{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:47:00Z","timestamp":1792180020781,"version":"4.4.0"},"reference-count":38,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sanofi"},{"name":"AstraZeneca"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>Background\/Objectives: Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) or without NP (CRSsNP) are common upper airway diseases with major impact on healthcare utilization. Little is known about the overall national financial burden of CRS. We aimed to assess the excess financial burden of CRS from a countrywide perspective. Methods: Annual expenditure from healthcare, welfare transfers and foregone income was retrieved from national databases, annualized and compared to matched healthy comparators. Results: Of the 303,475 patients included with CRS (mean age 51, 55% female), 18,142 were subclassified as CRSsNP (24%) or CRSwNP (76%). For CRS patients, annual excess healthcare costs were \u20ac1315 (1296\u20131333) compared to comparators. Patients with CRS earned \u20ac1356 (1230\u20131479) less annually compared to comparators. Patients with CRS of working age (18\u201364 years) had excess welfare transfers (\u20ac816 (782\u2013850) compared to comparators, driven by sick leave and disability. Increases in healthcare costs were seen for patients with CRSwNP (\u20ac5406 (4860\u20136012) annually) compared to CRSsNP (\u20ac4945 (4293\u20135696)) driven by increases in CRS-related costs. Total societal burden for the entire cohort was \u20ac686,052,898, of which systemic corticosteroid exposure-related conditions represented \u20ac20,332,825. Excess welfare transfers represented \u20ac174,394,048 annually. Conclusions: Chronic rhinosinusitis is associated with a significant financial burden, both in terms of societal healthcare and welfare expenditure and patients\u2019 personal finances due to lost income.<\/jats:p>","DOI":"10.3390\/medsci14010067","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T16:12:37Z","timestamp":1770048757000},"page":"67","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Individual and Societal Economic Burden of Chronic Rhinosinusitis with or Without Nasal Polyps"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5804-0740","authenticated-orcid":false,"given":"Kjell Erik Julius","family":"H\u00e5kansson","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Copenhagen University Hospital\u2013Hvidovre, 2650 Hvidovre, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3491-9790","authenticated-orcid":false,"given":"Steven Arild Wuyts","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head & Neck Surgery and Audiology, Copenhagen University Hospital\u2013Rigshospitalet, 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6905-4141","authenticated-orcid":false,"given":"Anders","family":"L\u00f8kke","sequence":"additional","affiliation":[{"name":"Department of Medicine, Little Belt Hospital, 7100 Vejle, Denmark"},{"name":"Department of Regional Health Research, University of Southern Denmark, 5230 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3075-3463","authenticated-orcid":false,"given":"Ole","family":"Hilberg","sequence":"additional","affiliation":[{"name":"Department of Medicine, Little Belt Hospital, 7100 Vejle, Denmark"},{"name":"Department of Regional Health Research, University of Southern Denmark, 5230 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9008-429X","authenticated-orcid":false,"given":"Rikke","family":"Ibsen","sequence":"additional","affiliation":[{"name":"i2Minds, 8000 Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8689-3695","authenticated-orcid":false,"given":"Charlotte Suppli","family":"Ulrik","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Copenhagen University Hospital\u2013Hvidovre, 2650 Hvidovre, Denmark"},{"name":"Institute of Clinical Medicine, University of Copenhagen, 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7806-7219","authenticated-orcid":false,"given":"Vibeke","family":"Backer","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head & Neck Surgery and Audiology, Copenhagen University Hospital\u2013Rigshospitalet, 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"ref_1","first-page":"374","article-title":"The potential role of biological treatment of chronic rhinosinusitis with nasal polyps: A nationwide cohort study","volume":"59","author":"Eriksen","year":"2021","journal-title":"Rhinology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1177\/0003489415576181","article-title":"Altered Quality of Life and Psychological Health (SCL-90-R) in Patients With Chronic Rhinosinusitis With Nasal Polyps","volume":"124","author":"Chung","year":"2015","journal-title":"Ann. 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PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0313122"}],"container-title":["Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3271\/14\/1\/67\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T05:15:13Z","timestamp":1770182113000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3271\/14\/1\/67"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,2]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["medsci14010067"],"URL":"https:\/\/doi.org\/10.3390\/medsci14010067","relation":{},"ISSN":["2076-3271"],"issn-type":[{"value":"2076-3271","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,2]]}}}