{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:55:21Z","timestamp":1787028921477,"version":"build-2736575974"},"reference-count":37,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Secretar\u00eda de Ciencia, Humanidades, Tecnolog\u00eda e Innovaci\u00f3n (SECIHTI) Mexico fellowships","award":["1101529"],"award-info":[{"award-number":["1101529"]}]},{"name":"Secretar\u00eda de Ciencia, Humanidades, Tecnolog\u00eda e Innovaci\u00f3n (SECIHTI) Mexico fellowships","award":["1101367"],"award-info":[{"award-number":["1101367"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>Background: Parkinsonism entails pronounced basal ganglia dysfunction, but emerging research suggests that broader subcortical networks, specifically the cerebellum, play a vital role in functional motor compensation following circuit-level destabilization. This study sought to characterize the electrophysiological dynamics of Multi-Unit Activity (MUA) amplitude in Crus II, the dentate nucleus (DN), and the inferior olive (IO) following a focal mechanical lesion of the ventrolateral striatum (VLS) as a circuit-level perturbation model during spontaneous behaviors. Methods: Bilateral mechanical VLS lesions were induced in 24 male Wistar rats. MUA signals were chronically recorded over a four-week protocol during self-grooming, horizontal locomotion, and rearing behaviors. Results: Crus II and the IO exhibited a structure-specific \u201cdynamic transition,\u201d shifting from early-stage hyperexcitability to significant late-stage attenuation by W4 (p &lt; 0.001), reflecting a divergence from control trajectories rather than internal temporal drift within the lesioned state. Conversely, the DN showed sustained hypoactivity compared to healthy controls throughout the recording period (p &lt; 0.05). Despite these robust neurophysiological shifts, the syntactic organization of grooming and exploratory patterns remained phenotypically preserved, indicating functional sufficiency despite underlying circuit noise. Conclusions: VLS injury triggers a rapid distributed reorganization across the striato-cerebellar network. The cerebellum acts as an active adaptive node, recalibrating internal network gain to mask early Parkinsonian-like circuit dysfunction at the level of functional sufficiency and maintain motor performance through active homeostatic gain regulation.<\/jats:p>","DOI":"10.3390\/medsci14010083","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:25:49Z","timestamp":1770816349000},"page":"83","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Changes in Cerebellar Multiunit Activity Associated with Ventrolateral Striatal Injury During Spontaneous Motor Behavior"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2139-1752","authenticated-orcid":false,"given":"Irais","family":"Viveros-Mart\u00ednez","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones Cerebrales, Universidad Veracruzana, Av. Dr. Luis Castelazo Ayala, Col. Industrial Las \u00c1nimas, Xalapa 91190, Veracruz, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6039-3745","authenticated-orcid":false,"given":"Cristofer","family":"Zarate-Calderon","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Cerebrales, Universidad Veracruzana, Av. Dr. Luis Castelazo Ayala, Col. Industrial Las \u00c1nimas, Xalapa 91190, Veracruz, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2259-9117","authenticated-orcid":false,"given":"Lizbeth V\u00e1squez","family":"Celaya","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Cerebrales, Universidad Veracruzana, Av. Dr. Luis Castelazo Ayala, Col. Industrial Las \u00c1nimas, Xalapa 91190, Veracruz, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Consuelo","family":"Morgado-Valle","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Cerebrales, Universidad Veracruzana, Av. Dr. Luis Castelazo Ayala, Col. Industrial Las \u00c1nimas, Xalapa 91190, Veracruz, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0179-989X","authenticated-orcid":false,"given":"Mar\u00eda Leonor","family":"L\u00f3pez-Meraz","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Cerebrales, Universidad Veracruzana, Av. Dr. Luis Castelazo Ayala, Col. Industrial Las \u00c1nimas, Xalapa 91190, Veracruz, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2094-5787","authenticated-orcid":false,"given":"Donaj\u00ed","family":"Chi-Casta\u00f1eda","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Cerebrales, Universidad Veracruzana, Av. Dr. Luis Castelazo Ayala, Col. Industrial Las \u00c1nimas, Xalapa 91190, Veracruz, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6967-1919","authenticated-orcid":false,"given":"Luis I.","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Cerebrales, Universidad Veracruzana, Av. Dr. Luis Castelazo Ayala, Col. Industrial Las \u00c1nimas, Xalapa 91190, Veracruz, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"di Biase, L., Di Santo, A., Caminiti, M.L., De Liso, A., Shah, S.A., Ricci, L., and Di Lazzaro, V. (2020). Gait Analysis in Parkinson\u2019s Disease: An Overview of the Most Accurate Markers for Diagnosis and Symptoms Monitoring. 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