{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T17:26:01Z","timestamp":1785345961903,"version":"3.55.0"},"reference-count":29,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T00:00:00Z","timestamp":1522022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>The relationship between the results of penile duplex Doppler ultrasound (PDDU) and response to vardenafil was investigated in patients diagnosed with erectile dysfunction (ED). Data from 148 patients with ED were analyzed retrospectively. Patients who did not respond to therapy were classified in to Group I (n = 32), those who responded partially were classified into Group II (n = 40), and complete responders were classified into Group III (n = 76). Age, comorbidities, and vascular and penile pathologies were compared among the three groups. While diabetes mellitus (DM) and dyslipidemia positivity adversely affected the response to treatment, the presence of hypertension (HT), Peyronie\u2019s disease and priapism increased the therapeutic response to the treatment (p &lt; 0.05). Arterial insufficiency was present in 20 (30.3%), 25 (37.9%) and 21 (31.8%) of the patients in Group I, Group II and Group III, respectively (p = 0.001). Venous insufficiency was observed in three (14.3%) patients in Group I and in eight (85.7%) patients in Group III (p = 0.001). Arterial\/venous insufficiency was seen in 9 (30%), 14 (46.7%) and 7 (23.3%) of the patients in Group I, Group II and Group III, respectively (p = 0.001). The response rate to treatment was highest in normal patients according to PDDU, followed by patients with venous insufficiency. In addition, it was found that DM decreased the response to treatment, whereas the response increased in cases with HT, priapism and Peyronie\u2019s disease.<\/jats:p>","DOI":"10.3390\/medsci6020028","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T03:43:29Z","timestamp":1522035809000},"page":"28","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Relationship between Response to PDE5 Inhibitors and Penile Duplex Doppler Ultrasound in Erectile Dysfunction"],"prefix":"10.3390","volume":"6","author":[{"given":"Ercan","family":"Ogreden","sequence":"first","affiliation":[{"name":"Department of Urology, Giresun University Faculty of Medicine, Giresun, Sa\u011fl\u0131k Uygulama ve Ara\u015ft\u0131rma Hastanesi Nizamiye Mah. Mumcular Sok. No: 1\/1, 1 nolu Sa\u011fl\u0131k Oca\u011f\u0131 Arkas\u0131, Merkez, Giresun P.K. 28200, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ural","family":"O\u011fuz","sequence":"additional","affiliation":[{"name":"Department of Urology, Giresun University Faculty of Medicine, Giresun, Sa\u011fl\u0131k Uygulama ve Ara\u015ft\u0131rma Hastanesi Nizamiye Mah. Mumcular Sok. No: 1\/1, 1 nolu Sa\u011fl\u0131k Oca\u011f\u0131 Arkas\u0131, Merkez, Giresun P.K. 28200, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erhan","family":"Demirelli","sequence":"additional","affiliation":[{"name":"Department of Urology, Giresun University Faculty of Medicine, Giresun, Sa\u011fl\u0131k Uygulama ve Ara\u015ft\u0131rma Hastanesi Nizamiye Mah. Mumcular Sok. No: 1\/1, 1 nolu Sa\u011fl\u0131k Oca\u011f\u0131 Arkas\u0131, Merkez, Giresun P.K. 28200, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alptekin","family":"Tosun","sequence":"additional","affiliation":[{"name":"Department of Radiology, Giresun University Faculty of Medicine, Giresun P.K. 28200, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orhan","family":"Yal\u00e7\u0131n","sequence":"additional","affiliation":[{"name":"Department of Urology, Giresun University Faculty of Medicine, Giresun, Sa\u011fl\u0131k Uygulama ve Ara\u015ft\u0131rma Hastanesi Nizamiye Mah. Mumcular Sok. No: 1\/1, 1 nolu Sa\u011fl\u0131k Oca\u011f\u0131 Arkas\u0131, Merkez, Giresun P.K. 28200, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,3,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"908","DOI":"10.4330\/wjc.v6.i9.908","article-title":"Management of erectile dysfunction in hypertension: Tips and tricks","volume":"26","author":"Viigimaa","year":"2014","journal-title":"World J. Cardiol."},{"key":"ref_2","first-page":"394","article-title":"Diagnosis and treatment of erectile dysfunction a practical update","volume":"2","author":"Persu","year":"2009","journal-title":"J. Med. 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