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This study aimed to develop an end-to-end dual-branch attention network capable of achieving high accuracy while preserving computational efficiency and transparency. Methods: The architecture integrates EfficientNetV2-B0 and MobileNetV3-Small backbones through a cross-gated fusion mechanism that adaptively balances global context and fine structural details. Efficient channel attention and generalized mean pooling enhance discriminative learning without external feature extraction or optimization stages. Results: The network achieved 99.84% accuracy, precision, recall, and F1-score, with an MCC of 0.998. Grad-CAM maps showed strong spatial correspondence with diagnostically relevant histological structures. Conclusions: The end-to-end framework enables the reliable, interpretable, and computationally efficient classification of lung and colon histopathology and has potential applicability to computer-assisted diagnostic workflows.<\/jats:p>","DOI":"10.3390\/medsci13040286","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T11:43:22Z","timestamp":1764157402000},"page":"286","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Lightweight Cross-Gated Dual-Branch Attention Network for Colon and Lung Cancer Diagnosis from Histopathological Images"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1824-5789","authenticated-orcid":false,"given":"Raquel","family":"Ochoa-Ornelas","sequence":"first","affiliation":[{"name":"Systems and Computation Department, Instituto Tecnol\u00f3gico de Ciudad Guzm\u00e1n, Tecnol\u00f3gico Nacional de M\u00e9xico, Ciudad Guzm\u00e1n 49100, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2366-7452","authenticated-orcid":false,"given":"Alberto","family":"Gudi\u00f1o-Ochoa","sequence":"additional","affiliation":[{"name":"Centro Universitario de Ciencias Exactas e Ingenier\u00edas (CUCEI), Electronics and Computing Division, Universidad de Guadalajara, Guadalajara 44430, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5492-299X","authenticated-orcid":false,"given":"Sergio Octavio","family":"Rosales-Aguayo","sequence":"additional","affiliation":[{"name":"Systems and Computation Department, Instituto Tecnol\u00f3gico de Ciudad Guzm\u00e1n, Tecnol\u00f3gico Nacional de M\u00e9xico, Ciudad Guzm\u00e1n 49100, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4708-7102","authenticated-orcid":false,"given":"Jes\u00fas Ezequiel","family":"Molinar-Sol\u00eds","sequence":"additional","affiliation":[{"name":"Electronics Department, Instituto Tecnol\u00f3gico de Ciudad Guzm\u00e1n, Tecnol\u00f3gico Nacional de M\u00e9xico, Ciudad Guzm\u00e1n 49100, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1260-6670","authenticated-orcid":false,"given":"Sonia","family":"Espinoza-Morales","sequence":"additional","affiliation":[{"name":"Instituto Tecnol\u00f3gico de Tepic, Tecnol\u00f3gico Nacional de M\u00e9xico, Tepic 63175, Nayarit, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Gudi\u00f1o-Venegas","sequence":"additional","affiliation":[{"name":"Instituto Tecnol\u00f3gico de Ciudad Guzm\u00e1n, Tecnol\u00f3gico Nacional de M\u00e9xico, Ciudad Guzm\u00e1n 49100, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sriharikrishnaa, S., Suresh, P.S., and Prasada, K.S. 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