{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:16:38Z","timestamp":1785417398819,"version":"3.56.0"},"reference-count":70,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Programa Nacional de Apoio \u00e0 Aten\u00e7\u00e3o Oncol\u00f3gica (PRONON) of the Brazilian Ministry of Health","award":["25000.043593\/2018-67"],"award-info":[{"award-number":["25000.043593\/2018-67"]}]},{"award":["25000.043593\/2018-67"],"award-info":[{"award-number":["25000.043593\/2018-67"]}],"id":[{"id":"https:\/\/ror.org\/02y7p0749","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Coordena\u00e7\u00e3o de Aperfeicoamento de Pessoal de N\u00edvel Superior","award":["001"],"award-info":[{"award-number":["001"]}]},{"award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"https:\/\/ror.org\/00x0ma614","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Fundo Estadual para Inf\u00e2ncia e Adolesc\u00eancia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>Background\/Objectives: Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Understanding its epidemiological characteristics is essential for guiding public health strategies. In this study, we characterized the epidemiological profiles that may contribute to the risk of ALL in children in southern Brazil. Methods: Clinical and epidemiological data from 71 children (1\u201315 years old) admitted and newly diagnosed with ALL at four hospitals in Curitiba, Paran\u00e1, Brazil, were retrieved and analyzed. Results: Among the 71 children with ALL, the majority were male (n = 43, 60.6%), with an age range of 1\u20133 years (n = 26, 36.6%), self-identified as White (n = 47, 66.2%), and were born in Paran\u00e1 state (n = 61, 85.9%). Nearly half had a family history of cancer (n = 33, 46.5%), primarily among grandparents (n = 36, 61%). Parental environmental exposures included smoking (n = 30, 42.3%) and occupational exposure to chemicals or radiation (n = 17, 23.9%). At diagnosis, most patients (n = 43, 60.5%) had a bone marrow blast count &gt; 70%, and 27 patients (38%) had a peripheral blood blast count &gt; 70%. B-cell ALL was the predominant subtype (n = 61, 85.9%). In B-cell ALL cases, the most frequent molecular subtype was high hyperdiploidy (n = 17, 23.9%). White blood cell counts differed significantly between the B-cell ALL and T-cell ALL groups (p = 0.029). Conclusions: Our findings provide insights into ALL epidemiology in southern Brazil and highlight regional differences across the country.<\/jats:p>","DOI":"10.3390\/medsci14020318","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:57:58Z","timestamp":1781513878000},"page":"318","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiological Profile of Pediatric Patients with Acute Lymphoblastic Leukemia Admitted to Four Hospitals in Curitiba, Southern Brazil"],"prefix":"10.3390","volume":"14","author":[{"given":"Regiane Nogueira","family":"Spalanzani","sequence":"first","affiliation":[{"name":"Faculdades Pequeno Pr\u00edncipe, Av. Igua\u00e7u, 333, Rebou\u00e7as, Curitiba CEP 80230-020, PR, Brazil"},{"name":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1458-4548","authenticated-orcid":false,"given":"Liana Alves","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6064-8448","authenticated-orcid":false,"given":"Sara Cristina","family":"Lobo-Alves","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8203-5252","authenticated-orcid":false,"given":"Tha\u00eds Muniz","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"Faculdades Pequeno Pr\u00edncipe, Av. Igua\u00e7u, 333, Rebou\u00e7as, Curitiba CEP 80230-020, PR, Brazil"},{"name":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiza Souza","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil"},{"name":"Laborat\u00f3rio Central do Estado do Paran\u00e1 (LACEN-PR), R. Sebastiana Santana Fraga, 1395, Guatup\u00ea, S\u00e3o Jos\u00e9 dos Pinhais CEP 83060-500, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1617-4315","authenticated-orcid":false,"given":"Damaris","family":"Krul","sequence":"additional","affiliation":[{"name":"Faculdades Pequeno Pr\u00edncipe, Av. Igua\u00e7u, 333, Rebou\u00e7as, Curitiba CEP 80230-020, PR, Brazil"},{"name":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9130-5103","authenticated-orcid":false,"given":"Adriele Celine","family":"Siqueira","sequence":"additional","affiliation":[{"name":"Faculdades Pequeno Pr\u00edncipe, Av. Igua\u00e7u, 333, Rebou\u00e7as, Curitiba CEP 80230-020, PR, Brazil"},{"name":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Curitiba Transcriptomics and Microbiomics ALL Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0475-3654","authenticated-orcid":false,"given":"Roberto","family":"Rosati","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9636-1817","authenticated-orcid":false,"given":"Libera Maria","family":"Dalla-Costa","sequence":"additional","affiliation":[{"name":"Faculdades Pequeno Pr\u00edncipe, Av. Igua\u00e7u, 333, Rebou\u00e7as, Curitiba CEP 80230-020, PR, Brazil"},{"name":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. 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