{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T11:54:21Z","timestamp":1776081261508,"version":"3.50.1"},"reference-count":55,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>Background\/Objectives: Regadenoson is increasingly used as a vasodilator stress agent for perfusion cardiac magnetic resonance (CMR) imaging due to its favorable pharmacologic profile. However, its long-term prognostic value in patients with myocardial ischemia remains insufficiently established. Methods: We retrospectively analyzed all regadenoson stress-CMR studies performed at our institution between May 2017 and July 2020, including patients with follow-up longer than three months. Inducible ischemia and late gadolinium enhancement (LGE) were assessed using standardized criteria. The primary composite endpoint included cardiovascular death, non-fatal myocardial infarction, late coronary revascularization (\u22653 months after CMR), or hospitalization for unstable angina. Event-free survival was analyzed with Kaplan\u2013Meier curves, and prognostic factors were evaluated using a Fine\u2013Gray competing-risks model. Results: Of 705 examinations, 698 were eligible, and 517 patients (78.5%) completed follow-up over a median of 1.93 years (IQR 1.37\u20132.79). Inducible ischemia was identified in 142 patients (27.5%). During follow-up, 38 composite events occurred. Event incidence was significantly higher in patients with ischemia (109.6 events\/1000 person-years; 95% CI 75.7\u2013158.7) than in those without (13.3 events\/1000 person-years; 95% CI 7.2\u201324.7; RR 8.25; 95% CI 4.01\u201316.98; p &lt; 0.001). In multivariable analysis, inducible ischemia independently predicted adverse outcomes (HR 4.50; 95% CI 1.86\u201310.9; p = 0.001), whereas LGE was not independently associated (HR 1.28; 95% CI 0.46\u20133.57; p = 0.63). Conclusions: Regadenoson stress-CMR provides robust medium-term risk stratification in patients with suspected or known coronary artery disease. Detection of inducible ischemia strongly predicts major cardiovascular events, underscoring its prognostic and clinical relevance.<\/jats:p>","DOI":"10.3390\/medsci14020190","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T12:01:52Z","timestamp":1775822512000},"page":"190","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Value of Regadenoson Stress Perfusion CMR"],"prefix":"10.3390","volume":"14","author":[{"given":"Javier","family":"Mu\u00f1iz-S\u00e1enz-Diez","sequence":"first","affiliation":[{"name":"Department of Cardiology, Cl\u00ednica Universidad de Navarra, 31008 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5502-2547","authenticated-orcid":false,"given":"Ana","family":"Ezponda","sequence":"additional","affiliation":[{"name":"Department of Radiology, Cl\u00ednica Universidad de Navarra, 31008 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meylin","family":"Caballeros","sequence":"additional","affiliation":[{"name":"Department of Radiology, Cl\u00ednica Universidad de Navarra, 28027 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"de la Fuente","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cl\u00ednica Universidad de Navarra, 28027 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8441-2875","authenticated-orcid":false,"given":"Nahikari","family":"Salterain","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cl\u00ednica Universidad de Navarra, 31008 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9493-6907","authenticated-orcid":false,"given":"Gorka","family":"Bastarrika","sequence":"additional","affiliation":[{"name":"Department of Radiology, Cl\u00ednica Universidad de Navarra, 31008 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"ref_1","first-page":"e9349","article-title":"Global Epidemiology of Ischemic Heart Disease: Results from the Global Burden of Disease Study","volume":"12","author":"Khan","year":"2020","journal-title":"Cureus"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1093\/eurheartj\/ehae177","article-title":"2024 ESC Guidelines for the management of chronic coronary syndromes","volume":"45","author":"Vrints","year":"2024","journal-title":"Eur. 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