{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T05:10:05Z","timestamp":1788585005895,"version":"build-2803163510"},"reference-count":82,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Organization for Medical Innovation and Collaboration for Science"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>Background: Monkeypox (Mpox) is a re-emerging zoonotic disease caused by the monkeypox virus (MPXV). Transmission occurs primarily through direct contact with lesions or contaminated materials, with sexual transmission playing a significant role in recent outbreaks. In 2022, Mpox triggered a major global outbreak and was declared a Public Health Emergency of International Concern (PHEIC) by the World Health Organization (WHO), prompting renewed interest in effective control strategies. Methods: This study developed a compartmental SEIR-based model to assess the epidemiological impact of key interventions, including vaccination and isolation, while incorporating critical epidemiological parameters. Sensitivity analyses were conducted to examine (1) disease dynamics in relation to the basic reproduction number, and (2) how different parameters influence the curve of symptomatic infections. Real-world continental-scale data were used to validate the model and identify the parameters that most significantly affect epidemic progression and potential control of Mpox. Results: Results showed that the basic reproduction number was most influenced by the recovery rate, vaccination rate, vaccine effectiveness, and transmission rates of symptomatic and asymptomatic individuals. In contrast, the progression of symptomatic cases was highly sensitive to the case fatality rate and incubation rate. Conclusions: These findings highlight the importance of integrated public health strategies combining vaccination, isolation, and early transmission control to mitigate future Mpox outbreaks.<\/jats:p>","DOI":"10.3390\/medsci13040226","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:32:47Z","timestamp":1760099567000},"page":"226","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Compartmental Mathematical Model to Assess the Impact of Vaccination, Isolation, and Key Epidemiological Parameters on Mpox Control"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2370-1419","authenticated-orcid":false,"given":"Pedro","family":"Pesantes-Grados","sequence":"first","affiliation":[{"name":"Unidad de Posgrado, Facultad de Ciencias Matem\u00e1ticas, Universidad Nacional Mayor de San Marcos, Lima 15081, Peru"},{"name":"Grupo de Investigaci\u00f3n Ciencias Matem\u00e1ticas para las Ciencias de la Vida, Lima 15081, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nah\u00eda","family":"Escalante-Ccoyllo","sequence":"additional","affiliation":[{"name":"Departamento de Computer Science, Facultad de Computaci\u00f3n, Universidad de Ingenier\u00eda y Tecnolog\u00eda\u2014UTEC, Barranco, Lima 15063, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0515-5875","authenticated-orcid":false,"given":"Olegario","family":"Mar\u00edn-Machuca","sequence":"additional","affiliation":[{"name":"Departamento Acad\u00e9mico de Ciencias Alimentarias, Facultad de Oceanograf\u00eda, Pesquer\u00eda, Ciencias Alimentarias y Acuicultura, Universidad Nacional Federico Villarreal, Miraflores, Lima 15074, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6930-5601","authenticated-orcid":false,"given":"Abel Walter","family":"Zambrano-Cabanillas","sequence":"additional","affiliation":[{"name":"Departamento de Acuicultura, Facultad de Oceanograf\u00eda, Pesquer\u00eda, Ciencias Alimentarias y Acuicultura, Universidad Nacional Federico Villarreal, Miraflores, Lima 15074, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9871-7058","authenticated-orcid":false,"given":"Homero","family":"Ango-Aguilar","sequence":"additional","affiliation":[{"name":"Programa Acad\u00e9mico de Microbiolog\u00eda. Facultad de Ciencias Biol\u00f3gicas, Universidad Nacional de San Crist\u00f3bal de Huamanga, Portal Independencia N\u00b0 57\u2014Huamanga, Ayacucho 05001, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2912-1191","authenticated-orcid":false,"given":"Obert","family":"Mar\u00edn-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Departamento Acad\u00e9mico de Microbiolog\u00eda M\u00e9dica, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Av. Carlos Germ\u00e1n Amezaga 375, Lima 15081, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1044-7450","authenticated-orcid":false,"given":"Ruy D.","family":"Chac\u00f3n","sequence":"additional","affiliation":[{"name":"Pathogen Genetics Research Group (PATHO-GEN), OMICS, Lima 15001, Peru"},{"name":"Department of Pathology, School of Veterinary Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-270, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1093\/cid\/cit703","article-title":"Human Monkeypox","volume":"58","author":"McCollum","year":"2014","journal-title":"Clin. Infect. Dis."},{"key":"ref_2","unstructured":"World Health Organization (WHO) (2025, June 04). Multi-Country Monkeypox Outbreak in Non-Endemic Countries. 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