{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T17:07:29Z","timestamp":1776272849068,"version":"3.50.1"},"reference-count":23,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015763","name":"Albert Szent-Gy\u00f6rgyi Medical School, Faculty Research Fund, G\u00e9za Het\u00e9nyi Fund","doi-asserted-by":"publisher","award":["IV-134-62-1\/2024.SZAOK"],"award-info":[{"award-number":["IV-134-62-1\/2024.SZAOK"]}],"id":[{"id":"10.13039\/501100015763","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003825","name":"J\u00e1nos Bolyai Research Fellowship of the Hungarian Academy of Sciences","doi-asserted-by":"publisher","award":["BO\/00340\/25"],"award-info":[{"award-number":["BO\/00340\/25"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015763","name":"University of Szeged","doi-asserted-by":"crossref","award":["8233"],"award-info":[{"award-number":["8233"]}],"id":[{"id":"10.13039\/501100015763","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>Background: Recent studies have identified multiple subtypes of non-conventional dysplastic lesions associated with inflammatory bowel disease (IBD). This study aimed to characterise and compare all IBD-associated dysplasias and determine their prevalence within a Southern Hungarian population. Methods: A consecutive cohort of IBD patients between 2011 and 2023 was retrospectively analysed. All available hyper- or neoplastic samples were reclassified according to current pathological criteria. Results: In this 13-year retrospective, single-centre, cohort study, 2396 IBD patients were identified, with 176 possessing samples for re-evaluation. Conventional dysplasia was identified in 130 patients (74%), non-conventional dysplasia in 50 patients (28%), and 33 patients were diagnosed with both (19%). Age (OR = 1.06; 95% CI: [1.03\u20131.09]; p &lt; 0.001) and male gender (OR = 2.63; 95% CI: [1.07\u20136.45]; p = 0.032) were associated with higher odds of conventional dysplasia, compared with non-conventional dysplasia. Colorectal carcinoma development and M stage were associated with lower odds of conventional dysplasia: OR = 0.17 ([0.06\u20130.47]; p &lt; 0.001) and OR = 0.05 ([0.01\u20130.5]; p = 0.006), respectively. Significant associations were observed with macroscopic appearance (p = 0.013), grade (p = 0.002), localisation (p &lt; 0.001), size (p = 0.016), macroscopic morphology (p = 0.004), grade (p &lt; 0.001), histological subtype (p = 0.001), T stage (p = 0.008) and microsatellite status (p = 0.019). Conclusions: Non-conventional dysplasias were identified in a substantial proportion of neoplastic lesions (50\/176; 28%) among IBD patients. These findings highlight the importance of thorough histopathological evaluation to confirm complete resection. Patients with IBD-associated dysplasia, particularly non-conventional types, may benefit from intensified surveillance strategies.<\/jats:p>","DOI":"10.3390\/medsci14010078","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T09:16:08Z","timestamp":1770801368000},"page":"78","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Conventional and Non-Conventional Dysplasias Associated with Inflammatory Bowel Disease\u2014A Single-Centre Experience"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9434-2989","authenticated-orcid":false,"given":"Anita","family":"Sejben","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Szeged, 6725 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8815-0557","authenticated-orcid":false,"given":"Zs\u00f3fia","family":"Balajthy","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Szeged, 6725 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zs\u00f3fia Krisztina","family":"T\u00f6r\u00f6k","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Szeged, 6725 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szintia","family":"Alm\u00e1si","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Szeged, 6725 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5081-7313","authenticated-orcid":false,"given":"Tam\u00e1s","family":"Lantos","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Informatics, University of Szeged, 6720 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1097\/DCR.0000000000000878","article-title":"A pilot study of the prevalence of anal human papillomavirus and dysplasia in a cohort of patients with IBD","volume":"60","author":"Cranston","year":"2017","journal-title":"Dis. Colon. Rectum"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1053\/j.gastro.2021.10.035","article-title":"Colorectal cancer in inflammatory bowel disease: Mechanisms and management","volume":"162","author":"Shah","year":"2022","journal-title":"Gastroenterology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.cgh.2012.01.010","article-title":"Risk of colorectal cancer in patients with ulcerative colitis: A meta-analysis of population-based cohort studies","volume":"10","author":"Jess","year":"2012","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.gtc.2021.12.011","article-title":"Intestinal cancer and dysplasia in Crohn\u2019s disease","volume":"51","author":"Friedberg","year":"2022","journal-title":"Gastroenterol. Clin. N. Am."},{"key":"ref_5","first-page":"7247238","article-title":"A comprehensive review and update on the pathogenesis of inflammatory bowel disease","volume":"1","author":"Guan","year":"2019","journal-title":"J. Immunol. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1093\/ibd\/izab177","article-title":"Colorectal strictures in patients with inflammatory bowel disease do not independently predict colorectal neoplasia","volume":"28","author":"Axelrad","year":"2022","journal-title":"Inflamm. Bowel. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/MEG.0000000000000576","article-title":"Increased risk of colorectal neoplasia in patients with primary sclerosing cholangitis and inflammatory bowel disease: A meta-analysis of 16 observational studies","volume":"28","author":"Zheng","year":"2016","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/ajg.2015.65","article-title":"Forty-year analysis of colonoscopic surveillance program for neoplasia in ulcerative colitis: An updated overview","volume":"110","author":"Choi","year":"2015","journal-title":"Am. J. Gastroenterol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/apt.15778","article-title":"Systematic review with meta-analysis: IBD-associated colon dysplasia prognosis in the videoendoscopic era (1990 to present)","volume":"52","author":"Kabir","year":"2020","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1111\/his.14294","article-title":"Non-conventional dysplasias of the tubular gut: A review and illustration of their histomorphological spectrum","volume":"78","author":"Pereira","year":"2021","journal-title":"Histopathology"},{"key":"ref_11","first-page":"38","article-title":"Non-conventional types of dysplastic changes in gastrointestinal tract mucosa\u2014Review of morphological features of individual subtypes","volume":"58","year":"2022","journal-title":"Ceskoslovenska. Patol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/s41379-019-0419-1","article-title":"Nonconventional dysplasia in patients with inflammatory bowel disease and colorectal carcinoma: A multicenter clinicopathologic study","volume":"33","author":"Choi","year":"2020","journal-title":"Mod. Pathol."},{"key":"ref_13","first-page":"481","article-title":"Hypermucinous dysplasia in inflammatory bowel disease: A heterogeneous condition with frequent foveolar differentiation","volume":"35","author":"Clauditz","year":"2022","journal-title":"Mod. Pathol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/PAP.0000000000000316","article-title":"The significance of flat\/invisible dysplasia and nonconventional dysplastic subtypes in inflammatory bowel disease: A review of their morphologic, clinicopathologic, and molecular characteristics","volume":"29","author":"Choi","year":"2022","journal-title":"Adv. Anat. Pathol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1111\/his.14298","article-title":"Non-conventional dysplasia in inflammatory bowel disease is more frequently associated with advanced neoplasia and aneuploidy than conventional dysplasia","volume":"78","author":"Lee","year":"2021","journal-title":"Histopathology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/his.13923","article-title":"DNA flow cytometric and interobserver study of crypt cell atypia in inflammatory bowel disease","volume":"75","author":"Wen","year":"2019","journal-title":"Histopathology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1093\/ecco-jcc\/jjab120","article-title":"Hypermucinous, goblet cell deficient and crypt cell dysplasias in inflammatory bowel disease are often associated with flat\/invisible endoscopic appearance and advanced neoplasia on follow-up","volume":"16","author":"Choi","year":"2022","journal-title":"J. Crohn\u2019s. Colitis"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.humpath.2022.06.018","article-title":"Exploring the spectrum of serrated epithelium encountered in inflammatory bowel disease","volume":"132","author":"Waters","year":"2023","journal-title":"Hum. Pathol."},{"key":"ref_19","unstructured":"Classification of Tumours Editorial Board (2019). World Health Organization Classification of Tumours: Digestive System Tumours, IARC Press. [5th ed]."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/his.15448","article-title":"Inflammatory bowel disease-associated serrated lesions with dysplasia are frequently associated with advanced neoplasia: Supporting a unified classification approach","volume":"87","author":"Bahceci","year":"2025","journal-title":"Histopathology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/S0046-8177(83)80175-0","article-title":"Dysplasia in inflammatory bowel disease: Standardized classification with provisional clinical applications","volume":"14","author":"Riddell","year":"1983","journal-title":"Hum. Pathol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1053\/j.gastro.2015.01.031","article-title":"SCENIC Guideline Development Panel. SCENIC international consensus statement on surveillance and management of dysplasia in inflammatory bowel disease","volume":"148","author":"Laine","year":"2015","journal-title":"Gastroenterology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1612105","DOI":"10.3389\/pore.2025.1612105","article-title":"Evaluation of dysplasias associated with inflammatory bowel disease-a single-center, retrospective, 5-year experience","volume":"31","author":"Balajthy","year":"2025","journal-title":"Pathol. Oncol. Res."}],"container-title":["Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3271\/14\/1\/78\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T05:12:54Z","timestamp":1770873174000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3271\/14\/1\/78"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,10]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["medsci14010078"],"URL":"https:\/\/doi.org\/10.3390\/medsci14010078","relation":{},"ISSN":["2076-3271"],"issn-type":[{"value":"2076-3271","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,10]]}}}