{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:45:30Z","timestamp":1785415530436,"version":"3.56.0"},"reference-count":45,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Goethe University Frankfurt"},{"id":[{"id":"https:\/\/ror.org\/04cvxnb49","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>Background: Patients with coronary artery disease (CAD) and severely reduced left ventricular ejection fraction (LVEF) \u2264 30% represent a high-risk group for coronary artery bypass grafting (CABG). Outcomes are of significant concern; therefore, real-world outcome data and predictors of early mortality remain important for perioperative decision-making. Aim: This study aims to evaluate early and mid-term outcomes in patients with severe ischemic cardiomyopathy (LVEF \u2264 30%) undergoing isolated CABG and to identify independent predictors of in-hospital mortality. Methods: We conducted a retrospective single-centre cohort analysis including patients with preoperative LVEF \u2264 30% undergoing isolated CABG (2017\u20132021). Early outcomes included in-hospital and 30-day mortality. The mid-term outcome was all-cause mortality up to 36 months. Multivariable logistic regression was used to identify independent predictors of in-hospital mortality. A predefined subgroup comparison was performed for LVEF \u2264 20% versus LVEF 20\u201330%. Results: The study comprised 147 patients with LVEF \u2264 30% undergoing isolated CABG. Overall, in-hospital mortality was 21.1%, and 30-day mortality was 23.8%. Cumulative all-cause mortality was 31.3%, 37.4%, and 42.9% at 12, 24 and 36 months respectively. Patients with LVEF \u2264 20% showed significantly higher early mortality (in-hospital 37.2% vs. 14.4%; 30-day 41.9% vs. 16.3%) and 36-month mortality (58.1% vs. 36.5%) compared with those with LVEF at 20\u201330%. Independent predictors of in-hospital mortality included preoperative hemodynamic instability, elevated operative risk scores, emergency status, prolonged cardiopulmonary bypass time, and major postoperative complications (all p &lt; 0.05). Conclusions: CABG in patients with LVEF \u2264 30% is associated with substantial early mortality, while mid-term survival remains acceptable. Severely reduced LVEF identifies a particularly high-risk subgroup requiring careful perioperative risk stratification.<\/jats:p>","DOI":"10.3390\/medsci14020216","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T08:12:31Z","timestamp":1777363951000},"page":"216","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes and Predictors of In-Hospital Mortality After Isolated Coronary Artery Bypass Grafting in Patients with Severe Ischemic Cardiomyopathy: A Single-Centre Retrospective Analysis"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5066-0838","authenticated-orcid":false,"given":"Mustafa","family":"Al-Obaidi","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, University Hospital, Goethe University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2818-9047","authenticated-orcid":false,"given":"Andreas","family":"Winter","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Hospital, Goethe University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afsaneh","family":"Karimian-Tabrizi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Hospital, Goethe University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Walther","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Hospital, Goethe University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Emrich","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Hospital, Goethe University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"ref_1","first-page":"e1096","article-title":"Correction to: 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data from the American Heart Association","volume":"151","author":"Martin","year":"2025","journal-title":"Circulation"},{"key":"ref_2","unstructured":"(2025, December 21). Causes of Death\u2014German Federal Statistical Office. Available online: https:\/\/www.destatis.de\/EN\/Themes\/Society-Environment\/Health\/Causes-Death\/_node.html."},{"key":"ref_3","unstructured":"(2025, December 21). Cardiovascular Diseases\u2014Rober Koch Institute (RKI). Available online: https:\/\/www.rki.de\/EN\/News\/Publications\/Journal-of-Health-Monitoring\/Issues\/2025\/JHealthMonit_Issue_2025-2.html."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1161\/CIRCULATIONAHA.106.623199","article-title":"Navigating the Crossroads of Coronary Artery Disease and Heart Failure","volume":"114","author":"Gheorghiade","year":"2006","journal-title":"Circulation"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"719","DOI":"10.2147\/VHRM.S524863","article-title":"Association Between Revascularization and 30-Day Survival of Ischemic Cardiomyopathy Patients in Dr. Hasan Sadikin General Hospital","volume":"21","author":"Raharjo","year":"2025","journal-title":"Vasc. Health Risk Manag."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: An update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.jacc.2014.10.070","article-title":"Revascularization in Severe Left Ventricular Dysfunction","volume":"65","author":"Velazquez","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/eurheartj\/ehy394","article-title":"2018 ESC\/EACTS Guidelines on myocardial revascularization","volume":"40","author":"Neumann","year":"2019","journal-title":"Eur. Heart J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e003255","DOI":"10.1161\/CIRCHEARTFAILURE.116.003255","article-title":"Survival Benefits of Invasive Versus Conservative Strategies in Heart Failure in Patients with Reduced Ejection Fraction and Coronary Artery Disease","volume":"10","author":"Wolff","year":"2017","journal-title":"Circ. Heart Fail."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1161\/CIRCULATIONAHA.115.021168","article-title":"Revascularization in Patients with Multivessel Coronary Artery Disease and Severe Left Ventricular Systolic Dysfunction","volume":"133","author":"Bangalore","year":"2016","journal-title":"Circulation"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1016\/j.jacc.2021.09.006","article-title":"2021 ACC\/AHA\/SCAI Guideline for Coronary Artery Revascularization: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"79","author":"Lawton","year":"2022","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1056\/NEJMoa2206606","article-title":"Percutaneous Revascularization for Ischemic Left Ventricular Dysfunction","volume":"387","author":"Perera","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1056\/NEJMoa1100356","article-title":"Coronary-artery bypass surgery in patients with left ventricular dysfunction","volume":"364","author":"Velazquez","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1056\/NEJMoa1602001","article-title":"Coronary-Artery Bypass Surgery in Patients with Ischemic Cardiomyopathy","volume":"374","author":"Velazquez","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1093\/eurheartj\/ehae177","article-title":"2024 ESC Guidelines for the management of chronic coronary syndromes","volume":"45","author":"Vrints","year":"2024","journal-title":"Eur. Heart J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/S0022-5223(96)70377-X","article-title":"Coronary artery bypass grafting in patients with an ejection fraction of twenty percent or less","volume":"111","author":"Kaul","year":"1996","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/0735-1097(95)00341-X","article-title":"Improving survival for patients with advanced heart failure: A study of 737 consecutive patients","volume":"26","author":"Stevenson","year":"1995","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"101412","DOI":"10.1016\/j.ijcha.2024.101412","article-title":"Predicting outcomes in patients with low ejection fraction undergoing coronary artery bypass graft","volume":"52","author":"Najafi","year":"2024","journal-title":"IJC Heart Vasc."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Pieri, M., Belletti, A., Monaco, F., Pisano, A., Musu, M., Dalessandro, V., Monti, G., Finco, G., Zangrillo, A., and Landoni, G. (2016). Outcome of cardiac surgery in patients with low preoperative ejection fraction. BMC Anesthesiol., 16.","DOI":"10.1186\/s12871-016-0271-5"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"I-344","DOI":"10.1161\/CIRCULATIONAHA.104.526277","article-title":"Coronary Artery Bypass Grafting in Patients with Low Ejection Fraction","volume":"112","author":"Topkara","year":"2005","journal-title":"Circulation"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1097\/HCO.0000000000000908","article-title":"Coronary artery bypass grafting in low ejection fraction: State of the art","volume":"36","author":"Robinson","year":"2021","journal-title":"Curr. Opin. Cardiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.athoracsur.2018.01.001","article-title":"The Society of Thoracic Surgeons Adult Cardiac Surgery Database: 2018 Update on Outcomes and Quality","volume":"105","author":"Jacobs","year":"2018","journal-title":"Ann. Thorac. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.athoracsur.2009.05.053","article-title":"The Society of Thoracic Surgeons 2008 cardiac surgery risk models: Part 1\u2014Coronary artery bypass grafting surgery","volume":"88","author":"Shahian","year":"2009","journal-title":"Ann. Thorac. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1016\/j.jacc.2013.02.014","article-title":"Inducible Myocardial Ischemia and Outcomes in Patients with Coronary Artery Disease and Left Ventricular Dysfunction","volume":"61","author":"Panza","year":"2013","journal-title":"JACC"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"I-414","DOI":"10.1161\/CIRCULATIONAHA.105.000661","article-title":"Outcome of Patients with Low Ejection Fraction Undergoing Coronary Artery Bypass Grafting","volume":"114","author":"Hillis","year":"2006","journal-title":"Circulation"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1093\/ajh\/hpaf074","article-title":"The Association Between Diabetes and Hypertension Time Course, Their Cumulative CoExposure, and PostCoronary Artery Bypass Graft Outcomes","volume":"38","author":"Jameie","year":"2025","journal-title":"Am. J. Hypertens."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.athoracsur.2024.12.026","article-title":"Long-Term Survival After Coronary Artery Bypass Graft Surgery","volume":"120","author":"Vyas","year":"2025","journal-title":"Ann. Thorac. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0140-6736(18)30423-9","article-title":"Mortality after coronary artery bypass grafting versus percutaneous coronary intervention with stenting for coronary artery disease: A pooled analysis of individual patient data","volume":"391","author":"Head","year":"2018","journal-title":"Lancet"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1055\/s-0040-1710569","article-title":"German Heart Surgery Report 2019: The Annual Updated Registry of the German Society for Thoracic and Cardiovascular Surgery","volume":"68","author":"Beckmann","year":"2020","journal-title":"Thorac. Cardiovasc. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e010225","DOI":"10.1161\/JAHA.118.010225","article-title":"Early and Mid-Term Outcomes of Patients Undergoing Coronary Artery Bypass Grafting in Ischemic Cardiomyopathy","volume":"8","author":"Jose","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.healun.2019.08.014","article-title":"Structured review of post-cardiotomy extracorporeal membrane oxygenation: Part 1\u2014Adult patients","volume":"38","author":"Lorusso","year":"2019","journal-title":"J. Heart Lung Transplant."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.athoracsur.2007.04.117","article-title":"Results and Predictors of Early and Late Outcome of Coronary Artery Bypass Grafting in Patients with Severely Depressed Left Ventricular Function","volume":"84","author":"Filsoufi","year":"2007","journal-title":"Ann. Thorac. Surg."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Wang, D., Lu, Y., Sun, M., Huang, X., Du, X., Jiao, Z., Sun, F., and Xie, F. (2022). Pneumonia After Cardiovascular Surgery: Incidence, Risk Factors and Interventions. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.911878"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.athoracsur.2008.12.081","article-title":"Survival After Isolated Coronary Artery Bypass Grafting in Patients with Severe Left Ventricular Dysfunction","volume":"87","author":"Ahmed","year":"2009","journal-title":"Ann. Thorac. Surg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/S0735-1097(02)01726-6","article-title":"Myocardial viability testing and impact of revascularization on prognosis in patients with coronary artery disease and left ventricular dysfunction: A meta-analysis","volume":"39","author":"Allman","year":"2002","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.acvd.2008.09.008","article-title":"Results and predictors of early and late outcome of coronary artery bypass graft surgery in patients with ejection fraction less than 20%","volume":"101","author":"Filsoufi","year":"2008","journal-title":"Arch. Cardiovasc. Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1056\/NEJMoa0900559","article-title":"Coronary Bypass Surgery with or without Surgical Ventricular Reconstruction","volume":"360","author":"Jones","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.xjon.2023.04.008","article-title":"Impact of complete revascularization in coronary artery bypass grafting for ischemic cardiomyopathy","volume":"15","author":"Nakae","year":"2023","journal-title":"JTCVS Open"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0140-6736(13)60141-5","article-title":"Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial","volume":"381","author":"Mohr","year":"2013","journal-title":"Lancet"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1056\/NEJMoa1211585","article-title":"Strategies for Multivessel Revascularization in Patients with Diabetes","volume":"367","author":"Farkouh","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.xjon.2021.11.008","article-title":"The magnitude of the survival benefit of internal thoracic artery grafting: Absolute risk reduction","volume":"9","author":"Ohno","year":"2022","journal-title":"JTCVS Open"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.21608\/ijma.2024.247713.1861","article-title":"Correlation between The Duration of Cardiopulmonary Bypass Time and The Occurrence of Morbidity and Mortality in Conventional Adult Cardiac Surgery","volume":"6","author":"Elgariah","year":"2024","journal-title":"Int. J. Med. Arts"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ijcard.2017.03.120","article-title":"Venoarterial extracorporeal membrane oxygenation after coronary artery bypass grafting: Results of a multicenter study","volume":"241","author":"Biancari","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"ref_44","first-page":"323","article-title":"Predictors of Postoperative Acute Kidney Injury after Coronary Artery Bypass Graft Surgery","volume":"33","author":"Carrascal","year":"2018","journal-title":"Braz. J. Cardiovasc. Surg."},{"key":"ref_45","first-page":"50","article-title":"Estimating the risk of complications related to re-exploration for bleeding after adult cardiac surgery: A systematic review and meta-analysis","volume":"41","author":"Biancari","year":"2012","journal-title":"Eur. J. Cardiothorac. Surg."}],"container-title":["Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3271\/14\/2\/216\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T08:56:28Z","timestamp":1777366588000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3271\/14\/2\/216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,27]]},"references-count":45,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["medsci14020216"],"URL":"https:\/\/doi.org\/10.3390\/medsci14020216","relation":{},"ISSN":["2076-3271"],"issn-type":[{"value":"2076-3271","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,27]]}}}