{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:21:58Z","timestamp":1785410518896,"version":"3.56.0"},"reference-count":52,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundaci\u00f3n Degen"},{"name":"Sociedad Espa\u00f1ola de Neurolog\u00eda"},{"id":[{"id":"https:\/\/ror.org\/01hw00g98","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Grupo de Estudio de Trastornos del Movimiento"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>Background and Objective: Sex differences in the treatment of people with Parkinson\u2019s disease (PwP) with a device-aided therapy (DAT) have been poorly investigated. Our aim was to analyze sex differences in the management and response to a DAT in PwP in daily clinical practice (DCP). Patients and Methods: Data collected in the DATs-PD GETM Spanish Registry until 30 October 2025 were used. This is a descriptive, observational, prospective, and multicenter clinical registry with progressive inclusion of PwP treated with a DAT in DCP conditions in more than 40 centers from Spain. Sex differences in the DAT received and changes in quality of life (QoL), motor symptoms (MS), non-motor symptoms (NMS), and autonomy for activities of daily living (AADL) after 6 months of treatment were analyzed. Results: A total of 618 PD patients (66.9 \u00b1 9.5 years old; 57.6% men) were treated with a DAT. A significant difference was observed in the DAT type according to sex (p = 0.006), with 73.1% of PwP who were treated with deep brain stimulation being men. At the time of DAT indication, women were older, received a higher levodopa equivalent daily dose, and had a worse health-related QoL and AADL. OFF time decreased, whereas MS and NMS burden and health-related QoL improved at 6 months follow-up in both groups (men and women). AADL improved only in men during the OFF state. Conclusion: Sex differences were detected in the use of DATs in PwP. Improvement in OFF time, MS, NMS, and QoL was detected in both groups.<\/jats:p>","DOI":"10.3390\/medsci14020217","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T08:12:31Z","timestamp":1777363951000},"page":"217","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sex Differences in the Treatment of People with Parkinson\u2019s Disease with a Device-Aided Therapy: A Prospective Real-World Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3126-5111","authenticated-orcid":false,"given":"Diego","family":"Santos Garc\u00eda","sequence":"first","affiliation":[{"name":"Department of Neurology, Hospital Universitario de A Coru\u00f1a (HUAC), Complejo Hospitalario Universitario de A Coru\u00f1a (CHUAC), C\/As Xubias 84, 15006 A Coru\u00f1a, Spain"},{"name":"Grupo de Investigaci\u00f3n en Enfermedad de Parkinson y Otros Trastornos del Movimiento, INIBIC (Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a), 15006 A Coru\u00f1a, Spain"},{"name":"Hospital San Rafael, 15006 A Coru\u00f1a, Spain"},{"name":"Fundaci\u00f3n Degen, 15006 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9248-9445","authenticated-orcid":false,"given":"\u00c1ngela","family":"Solleiro Vidal","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Universitario de A Coru\u00f1a (HUAC), Complejo Hospitalario Universitario de A Coru\u00f1a (CHUAC), C\/As Xubias 84, 15006 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3348-9992","authenticated-orcid":false,"given":"Marta","family":"Bl\u00e1zquez Estrada","sequence":"additional","affiliation":[{"name":"Hospital Universitario Central de Asturias (HUCA), 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Mir","sequence":"additional","affiliation":[{"name":"Unidad de Trastornos del Movimiento, Servicio de Neurolog\u00eda, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla, 41013 Seville, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28031 Madrid, Spain"},{"name":"Departamento de Medicina, Facultad de Medicina, Universidad de Sevilla, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7172-3191","authenticated-orcid":false,"given":"Nuria","family":"L\u00f3pez Ariztegui","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Toledo, 45071 Toledo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4561-5485","authenticated-orcid":false,"given":"D\u00e9borah","family":"Alonso Modino","sequence":"additional","affiliation":[{"name":"Hospital Universitario de la Candelaria, 38010 Santa Cruz de Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00e9s","family":"Legarda","sequence":"additional","affiliation":[{"name":"Hospital Universitario Son Espases, 07120 Palma de Mallorca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Peral","sequence":"additional","affiliation":[{"name":"Consorci Sanitari Integral, Hospital Mois\u00e9s Broggi, Sant Joan Desp\u00ed, 08970 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0386-8940","authenticated-orcid":false,"given":"Roc\u00edo","family":"Garc\u00eda-Ramos","sequence":"additional","affiliation":[{"name":"Hospital Universitario Cl\u00ednico San Carlos, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2436-6499","authenticated-orcid":false,"given":"Iria","family":"Cabo","sequence":"additional","affiliation":[{"name":"Complejo Hospitalario Universitario de Pontevedra (CHOP), 36071 Pontevedra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0496-4707","authenticated-orcid":false,"given":"Pilar","family":"S\u00e1nchez Alonso","sequence":"additional","affiliation":[{"name":"Hospital Universitario Puerta de Hierro, 28222 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9129-5224","authenticated-orcid":false,"given":"Jorge","family":"Hern\u00e1ndez-Vara","sequence":"additional","affiliation":[{"name":"Hospital Universitario Vall d\u2019Hebron, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Ru\u00edz Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Donostia, 20014 San Sebasti\u00e1n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"\u00c1lvarez Sauco","sequence":"additional","affiliation":[{"name":"Hospital General Universitario de Elche, 03203 Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9211-9927","authenticated-orcid":false,"given":"Gustavo","family":"Fern\u00e1ndez-Pajar\u00edn","sequence":"additional","affiliation":[{"name":"Complejo Hospitalario Universitario de Santiago de Compostela (CHUS), 15706 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Vela","sequence":"additional","affiliation":[{"name":"Hospital Universitario Fundaci\u00f3n de Alcorc\u00f3n, 28922 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2149-2668","authenticated-orcid":false,"given":"Francisco","family":"Escamilla Sevilla","sequence":"additional","affiliation":[{"name":"Servicio de Neurolog\u00eda, Hospital Universitario Virgen de las Nieves, Instituto de Investigaci\u00f3n Biosanitaria, ibs.GRANADA, 18014 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2868-4166","authenticated-orcid":false,"given":"Jes\u00fas","family":"Ram\u00edrez S\u00e1nchez-Ajofrin","sequence":"additional","affiliation":[{"name":"Hospital Universitario 12 de Octubre, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora M.","family":"Cerd\u00e1n Santacruz","sequence":"additional","affiliation":[{"name":"Hospital General de Segovia, 40002 Segovia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4763-3265","authenticated-orcid":false,"given":"Guillermo","family":"Gonz\u00e1lez Ortega","sequence":"additional","affiliation":[{"name":"Hospital Universitario de M\u00f3stoles, 28935 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DATs-PD GETM Spanish Registry Group","family":"DATs-PD GETM Spanish Registry Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1007\/s00702-024-02773-3","article-title":"Advanced therapies in Parkinson\u2019s disease: 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