{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T10:15:50Z","timestamp":1783073750605,"version":"3.54.6"},"reference-count":36,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>Background\/Objectives: Estrogen deficiency is associated with metabolic disturbances and impaired glucose homeostasis. Morin, a natural flavonol, has shown promising hypoglycemic and antioxidant properties, but its effects under hypoestrogenic diabetic conditions remain poorly understood. The aim of this study was to evaluate the effects of morin on body weight, fasting blood glucose, glucose tolerance, and selected serum biochemical markers in an experimental model of diabetes under estrogen-deficient conditions (ovariectomized diabetic female mice). Methods: Female CD1 mice underwent sham surgery or ovariectomy (OVX), and each surgical condition was further divided into non-diabetic and diabetic subgroups treated with vehicle, glibenclamide (10 mg\/kg), or morin (30 mg\/kg). Body weight and fasting blood glucose were monitored over a 15-day treatment period. Oral glucose tolerance was assessed on day 15, and serum biochemical markers, including glucose, cholesterol, triglycerides, uric acid, blood urea nitrogen, creatinine, ALT, and AST, were measured thereafter. Results: Ovariectomy aggravated diabetes-associated hyperglycemia, impaired glucose tolerance, and triglyceride elevation. Morin treatment reduced fasting blood glucose and improved glucose tolerance in diabetic mice, including ovariectomized animals. Morin also attenuated the increase in serum triglycerides and blood urea nitrogen in ovariectomized diabetic mice, although it did not significantly improve cholesterol, uric acid, creatinine, ALT, or AST levels. Compared with glibenclamide, morin showed relevant glucose-lowering activity but had a more limited effect on the overall biochemical profile. Conclusions: These findings suggest that morin may partially improve glycemic control and selected metabolic alterations in experimental diabetes associated with estrogen deficiency. Further studies are required to clarify its mechanisms of action, long-term efficacy, and translational relevance.<\/jats:p>","DOI":"10.3390\/medsci14030371","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T07:59:47Z","timestamp":1783065587000},"page":"371","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Morin Attenuates Hyperglycemia and Metabolic Dysregulation in Ovariectomized Diabetic Mouse Model"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8123-6343","authenticated-orcid":false,"given":"Josu\u00e9 Vidal","family":"Espinosa-Ju\u00e1rez","sequence":"first","affiliation":[{"name":"Escuela de Ciencias Qu\u00edmicas, Universidad Aut\u00f3noma de Chiapas (UNACH), Carretera Panamericana Ocozocoautla-Cintalapa Km. 2.5, Ocozocoautla de Espinosa 29140, Chiapas, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viridiana","family":"Orantes-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Escuela de Ciencias Qu\u00edmicas, Universidad Aut\u00f3noma de Chiapas (UNACH), Carretera Panamericana Ocozocoautla-Cintalapa Km. 2.5, Ocozocoautla de Espinosa 29140, Chiapas, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"G\u00f3mez-Morga","sequence":"additional","affiliation":[{"name":"Escuela de Ciencias Qu\u00edmicas, Universidad Aut\u00f3noma de Chiapas (UNACH), Carretera Panamericana Ocozocoautla-Cintalapa Km. 2.5, Ocozocoautla de Espinosa 29140, Chiapas, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0298-7948","authenticated-orcid":false,"given":"Citlaly Natali","family":"de la Torre-Sosa","sequence":"additional","affiliation":[{"name":"Escuela de Ciencias Qu\u00edmicas, Universidad Aut\u00f3noma de Chiapas (UNACH), Carretera Panamericana Ocozocoautla-Cintalapa Km. 2.5, Ocozocoautla de Espinosa 29140, Chiapas, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Briones-Aranda","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Humana Campus II, Universidad Aut\u00f3noma de Chiapas (UNACH), D\u00e9cima Sur Esquina Calle Central S\/N, Tuxtla Guti\u00e9rrez 29050, Chiapas, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5325-3760","authenticated-orcid":false,"given":"Osmar Antonio","family":"Jaramillo-Morales","sequence":"additional","affiliation":[{"name":"Departamento de Enfermer\u00eda y Obstetricia, Divisi\u00f3n de Ciencias de la Vida, Campus Irapuato-Salamanca, Universidad de Guanajuato, Ex Hacienda el Copal, Km. 9 Carretera Irapuato-Silao, A.P. 311, Irapuato 36500, Guanajuato, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8681-1140","authenticated-orcid":false,"given":"Josselin Carolina","family":"Corzo-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Escuela de Ciencias Qu\u00edmicas, Universidad Aut\u00f3noma de Chiapas (UNACH), Carretera Panamericana Ocozocoautla-Cintalapa Km. 2.5, Ocozocoautla de Espinosa 29140, Chiapas, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0151-0435","authenticated-orcid":false,"given":"Refugio","family":"Cruz-Trujillo","sequence":"additional","affiliation":[{"name":"Escuela de Ciencias Qu\u00edmicas, Universidad Aut\u00f3noma de Chiapas (UNACH), Carretera Panamericana Ocozocoautla-Cintalapa Km. 2.5, Ocozocoautla de Espinosa 29140, Chiapas, Mexico"},{"name":"Departamento de Qu\u00edmicos Farmacobi\u00f3logos, Universidad Pablo Guardado Ch\u00e1vez (UPGCH), Libramiento Norte Oriente No. 3450, Tuxtla Guti\u00e9rrez 29040, Chiapas, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6032-1962","authenticated-orcid":false,"given":"Ra\u00fal","family":"Cruz-Cadena","sequence":"additional","affiliation":[{"name":"Escuela de Ciencias Qu\u00edmicas, Universidad Aut\u00f3noma de Chiapas (UNACH), Carretera Panamericana Ocozocoautla-Cintalapa Km. 2.5, Ocozocoautla de Espinosa 29140, Chiapas, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6227-0511","authenticated-orcid":false,"given":"Raquel","family":"G\u00f3mez Pliego","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Ciencias de la Salud Humana, Departamento de Ciencias Biol\u00f3gicas, Facultad de Estudios Superiores Cuautitl\u00e1n, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Cuautitl\u00e1n Izcalli 54740, Estado de M\u00e9xico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Dilworth, L., Facey, A., and Omoruyi, F. 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