{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T04:20:08Z","timestamp":1787545208532,"version":"build-2736575974"},"reference-count":23,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Sci.","Medical Sciences"],"abstract":"<jats:p>Background: Alcohol-related conditions may influence both injury patterns and in-hospital management in orthopaedic trauma. This study evaluated the clinical characteristics, injury mechanisms, treatment patterns, and hospital outcomes of adults with acute orthopaedic trauma and documented alcohol use, with particular attention to geriatric vulnerability and alcohol withdrawal. Methods: This retrospective single-centre cohort included adults admitted between January 2018 and December 2025 with acute musculoskeletal trauma and an alcohol-related diagnosis during the same hospitalisation. Patients were classified according to their predominant recorded alcohol-related presentation. Geriatric patients, defined as those aged 65 years or older, were compared with younger adults. Injury mechanisms, comorbidities, operative treatment, intensive care unit involvement, hospital length of stay, mortality, and recorded hospitalisation costs were analysed. Results: The final cohort comprised 294 patients, including 87 geriatric patients. Geriatric patients more frequently sustained same-level or low-energy falls than younger adults (46.0% versus 25.6%; Holm-adjusted p = 0.005) and had a higher prevalence of proximal femoral fractures (40.2% versus 21.7%; OR 2.42, 95% CI 1.41 to 4.16). Any recorded ICU involvement was more frequent among geriatric patients, although prolonged ICU stays of 24 h or longer did not differ significantly between age groups. Alcohol withdrawal was documented in 46 patients and was associated with longer hospitalisation and a longer admission-to-surgery interval. In-hospital mortality occurred in 5 of 46 patients with documented withdrawal (10.9%) and 5 of 248 without withdrawal (2.0%; unadjusted OR 5.93, 95% CI 1.64 to 21.37; p = 0.010). Conclusions: Orthopaedic trauma patients with documented alcohol use represent a clinically heterogeneous population. Geriatric patients showed greater vulnerability to low-energy trauma, proximal femoral fracture, comorbidity, and intensive care involvement, while alcohol withdrawal identified patients with a more complex hospital course. Early recognition of withdrawal risk and enhanced inpatient safety measures may improve orthopaedic care. These findings support careful assessment of alcohol-related risk, early recognition of withdrawal, and heightened inpatient safety precautions.<\/jats:p>","DOI":"10.3390\/medsci14040504","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:20:36Z","timestamp":1787322036000},"page":"504","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Orthopaedic Trauma in Patients with Documented Alcohol Use: Injury Mechanisms, Clinical Characteristics, and Geriatric Vulnerability"],"prefix":"10.3390","volume":"14","author":[{"given":"Irina","family":"Sirbu","sequence":"first","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania"},{"name":"Orthopaedic and Traumatology Clinic, \u2018Sf. Spiridon\u2019 Clinical Emergency Hospital, 700111 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca-Ana","family":"Dmour","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania"},{"name":"Cardiology Clinic, \u201cSt. Spiridon\u201d County Clinical Emergency Hospital, 700111 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan-Dragos","family":"T\u00eernovanu","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania"},{"name":"Orthopaedic and Traumatology Clinic, \u2018Sf. Spiridon\u2019 Clinical Emergency Hospital, 700111 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9814-7742","authenticated-orcid":false,"given":"Bogdan","family":"Puha","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania"},{"name":"Orthopaedic and Traumatology Clinic, \u2018Sf. Spiridon\u2019 Clinical Emergency Hospital, 700111 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliza-Geanina","family":"Cogian","sequence":"additional","affiliation":[{"name":"\u201cIon Creang\u0103\u201d State Pedagogical University of Chi\u0219in\u0103u, 1 Ion Creang\u0103 Street, MD-2069 Chi\u0219in\u0103u, Moldova"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4890-2068","authenticated-orcid":false,"given":"Mariana","family":"Zubenschi","sequence":"additional","affiliation":[{"name":"\u201cIon Creang\u0103\u201d State Pedagogical University of Chi\u0219in\u0103u, 1 Ion Creang\u0103 Street, MD-2069 Chi\u0219in\u0103u, Moldova"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandru","family":"Filip","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania"},{"name":"Orthopaedic and Traumatology Clinic, \u2018Sf. Spiridon\u2019 Clinical Emergency Hospital, 700111 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana-Dana","family":"Alexa","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela-Camelia","family":"T\u00eernovanu","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Popescu","family":"Dragos-Cristian","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania"},{"name":"Orthopaedic and Traumatology Clinic, \u2018Sf. Spiridon\u2019 Clinical Emergency Hospital, 700111 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5300-8426","authenticated-orcid":false,"given":"Adrian-Claudiu","family":"Carp","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania"},{"name":"Orthopaedic and Traumatology Clinic, \u2018Sf. Spiridon\u2019 Clinical Emergency Hospital, 700111 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1154-7145","authenticated-orcid":false,"given":"Awad","family":"Dmour","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania"},{"name":"Orthopaedic and Traumatology Clinic, \u2018Sf. Spiridon\u2019 Clinical Emergency Hospital, 700111 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e001047","DOI":"10.1136\/tsaco-2022-001047","article-title":"Alcohol withdrawal syndrome in trauma patients: A study using the Trauma Quality Program Participant User File","volume":"8","author":"Jones","year":"2023","journal-title":"Trauma Surg. Acute Care Open"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.sopen.2024.05.001","article-title":"A National Analysis of Alcohol Withdrawal Syndrome in Patients with Operative Trauma","volume":"19","author":"Balian","year":"2024","journal-title":"Surg. Open Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e249","DOI":"10.5435\/JAAOS-D-17-00708","article-title":"Perioperative Management of the Orthopaedic Patient and Alcohol Use, Abuse, and Withdrawal","volume":"27","author":"Zamorano","year":"2019","journal-title":"J. Am. Acad. Orthop. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e001010","DOI":"10.1136\/tsaco-2022-001010","article-title":"Prevention of alcohol withdrawal syndrome in the surgical ICU: An American Association for the Surgery of Trauma Critical Care Committee Clinical Consensus Document","volume":"7","author":"Seshadri","year":"2022","journal-title":"Trauma Surg. Acute Care Open"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/BOT.0000000000000664","article-title":"Prevalence of Depression and Posttraumatic Stress Disorder After Acute Orthopaedic Trauma: A Systematic Review and Meta-Analysis","volume":"31","author":"Muscatelli","year":"2017","journal-title":"J. Orthop. Trauma"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e1359","DOI":"10.5435\/JAAOS-D-25-00641","article-title":"Alcohol Misuse, Posttraumatic Stress Symptoms, and Recovery After Musculoskeletal Injury: Implications for Effective Orthopaedic Care","volume":"34","author":"Bakhshaie","year":"2026","journal-title":"J. Am. Acad. Orthop. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/acer.14781","article-title":"Alcohol withdrawal in past-year drinkers with unhealthy alcohol use: Prevalence, characteristics, and correlates in a national epidemiologic survey","volume":"46","author":"Livne","year":"2022","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1111\/j.1532-5415.2006.00912.x","article-title":"Alcohol Intake and Its Relationship with Bone Mineral Density, Falls, and Fracture Risk in Older Men","volume":"54","author":"Cawthon","year":"2006","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_9","first-page":"1252","article-title":"Alcohol Use by Pedestrians Who Are Struck by Motor Vehicles: How Drinking Influences Behaviors, Medical Management, and Outcomes","volume":"71","author":"Dultz","year":"2011","journal-title":"J. Trauma Inj. Infect. Crit. Care"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/S0140-6736(07)61602-X","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: Guidelines for reporting observational studies","volume":"370","author":"Altman","year":"2007","journal-title":"Lancet"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Benchimol, E.I., Smeeth, L., Guttmann, A., Harron, K., Moher, D., Petersen, I., S\u00f8rensen, H.T., von Elm, E., and Langan, S.M. (2015). The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) Statement. PLoS Med., 12.","DOI":"10.1371\/journal.pmed.1001885"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e161","DOI":"10.1097\/BOT.0b013e3182324460","article-title":"Geriatric Trauma","volume":"26","author":"Keller","year":"2012","journal-title":"J. Orthop. Trauma"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1001\/jama.297.1.77","article-title":"Will My Patient Fall?","volume":"297","author":"Ganz","year":"2007","journal-title":"JAMA"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1159\/000507595","article-title":"Perioperative Management of Alcohol Withdrawal Syndrome","volume":"36","author":"Ungur","year":"2020","journal-title":"Visc. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"ii37","DOI":"10.1093\/ageing\/afl084","article-title":"Falls in older people: Epidemiology, risk factors and strategies for prevention","volume":"35","author":"Rubenstein","year":"2006","journal-title":"Age Ageing"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1080\/00952990.2018.1456545","article-title":"A review of the Alcohol Use Disorders Identification Test (AUDIT), AUDIT-C, and USAUDIT for screening in the United States: Past issues and future directions","volume":"44","author":"Babor","year":"2018","journal-title":"Am. J. Drug Alcohol Abus."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.drugalcdep.2010.02.011","article-title":"The more you drink, the harder you fall: A systematic review and meta-analysis of how acute alcohol consumption and injury or collision risk increase together","volume":"110","author":"Taylor","year":"2010","journal-title":"Drug Alcohol Depend."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.cjtee.2021.11.006","article-title":"Increased proportion of alcohol-related trauma in a South London major trauma centre during lockdown: A cohort study","volume":"25","author":"Brown","year":"2022","journal-title":"Chin. J. Traumatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.alcohol.2014.01.004","article-title":"The \u201cPrediction of Alcohol Withdrawal Severity Scale\u201d (PAWSS): Systematic literature review and pilot study of a new scale for the prediction of complicated alcohol withdrawal syndrome","volume":"48","author":"Maldonado","year":"2014","journal-title":"Alcohol"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/JTN.0000000000000414","article-title":"A Psychometric Analysis of CIWA-Ar in Acutely Ill and Injured Hospitalized Patients","volume":"26","author":"Higgins","year":"2019","journal-title":"J. Trauma Nurs."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1177\/00031348241290610","article-title":"Post-Traumatic Stress Disorder (PTSD) in Trauma Patients","volume":"91","author":"Radow","year":"2025","journal-title":"Am. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.1177\/15248380231221492","article-title":"The Effectiveness and Implementation of Psychological First Aid as a Therapeutic Intervention After Trauma: An Integrative Review","volume":"25","author":"Wang","year":"2024","journal-title":"Trauma Violence Abus."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/TA.0000000000001306","article-title":"Utility of the injured trauma survivor screen to predict PTSD and depression during hospital admission","volume":"82","author":"Hunt","year":"2017","journal-title":"J. Trauma Acute Care Surg."}],"container-title":["Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3271\/14\/4\/504\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T04:12:34Z","timestamp":1787544754000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3271\/14\/4\/504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,21]]},"references-count":23,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["medsci14040504"],"URL":"https:\/\/doi.org\/10.3390\/medsci14040504","relation":{},"ISSN":["2076-3271"],"issn-type":[{"value":"2076-3271","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,21]]}}}