{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:28:08Z","timestamp":1790216888852,"version":"4.1.0"},"reference-count":160,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>Eryptosis is a type of regulated cell death of mature erythrocytes characterized by excessive Ca2+ accumulation followed by phosphatidylserine externalization. Eryptosis facilitates erythrophagocytosis resulting in eradication of damaged erythrocytes, which maintains the population of healthy erythrocytes in blood. Over recent years, a wide array of diseases has been reported to be linked to accelerated eryptosis, which leads to anemia. A growing number of studies furnish evidence that eryptosis is implicated in the pathogenesis of liver diseases. Herein, we summarize the current knowledge of eryptosis signaling, its physiological role, and the impact of eryptosis on anemia and hypercoagulation. In this article, upon systemically analyzing the PubMed-indexed publications, we also provide a comprehensive overview of the role of eryptosis in the spectrum of hepatic diseases, its contribution to the development of complications in liver pathology, metabolites (bilirubin, bile acids, etc.) that might trigger eryptosis in liver diseases, and eryptosis-inducing liver disease medications. Eryptosis in liver diseases contributes to anemia, hypercoagulation, and endothelial damage (via ferroptosis of endothelial cells). Treatment-associated anemia in liver diseases might be at least partly attributed to drug-induced eryptosis. Ultimately, we analyze the concept of inhibiting eryptosis pharmaceutically to prevent eryptosis-associated anemia and thrombosis in liver diseases.<\/jats:p>","DOI":"10.3390\/medsci13030125","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T15:51:02Z","timestamp":1755013862000},"page":"125","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Eryptosis in Liver Diseases: Contribution to Anemia and Hypercoagulation"],"prefix":"10.3390","volume":"13","author":[{"given":"Saulesh","family":"Kurmangaliyeva","sequence":"first","affiliation":[{"name":"Department of Microbiology, Virology, and Immunology, NJSC \u201cWest Kazakhstan Marat Ospanov Medical University\u201d, 68 Maresyev st, Aktobe 030000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Baktikulova","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Virology, and Immunology, NJSC \u201cWest Kazakhstan Marat Ospanov Medical University\u201d, 68 Maresyev st, Aktobe 030000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1029-1636","authenticated-orcid":false,"given":"Anton","family":"Tkachenko","sequence":"additional","affiliation":[{"name":"BIOCEV, First Faculty of Medicine, Charles University, Pr\u016fmyslov\u00e1 595, 25250 Vestec, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bibigul","family":"Seitkhanova","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Virology, and Immunology, NJSC \u201cSouth Kazakhstan Medical Academy\u201d, Al-Farabi sq, Shymkent 160019, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0307-3048","authenticated-orcid":false,"given":"Liliya","family":"Tryfonyuk","sequence":"additional","affiliation":[{"name":"Institute of Health, National University of Water and Environmental Engineering, 11 Soborna st, 33028 Rivne, Ukraine"},{"name":"Rivne Regional Clinical Hospital, 78g Kyivska st, 33007 Rivne, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farida","family":"Rakhimzhanova","sequence":"additional","affiliation":[{"name":"Department of Microbiology, NJSC \u201cSemey Medical University\u201d, 103 Abay st, Semey 071400, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rustam","family":"Yussupov","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Virology, Republic NJSC \u201cKazakh National Medical University Named after S.D. Asfendiyarov\u201d, 94 Tole Bi, Almaty 005000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3579-9003","authenticated-orcid":false,"given":"Kairat","family":"Kurmangaliyev","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Virology, and Immunology, NJSC \u201cWest Kazakhstan Marat Ospanov Medical University\u201d, 68 Maresyev st, Aktobe 030000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Stanke, F., Janciauskiene, S., and Olejnicka, B. (2023). Editorial: Acute phase proteins as biomarkers and therapeutics in acute and chronic inflammatory conditions. Front. 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