{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:47:02Z","timestamp":1760060822717,"version":"build-2065373602"},"reference-count":13,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>Background: Erectile dysfunction (ED) is a disease whose occurrence is steadily increasing worldwide. This pathology is multifactorial and often combined with other diseases. ED of organic genesis in 50\u201380% of men is vasculogenic. Methods: A survey was conducted of 88 men (aged 44 to 62) who complained of erectile dysfunction. It consisted of a questionnaire administered according to the protocols \u201cInternational Index of Erectile Function\u201d and \u201cAging Male Screening\u201d, and was followed by a color Doppler ultrasound (Logiq 9 ExpertGE with a 7 MHz linear transducer using B mode) and penile scintigraphy (single-photon emission computed tomography). The procedures were initially performed at rest, then during pharmacologically induced erection, which was achieved through the intake of phosphodiesterase-5 (PDE5) inhibitors. Patients who did not respond to pharmacological stimulation and had IIEF scores below 5\u20137 were offered surgical treatment\u2014penile prosthesis followed by histological examination of the tissue of the corpus cavernosum. Statistical analysis was carried out using Microsoft Excel and STATISTICA 10.0 software. The Mann\u2013Whitney U test was used to assess differences between quantitative variables, with the significance level set at p \u2264 0.05. Results: Penile scintigraphy shows high sensitivity (85.2%) and specificity (83.3%), outperforming color Doppler ultrasonography in detecting vasculogenic ED. Conclusion: Penile scintigraphy is demonstrated to be a highly informative method, allowing us to analyze the condition of the magistral and organ blood flow, as well as the microcirculatory bed of the cavernous bodies of the penis. This improves the effectiveness of this method in diagnosing various types of vasculogenic erectile dysfunction (ED), which opens opportunities for its use together with ultrasound examination when the latter is less informative.<\/jats:p>","DOI":"10.3390\/medsci13040208","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T07:46:49Z","timestamp":1758786409000},"page":"208","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Penile Scintigraphy\u2014A Diagnostic Method for Vasculogenic Erectile Dysfunction"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4468-3670","authenticated-orcid":false,"given":"Nina","family":"Kulchenko","sequence":"first","affiliation":[{"name":"Department of Digital Oncomorphology, National Medical Research Centre of Radiology, 2nd Botkinsky Pass., 3, 125284 Moscow, Russia"},{"name":"Research and Educational Resource Center for Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis Innovative Technologies, Peoples\u2019 Friendship University of Russia (RUDN University), Miklukho-Maklaya Str. 6, 117198 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6870-0211","authenticated-orcid":false,"given":"Daniil","family":"Yuferov","sequence":"additional","affiliation":[{"name":"Laboratory of Histology and Immunohistochemistry, Institute of Translational Medicine and Biotechnology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya Str. 8\/2, 119048 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farid","family":"Mangutov","sequence":"additional","affiliation":[{"name":"Department of Digital Oncomorphology, National Medical Research Centre of Radiology, 2nd Botkinsky Pass., 3, 125284 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitri","family":"Kruglov","sequence":"additional","affiliation":[{"name":"Department of Digital Oncomorphology, National Medical Research Centre of Radiology, 2nd Botkinsky Pass., 3, 125284 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elina","family":"Korovyakova","sequence":"additional","affiliation":[{"name":"Research and Educational Resource Center for Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis Innovative Technologies, Peoples\u2019 Friendship University of Russia (RUDN University), Miklukho-Maklaya Str. 6, 117198 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petr","family":"Shegai","sequence":"additional","affiliation":[{"name":"Department of Digital Oncomorphology, National Medical Research Centre of Radiology, 2nd Botkinsky Pass., 3, 125284 Moscow, Russia"},{"name":"Department of Urology and Operative Nephrology, Peoples\u2019 Friendship University of Russia (RUDN University), Miklukho-Maklaya Str. 6, 117198 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Kaprin","sequence":"additional","affiliation":[{"name":"Department of Digital Oncomorphology, National Medical Research Centre of Radiology, 2nd Botkinsky Pass., 3, 125284 Moscow, Russia"},{"name":"Department of Urology and Operative Nephrology, Peoples\u2019 Friendship University of Russia (RUDN University), Miklukho-Maklaya Str. 6, 117198 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8447-2600","authenticated-orcid":false,"given":"Grigory","family":"Demyashkin","sequence":"additional","affiliation":[{"name":"Laboratory of Histology and Immunohistochemistry, Institute of Translational Medicine and Biotechnology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya Str. 8\/2, 119048 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.18773\/austprescr.2022.051","article-title":"Erectile dysfunction: Causes, assessment and management options","volume":"45","author":"Lowy","year":"2022","journal-title":"Aust. Prescr."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Pang, K., Pan, D., Xu, H., Ma, Y., Wang, J., Xu, P., Wang, H., and Zang, G. (2023). Advances in physical diagnosis and treatment of male erectile dysfunction. Front. Physiol., 13.","DOI":"10.3389\/fphys.2022.1096741"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Huang, W.L., Tung, S.Y., Tseng, C.S., Wang, T.D., Lee, W.J., Chen, J.H., Su, Y.R., Chang, H.C., and Chang, Y.K. (2022). The flow index provides a comprehensive assessment of erectile dysfunction by combining blood flow velocity and vascular diameter. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-19364-5"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.21037\/tau-23-116","article-title":"The effectiveness of radionuclide scintigraphy in confirming testicular torsion at delayed presentation","volume":"12","author":"Zondi","year":"2023","journal-title":"Transl. Androl. Urol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1093\/jsxmed\/qdae070","article-title":"Efficient use of penile Doppler ultrasound for investigating men with erectile dysfunction","volume":"21","author":"Flores","year":"2024","journal-title":"J. Sex. 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Cardiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1093\/ehjci\/jeaa298","article-title":"Myocardial perfusion scintigraphy for risk stratification of patients with coronary artery disease: The AMICO registry","volume":"23","author":"Gimelli","year":"2022","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1007\/s40620-023-01569-0","article-title":"Renal scintigraphy to predict persistent renal failure after acute kidney injury: An observational study","volume":"36","author":"Altarelli","year":"2023","journal-title":"J. Nephrol."}],"container-title":["Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3271\/13\/4\/208\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:49:05Z","timestamp":1760035745000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3271\/13\/4\/208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,24]]},"references-count":13,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["medsci13040208"],"URL":"https:\/\/doi.org\/10.3390\/medsci13040208","relation":{},"ISSN":["2076-3271"],"issn-type":[{"type":"electronic","value":"2076-3271"}],"subject":[],"published":{"date-parts":[[2025,9,24]]}}}