{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T15:56:32Z","timestamp":1781538992548,"version":"3.54.5"},"reference-count":115,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>Anxiety disorders and chronic stress are the most common types of mental disorder. According to the WHO, more than 359 million people worldwide suffered from these conditions in 2021. The function of mastication and the masticatory muscles undergo significant changes under the influence of a disturbed psychoemotional state. This manifests as their parafunctional activity, accompanied by increased tone and damage to elements of the dentofacial system, including increased tooth wear, chipping, cracks, and fractures. Attention to this problem is growing annually among researchers in both dental and neurological fields. This is evidenced by a wide range of therapeutic and preventive interventions aimed at correcting chronic stress, muscle hypertonia, and pathology of the dentofacial system. Despite the aforementioned measures, it is often only possible to slow down the pathological process rather than completely resolve it. This is because knowledge regarding the biology and pathophysiology of how chronic stress affects muscle activity remains limited. Understanding such mechanisms and establishing precise interrelationships could help identify targets for effective therapeutic interventions and eliminate the problem. This review of the literature systematizes information on how chronic stress and various autonomic stimuli affect changes in the functional activity of the masticatory muscles and the pathology of hard dental tissues.<\/jats:p>","DOI":"10.3390\/medsci14020320","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T15:00:48Z","timestamp":1781535648000},"page":"320","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Muscle Tone Regulation and Bruxism in Chronic Stress: Pathophysiological Links to Tooth Fractures and Dental Hard Tissue Pathology"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5795-6922","authenticated-orcid":false,"given":"Valekh","family":"Ashyrov","sequence":"first","affiliation":[{"name":"Department of Human Anatomy and Histology, Sechenov First Moscow State Medical University (Sechenov University), 125009 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4021-2167","authenticated-orcid":false,"given":"Maria","family":"Blagodatskikh","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Histology, Sechenov First Moscow State Medical University (Sechenov University), 125009 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Panferova","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Histology, Sechenov First Moscow State Medical University (Sechenov University), 125009 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4024-6101","authenticated-orcid":false,"given":"Irina","family":"Vineyard","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Histology, Sechenov First Moscow State Medical University (Sechenov University), 125009 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2756-1794","authenticated-orcid":false,"given":"Lucas Alves Sarmento","family":"Pires","sequence":"additional","affiliation":[{"name":"Morphology Department, Fluminense Federal University\u2014UFF, Niter\u00f3i 24210-201, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6842-1520","authenticated-orcid":false,"given":"Tatiana","family":"Zharikova","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Histology, Sechenov First Moscow State Medical University (Sechenov University), 125009 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3983-5342","authenticated-orcid":false,"given":"Andr\u00e9","family":"Pontes-Silva","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Physical Education, NERD Research Group, Federal University of Maranh\u00e3o, S\u00e3o Lu\u00eds 65080-805, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9636-3807","authenticated-orcid":false,"given":"Yury","family":"Zharikov","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Histology, Sechenov First Moscow State Medical University (Sechenov University), 125009 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2026, April 09). 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