{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T09:06:50Z","timestamp":1774688810129,"version":"3.50.1"},"reference-count":53,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>Background: The aim of this study was to evaluate the changes in platelet indices (PLT) provided by the ADVIA 2120 hematology analyzer (Siemens Hematology System) in the early stages of onset of infections and acute coronary syndromes (ACSs). Methods: Samples were selected from 40 patients admitted to the intensive care unit with suspected uncomplicated sepsis at presentation, from 40 patients with a biochemical diagnosis of ACS at presentation and from 40 apparently healthy subjects. These samples were tested for PLT and PLT indices [mean platelet volume (MPV); mean platelet mass (MPM); mean platelet component (MPC); immature platelets (RtcPlts)] obtained by automation with the ADVIA 2120 and specific biomarkers for sepsis [white blood cells (WBCs); neutrophil granulocytes (NGs); presepsin (PSP); procalcitonin (Pct); C-reactive protein (CRP)] and for SCA (hs cTnI). Results: Platelet indices (RtcPlts, MPV, MPM) were significantly altered (p &gt; 0.005) in patients with suspected sepsis and patients with ACS compared to control subjects; however, no statistically significant difference was observed between the two groups of patients with disease. Cutoff values (ROC curves) were obtained for platelet indices that best discriminated healthy subjects from subjects with severe infection or ACS. Conclusions: Our data show that, in subjects with suspected sepsis and ACS at disease onset, a state of early platelet activation exists that is not disease-specific. Immature platelets (RtcPlts) and the platelet indices MPM and MPV, provided by the ADVIA 2120 hematology analyzer, showed high sensitivity in subjects with suspected sepsis or ACS at disease onset.<\/jats:p>","DOI":"10.3390\/medsci13040232","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T05:48:21Z","timestamp":1760420901000},"page":"232","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of Platelet Indices and Reticulated Platelets Using the ADVIA 2120 Analyzer in Patients with Acute Infection or Acute Coronary Syndrome, at Onset"],"prefix":"10.3390","volume":"13","author":[{"given":"Vincenzo","family":"Brescia","sequence":"first","affiliation":[{"name":"Clinical Pathology Unit, AOU Policlinico Consorziale di Bari\u2014Ospedale Giovanni XXIII, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Mileti","sequence":"additional","affiliation":[{"name":"Clinical Pathology Unit, AOU Policlinico Consorziale di Bari\u2014Ospedale Giovanni XXIII, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Lovero","sequence":"additional","affiliation":[{"name":"Clinical Pathology Unit, AOU Policlinico Consorziale di Bari\u2014Ospedale Giovanni XXIII, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8292-923X","authenticated-orcid":false,"given":"Lucia","family":"Varraso","sequence":"additional","affiliation":[{"name":"Clinical Pathology Unit, AOU Policlinico Consorziale di Bari\u2014Ospedale Giovanni XXIII, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Pignataro","sequence":"additional","affiliation":[{"name":"Clinical Pathology Unit, AOU Policlinico Consorziale di Bari\u2014Ospedale Giovanni XXIII, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6089-1165","authenticated-orcid":false,"given":"Francesca","family":"Di Serio","sequence":"additional","affiliation":[{"name":"Clinical Pathology Unit, AOU Policlinico Consorziale di Bari\u2014Ospedale Giovanni XXIII, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0842-7351","authenticated-orcid":false,"given":"Angela Pia","family":"Cazzolla","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Universit\u00e0 degli Studi di Foggia, 71122 Foggia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5671-8124","authenticated-orcid":false,"given":"Luigi","family":"Santacroce","sequence":"additional","affiliation":[{"name":"Microbiology and Virology Lab., Ionian Department, Policlinico University Hospital, University of Bari \u201cAldo Moro\u201d, Piazza G. Cesare 11, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6722-6499","authenticated-orcid":false,"given":"Maria Eleonora","family":"Bizzoca","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Universit\u00e0 degli Studi di Foggia, 71122 Foggia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0236-0205","authenticated-orcid":false,"given":"Vito","family":"Crincoli","sequence":"additional","affiliation":[{"name":"Interdisciplinary Department of Medicine, University of Bari \u201cAldo Moro\u201d, Piazza G. Cesare 11, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2450-4425","authenticated-orcid":false,"given":"Maria Severa","family":"Di Comite","sequence":"additional","affiliation":[{"name":"Department of Translational Biomedicine and Neuroscience (DiBraiN), University of Bari \u201cAldo Moro\u201d, Piazza Giulio Cesare, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1083\/jcb.201304054","article-title":"The incredible journey: From megakaryocyte development to platelet formation","volume":"201","author":"Machlus","year":"2013","journal-title":"J. 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