{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T14:27:22Z","timestamp":1782484042537,"version":"3.54.5"},"reference-count":21,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>Background\/Objectives: Migraine is frequently comorbid with Meniere\u2019s disease, which may complicate interpretation of inner ear imaging and clinical diagnosis. While endolymphatic hydrops has been studied in Meniere\u2019s disease and vestibular migraine separately, comparative imaging data for Meniere\u2019s disease patients with and without migraine remain limited. Methods: We retrospectively analyzed 78 patients with definite Meniere\u2019s disease who underwent endolymphatic contrast-enhanced MRI (HYbriD of Reversed image of Positive endolymph signal and native image of positive perilymph signal; or \u201cHYDROPS\u201d). Patients were classified as Meniere\u2019s disease only group (n = 56), or Meniere\u2019s disease with migraine (n = 22). The degree of endolymphatic hydrops (negative, mild, or significant) was assessed separately in the inner ear, the cochlea, and the vestibule. Results: In Meniere\u2019s disease group, the affected ear consistently showed higher rates of significant endolymphatic hydrops compared to the healthy ear across the inner ear, cochlea, and vestibule (p &lt; 0.01). In contrast, Meniere\u2019s disease with migraine group showed no significant interaural differences. Meniere\u2019s disease with migraine group showed a significantly higher frequency of significant endolymphatic hydrops in the healthy cochlea (p &lt; 0.01). Similar patterns were observed in the inner ear (p &lt; 0.025) and vestibule (p = 0.05), although these differences did not reach statistical significance. Bilateral hydrops was significantly more frequent in Meniere\u2019s disease with migraine group than in Meniere\u2019s disease group among all regions investigated (p &lt; 0.05). Conclusions: Meniere\u2019s disease patients with migraine exhibit a distinct endolymphatic hydrops pattern, characterized by bilateral or symmetrical hydrops and involvement of the healthy ear. These findings suggest migraine-related mechanisms may contribute to endolymphatic hydrops, and bilateral endolymphatic hydrops on endolymphatic contrast-enhanced MRI in suspected Meniere\u2019s disease cases should prompt consideration of comorbid migraine, in addition to bilateral Meniere\u2019s disease or asymptomatic hydrops.<\/jats:p>","DOI":"10.3390\/medsci14010029","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T09:34:12Z","timestamp":1767778452000},"page":"29","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Characterizing Differences in Endolymphatic Hydrops Signatures Among Meniere\u2019s Disease Patients with and Without Migraine"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4976-6520","authenticated-orcid":false,"given":"Yoshiyuki","family":"Sasano","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL 33136, USA"},{"name":"Department of Otolaryngology, St. Marianna University School of Medicine, Kawasaki 216-8511, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8317-1491","authenticated-orcid":false,"given":"Fumihiro","family":"Mochizuki","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, St. Marianna University School of Medicine, Kawasaki 216-8511, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2382-8268","authenticated-orcid":false,"given":"Yusuke","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, St. Marianna University School of Medicine, Kawasaki 216-8511, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izumi","family":"Koizuka","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, St. Marianna University School of Medicine, Kawasaki 216-8511, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Hoffer","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8223-9186","authenticated-orcid":false,"given":"Manabu","family":"Komori","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, St. Marianna University School of Medicine, Kawasaki 216-8511, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/VES-150549","article-title":"Diagnostic criteria for Meni\u00cbre\u2019s disease","volume":"25","author":"Carey","year":"2015","journal-title":"J. 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