{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:15:43Z","timestamp":1783530943332,"version":"3.55.0"},"reference-count":30,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>Background: Pectus excavatum (PEX) is the most common congenital chest wall deformity and may result in cardiac compression and arrhythmias. The relationship between structural severity and exercise-induced electrocardiographic (ECG) abnormalities in pediatric patients remains unclear. Methods: We performed a retrospective study of patients aged 10\u201319 years that underwent standardized preoperative evaluation for PEX between 2015 and 2021, including ECG, transthoracic echocardiography (TTE), computed tomography (CT), and cardiopulmonary exercise testing (CPET). PEX severity was assessed using the Haller index (HI), while right ventricular (RV) compression was evaluated on CT. Tricuspid valve annular size (TVAS) on TTE was used as a surrogate marker of RV compression. Exercise-induced ECG abnormalities, including premature ventricular complexes (PVCs), were analyzed and correlated with HI, RV compression, and TVAS. Results: Among 124 patients (85% male; median age 15 years), 33% exhibited exercise-induced ECG abnormalities, most commonly PVCs (24% overall). PVC occurrence was not associated with Haller index severity (p = 0.35) but was significantly associated with RV compression on CT (92.6% vs. 62.1%, OR 7.64, p = 0.02). Patients with ECG abnormalities had significantly smaller TVAS compared to those without (1.98 \u00b1 0.31 cm vs. 2.09 \u00b1 0.33 cm, p = 0.04). Although PVCs were more frequent in patients with TVAS z-score \u2264 \u22122.0, this did not reach statistical significance. Conclusions: Exercise-induced ventricular ectopy in pediatric PEX is associated with right ventricular compression rather than structural severity as defined by HI. Echocardiographic measures such as TVAS may serve as noninvasive markers of clinically significant compression. These findings highlight the importance of cardiac\u2013thoracic relationships in predicting arrhythmic risk and suggest a potential for reversibility with surgical correction.<\/jats:p>","DOI":"10.3390\/medsci14030379","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T16:16:18Z","timestamp":1783527378000},"page":"379","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exercise-Induced ECG Abnormalities in Pediatric Pectus Excavatum: Evidence of Right Ventricular Compression Beyond the Haller Index"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6970-3850","authenticated-orcid":false,"given":"Karine","family":"Guerrier","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology, Le Bonheur Children\u2019s Hospital, Memphis, TN 38103, USA"},{"name":"Department of Pediatric Cardiology, The University of Tennessee Health Science Center, Memphis, TN 38163, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aram","family":"Bejnood","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0330-386X","authenticated-orcid":false,"given":"Sharvari","family":"Shyam","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Le Bonheur Children\u2019s Hospital, Memphis, TN 38103, USA"},{"name":"Department of Pediatric Cardiology, The University of Tennessee Health Science Center, Memphis, TN 38163, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca Ann","family":"Hyde","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Le Bonheur Children\u2019s Hospital, Memphis, TN 38103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Hendrickson","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Le Bonheur Children\u2019s Hospital, Memphis, TN 38103, USA"},{"name":"Department of Pediatric Cardiology, The University of Tennessee Health Science Center, Memphis, TN 38163, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trey","family":"Eubanks","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Le Bonheur Children\u2019s Hospital, Memphis, TN 38103, USA"},{"name":"Department of Pediatric Surgery, The University of Tennessee Health Science Center, Memphis, TN 38163, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6014-8259","authenticated-orcid":false,"given":"Tim","family":"Jancelewicz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Le Bonheur Children\u2019s Hospital, Memphis, TN 38103, USA"},{"name":"Department of Pediatric Surgery, The University of Tennessee Health Science Center, Memphis, TN 38163, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjit","family":"Philip","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Le Bonheur Children\u2019s Hospital, Memphis, TN 38103, USA"},{"name":"Department of Pediatric Cardiology, The University of Tennessee Health Science Center, Memphis, TN 38163, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"ref_1","first-page":"106","article-title":"Pectus Excavatum: A Review of Diagnosis and Current Treatment Options","volume":"117","author":"Abid","year":"2017","journal-title":"J. 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