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Aim: To investigate the relationship between quality of life (QoL) and disease severity, as measured by a newly developed Lichen Sclerosus Score (LSc score), with respect to anatomical site before and after 12 weeks of treatment. Methods: A total of 136 patients diagnosed with LSc (88 men, 48 women) were enrolled between March and September 2022. Patients were clinically evaluated using the LSc score and completed the Dermatology Life Quality Index (DLQI). Treatment was individualized based on clinical findings and history. At 12 weeks, both clinical assessment and DLQI were repeated. Results: LSc scores significantly decreased following treatment (p &lt; 0.001), except in the female subgroup. In men, LSc scores were strongly correlated with DLQI scores both before (r = 0.709; p &lt; 0.001) and after (r = 0.492; p &lt; 0.001) treatment. Among women, a significant correlation was found only before treatment (r = 0.457; p &lt; 0.001). Significant associations were identified between LSc score and DLQI items 1, 8, and 9 in men and the overall cohort. No statistically significant differences in LSc scores or DLQI were observed across anatomical sites after correction for multiple comparisons. Conclusions: Disease severity in genital LSc is closely associated with QoL impairment. This is, to our knowledge, the first study to examine the correlation between a clinical severity score and DLQI. While anatomical site did not significantly affect scores, certain sites may have a disproportionate impact, underscoring the complex ways in which LSc affects patients\u2019 lives.<\/jats:p>","DOI":"10.3390\/medsci13030111","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T13:44:32Z","timestamp":1754401472000},"page":"111","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Assessing Quality of Life in Genital Lichen Sclerosus: The Role of Disease Severity and Localization\u2014A Swedish Prospective Cohort Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7572-7074","authenticated-orcid":false,"given":"Filippa","family":"Lundin","sequence":"first","affiliation":[{"name":"The Faculty of Medicine and Health Sciences, Linkoping University, 581 83 Linkoping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1345-4079","authenticated-orcid":false,"given":"Cassandra","family":"Jeppsson","sequence":"additional","affiliation":[{"name":"The Faculty of Medicine and Health Sciences, Linkoping University, 581 83 Linkoping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2045-7142","authenticated-orcid":false,"given":"Oliver","family":"Seifert","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Ryhov County Hospital, 553 05 Jonkoping, Sweden"},{"name":"Division of Cell Biology, Department of Biomedical and Clinical Sciences, Linkoping University, 581 83 Linkoping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1924-0149","authenticated-orcid":false,"given":"Georgios","family":"Kravvas","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University College London Hospitals NHS Foundation Trust, London NW1 2BU, UK"},{"name":"Department of Medicine, University College London, London NW1 2BU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1051-043X","authenticated-orcid":false,"given":"Sandra","family":"Jerkovic Gulin","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Ryhov County Hospital, 553 05 Jonkoping, Sweden"},{"name":"Division of Cell Biology, Department of Biomedical and Clinical Sciences, Linkoping University, 581 83 Linkoping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Oyama, N., and Hasegawa, M. 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