{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:33:21Z","timestamp":1787614401229,"version":"build-2736575974"},"reference-count":23,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T00:00:00Z","timestamp":1510012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>Subacute sclerosing panencephalitis (SSPE) is a rare progressive neurological disorder of early adolescence caused by persistent infection of the measles virus, which remains prevalent worldwide despite an effective vaccine. SSPE is a devastating disease with a characteristic clinical course in subcortical white matter; however, atypical presentations of brainstem involvement may be seen in rare cases. This review summarizes reports to date on brainstem involvement in SSPE, including the clinical course of disease, neuroimaging presentations, and guidelines for treatment. A comprehensive literature search was performed for English-language publications with keywords \u201csubacute sclerosing panencephalitis\u201d and \u201cbrainstem\u201d using the National Library of Medicine PubMed database (March 1981\u2013September 2017). Eleven articles focusing on SSPE of the brainstem were included. Predominant brainstem involvement remains uncharacteristic of SSPE, which may lead to misdiagnosis and poor outcome. A number of case reports have demonstrated brainstem involvement associated with other intracranial lesions commonly presenting in later SSPE stages (III and IV). However, brainstem lesions can appear in all stages, independent of higher cortical structures. The varied clinical presentations complicate diagnosis from a neuroimaging perspective. SSPE of the brainstem is a rare but important clinical entity. It may present like canonical SSPE or with unique clinical features such as absence seizures and pronounced ataxia. While SSPE generally progresses to the brainstem, it can also begin with a primary focus of infection in the brainstem. Awareness of varied SSPE presentations can aid in early diagnosis as well as guide management and treatment.<\/jats:p>","DOI":"10.3390\/medsci5040026","type":"journal-article","created":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T11:46:01Z","timestamp":1510055161000},"page":"26","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Subacute Sclerosing Panencephalitis of the Brainstem as a Clinical Entity"],"prefix":"10.3390","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2071-6965","authenticated-orcid":false,"given":"Pavan","family":"Upadhyayula","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, University of California, San Diego, 200 West Arbor Drive #8893, La Jolla, CA 92103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California, San Diego, 200 West Arbor Drive #8893, La Jolla, CA 92103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9694-7722","authenticated-orcid":false,"given":"John","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California, San Francisco, 400 Parnassus Avenue, San Francisco, CA 94122, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Ciacci","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California, San Diego, 200 West Arbor Drive #8893, La Jolla, CA 92103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,11,7]]},"reference":[{"key":"ref_1","unstructured":"CDC (2017, August 21). 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