"},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Miao, F., Li, Y., Zhang, Y., Gao, Y., Hu, M., and Zhu, Q. (2021). Antimicrobial peptides: The promising therapeutics for cutaneous wound healing. Macromol. Biosci., 21.","DOI":"10.1002\/mabi.202100103"},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Chen, Y., Qian, H., Peng, D., Jiang, Y., Liu, Q., Tan, Y., Feng, L., Cheng, B., and Li, G. (2024). Antimicrobial peptide-modified AIE visual composite wound dressing for promoting rapid healing of infected wounds. Front. Bioeng. Biotechnol., 11.","DOI":"10.3389\/fbioe.2023.1338172"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.actbio.2021.04.045","article-title":"Peptide-coated polyurethane material reduces wound infection and inflammation","volume":"128","author":"Ignatowicz","year":"2021","journal-title":"Acta Biomater."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"13422","DOI":"10.1021\/acsami.3c16061","article-title":"Hydrogel loaded with peptide-containing nanocomplexes: Symphonic cooperation of photothermal antimicrobial nanoparticls and prohealing peptides for the treatment of infected wounds","volume":"16","author":"Jia","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"105296","DOI":"10.1016\/j.phrs.2020.105296","article-title":"Discovery of a novel short peptide with efficacy in accelerating the healing of skin wounds","volume":"163","author":"Wang","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1742-481X.2008.00471.x","article-title":"Dressing-related pain in patients with chronic wounds: An international patient perspective","volume":"5","author":"Price","year":"2008","journal-title":"Int. Wound J."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"P22","DOI":"10.1186\/1757-1146-4-S1-P22","article-title":"What causes wound pain","volume":"4","author":"Frescos","year":"2011","journal-title":"J. Foot Ankle Res."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"75e","DOI":"10.1097\/PRS.0000000000011485","article-title":"A ropivacaine-eluting poly(lactide-co-caprolactone) wound dressing provided enhanced analgesia in partial-thickness porcine injuries","volume":"155","author":"Niederauer","year":"2025","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"109308","DOI":"10.1016\/j.eurpolymj.2019.109308","article-title":"Conductive polymeric film loaded with ibuprofen as a wound dressing material","volume":"121","author":"Aycan","year":"2019","journal-title":"Eur. Polym. J."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1742-481X.2007.00308.x","article-title":"A pilot (real-life) randomised clinical evaluation of a pain-relieving foam dressing: (ibuprofen-foam versus local best practice)","volume":"4","author":"Sibbald","year":"2007","journal-title":"Int. Wound J."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1743-6109.2006.00116.x","article-title":"Pain and quality of life for patients with venous leg ulcers: Proof of concept of the efficacy of Biatain-Ibu, a new pain reducing wound dressing","volume":"14","author":"Friis","year":"2006","journal-title":"Wound Repair Regen."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.1524-475X.2008.00412.x","article-title":"Reducing wound pain in venous leg ulcers with Biatain Ibu: A randomized, controlled double-blind clinical investigation on the performance and safety","volume":"16","author":"Gottrup","year":"2008","journal-title":"Wound Repair Regen."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1742-481X.2007.00310.x","article-title":"Why combine a foam dressing with ibuprofen for wound pain and moist wound healing","volume":"4","author":"Price","year":"2007","journal-title":"Int. Wound J."},{"key":"ref_173","first-page":"84","article-title":"Factors that impair wound healing","volume":"4","author":"Anderson","year":"2014","journal-title":"J. Am. Coll. Clin. Wound Spec."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1590\/S0102-86502014000500007","article-title":"Diclofenac topical gel in excisional wounds maintains heal quality and reduces phlogistic signals","volume":"29","author":"Costa","year":"2014","journal-title":"Acta Cir. Bras."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.burns.2020.10.006","article-title":"Analgesic efficacy of sufentanil in dressings after surgical treatment of burn wounds","volume":"47","author":"Kowalski","year":"2021","journal-title":"Burns"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1097\/00000542-200106000-00018","article-title":"Analgesic and antiinflammatory effects of two novel kappa-opioid peptides","volume":"94","author":"Binder","year":"2021","journal-title":"Anesthesiology"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0028-3908(01)00173-3","article-title":"Comparison of the peripheral and central effects of the opioid agonists loperamide and morphine in the formalin test in rats","volume":"42","author":"Shannon","year":"2002","journal-title":"Neuropharmacology"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1093\/brain\/awg115","article-title":"Peripheral opioid analgesia in experimental human pain models","volume":"126","author":"Tegeder","year":"2003","journal-title":"Brain"},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Stein, C. (2013). Targeting pain and inflammation by peripherally acting opioids. Front. Pharmacol., 4.","DOI":"10.3389\/fphar.2013.00123"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1089\/wound.2023.0037","article-title":"Morphine (10, 20 mg) in a postoperative dressing used with patients after surgical debridement of burn wounds: A prospective, double-blinded, randomized controlled trial","volume":"13","author":"Kowalski","year":"2023","journal-title":"Adv. Wound Care"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/0196-9781(82)90173-5","article-title":"Double-enkephalins\u2014Synthesis, activity on guinea-pig ileum, and analgesic effect","volume":"3","author":"Lipkowski","year":"1982","journal-title":"Peptides"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.trsl.2017.05.003","article-title":"Opioids and opioid receptors orchestrate wound repair","volume":"185","author":"Wang","year":"2017","journal-title":"Transl. Res."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"25783","DOI":"10.18632\/oncotarget.15419","article-title":"Opioids: Modulators of angiogenesis in wound healing and cancer","volume":"8","author":"Ondrovics","year":"2017","journal-title":"Oncotarget"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1182\/blood.V118.21.2118.2118","article-title":"Morphine stimulates wound healing via mu opioid receptor and promotes wound closure in sickle mice","volume":"118","author":"Vang","year":"2011","journal-title":"Blood"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1177\/0885328218801114","article-title":"Development of a novel keratin dressing which accelerates full-thickness skin wound healing in diabetic mice: In vitro and in vivo studies","volume":"33","author":"Konop","year":"2018","journal-title":"J. Biomater. Appl."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1046\/j.1523-1747.1999.00784.x","article-title":"The function of nitric oxide in wound repair: Inhibition of inducible nitric oxide-synthase severely impairs wound reepithelialization","volume":"113","author":"Stallmeyer","year":"1999","journal-title":"J. Investig. Dermatol."},{"key":"ref_187","first-page":"25","article-title":"Effect of non-steroidal anti-inflammatory drugs on post-surgical complications against the backdrop of the opioid crisis","volume":"13","author":"Hand","year":"2018","journal-title":"Burns Trauma"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/QCO.0000000000000160","article-title":"The roles of injury and nonsteroidal anti-inflammatory drugs in the development and outcomes of severe group A streptococcal soft tissue infections","volume":"28","author":"ABryant","year":"2015","journal-title":"Curr. Opin. Infect. Dis."},{"key":"ref_189","unstructured":"(2025, July 21). Available online: https:\/\/www.fda.gov\/media\/80384\/download."},{"key":"ref_190","unstructured":"(2025, July 21). Available online: https:\/\/www.fda.gov\/regulatory-information\/search-fda-guidance-documents\/purpose-and-content-use-related-risk-analyses-drugs-biological-products-and-combination-products."},{"key":"ref_191","unstructured":"(2025, July 21). Available online: https:\/\/www.exponent.com\/article\/fda-proposes-new-rule-reclassification-wound-dressings."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1080\/21691401.2018.1439836","article-title":"Role of growth factors and biomaterials in wound healing","volume":"46","author":"Zarei","year":"2018","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_193","first-page":"1445","article-title":"Vascular endothelial growth factor mediates angiogenic activity during the proliferative phase of wound healing","volume":"152","author":"Nissen","year":"1998","journal-title":"Am. J. Pathol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jss.2008.04.023","article-title":"The role of vascular endothelial growth factor in wound healing","volume":"153","author":"Bao","year":"2009","journal-title":"J. Surg. Res."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/jcb.240450407","article-title":"EGF and TGF-alpha in wound healing and repair","volume":"45","author":"Schultz","year":"1991","journal-title":"J. Cell Biochem."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1101\/gad.1653708","article-title":"Role of platelet-derived growth factors in physiology and medicine","volume":"22","author":"Andrae","year":"2008","journal-title":"Genes Dev."},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Mullin, J.A., Rahmani, E., Kiick, K.L., and Sullivan, M.O. (2023). Growth factors and growth factor gene therapies for treating chronic wounds. Bioeng. Transl. Med., 9.","DOI":"10.1002\/btm2.10642"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2015.11.007","article-title":"Engineering growth factors for regenerative medicine applications","volume":"30","author":"Mitchell","year":"2016","journal-title":"Acta Biomater."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1046\/j.1524-475x.2000.00162.x","article-title":"Recombinant human platelet-derived growth factor-BB (becaplermin) for healing chronic lower extremity diabetic ulcers: An open-label clinical evaluation of efficacy","volume":"8","author":"Embil","year":"2000","journal-title":"Wound Repair Regen."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0741-5214(95)70245-8","article-title":"Clinical evaluation of recombinant human platelet-derived growth factor for the treatment of lower extremity diabetic ulcers","volume":"21","author":"Steed","year":"1995","journal-title":"J. Vasc. Surg."},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Chakrabarti, S., Mazumder, B., Rajkonwar, J., Pathak, M.P., Patowary, P., and Chattopadhyay, P. (2021). bFGF and collagen matrix hydrogel attenuates burn wound inflammation through activation of ERK and TRK pathway. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-82888-9"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"218142","DOI":"10.4061\/2010\/218142","article-title":"Fibroblast growth factors: Biology, function, and application for tissue regeneration","volume":"2010","author":"Yun","year":"2010","journal-title":"J. Tissue Eng."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1021\/bm801103c","article-title":"Growth factor delivery approaches in hydrogels","volume":"10","author":"Silva","year":"2008","journal-title":"Biomacromolecules"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1524-475X.2008.00410.x","article-title":"Growth factors and cytokines in wound healing","volume":"16","author":"Barrientos","year":"2008","journal-title":"Wound Repair Regen."},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Asiri, A., Saidin, S., Sani, M.H., and Al, R.H. (2021). Epidermal and fibroblast growth factors incorporated polyvinyl alcohol electrospun nanofibers as biological dressing scaffold. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-85149-x"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1097\/01.prs.0000299922.96006.24","article-title":"Wound therapy by marrow mesenchymal cell transplantation","volume":"121","author":"Yoshikawa","year":"2008","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1007\/s00018-015-1856-8","article-title":"Instability restricts signaling of multiple fibroblast growth factors","volume":"72","author":"Buchtova","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1097\/ICO.0b013e318186321e","article-title":"Time- and temperature-dependent stability of growth factor peptides in human autologous serum eye drops","volume":"28","author":"Bradley","year":"2009","journal-title":"Cornea"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/stem.1021","article-title":"Thermal stability of fibroblast growth factor protein is a determinant factor in regulating self-renewal, differentiation, and reprogramming in human pluripotent stem cells","volume":"30","author":"Chen","year":"2012","journal-title":"Stem Cells"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"141","DOI":"10.15171\/apb.2015.021","article-title":"The effect of hypoxia on mesenchymal stem cell biology","volume":"5","author":"Ejtehadifar","year":"2015","journal-title":"Adv. Pharm. Bull."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1098\/rsif.2012.0271","article-title":"The sensitivity of human mesenchymal stem cells to vibration and cold storage conditions representative of cold transportation","volume":"9","author":"Nikolaev","year":"2012","journal-title":"J. R. Soc. Interface"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"e13267","DOI":"10.1111\/sji.13267","article-title":"Immunogenicity of mesenchymal stromal\/stem cells","volume":"97","author":"Chen","year":"2023","journal-title":"Scand. J. Immunol."},{"key":"ref_213","doi-asserted-by":"crossref","unstructured":"Mello, D.B., Mesquita, F.C.P., Santos, D.S.O., Asensi, K.D., Dias, M.L., de Carvalho, A.C.C., Goldenberg, R.C.D.S., and Kasai-Brunswick, T.H. (2024). Mesenchymal stromal cel-based products: Challenges and clinical therapeutic options. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25116063"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2217\/rme.14.73","article-title":"The translation of cell-based therapies: Clinical landscape and manufacturing challenges","volume":"10","author":"Heathman","year":"2015","journal-title":"Regen. Med."},{"key":"ref_215","unstructured":"(2025, July 21). Available online: https:\/\/www.ema.europa.eu\/en\/human-regulatory-overview\/marketing-authorisation\/advanced-therapies-marketing-authorisation\/scientific-recommendations-classification-advanced-therapy-medicinal-products."},{"key":"ref_216","unstructured":"(2025, July 21). Available online: https:\/\/eur-lex.europa.eu\/eli\/reg\/2007\/1394\/oj\/eng."}],"container-title":["Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3271\/13\/3\/106\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:21:09Z","timestamp":1760034069000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3271\/13\/3\/106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,1]]},"references-count":216,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["medsci13030106"],"URL":"https:\/\/doi.org\/10.3390\/medsci13030106","relation":{},"ISSN":["2076-3271"],"issn-type":[{"value":"2076-3271","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,1]]}}}