{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T22:42:40Z","timestamp":1772318560037,"version":"3.50.1"},"reference-count":73,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T00:00:00Z","timestamp":1615420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>The effect of limonoids and spermine (Spm) extracted from yuzu (Citrus junos) seeds on the gut and the brain in a mouse model with Sandhoff disease (SD) was investigated. Wild-type and SD mice were fed a normal diet, or a diet supplemented with limonoid, Spm, or limonoid + Spm for 14\u201318 weeks, and then 16S rRNA gene amplicon sequencing with extracted DNA from their feces was executed. For SD control mice, intestinal microbiota was mostly composed of Lactobacillus and linked to dysbiosis. For SD and wild-type mice fed with limonoids + Spm or limonoids alone, intestinal microbiota was rich in mucin-degrading bacteria, including Bacteroidetes, Verrucomicrobia, and Firmicutes, and displayed a higher production of short-chain fatty acids and immunoglobulin A. Additionally, SD mice fed with limonoids + Spm or limonoids alone had less inflammation in hypothalamic tissues and displayed a greater number of neurons. Administration of limonoids and\/or Spm improved the proportions of beneficial intestinal microbiota to host health and reduced neuronal degeneration in SD mice. Yuzu seed limonoids and Spermine may help to maintain the homeostasis of intestinal microbiota and hypothalamic tissue in the SD mouse model.<\/jats:p>","DOI":"10.3390\/medsci9010017","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T20:17:40Z","timestamp":1615493860000},"page":"17","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of Yuzu (Citrus junos) Seed Limonoids and Spermine on Intestinal Microbiota and Hypothalamic Tissue in the Sandhoff Disease Mouse Model"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3112-536X","authenticated-orcid":false,"given":"Mayumi","family":"Minamisawa","sequence":"first","affiliation":[{"name":"Faculty of Advanced Engineering, Chiba Institute of Technology, 2-1-1 Shibazono Narashino, Chiba 275-0023, Japan"},{"name":"Graduate School of Engineering, Chiba Institute of Technology, 2-17-1 Tsudanuma Narashino, Chiba 275-0016, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuma","family":"Suzumura","sequence":"additional","affiliation":[{"name":"Graduate School of Engineering, Chiba Institute of Technology, 2-17-1 Tsudanuma Narashino, Chiba 275-0016, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudeep","family":"Bose","sequence":"additional","affiliation":[{"name":"Amity Institute of Biotechnology and Molecular Medicine, Amity University, Uttar Pradesh, Noida 201313, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuyuki","family":"Taniai","sequence":"additional","affiliation":[{"name":"Faculty of Advanced Engineering, Chiba Institute of Technology, 2-1-1 Shibazono Narashino, Chiba 275-0023, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1480-2840","authenticated-orcid":false,"given":"Gota","family":"Kawai","sequence":"additional","affiliation":[{"name":"Faculty of Advanced Engineering, Chiba Institute of Technology, 2-1-1 Shibazono Narashino, Chiba 275-0023, Japan"},{"name":"Graduate School of Engineering, Chiba Institute of Technology, 2-17-1 Tsudanuma Narashino, Chiba 275-0016, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Suzuki","sequence":"additional","affiliation":[{"name":"School of Medicine, Yokohama City University, 3-9 Fukuura Kanazawa Kanagawa, Yokohama 236-0004, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Yokohama City University, Yokohama 236-0004, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoji","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Department of Pathology, Yokohama City University, Yokohama 236-0004, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.jff.2017.09.043","article-title":"Functional evaluation of yuzu (Citrus junos) extracts containing limonoids and polyamine for life extension","volume":"38","author":"Minamisawa","year":"2017","journal-title":"J. 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