{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T09:24:04Z","timestamp":1788341044847,"version":"build-2803163510"},"reference-count":41,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Sci.","Medical Sciences"],"abstract":"<jats:p>Background: Clinical remission is an emerging therapeutic goal in severe asthma treated with biologics. However, remission may evolve beyond the conventional 12-month assessment, and limited real-world data are available on patients who continue the same biologic after incomplete remission at 12 months. We evaluated longitudinal remission trajectories in patients with severe T2-high asthma continuing the same biologic therapy. Methods: This retrospective real-world single-center SANI cohort included adults with severe asthma treated with one biologic agent and followed for at least 18 months. Clinical outcomes and remission status were assessed at 12 and 18 months according to the SANI definition, distinguishing complete remission, partial remission, and no remission. Results: The cohort included 146 patients; 64.4% were female, median age was 61 years, and all had a T2-high phenotype. Maintenance oral corticosteroid use decreased from 83.6% at baseline to 6.8% at 18 months, while symptomatic patients decreased from 100.0% to 11.0%. Median ACT improved from 12.0 to 22.0, and patients with \u22651 exacerbation decreased to 4.1% at 18 months. Complete remission increased from 36.3% at 12 months to 67.1% at 18 months, while no remission decreased from 54.1% to 16.4%. Among patients not in remission at 12 months, 43.0% achieved complete remission and 26.6% achieved partial remission at 18 months. Baseline oral corticosteroid use was associated with lower remission likelihood, whereas preserved baseline FEV1 favored remission at 18 months. Conclusions: Among patients with severe T2-high asthma selected for continuing an unchanged biologic for at least 18 months, remission status was more favorable at 18 months than at 12 months. This observation describes the trajectory of biologic continuers and should not be generalized to all patients who remain outside remission at 12 months. Because patients who discontinued or switched biologics were excluded, these data do not establish that continuation is preferable to switching after an incomplete 12-month response.<\/jats:p>","DOI":"10.3390\/medsci14050523","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:47:13Z","timestamp":1787849233000},"page":"523","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Remission Trajectories Beyond 12 Months in Severe Asthma Patients Continuing a Single Biologic: A Real-World Single SANI Center Cohort"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1267-4320","authenticated-orcid":false,"given":"Simone","family":"Negrini","sequence":"first","affiliation":[{"name":"Immunology and Allergy Unit, Azienda Ospedaliera Ordine Mauriziano di Torino, 10128 Turin, Italy"},{"name":"Department of Medical Sciences, University of Turin, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Stefania","family":"Nicola","sequence":"additional","affiliation":[{"name":"Immunology and Allergy Unit, Azienda Ospedaliera Ordine Mauriziano di Torino, 10128 Turin, Italy"},{"name":"Department of Medical Sciences, University of Turin, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Francesco","family":"Sardanapoli","sequence":"additional","affiliation":[{"name":"Immunology and Allergy Unit, Azienda Ospedaliera Ordine Mauriziano di Torino, 10128 Turin, Italy"},{"name":"Department of Medical Sciences, University of Turin, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3999-5298","authenticated-orcid":false,"given":"Rocco Francesco","family":"Rinaldo","sequence":"additional","affiliation":[{"name":"Pneumology Unit, City of Health and Science, Molinette Hospital, Department of Medical Sciences, University of Turin, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Marco","family":"Russo","sequence":"additional","affiliation":[{"name":"Immunology and Allergy Unit, Azienda Ospedaliera Ordine Mauriziano di Torino, 10128 Turin, Italy"},{"name":"Department of Medical Sciences, University of Turin, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Iuliana","family":"Badiu","sequence":"additional","affiliation":[{"name":"Immunology and Allergy Unit, Azienda Ospedaliera Ordine Mauriziano di Torino, 10128 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Anna","family":"Quinternetto","sequence":"additional","affiliation":[{"name":"Immunology and Allergy Unit, Azienda Ospedaliera Ordine Mauriziano di Torino, 10128 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4201-3456","authenticated-orcid":false,"given":"Luca","family":"Lo Sardo","sequence":"additional","affiliation":[{"name":"Immunology and Allergy Unit, Azienda Ospedaliera Ordine Mauriziano di Torino, 10128 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2285-9970","authenticated-orcid":false,"given":"Francesco","family":"Blasi","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation, Universit\u00e0 degli Studi di Milano, 20100 Milan, Italy"},{"name":"Respiratory and Cystic Fibrosis Unit, Internal Medicine Department, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico Milano, 20100 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Pierluigi","family":"Paggiaro","sequence":"additional","affiliation":[{"name":"Department of Surgery, Medicine, Molecular Biology and Critical Care, University of Pisa, 56100 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0492-5663","authenticated-orcid":false,"given":"Enrico","family":"Heffler","sequence":"additional","affiliation":[{"name":"Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rozzano, 20089 Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20072 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5997-7172","authenticated-orcid":false,"given":"Giovanni","family":"Rolla","sequence":"additional","affiliation":[{"name":"Immunology and Allergy Unit, Azienda Ospedaliera Ordine Mauriziano di Torino, 10128 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9941-9236","authenticated-orcid":false,"given":"Caterina","family":"Bucca","sequence":"additional","affiliation":[{"name":"Immunology and Allergy Unit, Azienda Ospedaliera Ordine Mauriziano di Torino, 10128 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8467-2557","authenticated-orcid":false,"given":"Giorgio Walter","family":"Canonica","sequence":"additional","affiliation":[{"name":"Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rozzano, 20089 Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20072 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]},{"given":"Fulvia","family":"Ribolla","sequence":"additional","affiliation":[{"name":"Pneumology Unit, City of Health and Science, Molinette 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Ospedaliera Ordine Mauriziano di Torino, 10128 Turin, Italy"},{"name":"Department of Medical Sciences, University of Turin, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"ref_1","unstructured":"Global Initiative for Asthma (2026, August 23). Global Strategy for Asthma Management and Prevention. 2025 Update. Available online: https:\/\/ginasthma.org\/wp-content\/uploads\/2025\/11\/GINA-2025-Update-25_11_08-WMS.pdf."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"240088","DOI":"10.1183\/16000617.0088-2024","article-title":"Biologics in severe asthma: A state-of-the-art review","volume":"34","author":"Gyawali","year":"2025","journal-title":"Eur. Respir. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Borrelli, R., Brussino, L., Lo Sardo, L., Quinternetto, A., Vitali, I., Bagnasco, D., Boem, M., Corradi, F., Badiu, I., and Negrini, S. (2025). Sex-Based Differences in Asthma: Pathophysiology, Hormonal Influence, and Genetic Mechanisms. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26115288"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1800703","DOI":"10.1183\/13993003.00703-2018","article-title":"Consequences of long-term oral corticosteroid therapy and its side-effects in severe asthma in adults: A focused review of the impact data in the literature","volume":"52","author":"Volmer","year":"2018","journal-title":"Eur. Respir. J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"552265","DOI":"10.2147\/JIR.S552265","article-title":"Predictive Factors And Treatments Associated with Clinical Remission in Severe Eosinophilic Asthma","volume":"19","author":"Lupia","year":"2026","journal-title":"J. Inflamm. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jaci.2017.04.009","article-title":"Oral corticosteroid exposure and adverse effects in asthmatic patients","volume":"141","author":"Sullivan","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"168","DOI":"10.18176\/jiaci.0856","article-title":"Severe Asthma and Biologics: Managing Complex Patients","volume":"33","author":"Matucci","year":"2023","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Suruki, R.Y., Daugherty, J.B., Boudiaf, N., and Albers, F.C. (2017). The frequency of asthma exacerbations and healthcare utilization in patients with asthma from the UK and USA. BMC Pulm. Med., 17.","DOI":"10.1186\/s12890-017-0409-3"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/S0140-6736(14)60617-6","article-title":"Outdoor air pollution and asthma","volume":"383","author":"Guarnieri","year":"2014","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Hough, K.P., Curtiss, M.L., Blain, T.J., Liu, R.M., Trevor, J., Deshane, J.S., and Thannickal, V.J. (2020). Airway Remodeling in Asthma. Front. Med., 7.","DOI":"10.3389\/fmed.2020.00191"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Kardas, G., Kuna, P., and Panek, M. (2020). Biological Therapies of Severe Asthma and Their Possible Effects on Airway Remodeling. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.01134"},{"key":"ref_12","first-page":"1234","article-title":"Is Asthma Remission a New Achievable Goal? A Review of the Current Drug-Related Evidence and Predictors","volume":"81","author":"Gunaydin","year":"2026","journal-title":"Allergy"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.jaci.2019.12.006","article-title":"An expert consensus framework for asthma remission as a treatment goal","volume":"145","author":"Bafadhel","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Pastore, D., Lupia, C., Chiarella, E., Piazzetta, G.L., Mazza, G., Neri, G., Bruni, A., Longhini, F., Garofalo, E., and Pelaia, G. (2026). Severe Eosinophilic Asthma: From Immunopathology to Pharmacological Treatment. J. Clin. Med., 15.","DOI":"10.3390\/jcm15103845"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1056\/NEJMra2032506","article-title":"Biologic therapies for severe asthma","volume":"386","author":"Brusselle","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Bagnasco, D., Bondi, B., Brussino, L., Nicola, S., Cameli, P., Tiotiu, A., Guida, G., Gollinucci, C., Visca, D., and Spanevello, A. (2025). Dupilumab Effectiveness in Patients with Severe Allergic Asthma Non-Responsive to Omalizumab. J. Pers. Med., 15.","DOI":"10.3390\/jpm15020043"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Caminati, M., Maule, M., Benoni, R., Bagnasco, D., Beghe, B., Braido, F., Brussino, L., Cameli, P., Candeliere, M.G., and Carpagnano, G.E. (2024). Dupilumab Efficacy on Asthma Functional, Inflammatory, and Patient-Reported Outcomes across Different Disease Phenotypes and Severity: A Real-Life Perspective. Biomedicines, 12.","DOI":"10.3390\/biomedicines12020390"},{"key":"ref_18","first-page":"334","article-title":"Upper and lower airways response to tezepelumab in asthma patients with\/without comorbid nasal polyposis: A 6-month real-life perspective","volume":"64","author":"Caminati","year":"2026","journal-title":"Rhinology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e70164","DOI":"10.1002\/clt2.70164","article-title":"Clinical Remission in Severe T2-High Asthma in Real Life After Anti-IgE, Anti-IL-5 and Anti-IL5R: A Potential Role for CRP as a Biomarker","volume":"16","author":"Vervier","year":"2026","journal-title":"Clin. Transl. Allergy"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"M\u0103rginean, C., Safta, A.C., Hu\u021banu, D., Budin, C.E., Iano\u0219i, M.B., Jimborean, G., and Iano\u0219i, E.S. (2026). Long-Term Clinical and Biological Outcomes of Biologic Therapy in Severe Asthma: 24-Month Real-World Cohort Study from Romania. J. Clin. Med., 15.","DOI":"10.3390\/jcm15062444"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.jaip.2020.10.010","article-title":"Long-Term Therapy Response to Anti-IL-5 Biologics in Severe Asthma-A Real-Life Evaluation","volume":"9","author":"Eger","year":"2021","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2300819","DOI":"10.1183\/13993003.00819-2023","article-title":"Clinical remission in severe asthma with biologic therapy: An analysis from the UK Severe Asthma Registry","volume":"62","author":"McDowell","year":"2023","journal-title":"Eur. Respir. J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1016\/j.jaip.2023.07.041","article-title":"Severe Asthma Network Italy Definition of Clinical Remission in Severe Asthma: A Delphi Consensus","volume":"11","author":"Canonica","year":"2023","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1080\/02770903.2024.2376919","article-title":"SANI clinical remission definition: A useful tool in severe asthma management","volume":"61","author":"Canonica","year":"2024","journal-title":"J. Asthma"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Ledda, A.G., Costanzo, G., Canalis, S., Puci, M.V., Sambugaro, G., Taurisano, G., Piano, E., Bullita, M., Sotgiu, G., and Firinu, D. (2026). Evaluation of the concordance of asthma remission definitions according to international guidelines in a cohort of patients treated with monoclonal antibodies for severe asthma. Front. Pharmacol., 17.","DOI":"10.3389\/fphar.2026.1776527"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1111\/all.70333","article-title":"Patterns and Clinical Efficacy of Biologics Switching in Patients with Severe Asthma: A Systematic Review and Meta-Analysis","volume":"81","author":"Zheng","year":"2026","journal-title":"Allergy"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1183\/13993003.00436-2016","article-title":"What is asthma-COPD overlap syndrome? Towards a consensus definition from a round table discussion","volume":"48","author":"Sin","year":"2016","journal-title":"Eur. Respir. J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1080\/17476348.2016.1249853","article-title":"Developments in the diagnosis and treatment of allergic bronchopulmonary aspergillosis","volume":"10","author":"Agarwal","year":"2016","journal-title":"Expert Rev. Respir. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/S2213-2600(15)00050-8","article-title":"Diagnostic accuracy of minimally invasive markers for detection of airway eosinophilia in asthma: A systematic review and meta-analysis","volume":"3","author":"Korevaar","year":"2015","journal-title":"Lancet Respir. Med."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"American Thoracic Society, and European Respiratory Society (2005). ATS\/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide. Am. J. Respir. Crit. Care Med., 171, 912\u2013930.","DOI":"10.1164\/rccm.200406-710ST"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1164\/rccm.9120-11ST","article-title":"An official ATS clinical practice guideline: Interpretation of exhaled nitric oxide levels (FENO) for clinical applications","volume":"184","author":"Dweik","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.jaip.2024.01.023","article-title":"Phenotyping of Severe Asthma in the Era of Broad-Acting Anti-Asthma Biologics","volume":"12","author":"Bourdin","year":"2024","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1164\/rccm.200801-060ST","article-title":"An official American Thoracic Society\/European Respiratory Society statement: Asthma control and exacerbations: Standardizing endpoints for clinical asthma trials and clinical practice","volume":"180","author":"Reddel","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jaci.2003.09.008","article-title":"Development of the Asthma Control Test: A survey for assessing asthma control","volume":"113","author":"Nathan","year":"2004","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1016\/S0140-6736(16)31322-8","article-title":"Benralizumab, an anti-interleukin-5 receptor alpha monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): A randomised, double-blind, placebo-controlled phase 3 trial","volume":"388","author":"FitzGerald","year":"2016","journal-title":"Lancet"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1056\/NEJMoa1403290","article-title":"Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma","volume":"371","author":"Ortega","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1164\/rccm.201904-0903SO","article-title":"Systematic Literature Review of Systemic Corticosteroid Use for Asthma Management","volume":"201","author":"Bleecker","year":"2020","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.jaip.2025.07.041","article-title":"Effects of obesity on response to asthma biologic treatment: Longitudinal data from the United Kingdom Severe Asthma Registry","volume":"13","author":"Gonem","year":"2025","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.jaip.2024.09.013","article-title":"Eosinophilia and Adverse Effects of Dupilumab for Respiratory Indications: A Real-World Setting","volume":"13","author":"Li","year":"2025","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jaip.2023.10.012","article-title":"Tobacco Exposure and Efficacy of Biologic Therapy in Patients with Severe Asthma: A Nationwide Study from the Danish Severe Asthma Register","volume":"12","author":"Hansen","year":"2024","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2102583","DOI":"10.1183\/13993003.02583-2021","article-title":"Asthma remission: What is it and how can it be achieved?","volume":"60","author":"Thomas","year":"2022","journal-title":"Eur. Respir. 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