{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:23:31Z","timestamp":1785425011068,"version":"3.56.0"},"reference-count":39,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures","award":["171\/09.01.2024"],"award-info":[{"award-number":["171\/09.01.2024"]}]},{"award":["171\/09.01.2024"],"award-info":[{"award-number":["171\/09.01.2024"]}],"id":[{"id":"https:\/\/ror.org\/03gwbzf29","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Sci.","Medical Sciences"],"abstract":"<jats:p>Background: Opportunistic salpingectomy is widely used in gynecological surgery as a preventive measure against ovarian carcinoma. Questions have been raised about the potential impact of salpingectomy on ovarian function, given the possibility of ovarian vascularity disruption through the utero-ovarian arch located in the mesosalpinx. The aim of this study was to evaluate the short-term effects of bilateral salpingectomy on ovarian reserve. Methods: This prospective cohort study included forty premenopausal women, aged 34\u201350 years, who underwent hysterectomy with bilateral salpingectomy and ovarian preservation for benign uterine conditions. Ovarian reserve was evaluated before surgery and three months postoperatively, using serum anti-M\u00fcllerian hormone (AMH), follicle-stimulating hormone (FSH) and antral follicle count (AFC). Health-related quality of life was assessed using the Women\u2019s Health Questionnaire (WHQ). Results: Serum FSH levels increased significantly after surgery, while AMH levels decreased significantly (both p &lt; 0.05). No significant postoperative changes were observed in AFC. The overall WHQ score increased significantly, indicating a mild deterioration in health-related quality of life. The greatest postoperative changes were observed in the depressive, somatic and sexual domains, where menstrual symptoms improved following surgery. No significant correlation was found between WHQ scores and hormonal or ultrasonographic markers of ovarian reserve. Conclusions: Bilateral salpingectomy performed during hysterectomy was associated with significant short-term hormonal changes, while AFC remained stable. Although patient-reported quality of life slightly worsened after surgery, these changes were not correlated with hormonal or ultrasonographic markers of ovarian reserve. Larger controlled studies with longer follow-up are required to determine the long-term clinical significance of these findings.<\/jats:p>","DOI":"10.3390\/medsci14030416","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T01:01:28Z","timestamp":1784768488000},"page":"416","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Bilateral Salpingectomy on Ovarian Reserve: A Prospective Analysis of Hormonal, Ultrasound and Clinical Correlations"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1941-7913","authenticated-orcid":false,"given":"Teodora","family":"Radu","sequence":"first","affiliation":[{"name":"Doctoral School of Medicine, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Gheorghe Marinescu Street No. 38, 540142 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matyas","family":"Mar","sequence":"additional","affiliation":[{"name":"Doctoral School of Medicine, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Gheorghe Marinescu Street No. 38, 540142 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Gliga","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology 2, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Gheorghe Marinescu Street No. 38, 540136 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu","family":"Marginean","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology 2, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Gheorghe Marinescu Street No. 38, 540136 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.2147\/IJWH.S197604","article-title":"Ovarian Cancer in the World: Epidemiology and Risk Factors","volume":"11","author":"Momenimovahed","year":"2019","journal-title":"Int. J. Womens Health"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"(2019). ACOG Committee Opinion No. 773 Summary: The Use of Antim\u00fcllerian Hormone in Women Not Seeking Fertility Care. Obstet. Gynecol., 133, 840\u2013841.","DOI":"10.1097\/AOG.0000000000003163"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1158\/1940-6207.CAPR-14-0293","article-title":"Salpingectomy as a Means to Reduce Ovarian Cancer Risk","volume":"8","author":"Daly","year":"2015","journal-title":"Cancer Prev. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/humupd\/dmq030","article-title":"Tubal Ligation and the Risk of Ovarian Cancer: Review and Meta-Analysis","volume":"17","author":"Cibula","year":"2011","journal-title":"Hum. Reprod. Update"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.humpath.2011.03.003","article-title":"Molecular Pathogenesis and Extraovarian Origin of Epithelial Ovarian Cancer\u2014Shifting the Paradigm","volume":"42","author":"Kurman","year":"2011","journal-title":"Hum. Pathol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1158\/1940-6207.CAPR-10-0266","article-title":"Microscopic and Early-Stage Ovarian Cancers in BRCA1\/2 Mutation Carriers: Building a Model for Early BRCA-Associated Tumorigenesis","volume":"4","author":"Yates","year":"2011","journal-title":"Cancer Prev. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"471.e1\u2013471.e11","DOI":"10.1016\/j.ajog.2014.01.003","article-title":"Opportunistic Salpingectomy: Uptake, Risks, and Complications of a Regional Initiative for Ovarian Cancer Prevention","volume":"210","author":"McAlpine","year":"2014","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.ajog.2014.01.006","article-title":"Salpingectomy, Why Not?","volume":"210","author":"Backes","year":"2014","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1007\/s00404-025-07974-z","article-title":"Intergroup Statement: Opportunistic Salpingectomy\u2014Molecular Pathology, Clinical Outcomes and Implications for Practice (German Ovarian Cancer Commission, the North-Eastern German Society of Gynecologic Oncology (NOGGO), AGO Austria and AGO Swiss)","volume":"311","author":"Wimberger","year":"2025","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.ajog.2020.09.011","article-title":"Salpingectomy vs Tubal Ligation for Sterilization: A Systematic Review and Meta-Analysis","volume":"224","author":"Mills","year":"2021","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_11","first-page":"e59434","article-title":"The Effect of Salpingectomy on Ovarian Reserve Using Two Different Electrosurgical Instruments: Ultrasonic Shears Versus Bipolar Electrocautery","volume":"16","author":"Zangmo","year":"2024","journal-title":"Cureus"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"10152","DOI":"10.3390\/curroncol30120739","article-title":"Beyond Sterilization: A Comprehensive Review on the Safety and Efficacy of Opportunistic Salpingectomy as a Preventative Strategy for Ovarian Cancer","volume":"30","author":"Etchegary","year":"2023","journal-title":"Curr. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1093\/humupd\/dmac045","article-title":"Anti-M\u00fcllerian Hormone for the Diagnosis and Prediction of Menopause: A Systematic Review","volume":"29","author":"Nelson","year":"2023","journal-title":"Hum. Reprod. Update"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.maturitas.2017.04.018","article-title":"Anti-M\u00fcllerian Hormone, Follicle Stimulating Hormone, Antral Follicle Count, and Risk of Menopause within 5 Years","volume":"102","author":"Kim","year":"2017","journal-title":"Maturitas"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1477-7525-1-41","article-title":"The Women\u2019s Health Questionnaire (WHQ): Frequently Asked Questions (FAQ)","volume":"1","author":"Hunter","year":"2003","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.1210\/clinem\/dgaa513","article-title":"Anti-M\u00fcllerian Hormone and Ovarian Reserve: Update on Assessing Ovarian Function","volume":"105","author":"Moolhuijsen","year":"2020","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s13048-023-01296-x","article-title":"Potential Factors Result in Diminished Ovarian Reserve: A Comprehensive Review","volume":"16","author":"Zhu","year":"2023","journal-title":"J. Ovarian Res."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Tavana, Z., Askary, E., Poordast, T., Soltani, M., and Vaziri, F. (2021). Does Laparoscopic Hysterectomy + Bilateral Salpingectomy Decrease the Ovarian Reserve More than Total Abdominal Hysterectomy? A Cohort Study, Measuring Anti-M\u00fcllerian Hormone before and after Surgery. BMC Womens Health, 21.","DOI":"10.1186\/s12905-021-01472-5"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.jmig.2018.10.013","article-title":"Ovarian Reserve and Assisted Reproductive Technique Outcomes After Laparoscopic Proximal Tubal Occlusion or Salpingectomy in Women with Hydrosalpinx Undergoing in Vitro Fertilization: A Randomized Controlled Trial","volume":"26","author":"Vignarajan","year":"2019","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.bpobgyn.2019.01.011","article-title":"Hydrosalpinx\u2014Salpingostomy, Salpingectomy or Tubal Occlusion","volume":"59","author":"Ng","year":"2019","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"547","DOI":"10.3109\/01443615.2014.985768","article-title":"Management of Hydrosalpinx before IVF: A Literature Review","volume":"35","author":"Franceschetti","year":"2015","journal-title":"J. Obstet. Gynaecol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jmig.2016.08.833","article-title":"3 to 5 Years Later: Long-Term Effects of Prophylactic Bilateral Salpingectomy on Ovarian Function","volume":"24","author":"Venturella","year":"2017","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3980","DOI":"10.21608\/ejhm.2021.206443","article-title":"Impact of Total Salpingectomy Versus Tubal Conservation During Abdominal Hysterectomy on Ovarian Function","volume":"85","author":"Lashin","year":"2021","journal-title":"Egypt. J. Hosp. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13048-021-00825-w","article-title":"The Effect of Prophylactic Bilateral Salpingectomy on Ovarian Reserve in Patients Who Underwent Laparoscopic Hysterectomy","volume":"14","author":"Wang","year":"2021","journal-title":"J. Ovarian Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s10397-016-0940-x","article-title":"Effect of Salpingectomy, Ovarian Cystectomy and Unilateral Salpingo-Oopherectomy on Ovarian Reserve","volume":"13","author":"Rustamov","year":"2016","journal-title":"Gynecol. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/j.1479-828X.2008.00893.x","article-title":"A Prospective Study of Outcomes Five Years after Hysterectomy in Premenopausal Women","volume":"48","author":"Farquhar","year":"2008","journal-title":"Aust. N. Z. J. Obstet. Gynaecol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1001\/jama.291.12.1447","article-title":"Effect of Hysterectomy vs Medical Treatment on Health-Related Quality of Life and Sexual Functioning: The Medicine or Surgery (Ms) Randomized Trial","volume":"291","author":"Kuppermann","year":"2004","journal-title":"JAMA"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1001\/archpsyc.63.4.375","article-title":"Associations of Hormones and Menopausal Status with Depressed Mood in Women with No History of Depression","volume":"63","author":"Freeman","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S0015-0282(02)03001-7","article-title":"Hormones, Mood, Sexuality, and the Menopausal Transition","volume":"77","author":"Dennerstein","year":"2002","journal-title":"Fertil. Steril."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1467-9450.2008.00701.x","article-title":"The Women\u2019s Health Questionnaire (WHQ): A Psychometric Evaluation of the 36-item Norwegian Version","volume":"50","author":"Borud","year":"2009","journal-title":"Scand. J. Psychol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/aogs.13133","article-title":"Ovarian Reserve after Salpingectomy: A Systematic Review and Meta-analysis","volume":"96","author":"Mohamed","year":"2017","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1016\/j.fertnstert.2013.07.1997","article-title":"Short-Term Effects of Salpingectomy during Laparoscopic Hysterectomy on Ovarian Reserve: A Pilot Randomized Controlled Trial","volume":"100","author":"Findley","year":"2013","journal-title":"Fertil. Steril."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s10397-017-1019-z","article-title":"Effects of Salpingectomy during Abdominal Hysterectomy on Ovarian Reserve: A Randomized Controlled Trial","volume":"14","author":"Tehranian","year":"2017","journal-title":"Gynecol. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.jmig.2017.02.014","article-title":"The Effect of Salpingectomy on Ovarian Function","volume":"24","author":"Kotlyar","year":"2017","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.maturitas.2022.08.002","article-title":"The Effect of Opportunistic Salpingectomy for Primary Prevention of Ovarian Cancer on Ovarian Reserve: A Systematic Review and Meta-Analysis","volume":"166","author":"Gelderblom","year":"2022","journal-title":"Maturitas"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"53.e1\u201353.e10","DOI":"10.1016\/j.ajog.2014.07.027","article-title":"A Retrospective Analysis of the Effect of Salpingectomy on Serum antiM\u00fcllerian Hormone Level and Ovarian Reserve","volume":"212","author":"Ye","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.jmig.2017.01.001","article-title":"The Role of Opportunistic Bilateral Salpingectomy vs Tubal Occlusion or Ligation for Ovarian Cancer Prophylaxis","volume":"24","author":"Ely","year":"2017","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"162635","DOI":"10.1016\/j.cej.2025.162635","article-title":"Bioengineered Extracellular Vesicles Presenting PD-L1 and Gal-9 to Ameliorate New-Onset Primary Ovarian Insufficiency (POI)","volume":"512","author":"Gu","year":"2025","journal-title":"Chem. Eng. J."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1186\/s12964-025-02226-8","article-title":"Identification of Genetically Engineered Strategies to Manipulate Nano-Platforms Presenting Immunotherapeutic Ligands for Alleviating Primary Ovarian Insufficiency Progression","volume":"23","author":"Zhou","year":"2025","journal-title":"Cell Commun. Signal."}],"container-title":["Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3271\/14\/3\/416\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T01:11:21Z","timestamp":1784769081000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3271\/14\/3\/416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,22]]},"references-count":39,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["medsci14030416"],"URL":"https:\/\/doi.org\/10.3390\/medsci14030416","relation":{},"ISSN":["2076-3271"],"issn-type":[{"value":"2076-3271","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,22]]}}}