{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T14:41:01Z","timestamp":1772548861100,"version":"3.50.1"},"reference-count":30,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>Introduction: The COVID-19 pandemic created an urgent need for safe and accessible outpatient treatments. Polymerized type I collagen (PTIC) has demonstrated potential immunomodulatory effects, but its clinical utility in patients with COVID-19 remains underexplored. This study aimed to evaluate the clinical evolution and health outcomes of a cohort of patients with COVID-19 treated with standard medical care plus PTIC during the pandemic emergency, in order to explore its potential role as an adjuvant therapy. Methods: A retrospective cohort study was conducted in 46 outpatients with confirmed COVID-19 treated with PTIC (Fibroquel\u00ae) plus standard care, and 15 controls with standard care alone. Clinical and laboratory data were collected on Days 1 and 10. Patients were stratified by COVID-19 severity and SARS-CoV-2 variant. Analyses included odds ratios and Kaplan\u2013Meier survival curves. Results: Oxygen saturation levels increased significantly from 88.5 \u00b1 5.22 to 95.1 \u00b1 2.07 after PTIC treatment. Supplemental oxygen was required for 26.1% of patients receiving treatment, compared to 60% of those in the untreated group (p &lt; 0.05). Complete recovery was observed in all patients treated with PTIC, compared with 80% recovery in the standard care group. There were no deaths from COVID-19 in the PTIC group. In contrast, 20% of the participants in the untreated group died due to complications from the disease (p = 0.013). PTIC improved the survival rate of patients with the disease. Conclusions: PTIC significantly improved clinical parameters in patients with COVID-19. It improves oxygen saturation levels, decreases the need for supplemental oxygen, and improves survival compared to patients who are not treated with PTIC. Additional studies are needed to validate the use of PTIC as an adjunctive therapy for patients with COVID-19.<\/jats:p>","DOI":"10.3390\/medsci14010118","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T09:45:12Z","timestamp":1772531112000},"page":"118","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Evolution of a Cohort of Patients with COVID-19 Treated with Usual Medical Care Plus Polymerized Type I Collagen During the Pandemic Emergency"],"prefix":"10.3390","volume":"14","author":[{"given":"Aurelio","family":"Perez-Favila","sequence":"first","affiliation":[{"name":"Molecular Medicine Laboratory, Unidad Acad\u00e9mica de Medicina Humana y Ciencias de la Salud, Universidad Aut\u00f3noma de Zacatecas, Zacatecas 98160, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6307-1696","authenticated-orcid":false,"given":"Idalia","family":"Garza-Veloz","sequence":"additional","affiliation":[{"name":"Molecular Medicine Laboratory, Unidad Acad\u00e9mica de Medicina Humana y Ciencias de la Salud, Universidad Aut\u00f3noma de Zacatecas, Zacatecas 98160, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia S.","family":"Hernandez-Marquez","sequence":"additional","affiliation":[{"name":"Molecular Medicine Laboratory, Unidad Acad\u00e9mica de Medicina Humana y Ciencias de la Salud, Universidad Aut\u00f3noma de Zacatecas, Zacatecas 98160, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7906-643X","authenticated-orcid":false,"given":"Maria C.","family":"Martinez-Vazquez","sequence":"additional","affiliation":[{"name":"Molecular Medicine Laboratory, Unidad Acad\u00e9mica de Medicina Humana y Ciencias de la Salud, Universidad Aut\u00f3noma de Zacatecas, Zacatecas 98160, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar F.","family":"Gutierrez-Vela","sequence":"additional","affiliation":[{"name":"Molecular Medicine Laboratory, Unidad Acad\u00e9mica de Medicina Humana y Ciencias de la Salud, Universidad Aut\u00f3noma de Zacatecas, Zacatecas 98160, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9848-862X","authenticated-orcid":false,"given":"Ivan","family":"Delgado-Enciso","sequence":"additional","affiliation":[{"name":"State Cancerology Institute of Colima, Health Services of the Mexican Social Security Institute for Welfare (IMSS-BIENESTAR), Colima 28085, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5821-9537","authenticated-orcid":false,"given":"Alfredo","family":"Salazar de Santiago","sequence":"additional","affiliation":[{"name":"Unidad Acad\u00e9mica de Odontolog\u00eda, Universidad Aut\u00f3noma de Zacatecas, Zacatecas 98160, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Luna-Pacheco","sequence":"additional","affiliation":[{"name":"Unidad Acad\u00e9mica de Odontolog\u00eda, Universidad Aut\u00f3noma de Zacatecas, Zacatecas 98160, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celia E.","family":"Luna-Pacheco","sequence":"additional","affiliation":[{"name":"Unidad Acad\u00e9mica de Odontolog\u00eda, Universidad Aut\u00f3noma de Zacatecas, Zacatecas 98160, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0138-6390","authenticated-orcid":false,"given":"Ana G.","family":"Casta\u00f1eda-Miranda","sequence":"additional","affiliation":[{"name":"Laboratorio de Magnetismo Ambiental, Posgrado en Ingenier\u00eda para la Innovaci\u00f3n Tecnol\u00f3gica, Unidad Acad\u00e9mica de Ingenier\u00eda El\u00e9ctrica, Universidad Aut\u00f3noma de Zacatecas, Zacatecas 98000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1478-9068","authenticated-orcid":false,"given":"Margarita L.","family":"Martinez-Fierro","sequence":"additional","affiliation":[{"name":"Molecular Medicine Laboratory, Unidad Acad\u00e9mica de Medicina Humana y Ciencias de la Salud, Universidad Aut\u00f3noma de Zacatecas, Zacatecas 98160, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1136\/postgradmedj-2020-138234","article-title":"Origin, transmission, diagnosis and management of coronavirus disease 2019 (COVID-19)","volume":"96","author":"Umakanthan","year":"2020","journal-title":"Postgrad. 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