{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:16:37Z","timestamp":1791497797457,"version":"4.3.4"},"reference-count":33,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>Background\/Objectives: The incidence of inflammatory bowel disease (IBD) is rising worldwide, particularly in Asia, while the highest prevalence remains in North America and Europe. Evidence on the relationship between IBD and the development of autoimmune thyroiditis is limited. This study investigated the association between IBD and a subsequent autoimmune thyroiditis in a large German primary care cohort over a 10-year period. Methods: Patients with IBD were propensity score matched to non-IBD individuals in a 1:5 ratio based on age, sex, index year, and average annual number of physician visits during follow-up. A total of 20,084 IBD patients\u2014including 8791 with Crohn\u2019s disease and 11,293 with ulcerative colitis\u2014and 100,420 matched controls were included. The primary outcome was the cumulative incidence of autoimmune thyroiditis, including Hashimoto\u2019s thyroiditis and Graves\u2019 disease. The association between IBD and autoimmune thyroiditis was evaluated using univariable conditional Cox regression analysis. Results: In the overall cohort, no significant association was found between IBD (Crohn\u2019s disease or ulcerative colitis) and autoimmune thyroiditis (Hashimoto\u2019s or Graves\u2019 disease). However, among patients aged \u2265 65 years, IBD was associated with a significantly increased risk of Graves\u2019 disease (HR 2.83; 95% CI 1.56\u20135.15), an effect observed in both Crohn\u2019s disease (HR 3.23; 95% CI 1.20\u20138.69) and ulcerative colitis (HR 2.64; 95% CI 1.25\u20135.60). Conclusions: While IBD was not associated with autoimmune thyroiditis overall, a significant positive association with Graves\u2019 disease was observed among patients aged \u2265 65 years, highlighting the importance of age-specific risk assessment.<\/jats:p>","DOI":"10.3390\/medsci14010065","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T16:12:37Z","timestamp":1770048757000},"page":"65","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Inflammatory Bowel Diseases Are Not Associated with an Increased Risk of Autoimmune Thyroiditis"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6412-668X","authenticated-orcid":false,"given":"Alexander","family":"Barton","sequence":"first","affiliation":[{"name":"Department of Medicine II, Saarland University Medical Center, Saarland University, 66421 Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8390-9663","authenticated-orcid":false,"given":"Christian","family":"Labenz","sequence":"additional","affiliation":[{"name":"First Department of Medicine, University Medical Center of the Johannes Gutenberg-University, 55131 Mainz, Germany"},{"name":"Cirrhosis Center Mainz (CCM), University Medical Center of the Johannes Gutenberg-University, 55131 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6863-8719","authenticated-orcid":false,"given":"Stephan","family":"Grabbe","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Medical Center of the Johannes Gutenberg-University, 55131 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4224-4703","authenticated-orcid":false,"given":"J\u00f6rn M.","family":"Schattenberg","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Saarland University Medical Center, Saarland University, 66421 Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4782-8003","authenticated-orcid":false,"given":"Leonard","family":"Kaps","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Saarland University Medical Center, Saarland University, 66421 Homburg, Germany"},{"name":"Cirrhosis Center Mainz (CCM), University Medical Center of the Johannes Gutenberg-University, 55131 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2124-7227","authenticated-orcid":false,"given":"Karel","family":"Kostev","sequence":"additional","affiliation":[{"name":"Epidemiology, IQVIA, 60549 Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nrgastro.2015.150","article-title":"The global burden of IBD: From 2015 to 2025","volume":"12","author":"Kaplan","year":"2015","journal-title":"Nat. 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