{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T02:43:31Z","timestamp":1789872211438,"version":"4.0.1"},"reference-count":73,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T00:00:00Z","timestamp":1564963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2018-02435"],"award-info":[{"award-number":["2018-02435"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF18OC0033992"],"award-info":[{"award-number":["NNF18OC0033992"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Strategic Research Program (SRP) in Diabetes at Karolinska Institutet","award":["na"],"award-info":[{"award-number":["na"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>Women with polycystic ovary syndrome (PCOS) exhibit compromised psychiatric health. Independent of obesity, women with PCOS are more susceptible to have anxiety and depression diagnoses and other neuropsychiatric disorders. During pregnancy women with PCOS display high circulating androgen levels that may cause prenatal androgen exposure affecting the growing fetus and increasing the risk of mood disorders in offspring. Increasing evidence supports a non-genetic, maternal contribution to the development of PCOS and anxiety disorders in the next generation. Prenatal androgenized rodent models reflecting the anxiety-like phenotype of PCOS in the offspring, found evidence for the altered placenta and androgen receptor function in the amygdala, together with changes in the expression of genes associated with emotional regulation and steroid receptors in the amygdala and hippocampus. These findings defined a previously unknown mechanism that may be critical in understanding how maternal androgen excess can increase the risk of developing anxiety disorders in daughters and partly in sons of PCOS mothers. Maternal obesity is another common feature of PCOS causing an unfavorable intrauterine environment which may contribute to psychiatric problems in the offspring. Whether environmental factors such as prenatal androgen exposure and obesity increase the offspring\u2019s susceptibility to develop psychiatric ill-health will be discussed.<\/jats:p>","DOI":"10.3390\/medsci7080086","type":"journal-article","created":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T11:17:47Z","timestamp":1565003867000},"page":"86","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Origins and Impact of Psychological Traits in Polycystic Ovary Syndrome"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3424-1502","authenticated-orcid":false,"given":"Elisabet","family":"Stener-Victorin","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4370-4780","authenticated-orcid":false,"given":"Maria","family":"Manti","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Fornes","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden"},{"name":"Centre for Translational Microbiome Research (CTMR), Department of Microbiology, Tumor and Cell biology, Karolinska Institutet, 171 77 Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjiv","family":"Risal","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haojiang","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Benrick","sequence":"additional","affiliation":[{"name":"Department of Physiology, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden"},{"name":"School of Health and Education, University of Sk\u00f6vde, 541 28 Sk\u00f6vde, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,8,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1210\/er.2015-1018","article-title":"Scientific Statement on the Diagnostic Criteria, Epidemiology, Pathophysiology, and Molecular Genetics of Polycystic Ovary Syndrome","volume":"36","author":"Dumesic","year":"2015","journal-title":"Endocr. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1093\/humrep\/dex044","article-title":"High prevalence of moderate and severe depressive and anxiety symptoms in polycystic ovary syndrome: A systematic review and meta-analysis","volume":"32","author":"Cooney","year":"2017","journal-title":"Hum. Reprod."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.fertnstert.2018.01.038","article-title":"Androgen Excess\u2014Polycystic Ovary Syndrome Society: Position statement on depression, anxiety, quality of life, and eating disorders in polycystic ovary syndrome","volume":"109","author":"Dokras","year":"2018","journal-title":"Fertil. Steril."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1016\/j.psyneuen.2011.04.001","article-title":"Sex steroids, insulin sensitivity and sympathetic nerve activity in relation to affective symptoms in women with polycystic ovary syndrome","volume":"36","author":"Jedel","year":"2011","journal-title":"Psychoneuroendocrinology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1002\/ajp.20679","article-title":"Fetal, infant, adolescent and adult phenotypes of polycystic ovary syndrome in prenatally androgenized female rhesus monkeys","volume":"71","author":"Abbott","year":"2009","journal-title":"Am. J. Primatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1530\/EC-17-0218","article-title":"Reproductive and metabolic features during puberty in sons of women with polycystic ovary syndrome","volume":"6","author":"Crisosto","year":"2017","journal-title":"Endocr. Connect."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/s12020-018-1692-3","article-title":"Psychiatric disorders in women with polycystic ovary syndrome: A systematic review and meta-analysis","volume":"62","author":"Brutocao","year":"2018","journal-title":"Endocrine"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1093\/humrep\/dey256","article-title":"Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"33","author":"Teede","year":"2018","journal-title":"Hum. Reprod."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.3906\/sag-1511-112","article-title":"Do anxiety and depression statuses differ in differentpolycystic ovary syndrome phenotypes?","volume":"46","author":"Dilbaz","year":"2016","journal-title":"Turk. J. Med. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jad.2015.06.043","article-title":"Evaluation of affective temperament and anxiety-depression levels of patients with polycystic ovary syndrome","volume":"185","author":"Asik","year":"2015","journal-title":"J. Affect. Disord."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"366","DOI":"10.5152\/npa.2015.12363","article-title":"Relationship Between the Clinical and Biochemical Findings of Polycystic Ovary Syndrome and Depression and Anxiety","volume":"53","author":"Baskoy","year":"2016","journal-title":"Noro Psikiyatr Ars."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"44","DOI":"10.5005\/jp-journals-10006-1384","article-title":"Depression and anxiety in women with polycystic ovary syndrome and its biochemical associates","volume":"8","author":"Batool","year":"2016","journal-title":"J. SAFOG"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.psyneuen.2017.08.007","article-title":"Polycystic ovary syndrome, personality, and depression: A twin study","volume":"85","author":"Cesta","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.fertnstert.2018.10.034","article-title":"Polycystic ovary syndrome, obesity, and depression: Identifying the highest-risk group among an already high-risk group","volume":"111","author":"Cooney","year":"2019","journal-title":"Fertil. Steril."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s11920-017-0834-2","article-title":"Depression and Anxiety in Polycystic Ovary Syndrome: Etiology and Treatment","volume":"19","author":"Cooney","year":"2017","journal-title":"Curr. Psychiatry Rep."},{"key":"ref_16","first-page":"322","article-title":"Women with polycystic ovary syndrome are at increased risk of postnatal depression","volume":"Volume 33","author":"Davies","year":"2018","journal-title":"Human Reproduction"},{"key":"ref_17","first-page":"531","article-title":"Anxiety and depression states of adolescents with polycystic ovary syndrome","volume":"48","author":"Emeksiz","year":"2018","journal-title":"Turk. J. Med. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"5820","DOI":"10.19082\/5820","article-title":"Association between severity of depression and clinico-biochemical markers of polycystic ovary syndrome","volume":"9","author":"Enjezab","year":"2017","journal-title":"Electron. Phys."},{"key":"ref_19","first-page":"1","article-title":"Depression and clinical markers in polycystic ovary syndrome","volume":"13","author":"Enjezab","year":"2015","journal-title":"Iran. J. Reprod. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e64","DOI":"10.1016\/j.fertnstert.2017.07.203","article-title":"Quality of life and depression in polycystic ovary syndrome","volume":"108","author":"Greenwood","year":"2017","journal-title":"Fertil. Steril."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.fertnstert.2018.03.009","article-title":"Insulin resistance is associated with depression risk in polycystic ovary syndrome","volume":"110","author":"Greenwood","year":"2018","journal-title":"Fertil. Steril."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"279. e1","DOI":"10.1016\/j.ajog.2018.06.017","article-title":"Association among depression, symptom experience, and quality of life in polycystic ovary syndrome","volume":"219","author":"Greenwood","year":"2018","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.fertnstert.2015.05.019","article-title":"Putative role for insulin resistance in depression risk in polycystic ovary syndrome","volume":"104","author":"Greenwood","year":"2015","journal-title":"Fertil. Steril."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.fertnstert.2018.10.004","article-title":"Clinical course of depression symptoms and predictors of enduring depression risk in women with polycystic ovary syndrome: Results of a longitudinal study","volume":"111","author":"Greenwood","year":"2019","journal-title":"Fertil. Steril."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1210\/jc.2019-00234","article-title":"Depression over the lifespan in a population-based cohort of women with polycystic ovary syndrome: Longitudinal analysis","volume":"15","author":"Greenwood","year":"2019","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/JXX.0000000000000125","article-title":"A mixed-methods study of coping and depression in adolescent girls with polycystic ovary syndrome","volume":"31","author":"Hopkins","year":"2019","journal-title":"J. Am. Assoc. Nurse Pract."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ejogrb.2014.10.028","article-title":"Depression in relation to biochemical parameters and age in women with polycystic ovary syndrome","volume":"184","author":"Klimczak","year":"2015","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.jad.2019.05.006","article-title":"Body image and its relationships with sexual functioning, anxiety, and depression in women with polycystic ovary syndrome","volume":"253","author":"Kogure","year":"2019","journal-title":"J. Affect. Disord."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1111\/aogs.13332","article-title":"Postnatal depression in a community-based study of women with polycystic ovary syndrome","volume":"97","author":"March","year":"2018","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_30","first-page":"95","article-title":"The effect of depression and anxiety on cognitive performance in women with polycystic ovary syndrome","volume":"10","author":"Mehrabadi","year":"2016","journal-title":"Int. J. Fertil. Steril."},{"key":"ref_31","first-page":"159","article-title":"Association of depression and anxiety with cognitive function in patients with polycystic ovary syndrome","volume":"27","author":"Mehrabadi","year":"2017","journal-title":"J. Maz. Univ. Med. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00737-014-0458-z","article-title":"Predictors of depression in women with polycystic ovary syndrome","volume":"18","author":"Naqvi","year":"2015","journal-title":"Arch. Women Ment. Health"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.psychres.2016.11.043","article-title":"The relationship between atypical depression and insulin resistance in patients with polycystic ovary syndrome and major depression","volume":"258","author":"Ozdemir","year":"2017","journal-title":"Psychiatry Res."},{"key":"ref_34","first-page":"180","article-title":"The comparative study of depression in women with polycystic ovary syndrome and control group","volume":"18","author":"Salehifar","year":"2016","journal-title":"Iran. J. Endocrinol. Metab."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1080\/09513590.2018.1427713","article-title":"Depression, sexual satisfaction, and other psychological issues in women with polycystic ovary syndrome","volume":"34","author":"Grabowska","year":"2018","journal-title":"Gynecol. Endocrinol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3109\/10253890.2014.974030","article-title":"Impact of a mindfulness stress management program on stress, anxiety, depression and quality of life in women with polycystic ovary syndrome: A randomized controlled trial","volume":"18","author":"Stefanaki","year":"2015","journal-title":"Stress"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s00737-015-0543-y","article-title":"Vitamin D supplementation for depression in women with polycystic ovary syndrome: Killing two birds with one stone?","volume":"18","author":"Xiang","year":"2015","journal-title":"Arch. Women Ment. Health"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod.116.142117","article-title":"Depression-Like Behavior in a Dehydroepiandrosterone-Induced Mouse Model of Polycystic Ovary Syndrome","volume":"95","author":"Yu","year":"2016","journal-title":"Biol. Reprod."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Carron, R.C. (2014). The Effects of Depressive and Anxiety Symptoms, Perceived Stress, Body Mass Index, and Coping Processes on the Health-Related Quality of Life of Adult Women with Polycystic Ovary Syndrome. [Ph.D. Thesis, University of Colorado Anschutz Medical Campus].","DOI":"10.1016\/j.fertnstert.2014.07.105"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"159","DOI":"10.5114\/hpr.2016.55963","article-title":"Loss of attributes of femininity, anxiety and value crisis. Women with polycystic ovary syndrome compared to women after mastectomy and in menopause","volume":"4","author":"Macik","year":"2016","journal-title":"Health Psychol. Rep."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"14956","DOI":"10.1073\/pnas.95.25.14956","article-title":"Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome","volume":"95","author":"Legro","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Day, F., Karaderi, T., Jones, M.R., Meun, C., He, C., Drong, A., Kraft, P., Lin, N., Huang, H., and Broer, L. (2018). Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria. PLoS Genet., 14.","DOI":"10.1371\/journal.pgen.1007813"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/nrendo.2015.230","article-title":"PCOS in 2015: New insights into the genetics of polycystic ovary syndrome","volume":"12","author":"Azziz","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.fertnstert.2009.10.020","article-title":"Epigenetics in polycystic ovary syndrome: A pilot study of global DNA methylation","volume":"94","author":"Xu","year":"2010","journal-title":"Fertil. Steril."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Xu, N., Kwon, S., Abbott, D.H., Geller, D.H., Dumesic, D.A., Azziz, R., Guo, X., and Goodarzi, M.O. (2011). Epigenetic mechanism underlying the development of polycystic ovary syndrome (PCOS)-like phenotypes in prenatally androgenized rhesus monkeys. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0027286"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"22883","DOI":"10.1038\/srep22883","article-title":"Epigenetic and Transcriptional Alterations in Human Adipose Tissue of Polycystic Ovary Syndrome","volume":"6","author":"Kokosar","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.1210\/jc.2018-00935","article-title":"Transcriptional and epigenetic changes influencing skeletal muscle metabolism in women with polycystic ovary syndrome","volume":"103","author":"Nilsson","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Jones, M.R., Brower, M.A., Xu, N., Cui, J., Mengesha, E., Chen, Y.D., Taylor, K.D., Azziz, R., and Goodrari, M.O. (2015). Systems Genetics Reveals the Functional Context of PCOS Loci and Identifies Genetic and Molecular Mechanisms of Disease Heterogeneity. PLoS Genet., 11.","DOI":"10.1371\/journal.pgen.1005455"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1080\/17446651.2019.1576522","article-title":"Hyperandrogenic origins of polycystic ovary syndrome\u2014Implications for pathophysiology and therapy","volume":"14","author":"Abbott","year":"2019","journal-title":"Expert Rev. Endocrinol. Metab."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1093\/humrep\/deu351","article-title":"Placental STAT3 signaling is activated in women with polycystic ovary syndrome","volume":"30","author":"Maliqueo","year":"2015","journal-title":"Hum. Reprod."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41390-019-0405-9","article-title":"Placental programming of neuropsychiatric disease","volume":"86","author":"Kratimenos","year":"2019","journal-title":"Pediatric Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.psyneuen.2009.09.009","article-title":"Organizational effects of fetal testosterone on human corpus callosum size and asymmetry","volume":"35","author":"Chura","year":"2010","journal-title":"Psychoneuroendocrinology"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1210\/jc.2015-2318","article-title":"White Matter Microstructure and Cognitive Function in Young Women With Polycystic Ovary Syndrome","volume":"101","author":"Rees","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.biopsych.2012.05.027","article-title":"Fetal programming effects of testosterone on the reward system and behavioral approach tendencies in humans","volume":"72","author":"Lombardo","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1210\/jc.2017-02667","article-title":"Polycystic Ovary Syndrome Is Associated With Adverse Mental Health and Neurodevelopmental Outcomes","volume":"103","author":"Berni","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.psyneuen.2016.08.005","article-title":"Polycystic ovary syndrome and psychiatric disorders: Co-morbidity and heritability in a nationwide Swedish cohort","volume":"73","author":"Cesta","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Cesta, C.E., Oberg, A.S., Ibrahimson, A., Yusuf, I., Larsson, H., Almqvist, C., D\u2019Onofrio, B.M., Bulik, C.M., de la Cru, L.F., and Mataix-Cols, D. (2019). Maternal polycystic ovary syndrome and risk of neuropsychiatric disorders in offspring: Prenatal androgen exposure or genetic confounding?. Psychol. Med., 1\u20139.","DOI":"10.1017\/S0033291719000424"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1038\/mp.2015.183","article-title":"Maternal polycystic ovary syndrome and the risk of autism spectrum disorders in the offspring: A population-based nationwide study in Sweden","volume":"21","author":"Kosidou","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.biopsych.2016.09.022","article-title":"Maternal Polycystic Ovary Syndrome and Risk for Attention-Deficit\/Hyperactivity Disorder in the Offspring","volume":"82","author":"Kosidou","year":"2017","journal-title":"Biol Psychiatry"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1017\/S2040174417001118","article-title":"Anogenital distance in newborn daughters of women with polycystic ovary syndrome indicates fetal testosterone exposure","volume":"9","author":"Barrett","year":"2018","journal-title":"J. Dev. Orig. Health Dis."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1093\/humrep\/17.10.2573","article-title":"Maternal serum androgens in pregnant women with polycystic ovarian syndrome: Possible implications in prenatal androgenization","volume":"17","author":"Maliqueo","year":"2002","journal-title":"Hum. Reprod."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1210\/jc.2007-0267","article-title":"Anti-M\u00fcllerian hormone levels in peripubertal daughters of women with polycystic ovary syndrome","volume":"92","author":"Crisosto","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s00424-013-1268-2","article-title":"Prenatal and postnatal hormone effects on the human brain and cognition","volume":"465","author":"Auyeung","year":"2013","journal-title":"Pflug. Arch. Eur. J. Physiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.2147\/NDT.S136717","article-title":"Potential role of pre- and postnatal testosterone levels in attention-deficit\/hyperactivity disorder: Is there a sex difference?","volume":"13","author":"Wang","year":"2017","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"14348","DOI":"10.1073\/pnas.1507514112","article-title":"Maternal testosterone exposure increases anxiety-like behavior and impacts the limbic system in the offspring","volume":"112","author":"Hu","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1096\/fj.08-116889","article-title":"High-fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57\/BL6 mice","volume":"23","author":"Jones","year":"2009","journal-title":"FASEB J."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/1477-7827-9-110","article-title":"Prenatal testosterone-induced fetal growth restriction is associated with down-regulation of rat placental amino acid transport","volume":"9","author":"Sathishkumar","year":"2011","journal-title":"Reprod. Biol. Endocrin."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ejogrb.2012.10.015","article-title":"Placental steroidogenesis in pregnant women with polycystic ovary syndrome","volume":"166","author":"Maliqueo","year":"2013","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.celrep.2016.05.065","article-title":"Maternal Metabolic Syndrome Programs Mitochondrial Dysfunction via Germline Changes across Three Generations","volume":"16","author":"Saben","year":"2016","journal-title":"Cell Rep."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00125-014-3466-7","article-title":"Pre-gestational vs. gestational exposure to maternal obesity differentially programs the offspring in mice","volume":"58","author":"Sasson","year":"2015","journal-title":"Diabetologia"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1192\/bjp.bp.113.143693","article-title":"Fetal growth and psychiatric and socioeconomic problems: Population-based sibling comparison","volume":"205","author":"Class","year":"2014","journal-title":"Br. J. Psychiatry"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.1096\/fj.201701263RR","article-title":"Maternal androgen excess and obesity induce sexually dimorphic anxiety-like behavior in the offspring","volume":"32","author":"Manti","year":"2018","journal-title":"FASEB J."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Fornes, R., Manti, M., Qi, X., Vorontsov, E., Sihlbom, C., Nystrom, J., Jerlhag, E., Maliqueo, M., Hirschberg, A.L., and Carlstr\u00f6m, M. (2019). Mice exposed to maternal androgen excess and diet-induced obesity have altered phosphorylation of catechol-O-methyltransferase in the placenta and fetal liver. Int J. Obes.","DOI":"10.1038\/s41366-018-0314-8"}],"container-title":["Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3271\/7\/8\/86\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:13:27Z","timestamp":1760188407000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3271\/7\/8\/86"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,5]]},"references-count":73,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2019,8]]}},"alternative-id":["medsci7080086"],"URL":"https:\/\/doi.org\/10.3390\/medsci7080086","relation":{},"ISSN":["2076-3271"],"issn-type":[{"value":"2076-3271","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,5]]}}}