{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T17:20:11Z","timestamp":1772644811749,"version":"3.50.1"},"reference-count":28,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"JSPS KAKENHI","doi-asserted-by":"publisher","award":["24K13543"],"award-info":[{"award-number":["24K13543"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>Background and Objectives: Non-O ABO blood groups have been linked to higher coronary risk, plausibly via hemostatic and lipid pathways. However, evidence in Japanese populations and imaging-defined disease is limited. We examined whether ABO status relates to serum lipids and coronary CT imaging findings in Japanese adults. Materials and Methods: We reviewed adults who underwent coronary CT angiography (CCTA) at our institution. After prespecified exclusions, 865 patients comprised the imaging cohort. For lipid analyses, we excluded patients receiving lipid-lowering therapy at the time of blood sampling, leaving 636 patients (lipid subset). ABO blood group was obtained from the medical record as recorded at registration (patient-reported) and was not re-confirmed by laboratory testing for this study. Outcomes were any coronary artery calcium (Agatston score &gt; 0) and \u226550% luminal stenosis on CCTA. Results: In the lipid subset (n = 636), coronary calcium was present in 44\u201354% of patients across the four ABO groups and did not differ across groups (p = 0.33). Among assessable scans in the imaging cohort, \u226550% stenosis did not differ across the four ABO groups. In multivariable models (n = 636), older age, male sex, hypertension, and diabetes were independently associated with both outcomes (CAC presence and \u226550% stenosis) (all p &lt; 0.05). For \u226550% stenosis, higher High-Density Lipoprotein-cholesterol (HDL-C) was additionally associated with lower odds (p &lt; 0.05). ABO status (O vs. non-O) was not independently associated with either outcome. Conclusions: In Japanese adults undergoing CCTA, type O blood was tied to lower HDL-C and higher diastolic pressure\u2014features that track with cardiometabolic risk\u2014yet ABO type did not independently relate to coronary calcium or CT-defined stenosis once standard risk factors were considered. These data suggest that, in this setting, ABO adds little beyond conventional risk profiling.<\/jats:p>","DOI":"10.3390\/medsci14010121","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T13:11:36Z","timestamp":1772629896000},"page":"121","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["ABO Blood Groups, Lipids, and Coronary CT Imaging in A Japanese Single-Center Cohort"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1014-2833","authenticated-orcid":false,"given":"Hiroyuki","family":"Tokue","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Gunma University Hospital, 3-39-22 Showa-Machi, Maebashi 371-8511, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azusa","family":"Tokue","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Gunma University Hospital, 3-39-22 Showa-Machi, Maebashi 371-8511, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshito","family":"Tsushima","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Gunma University Hospital, 3-39-22 Showa-Machi, Maebashi 371-8511, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"23250","DOI":"10.1038\/srep23250","article-title":"ABO blood group system and the coronary artery disease: An updated systematic review and meta-analysis","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. 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