{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:15:20Z","timestamp":1789128920362,"version":"build-2803163510"},"reference-count":114,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of T\u00e2rgu Mure\u0219","award":["859\/7\/22.01.2026"],"award-info":[{"award-number":["859\/7\/22.01.2026"]}]},{"award":["859\/7\/22.01.2026"],"award-info":[{"award-number":["859\/7\/22.01.2026"]}],"id":[{"id":"https:\/\/ror.org\/03gwbzf29","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Sci.","Medical Sciences"],"abstract":"<jats:p>Background\/Objectives: Gastric cancer is a major global health challenge with multifactorial aetiology. Vitamin D has been investigated for a potential role in gastric carcinogenesis, but evidence remains heterogeneous. This systematic review aimed to synthesise evidence on serum 25(OH)D, dietary vitamin D intake and VDR polymorphisms in relation to gastric cancer in adults and children. Methods: A systematic search following PRISMA 2020 standards was conducted in PubMed, Web of Science, Scopus and Lens.org for studies published from January 2007 to January 2026. Observational studies evaluating vitamin D exposure or VDR polymorphisms in relation to gastric cancer were eligible. Risk of bias was assessed using established instruments. Where comparable data were available, random-effects meta-analyses were performed, with REML estimation and Knapp\u2013Hartung adjustment. Results: Twenty-four studies met the inclusion criteria, and no eligible paediatric studies were identified. Four studies evaluating serum 25(OH)D showed a non-significant tendency towards lower concentrations in gastric cancer patients (MD = \u22128.82 ng\/mL, 95% CI \u221218.15 to 0.51). Five studies evaluating dietary vitamin D showed no significant association with gastric cancer risk (OR = 0.87, 95% CI 0.47\u20131.60). Five studies evaluating the VDR FokI polymorphism under the dominant model demonstrated increased gastric cancer susceptibility among variant carriers (OR = 1.44, 95% CI 1.03\u20132.01). Conclusions: Associations between vitamin D and gastric cancer varied by exposure type. Serum 25(OH)D and dietary intake showed no significant pooled associations, whereas VDR FokI was associated with increased gastric cancer susceptibility. The absence of paediatric evidence highlights an important knowledge gap.<\/jats:p>","DOI":"10.3390\/medsci14050562","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T10:51:37Z","timestamp":1789123897000},"page":"562","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vitamin D and Gastric Cancer: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"14","author":[{"given":"Roxana","family":"P\u00e2ntea","sequence":"first","affiliation":[{"name":"Faculty of Medicine, \u201cGeorge Emil Palade\u201d University of Medicine, Pharmacy, Sciences and Technology of T\u00e2rgu Mure\u0219, Gheorghe Marinescu Street No. 38, 540139 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena Elena","family":"Meli\u021b","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cGeorge Emil Palade\u201d University of Medicine, Pharmacy, Sciences and Technology of T\u00e2rgu Mure\u0219, Gheorghe Marinescu Street No. 38, 540139 T\u00e2rgu Mure\u0219, Romania"},{"name":"Department of Paediatrics II, \u201cGeorge Emil Palade\u201d University of Medicine, Pharmacy, Sciences and Technology of T\u00e2rgu Mure\u0219, Gheorghe Marinescu Street No. 38, 540139 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"ref_1","unstructured":"Cancer Today Incidence (2026, April 04). Available online: https:\/\/gco.iarc.who.int\/today\/en\/dataviz\/tables?mode=population&cancers=7&types=0."},{"key":"ref_2","unstructured":"Cancer Today Mortality (2026, April 04). Available online: https:\/\/gco.iarc.who.int\/today\/en\/dataviz\/tables?mode=population&cancers=7&types=1."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.annonc.2022.07.004","article-title":"Gastric Cancer: ESMO Clinical Practice Guideline for Diagnosis, Treatment and Follow-Up","volume":"33","author":"Lordick","year":"2022","journal-title":"Ann. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Machlowska, J., Baj, J., Sitarz, M., Maciejewski, R., and Sitarz, R. (2020). Gastric Cancer: Epidemiology, Risk Factors, Classification, Genomic Characteristics and Treatment Strategies. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21114012"},{"key":"ref_5","first-page":"591","article-title":"Risk Factors for Gastric Cancer: A Systematic Review","volume":"19","author":"Yusefi","year":"2018","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Liang, J., Yuan, H., Quan, C., and Chen, J. (2025). Risk Factors for Gastric Cancer: An Umbrella Review of Systematic Reviews and Meta-Analyses. Front. Oncol., 15.","DOI":"10.3389\/fonc.2025.1564575"},{"key":"ref_7","unstructured":"IARC (1994). Monographs on the Evaluation of Carcinogenic Risks to Humans. Schistosomes, Liver Flukes and Helicobacter pylori, International Agency for Research on Cancer."},{"key":"ref_8","unstructured":"Feingold, K.R., Adler, R.A., Ahmed, S.F., Anawalt, B., Blackman, M.R., Chrousos, G., Corpas, E., de Herder, W.W., Dhatariya, K., and Dungan, K. (2000). Vitamin D: Production, Metabolism, and Mechanism of Action. Endotext, MDText.com, Inc."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00223-012-9619-0","article-title":"Molecular Mechanisms of Vitamin D Action","volume":"92","author":"Haussler","year":"2013","journal-title":"Calcif. Tissue Int."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Mu\u00f1oz, A., and Grant, W.B. (2022). Vitamin D and Cancer: An Historical Overview of the Epidemiology and Mechanisms. Nutrients, 14.","DOI":"10.3390\/nu14071448"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"114735","DOI":"10.1016\/j.bcp.2021.114735","article-title":"Vitamin D and the Risk for Cancer: A Molecular Analysis","volume":"196","author":"Carlberg","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"571200","DOI":"10.2147\/CMAR.S571200","article-title":"Vitamin D Receptor in Cancer: Biological Functions, Mechanistic Insights, and Clinical Relevance","volume":"18","author":"Liang","year":"2026","journal-title":"Cancer Manag. Res."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Ghaseminejad-Raeini, A., Ghaderi, A., Sharafi, A., Nematollahi-Sani, B., Moossavi, M., Derakhshani, A., and Sarab, G.A. (2023). Immunomodulatory Actions of Vitamin D in Various Immune-Related Disorders: A Comprehensive Review. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.950465"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.7150\/jca.81034","article-title":"Molecular Mechanism of Vitamin D Receptor Modulating Wnt\/\u03b2-Catenin Signaling Pathway in Gastric Cancer","volume":"14","author":"Zhang","year":"2023","journal-title":"J. Cancer"},{"key":"ref_15","first-page":"1","article-title":"Vitamin D and Gastrointestinal Cancer","volume":"10","author":"Mahendra","year":"2018","journal-title":"J. Lab. Physicians"},{"key":"ref_16","first-page":"155","article-title":"Effect of Vitamin D on Helicobacter Pylori Infection and Eradication: An Updated Systematic Review and Meta-Analysis","volume":"2","author":"Albatineh","year":"2023","journal-title":"J. Prev. Complement. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"790","DOI":"10.4103\/1735-1995.168404","article-title":"Vitamin D Intake, Serum Vitamin D Levels, and Risk of Gastric Cancer: A Systematic Review and Meta-Analysis","volume":"20","author":"Khayyatzadeh","year":"2015","journal-title":"J. Res. Med. Sci."},{"key":"ref_18","first-page":"15","article-title":"The Relationship Between Vitamin D Status and Risk of Gastric Cancer","volume":"72","author":"Parizadeh","year":"2020","journal-title":"Nutr. Cancer"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"8390","DOI":"10.3390\/curroncol29110661","article-title":"Correlation between Serum 25-Hydroxyvitamin D Levels and Gastric Cancer: A Systematic Review and Meta-Analysis","volume":"29","author":"Liu","year":"2022","journal-title":"Curr. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e39527","DOI":"10.1097\/MD.0000000000039527","article-title":"Common Variants of Vitamin D Receptor Gene Polymorphisms and Risk of Gastric Cancer A Meta-Analysis","volume":"103","author":"Guan","year":"2024","journal-title":"Medicine"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e00899","DOI":"10.14309\/ctg.0000000000000899","article-title":"Dietary and Circulating Vitamins, Polymorphisms of Vitamin Metabolism Genes, and the Risk of Gastrointestinal Cancers: A Systematic Review and Meta-Analysis","volume":"16","author":"Wang","year":"2025","journal-title":"Clin. Transl. Gastroenterol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3836","DOI":"10.2174\/0929867328666211111163304","article-title":"The Role of Vitamin D in Gastrointestinal Diseases: Inflammation, Gastric Cancer, and Colorectal Cancer","volume":"29","author":"Chen","year":"2022","journal-title":"Curr. Med. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.4103\/jcrt.jcrt_527_21","article-title":"Relationship of Vitamin D Intake, Serum 25(OH) D, and Solar Ultraviolet-B Radiation with the Risk of Gastric Cancer: A Meta-Analysis","volume":"18","author":"Chen","year":"2022","journal-title":"J. Cancer Res. Ther."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"n160","DOI":"10.1136\/bmj.n160","article-title":"PRISMA 2020 Explanation and Elaboration: Updated Guidance and Exemplars for Reporting Systematic Reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 Statement: An Updated Guideline for Reporting Systematic Reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","article-title":"Rayyan\u2014A Web and Mobile App for Systematic Reviews","volume":"5","author":"Ouzzani","year":"2016","journal-title":"Syst. Rev."},{"key":"ref_27","unstructured":"Newcastle-Ottawa Scale (NOS)|Ottawa Hospital Research Institute (2026, April 23). Available online: https:\/\/ohri.ca\/en\/who-we-are\/core-facilities-and-platforms\/ottawa-methods-centre\/newcastle-ottawa-scale."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e011458","DOI":"10.1136\/bmjopen-2016-011458","article-title":"Development of a critical appraisal tool to assess the quality of cross-sectional studies (AXIS)","volume":"6","author":"Downes","year":"2016","journal-title":"BMJ Open"},{"key":"ref_29","unstructured":"Totten, A.M., Cheney, T.P., O\u2019Neil, M.E., Newgard, C.D., Daya, M., Fu, R., Wasson, N., Hart, E.L., and Chou, R. (2026, April 23). Table E1, Quality in Prognostic Studies (QUIPS) Tool, Modified, Available online: https:\/\/www.ncbi.nlm.nih.gov\/sites\/books\/NBK537447\/table\/appe.tab1\/."},{"key":"ref_30","unstructured":"(2026, April 25). CRAN: Manuals. Available online: https:\/\/cran.r-project.org\/manuals.html."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1093\/aje\/kwq121","article-title":"Circulating 25-Hydroxyvitamin D and Risk of Esophageal and Gastric Cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers","volume":"172","author":"Abnet","year":"2010","journal-title":"Am. J. Epidemiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/sj.bjc.6603834","article-title":"Prospective Study of Serum 25(OH)-Vitamin D Concentration and Risk of Oesophageal and Gastric Cancers","volume":"97","author":"Chen","year":"2007","journal-title":"Br. J. Cancer"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"6413","DOI":"10.1007\/s11033-019-05088-9","article-title":"The Effects of Serum Levels, and Alterations in the Genes of Binding Protein and Receptor of Vitamin D on Gastric Cancer","volume":"46","author":"Durak","year":"2019","journal-title":"Mol. Biol. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"257","DOI":"10.7555\/JBR.32.20170089","article-title":"Dietary Vitamin D Intake and Vitamin D Related Genetic Polymorphisms Are Not Associated with Gastric Cancer in a Hospital-Based Case-Control Study in Korea","volume":"32","author":"Eom","year":"2018","journal-title":"J. Biomed. Res."},{"key":"ref_35","first-page":"155","article-title":"Association between Serum 25-Hydroxy Vitamin D Level and Gastric Adenocarcinoma-A Cross Sectional Study","volume":"16","author":"Kevin","year":"2021","journal-title":"Prz. Gastroenterol."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Kwak, J.H., and Paik, J.K. (2020). Vitamin d Status and Gastric Cancer: A Cross-Sectional Study in Koreans. Nutrients, 12.","DOI":"10.3390\/nu12072004"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s12262-024-04152-4","article-title":"Association between Gastric Cancer and Vitamin D in Kashmiri Population: A 2 Year Case\u2013Control Study at a Tertiary Care Hospital","volume":"87","author":"Mushtaq","year":"2025","journal-title":"Indian. J. Surg."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ejca.2019.05.011","article-title":"High Prevalence of Severe Hypovitaminosis D in Patients with Advanced Gastric Cancer Treated with First-Line Chemotherapy with or without Anti-EGFR\u2013Directed Monoclonal Antibody (EXPAND Trial) Showing No Prognostic Impact","volume":"116","author":"Obermannova","year":"2019","journal-title":"Eur. J. Cancer"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1479-5876-10-16","article-title":"Prognostic Effects of 25-Hydroxyvitamin D Levels in Gastric Cancer","volume":"10","author":"Ren","year":"2012","journal-title":"J. Transl. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"688","DOI":"10.4251\/wjgo.v8.i9.688","article-title":"Association between Serum Vitamin D Levels and Gastric Cancer: A Retrospective Chart Analysis","volume":"8","author":"Vyas","year":"2016","journal-title":"World J. Gastrointest. Oncol."},{"key":"ref_41","first-page":"163","article-title":"Protective Effect of Dietary Micronutrients on Gastric Cancer Risk among Jordanians","volume":"41","author":"Allehdan","year":"2024","journal-title":"Nutr. Hosp."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Chen, X., Chen, Y., Luo, Z., Cheng, L., Wang, Q., Zou, F., and Lin, Y. (2025). Association between the Chinese Dietary Inflammatory Index and Risk of Gastric Cancer: A Case-Control Study in Southeastern China. Front. Nutr., 12.","DOI":"10.3389\/fnut.2025.1653575"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Nguyen, M.T., Huynh, N.N.Y., Nguyen, D.D., Ta, N.H., van Nguyen, T., Dang, H.T., and Ngoan, N.T. (2022). Vitamin D Intake and Gastric Cancer in Viet Nam: A Case-Control Study. BMC Cancer, 22.","DOI":"10.1186\/s12885-022-09933-2"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/annonc\/mdn536","article-title":"Dietary Intake of Selected Micronutrients and Gastric Cancer Risk: An Italian Case-Control Study","volume":"20","author":"Pelucchi","year":"2009","journal-title":"Ann. Oncol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"602","DOI":"10.5009\/gnl230354","article-title":"Daily Diet and Nutrition Risk Factors for Gastric Cancer Incidence in a Japanese Population","volume":"18","author":"Takasu","year":"2024","journal-title":"Gut Liver"},{"key":"ref_46","first-page":"474","article-title":"Vitamins and Stomach Cancer: A Hospital Based Case-Control Study in Iran","volume":"7","author":"Toorang","year":"2022","journal-title":"J. Nutr. Food. Secur."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e9747","DOI":"10.5812\/ijcm.9747","article-title":"The Association between Index of Nutritional Quality (INQ) and Gastric Cancer and Evaluation of Nutrient Intakes of Gastric Cancer Patients: A Case-Control Study","volume":"11","author":"Vahid","year":"2018","journal-title":"Int. J. Cancer Manag."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1620\/tjem.236.219","article-title":"Foki Polymorphism of the Vitamin d Receptor Gene Is Associated with Susceptibility to Gastric Cancer: A Case-Control Study","volume":"236","author":"Cong","year":"2015","journal-title":"Tohoku J. Exp. Med."},{"key":"ref_49","first-page":"435","article-title":"Association of Vitamin D Receptor Polymorphisms (FokI (Rs2228570), ApaI (Rs7975232), BsmI (Rs1544410), and TaqI (Rs731236)) with Gastric Cancer in a Kurdish Population from West of Iran","volume":"9","author":"Hosseinkhani","year":"2021","journal-title":"Rep. Biochem. Mol. Biol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"15044","DOI":"10.1002\/jcp.28145","article-title":"Positive Correlation between Vitamin D Receptor Gene TaqI Variant and Gastric Cancer Predisposition in a Sample of Iranian Population","volume":"234","author":"Parsamanesh","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1007\/s11033-021-06376-z","article-title":"Association of Vitamin D Receptor Gene Variations with Gastric Cancer Risk in Kashmiri Population","volume":"48","author":"Qadir","year":"2021","journal-title":"Mol. Biol. Rep."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.4103\/jcrt.jcrt_1479_21","article-title":"Vitamin D Receptor Gene Variations and Their Haplotypic Association: Possible Impact on Gastric Cancer Risk","volume":"19","author":"Qadir","year":"2023","journal-title":"J. Cancer Res. Ther."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12032-014-0196-0","article-title":"Screening of Susceptibility Genes and Multi-Gene Risk Analysis in Gastric Cancer","volume":"31","author":"Shen","year":"2014","journal-title":"Med. Oncol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"45531","DOI":"10.18632\/oncotarget.17270","article-title":"Polymorphisms of VDR Gene and Risk of Gastric Cardiac Adenocarcinoma in Chinese Population","volume":"8","author":"Yin","year":"2017","journal-title":"Oncotarget"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Martin-Gorgojo, A., and Martin-Moreno, J.M. (2024). Insights into the Role of Vitamin D in the Prevention and Control of Cancer and Other Chronic Noncommunicable Diseases: Shedding Further Light on a Captivating Subject. Nutrients, 16.","DOI":"10.3390\/nu16132166"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Nguyen, T.T.-N., Nojiri, K., Kurokawa, T., Sawada, T., Kanemoto, Y., and Kato, S. (2026). Vitamin D Receptor Signaling and Ligand Modulation: Molecular Mechanisms and Therapeutic Implications. Int. J. Mol. Sci., 27.","DOI":"10.3390\/ijms27052396"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"109271","DOI":"10.1016\/j.steroids.2023.109271","article-title":"Genomic Signaling of Vitamin D","volume":"198","author":"Carlberg","year":"2023","journal-title":"Steroids"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"100737","DOI":"10.1016\/j.mgene.2020.100737","article-title":"Assessment of Expression of Vitamin D Receptor-Associated lncRNAs in Gastric Cancer","volume":"25","author":"Salehnezhad","year":"2020","journal-title":"Meta Gene"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"106308","DOI":"10.1016\/j.jsbmb.2023.106308","article-title":"The Impact of Vitamin D on Cancer: A Mini Review","volume":"231","author":"Seraphin","year":"2023","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_60","first-page":"e18275","article-title":"Vitamin D and Gastric Cancer: A Ray of Sunshine?","volume":"13","author":"Shah","year":"2021","journal-title":"Cureus J. Med. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Bhoora, S., and Punchoo, R. (2020). Policing Cancer: Vitamin D Arrests the Cell Cycle. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21239296"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"29474","DOI":"10.18632\/oncotarget.15298","article-title":"Pathogenic Roles of Alterations in Vitamin D and Vitamin D Receptor in Gastric Tumorigenesis","volume":"8","author":"Du","year":"2017","journal-title":"Oncotarget"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.3892\/ijmm.2014.1664","article-title":"1,25-Dihydroxyvitamin D3and Cisplatin Synergistically Induce Apoptosis and Cell Cycle Arrest in Gastric Cancer Cells","volume":"33","author":"Bao","year":"2014","journal-title":"Int. J. Mol. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"8587","DOI":"10.18632\/aging.102349","article-title":"A Molecular Sub-Cluster of Colon Cancer Cells with Low VDR Expression Is Sensitive to Chemotherapy, BRAF Inhibitors and PI3K-mTOR Inhibitors Treatment","volume":"11","author":"Wang","year":"2019","journal-title":"Aging"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.2147\/OTT.S195642","article-title":"1,25-Dihydroxyvitamin D3 Affects Gastric Cancer Progression by Repressing BMP3 Promoter Methylation","volume":"12","author":"Zhao","year":"2019","journal-title":"OncoTargets Ther."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"3702","DOI":"10.21037\/tcr-24-2068","article-title":"Vitamin D-Regulated miRNA Expression in Tumoral and Normal Adjacent Tissue of Localized Gastric Cancer Patients: The Impact on Survival and Time to Relapse","volume":"14","year":"2025","journal-title":"Transl. Cancer Res."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Chen, L., Chang, L., Hua, C., Cheng, T., and Lee, C. (2021). Comparing the Expressions of Vitamin D Receptor, Cell Proliferation, and Apoptosis in Gastric Mucosa with Gastritis, Intestinal Metaplasia, or Adenocarcinoma Change. Front. Med., 8.","DOI":"10.3389\/fmed.2021.766061"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Juh\u00e1sz, O., J\u00e1kob, N., Rajnai, H., Imrei, M., and Garami, M. (2022). Immunohistochemical Detection of the Presence of Vitamin D Receptor in Childhood Solid Tumors. Cancers, 14.","DOI":"10.3390\/cancers14143295"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"156155","DOI":"10.1016\/j.prp.2025.156155","article-title":"Association of Vitamin D Receptor Gene Polymorphisms in Gastrointestinal Cancer: A Systematic Review and Meta-Analysis","volume":"274","author":"Wang","year":"2025","journal-title":"Pathol. Res. Pract."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"111413","DOI":"10.1016\/j.nut.2021.111413","article-title":"Vitamin D Suppressed Gastric Cancer Cell Growth through Downregulating CD44 Expression in Vitro and in Vivo","volume":"91\u201392","author":"Li","year":"2021","journal-title":"Nutrition"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Singh, K., Gandhi, S., and Batool, R. (2018). A Case-Control Study of the Association between Vitamin D Levels and Gastric Incomplete Intestinal Metaplasia. Nutrients, 10.","DOI":"10.3390\/nu10050629"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s12272-026-01618-9","article-title":"Vitamin D Remodels the Tumor Microenvironment to Suppress Gastric Cancer Progression through Cancer-Associated Fibroblasts-Secreted Exosomal miR-378c Targeting KDSR","volume":"49","author":"Li","year":"2026","journal-title":"Arch. Pharm. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"025150096","DOI":"10.36922\/EJMO025150096","article-title":"Vitamin D\/Vitamin D Receptor Signaling Suppresses Gastric Cancer Metastasis through Autophagy-Related Protein 13\/Beclin1-Mediated Autophagy","volume":"10","author":"Yang","year":"2025","journal-title":"Eurasian J. Med. Oncol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13045-024-01563-4","article-title":"Wnt\/\u03b2-Catenin Signaling Pathway in Carcinogenesis and Cancer Therapy","volume":"17","author":"Song","year":"2024","journal-title":"J. Hematol. Oncol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"105723","DOI":"10.1016\/j.jsbmb.2020.105723","article-title":"Vitamin D Modulates E-Cadherin Turnover by Regulating TGF-\u03b2 and Wnt Signalings during EMT-Mediated Myofibroblast Differentiation in A459 Cells","volume":"202","author":"Sari","year":"2020","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Davidopoulou, S., Makedou, K., Kourti, A., Gkeka, I., Karakostas, P., Pikilidou, M., Tolidis, K., and Kalfas, S. (2025). Vitamin D and LL-37 in Serum and Saliva: Insights into Oral Immunity. Curr. Issues Mol. Biol., 47.","DOI":"10.3390\/cimb47020102"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Nabavi-Rad, A., Jamshidizadeh, S., Azizi, M., Yadegar, A., Robinson, K., Monaghan, T.M., and Zali, M.R. (2023). The Synergistic Effect of Levilactobacillus Brevis IBRC-M10790 and Vitamin D3 on Helicobacter Pylori-Induced Inflammation. Front. Cell Infect. Microbiol., 13.","DOI":"10.3389\/fcimb.2023.1171469"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"M\u0103rginean, C.O., Meli\u021b, L.E., Borka Balas, R., V\u0103sie\u0219iu, A.M., and Fle\u0219eriu, T. (2022). The Crosstalk between Vitamin D and Pediatric Digestive Disorders. Diagnostics, 12.","DOI":"10.3390\/diagnostics12102328"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Wimalawansa, S.J. (2025). Vitamin D\u2019s Impact on Cancer Incidence and Mortality: A Systematic Review. Nutrients, 17.","DOI":"10.3390\/nu17142333"},{"key":"ref_80","first-page":"1080","article-title":"Vitamin D and Gastric Cancer\u2014A Systematic Review and Meta-Analysis","volume":"40","author":"Zhao","year":"2023","journal-title":"Nutr. Hosp."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Henn, M., Martin-Gorgojo, V., and Martin-Moreno, J.M. (2022). Vitamin D in Cancer Prevention: Gaps in Current Knowledge and Room for Hope. Nutrients, 14.","DOI":"10.3390\/nu14214512"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"e11290","DOI":"10.1016\/j.heliyon.2022.e11290","article-title":"Vitamin D Supplementation for the Prevention of Total Cancer Incidence and Mortality: An Updated Systematic Review and Meta-Analysis","volume":"8","author":"Cheema","year":"2022","journal-title":"Heliyon"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Muszy\u0144ski, T., Polak, K., Fr\u0105tczak, A., Miziolek, B., Bergler-Czop, B., and Szczepanik, A. (2022). Vitamin D\u2014The Nutritional Status of Post-Gastrectomy Gastric Cancer Patients\u2014Systematic Review. Nutrients, 14.","DOI":"10.3390\/nu14132712"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.clnu.2014.12.023","article-title":"Systematic Review and Meta-Analysis: Prevalence and Possible Causes of Vitamin D Deficiency and Insufficiency in Pediatric Cancer Patients","volume":"35","author":"Iniesta","year":"2016","journal-title":"Clin. Nutr."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Mo, X., He, C., Han, F., Yan, H., Chen, X., Wang, Y., and Zhou, M. (2024). Association of Serum 25-Hydroxy-Vitamin D Concentration and Risk of Mortality in Cancer Survivors in the United States. BMC Cancer, 24.","DOI":"10.1186\/s12885-024-12304-8"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00394-025-03768-w","article-title":"Dietary Vitamin D and Gastric Cancer Risk within the Stomach Cancer Pooling (Stop) Project","volume":"64","author":"Santucci","year":"2025","journal-title":"Eur. J. Nutr."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Grant, W.B. (2023). Long Follow-Up Times Weaken Observational Diet-Cancer Study Outcomes: Evidence from Studies of Meat and Cancer Risk. Nutrients, 16.","DOI":"10.3390\/nu16010026"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Wu, X., Zhang, Q., Guo, H., Wang, N., Fan, X., Zhang, B., Zhang, W., Wang, W., Fang, Z., and Wu, J. (2023). Dietary Patterns and Risk for Gastric Cancer: A Case-Control Study in Residents of the Huaihe River Basin, China. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1118113"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/php.12915","article-title":"Annual Ambient UVB at Wavelengths That Induce Vitamin D Synthesis Is Associated with Reduced Esophageal and Gastric Cancer Risk: A Nested Case\u2013Control Study","volume":"94","author":"Zgaga","year":"2018","journal-title":"Photochem. Photobiol."},{"key":"ref_90","first-page":"181","article-title":"Can Vitamin D Be the Ray of Sunshine That Lights up the Treatment of Gastric Cancer?","volume":"23","year":"2023","journal-title":"Rev. Fac. Med. Humana"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"21451","DOI":"10.18632\/aging.203484","article-title":"Identification and epidemiological evaluation of gastric cancer risk factors: Based on a field synopsis and meta-analysis in Chinese population","volume":"13","author":"Duan","year":"2021","journal-title":"Aging"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"pkac019","DOI":"10.1093\/jncics\/pkac019","article-title":"Prediagnostic Serum Vitamin D, Vitamin D Binding Protein Isoforms, and Cancer Survival","volume":"6","author":"Weinstein","year":"2022","journal-title":"JNCI Cancer Spectr."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Meli\u021b, L.E., M\u0103rginean, C.O., and Borka Balas, R. (2024). The Most Recent Insights into the Roots of Gastric Cancer. Life, 14.","DOI":"10.3390\/life14010095"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"e21985","DOI":"10.1097\/MD.0000000000021985","article-title":"Pediatric Gastritis and Its Impact on Hematologic Parameters","volume":"99","author":"Mocan","year":"2020","journal-title":"Medicine"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"e3616","DOI":"10.1097\/MD.0000000000003616","article-title":"The Associations Between Helicobacter Pylori Infection, Serum Vitamin D, and Metabolic Syndrome A Community-Based Study","volume":"95","author":"Chen","year":"2016","journal-title":"Medicine"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Alexandru, A., Ivan, C.-S., Tanasescu, S., Oprisoni, L.A., Dragomir, T.-L., Varga, N.-I., Mateescu, D., Diaconu, M., Margan, M.-M., and Boeriu, E. (2024). Are Pediatric Cancer Patients a Risk Group for Vitamin D Deficiency? A Systematic Review. Cancers, 16.","DOI":"10.3390\/cancers16244201"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Arshad, S., and Zaidi, S.J.A. (2022). Vitamin D Levels among Children, Adolescents, Adults, and Elders in Pakistani Population: A Cross-Sectional Study. BMC Public Health, 22.","DOI":"10.1186\/s12889-022-14526-6"},{"key":"ref_98","first-page":"483","article-title":"Correlation between 25-hydroxyvitamin D and nephroblastoma in children and its value in assessing disease prognosis","volume":"25","author":"Zhao","year":"2023","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1080\/01635581.2016.1180408","article-title":"The Incidence of and Factors Associated with Vitamin D Deficiency in Newly Diagnosed Children with Cancer","volume":"68","author":"Genc","year":"2016","journal-title":"Nutr. Cancer"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1210\/jc.2010-2133","article-title":"Vitamin D Insufficiency in Korea\u2014A Greater Threat to Younger Generation: The Korea National Health and Nutrition Examination Survey (KNHANES) 2008","volume":"96","author":"Choi","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S2213-8587(21)00345-4","article-title":"The D-Health Trial: A Randomised Controlled Trial of the Effect of Vitamin D on Mortality","volume":"10","author":"Neale","year":"2022","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1017\/S000711451500433X","article-title":"Vitamin D Status and Its Determinants during Autumn in Children at Northern Latitudes: A Cross-Sectional Analysis from the Optimal Well-Being, Development and Health for Danish Children through a Healthy New Nordic Diet (OPUS) School Meal Study","volume":"115","author":"Petersen","year":"2016","journal-title":"Br. J. Nutr."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"500","DOI":"10.47391\/JPMA.5512","article-title":"Inappropriate Supplementation of Vitamin D Can Result in Toxicity: A Crosssectional Study of Paediatrics Population","volume":"73","author":"Shamim","year":"2023","journal-title":"J. Pak. Med. Assoc."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"e29217","DOI":"10.1002\/pbc.29217","article-title":"Improving Vitamin D Testing and Supplementation in Children with Newly Diagnosed Cancer: A Quality Improvement Initiative at Rady Children\u2019s Hospital San Diego","volume":"68","author":"Shliakhtsitsava","year":"2021","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.1002\/cam4.4013","article-title":"Vitamin D Supplementation for Children with Cancer: A Systematic Review and Consensus Recommendations","volume":"10","author":"Verhagen","year":"2021","journal-title":"Cancer Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"e343","DOI":"10.1097\/MPH.0000000000001069","article-title":"Evaluation of Serum Trace Element and Vitamin Levels in Children with Cancer in the First 6 Months After Diagnosis","volume":"40","author":"Emir","year":"2018","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"e953","DOI":"10.1097\/MPH.0000000000002762","article-title":"Vitamin D Status in Children With High-Risk Neuroblastoma","volume":"45","author":"Mora","year":"2023","journal-title":"J. Pediatr. Hematol.\/Oncol."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Fullmer, M., Su, A., Bachrach, S., Hossain, J., and Kecskemethy, H.H. (2022). Newly Diagnosed Children with Cancer Have Lower 25-Vitamin D Levels than Their Cancer-Free Peers: A Comparison across Age, Race, and Sex. Cancers, 14.","DOI":"10.3390\/cancers14102378"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1080\/08880018.2020.1721629","article-title":"Sociodemographic and Clinical Characteristics Associated with Vitamin D Status in Newly Diagnosed Pediatric Cancer Patients","volume":"37","author":"Aristizabal","year":"2020","journal-title":"Pediatr. Hematol. Oncol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"14","DOI":"10.4103\/0971-5851.177009","article-title":"Vitamin D Insufficiency among Children with Cancer in India","volume":"37","author":"Mohan","year":"2016","journal-title":"Indian J. Med. Paediatr. Oncol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1080\/07315724.2019.1616233","article-title":"Examining the Vitamin D Status of Children with Solid Tumors","volume":"39","author":"Jakab","year":"2020","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"K\u00e1r\u00e1sz, N., Juh\u00e1sz, O., Imrei, M., and Garami, M. (2023). Long-Term Prognosis in Relation to Vitamin D Status in Pediatric Solid Tumor Patients. Nutrients, 15.","DOI":"10.3390\/nu15214571"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Kittivisuit, S., Sripornsawan, P., Songthawee, N., Chavananon, S., Yam-ubon, U., McNeil, E.B., Jaruratanasirikul, S., and Chotsampancharoen, T. (2023). Vitamin D Deficiency in Childhood Cancer Survivors: Results from Southern Thailand. Nutrients, 15.","DOI":"10.3390\/nu15061328"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1093\/ajcn\/86.5.1722","article-title":"Childhood Dairy Intake and Adult Cancer Risk: 65-y Follow-up of the Boyd Orr Cohort2","volume":"86","author":"Bain","year":"2007","journal-title":"Am. J. Clin. 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